Ramanan Laxminarayan: The coming crisis in antibiotics

Рет қаралды 105,083

9 жыл бұрын

Antibiotic drugs save lives. But we simply use them too much - and often for non-lifesaving purposes, like treating the flu and even raising cheaper chickens. The result, says researcher Ramanan Laxminarayan, is that the drugs will stop working for everyone, as the bacteria they target grow more and more resistant. He calls on all of us (patients and doctors alike) to think of antibiotics - and their ongoing effectiveness - as a finite resource, and to think twice before we tap into it. It’s a sobering look at how global medical trends can strike home.
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Пікірлер: 177

@dapartyrokr 4 жыл бұрын

Who’s here after his interview during Corona in India 2020 ?

@bangaliwork2810 4 жыл бұрын

very few, because neither the video has gone viral(which i think it should, though its too late) , nor we are too keen to agree with him since he is ONE against HUNDRED..having sleepless nights after watching his interview.

@sanchit7225 4 жыл бұрын

@@bangaliwork2810 lol he's an economist not a doctor. He has a PhD is economics. Chill.

@bangaliwork2810 4 жыл бұрын

@@sanchit7225 Thanks for enlighten me, really appreciate your comprehensive knowledge.And just to put things to perspective, yes I do want him to be proven wrong in his facts

@sanchit7225 4 жыл бұрын

@@bangaliwork2810 things will get bad no doubt about that. We all know it. But the credibility which he used to get the interview was wrong. And what he said is being said by all the doctors already in India. Take care bro

@bangaliwork2810 4 жыл бұрын

@@sanchit7225 Thanks and you too.As per the credibility goes I am sure it is the people like Karna Thapars, Barkha Dutts who have got in touch with him and not the other way round for these interviews.Also at least on you tube not even a single person have been bold enough to come up with such a magnitude of destruction which is on our way.It definitely can back fire and especially in a country like India but he still has gone ahead and shared his point of view.Also just to quote Dr Fauci, We'll be thankful that we're overreacting.

@OnlyKnowsGod 9 жыл бұрын

As a microbiologist ive known about this topic for some time. I think that the best course of action would be to:- 1)Restrict production of antibiotics to goverment run production facilities that would make sure that quality and use was maintained and that sales to only autorised people or institutions could occur. 2)Stop all use of antibiotics on plants and animals for human consumption. 3)increase production and research into vaccines for common bacterial infections. 4) increase research into immuno enhancing drugs to help fight infection before having to use antibiotics. 5) make a statutory rule preventing antibiotic use before species identification has been identified, thus ending the use of broad spectrum antibiotics. 6) make the sale of antibiotics without clinical diagnosis a violation of WHO and punishable by finanshal sanctions implimented by the world traid orginisation and the UN. This may seem abit of an over kill but there are many countrys that allow sales of antibiotics in pharmacys without a doctor being present and this is a matter of goverment policy that they have allowed free sale of antibiotics somthing they wouldnt do with othrr drugs.. But all you now know from watching this vid resistance to antibiotics spreads and effects other populations not just your own. I know many will see these surgestions as an attack on civil rights; but remember bacterial dieases dont care about individual rights nor respect boarders or age or how rich or poor you are. There never ending flight to infect and kill all humans on the planet keeps on going and thus the human race must act together in one voice to slow there spead.

@mickelodiansurname9578 9 жыл бұрын

Or stop using the antibiotics nation by nation....at which point the bacteria would revert to their wild variety since the selective pressure would be reversed and immunity to a drug is a very expensive trait for any organism if the drug is no longer present.

@kakashi76767 9 жыл бұрын

You don't have to be a microbiologist to have known about this for a long time.

@farvision 9 жыл бұрын

Why should we listen to someone who "only knows god"? Doesn't that announce to the world that you have "faith" that everything will work out ok? Maybe it's time to drop that name or at least begin to think about how beliefs in mythical beings has severely damaged our ability to respond to crises like this one. In other words, your user name is supporting the ignorant people who scream that evolution doesn't occur. Of course that muddies the waters so that the solutions you are suggesting get ignored.

@mickelodiansurname9578 9 жыл бұрын

***** Erm... yes it does work.... coding is lost as well as created in several ways.... by subfunctionalisation, neosubfunctionalisation etc during duplication... in other words the bacteria returning to their wild state really do lose the resistance from their DNA... the coding literally goes away... its deleted...as if it never existed in the first place...its not just put aside as junk DNA or non expressed genetic data.... its lost or overwritten... You are thinking of the fact that humans for example retain the coding for tails, and gills etc. and that's true.... but if a selective pressure was put on humans to use a tail again it is not written in stone they would use the coding thats present ... this is after all a totally blind process. A good example of that on a macro scale is the dolphin.... yes it managed to grow a tail over millions of years.... but it did not use the preexisting DNA already present to do that... it had to literally recreate new DNA.... new DNA that when expressed in protein coding created almost the same tail from a visual perspective....... (except with obvious differences to fish since a dolphins tail as a mammal is inverted 90 degrees). Now the reason the dolphins tail is inverted 90 degrees is because fish move by having the ability to move their spine sideways.... only mammals can move their spine up and down.... so this is what was used rather than the existing code... The selective pressure was for re-coding of the spine as it stood when the dolphins ancestors took to the rivers and sea... the same result... different solution... In the case of bacteria as relatively small animals in an open environment they would of course then recreate the resistance (likely using the same functions if they were available) if the drug was reintroduced.... but that would take more time if the functions were utterly overwritten or discarded.... so a rolling plan of introduction and removal of the long list of antibiotics is at least a workable plan... It might however have a downside in that doing that repeatedly might create even more superbugs with an overall resistance to the entire modus operandi of antibiotics.... that would be bad for us at least.... But the fact remains that bacterial infection was really bad in a world with 1 billions folks and when it took two years for a letter to arrive in the UK from India.... its would be an absolute nightmare if it got hold in the middle of the 21st century when it might take 4 hours to get from Delhi to London...

@Pachinko1 9 жыл бұрын

Extremely relevant and thought provoking. As a survivor of meningococcal B in 1998 I believe antibiotics saved my life. A life without the ability to pay for antibiotics is frightening!

@albertzhou1653 4 жыл бұрын

Watching this for biology in school, found it interesting, would recommend, 4 out of 5 stars.

@neomedicine4422 7 жыл бұрын

Thanks for your presentation, sir! It was a great honour to meet you on ESC this year!

@TheDrunkardHu 9 жыл бұрын

finally, an idea worth spreading!

@kartiksv5643 4 жыл бұрын

Very good talk and eye opener for common people who have little knowledge on huge profits that pharmaceutical company does. Few idea are thought provoking

@MirzaAslam786 4 жыл бұрын

Came here after wathing his interview on projection of coronavirus cases based on some methematical models....

@redribbon9432 4 жыл бұрын

I m very scared because of him😭😭😭

@MirzaAslam786 4 жыл бұрын

@Raj Tiwari kya hua bhai Kyun gaali de rahe ho

@sagarshetty3175 4 жыл бұрын

Lol. KZfaq algorithm. But don't be scared . You will weaken your mental state. You must be mentally strong at this time. 2ndly don't hoarde supplies and masks.

@pranav1709 6 жыл бұрын

We are living in times where the main pillar of modern medicine, antibiotics, is collapsing due to the growing problem of resistance. We are in a post-antibiotic era. I contracted an antibiotic resistant infection in my prostate and had multiple failed treatments with 5 different antibiotics. Thats when I came across phage therapy and that saved my life by helping me eradicating the infection and recover my health. Since then, I have across so many people with infections similar to mine where antibiotics fail to eradicate bacterial infections. Alternatives like phage therapy need to be highlighted more.

@TopLass1 9 жыл бұрын

I am a pharmacist and the over prescribing of antibiotics staggers me on a daily basis. We get whole families prescribed them because the all have the common cold. I asked one GP why he did this and he said "Oh well they expect them".

@sn-7754 4 жыл бұрын

Give them antihistamine or codine not antibiotic !they fell way good with this drugs then antibiotics .just be rational man.

@SuperFarmerben 9 жыл бұрын

As farmer managing herbicide resistance, I found this presentation very interesting. I would like to see an international chemical resistance conference. The agricultural industries have found some innovative ways to manage chemical resistance and I'm sure other sectors have too. Sharing success stories may inspire some creative ideas.

@miketothe2ndpwr 9 жыл бұрын

I know it''s actually coming but I've been hearing about this for 15 years.

@benderbg 9 жыл бұрын

I went to the doctor the other day (symptoms were pain when swallowing, fever). Asked him to prescribe my usual antibiotics but he said that those are no longer good and gave me the new ones that treat new bacteria better. The new pills cost about x4 more than the old ones. I might be crazy but there is a spark in my mind saying to me that all this might be some big plan for pharmaceutical companies to plunge us with higher cost medicine.

@MrDaddynomates 9 жыл бұрын

Not another conspiracy theory Lol

@Loilane 9 жыл бұрын

Antibiotic resistance and the selective pressure imposed by the agents on bacteria are a real phenomenon. It is effectively the same scenario as what we have done with domesticated animals. In dogs, for instance, we, humans, have selected for behaviour, size, fitness, type of coat etc by only breeding those pups that showed the desired characteristics. In antibiotics case, the bug that displays the strength against the agent and survives is allowed to reproduce and pass on this characteristic on it's offspring. In your case, what might have happened, is that the new antibiotic you are taking is actually a mix of several agents, old and new, cheap and expensive. This mix maximizes the possibility of killing everything, tackling the problem in multiple ways, such that the chance of anything surviving and developing resistance is significantly minimized. It is much cheaper for your and for the rest of us to deal with the problem now, even it is more expensive than what we used to, than to try and do it in the future, where it will be orders of magnitude more expensive.

@Mtaalas 9 жыл бұрын

Or you should stop taking antibiotics to a simple flu/cold... damn it people... that's exactly why antibiotic resistance is a problem!

@jamesward5402 9 жыл бұрын

Theres no doubt that big business will adapt to maximize profits in response, however a number of independent medical organizations throughout the developed world agree with the concern of antibiotic resistant drugs through over-perscriptions. Its much like global warming --certain companies and governments will use it for financial gain, but it doesn't detract from the authenticity of the issue.

@lionlol 9 жыл бұрын

The doctor should have sent you home and told you comeback when you're dying.

@VikasSharma-vt4kl 3 жыл бұрын

Super interesting talk! Interesting insights!

@NoobMaster-or2jf 4 жыл бұрын

Who's here after the Karan Thapar show?

@samt1705 4 жыл бұрын

bacteria festering in wounds is because of excess sugar in blood coming out of the modern carb heavy diets. As a solution to heal wounds, do 5 days fasts to get your immunity into order combined with autophagy. To prevent any trouble with wounds, one should remove all sugar/fructose from diet first and start low carb, high fat (LCHF) intermittent fasting. Also, practice Wim Hof breathing and cold shower method. Consult experts, I speak from my experience, but I'm a layman. Peace. ✌🏼 #lchf #IntermittentFasting #KetogenicDiet #Autophagy #Diabetes #SugarIsPoison #AvoidGrains #WimHofBreathing

@mohammedsaleem961 4 жыл бұрын

I am following

@florinapostoiu 4 жыл бұрын

Wherever money, profit and business are involved, sooner or later (without exceptions) human stupidity will prove to be bigger than the universe itself, even if eventually it will lead to unconscious self sabotage.

@carsreview7729 4 жыл бұрын

Doctorate in Economics is good enough to teach and talk about antibiotics

@bobbyaiyer1037 9 жыл бұрын

Nice talk. Understanding the comparison he made between this and Peak Oil is significant, but also flawed. Oil is non-renewable, but we have also found a solution to it- renewable energy- which is all but widespread as of now. Once renewable energy becomes a widespread energy source, fuel-shortage related of problems will be minimized vastly. However, like he said, nature will adopt. If we develop new antibiotics, nature will find a way to counter them. He was promoting that idea, which is ridiculous. We need to curb usage of antibiotics, and implement ways to make nature adopt at a slower rate. For example, introducing probiotics and symbiotics around 80 years apart will mean that these two medical cures will both serve til the end of their respective useful lifespans, and can be replaced. This will mean that we can solve 80 year of antibiotic usage per new discovery. Of course, this is only short term, as sources to produce these types of medication will become limited and in my opinion, genetic changes to prevent infection will become the thing of the future.

@edi9892 9 жыл бұрын

A related problem is that treatments are stopped to early due to a lack of funds this helps diseases like Tuberculosis in particular as it requires relativly long continues treatment.

@angelikmayhem 9 жыл бұрын

(8:15) Even in a lecture ABOUT antibiotic abuse, we can't talk about the fact that The Flu is a virus and not a bacteria -- thus the antibiotic has no effect. He'll mention that Flu season drives this abuse skyward, but refuses to say specifically that antibiotics have no effect on the flu. In fact, later on (12:50), he actually lists antibiotic resistant viruses as a problem facing the world. He also talks about flu vaccinations but fails to reveal that flu vaccines only innoculate you against four to eight of the millions of strains of flu in the world, and are localized to your specific area (meaning if you travel then your shot is worthless to you). Gotta make that dough, baby!

@universeofopulence 4 жыл бұрын

.... phew... thanks...😢

@drnv150 9 жыл бұрын

Mayo Clinic published a report saying close to 96% of sinusitis issues are fungus related, yet almost every single ENT doctor prescribes antibiotics. I am not in any medical field, yet I see things done in the medical industry, that appear to be done just to make profits alone. I have never fully trusted doctors because of articles I read, personal experiences and the astronomical prices. I do think technology will provide treatments, I just hope we will afford the costs.

@meritapetelo3599 5 жыл бұрын

should we be satisfied about the appearance of superbugs? I hope someone will answer my question before 12 this sunday

@JtheArgonaut 9 жыл бұрын

Simple solution to the problem: invest in lawnmower.

@MrSlatra 9 жыл бұрын

I see antibacterial soap everywhere, these days. It's basically being poured into our waste water. Something like that *should* be cost prohibitive to people that do not need it.

@MrSlatra 9 жыл бұрын

Don't get me wrong. Some folks *need* it, but they are few and far between. Doctors, Transplant Recipients and people with immune deficiencies to name a few. However, watch and see how often you see the stuff, especially as your area heads into flu season.

@Jack_Tilstone 9 жыл бұрын

Antibiotic taxes? i dont think he's thought that one through

@TheVera9966 4 жыл бұрын

Doctors play an important role when prescribing antibiotics to patients when there is no necessity of it.

@lxc647 9 жыл бұрын

Good thing someone discovered something that can destroy the superbacteria's immunity to antibiotics! Not sure how that's coming but I saw it in the news half a year ago.

@lxc647 9 жыл бұрын

Mick Wright I'm talking about a fungus people discovered in nova scotia that can reverse most of the baterias' resistance to antibiotic. They've tested it on lab rats but not on humans yet.

@mickelodiansurname9578 9 жыл бұрын

David Chen Problem is that would be something that would create selective pressure on bacteria and eventually (sooner rather than later) the bacteria would have a resistance to it.... now you might say it reverse the resistance... but the resistance to resistance is also a selective pressure. In biological terms anything introduced into the system that that alters the populations DNA is a selective pressure... this included... whats needed is something that cannot be considered a selective tool.... something that cannot be used by the bacteria to mutate their way out of the problem.... Thats difficult I grant you but not impossible. All it needs to be is something that has zero effect on the bacteria genetics, that has a near 100% fatality rate and is a physical barrier to reproduction ....

@iluan_ 9 жыл бұрын

David Chen That fungus is called Aspergillus versicolor and the substance is called Aspergillomarasmine. Besides the obvious problem of selection that Mick Wright mentioned there is a couple issues with the way it works that restrict its widespread use. Firsth it only works with for a kind of antibiotics called carbapenems, and as far as I can tell it would only work in gram negative bacteria. That is because wath Aspergillomarasmine does is to inhibit the action of a protein called metalo-beta-lactamase (mlb) wich is responsable for carbapen resistance; that is because mlb needs Zinc to work and Aspergillomarasmine deplets Zinc without hurting anything else (at least in rats). For normal beta-lactamases (normal= can't fight carbapems, but also don't require any metal to work) this would be useless, and there are already some betalactmases that use Iron instead of ZInc so Aspergillomarasmine just wouldn't do the trick. It would still be usefull for treating patients with severe cases, but for most widespread antibiotics it would be useless.

@mickelodiansurname9578 9 жыл бұрын

iluan Hernandez Wasn't aware of either the drug or its limitations... you learn something new every day. However you raise an interesting point in that perhaps the entire model of searching for anti-biotic armament is simply not going to work.... to my mind its a Chinese finger puzzle in that the more ammunition thats expended on the issue the more intractable it becomes. Maybe more resources should be expended nanotechnology the heck out of bacterial infections... let the patient get infected... who cares if theres an army of microscopic tissue repair guys waiting in the bloodstream to simply repair the damage... or even act a decoys... and if the patient is not symptomatic and there is no harm to them....then in fairness who cares if they have a heap load of infectious organisms crawling all over them.... We have that now anyway and most folks don't realise it. Half the human body is other living things....and nobody cares... in fact being truly strict about the thing even mitochondria are not originally human or even mammalian... Anyway I digress..; If physicists in that field are as bright as I suspect they are then incorporating a little bioinformatics into the nano-tech would make them a predator in the bacteria's environment (the human body). They too could be allowed to evolved there in an arms race with the bacteria that will eventually balance out. Of course creating an entirely new artificial organism that is now also susceptible to the general laws of evolution would open a can of worms that would be a real pain to put the lid on....

@changemakers1402 4 жыл бұрын

How to access his research papers.

@redribbon9432 4 жыл бұрын

I m very scared because of him😭

@NavaVive 9 жыл бұрын

I suppose the real problem is we've used antibiotics as a handicap, we're behind in giving our immune system a chance to evolve as well, or maybe not who knows till we know.

@gandalfthegreatwhite4393 9 жыл бұрын

Making money or saving lives .... Which is more important to pharmaceutical companies? Which would you choose? The _"incentivized"_ choice is as simple as an old fashioned robbery: *Your money or your LiFE?!"*

@jennichastain1548 6 жыл бұрын

PREACH!

@Astrolime 9 жыл бұрын

Too bad Pharma companies don't see antibiotic development as profitable. :(

@angrysloth 9 жыл бұрын

where can i buy a vest thing like that

@angrysloth 9 жыл бұрын

wait is that a tunic

@universeofopulence 4 жыл бұрын

...u can buy it in india..it's quite commonly worn in all of south asia.. maybe s.e.asia too.

@z0rdic99 9 жыл бұрын

Use antibiotics as a last result and if you ever use it, make sure you finish the whole thing, so that bacteria won''t develop resistance.

@TheVera9966 4 жыл бұрын

Be aware of China, related tradeable permits. Development of new antibiotics is of the pharmaceutical industry interest, because they make money..

@jasonale 7 жыл бұрын

Lmao "from that famous dinosaur movie"

@jitendervashisht8041 4 жыл бұрын

Dr. Ramanan Laxminarayan .....your controversial interview on Covid 19 and India...shame on you man...where your numbers stand now..

@jordi9844 9 жыл бұрын

did he just mis used the evolutoin theory ??

@Nerfe3d 9 жыл бұрын

$£€¥₩? Can we leave money out this is sad to think that we need to jack price up to save lifes. We should educat more, lol this idea will not maje money for those drugs company but it will save lifes regardless of rich or the poor. I know I going to reply form many say I am an idiot and so on but I believe knowledge and education will fix the problem we facing in the world.

@sangouda1645 4 жыл бұрын

He ended his speech with picture of coronavirus, interesting...

@sagarshetty3175 4 жыл бұрын

Thats general picture of virus lol.

@sangouda1645 4 жыл бұрын

@@sagarshetty3175 nope, a picture of coronavirus family of viruses

@sagarshetty3175 4 жыл бұрын

@@sangouda1645 you think only corona virus family looks like that?

@Kongolox 9 жыл бұрын

thats just stupid! Increasing the price or putting a tax antibiotics usage is really a bad thing, if u want ppl to use less antibiotics u need to educate them more and focus on preventive medicine and good and balanced diet.