They're not sure about the antigen that triggers psoriasis vulgaris. I've seen LL-37, an antimicrobial peptide produced by keratinocytes, mentioned before as a possible trigger. Then it's the usual: DC to lymf nodes, T-cell activation although I would argue it's both Th1 and Th17, migration to the skin, inflammation. Can't remember which molecule, but probably a T-cell produced interleukin (12, 17, 21 or 22) stimulates keratinocytes to proliferate which causes hyperkeratosis which in turn causes even more LL-37 and cell components which further trigger the immune system

@@Bolcjek Thank you so much