Description of excitation contraction coupling... how a neuronal signal causes a muscle fiber to contract. Recorded at Glen Oaks Community College, Centreville, Michigan by Dr Ren Allen Hartung.
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@carlaparsons18556 жыл бұрын
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@1tippytop12 жыл бұрын
I have been studying and trying to understand excitation contraction coupling for the past 2 weeks..I had ALL the correct pieces to this puzzle, but I just couln't see the whole the picture. It was driving me crazy..especially since I knew this is going to be on the final...I watched your video the first time and BAM!!!...it just clicked...sometimes it just takes another perspective..You truely have a gift..Thank you so much!
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@CoimbatoreCulturalClub Жыл бұрын
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@gentlestormwyatt8 жыл бұрын
Amazingly explained. This helped for my final for tomorrow. Thanks
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@jdoll121212 жыл бұрын
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@MsGemmaRichards11 жыл бұрын
Thank you very much, incredibly helpful in explaining in better detail than a 50 min class lecture!
@marrrio1411 жыл бұрын
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@stevespassport12 жыл бұрын
I am currently taking A & P at a very respected college but if you were to offer online classes I would opt for your classes in a minute. I really appreciate the understandable way you present. Thank you for all your work. I think Glen Oaks would do well to offer an online program with you teaching. Sincerely, Steve
@tucho88810 жыл бұрын
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@amandam13899 жыл бұрын
I'm writing a short essay on excitation-contraction coupling and unfortunately was extremely confused & had no idea where to start -- there's a lot going on! Your explanation made it a lot clearer! Thank you!
@deegonzalez647511 жыл бұрын
Thank you so much! I could hug you! You made this so clear and understandable! Please don't stop what you are doing, it has helped me tremendously!
@renhartung12 жыл бұрын
@MissShenava -- I'm not aware of any mitochondria in the synaptic cleft, however there are plenty of mitochondria inside of the presynaptic and postsynaptic cells. They are needed in order to have enough ATP to power exocytosis by the presynaptic membrane (exocytosis is a form of active transport). In the postsynaptic cell ATP is required by the sodium/potassium pumps that help set up and maintain resting potential. I'm sure there are more reasons, but those come to mind first.
@Lorgirl61412 жыл бұрын
This is an awesome explanation! I wish my instructor was so clear and concise as you! Thank you for helping me study for my test! :)
@tcstcyoung12 жыл бұрын
Great videos! I especially appreciated that you pointed out that the next video, sliding filament theory, picks up where this one left off. I am enrolled in a hybrid course on A&P and your videos have helped me where the course lacks in lecture material! Thank you for taking the time to make these.
@sensualberry699 жыл бұрын
This was so awesome and helped me understand it much better than how my teacher taught it… thank you
@LarryJ27KC10 жыл бұрын
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@alexandergugala699010 жыл бұрын
You taught me more than my professor and my TA combined
@aapland98711 жыл бұрын
Thank you! Very clearly and thoroughly explained, helped me study for my Anatomy final. I enjoy your videos!
@eg77379 жыл бұрын
Thank you for helping me understand this.
@mikulaskozar34045 жыл бұрын
Great video. Better lecture, than from my biology teacher.
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@khadijaalbalushi461610 жыл бұрын
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Just awesome i am struggling with this topic and i pretty much confident about it for my final exam tommorrow..
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@renhartung11 жыл бұрын
Acetylcholine is a neurotransmitter for skeletal muscles (somatic motor pathways) but is also used in both sympathetic and parasympathetic innervation (autonomic motor pathways). Norepinephrine is a neurotransmitter that is used in the last step of a sympathetic autonomic motor pathway. Complicated enough for you :)
@deathnotelover1110 жыл бұрын
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@lililankarani130710 жыл бұрын
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@skrozneobican11 жыл бұрын
Thank you professor!
@cherry16pie0811 жыл бұрын
This was so helpful!! Thank you!!!
@renhartung11 жыл бұрын
Calcium ions are at higher concentration outside of cells. Cells tend to pump Ca++ outside of their membranes (and into their smooth endoplasmic reticulum). So, the fluid around the axon terminal is where the Ca++ comes from :)
@saraloveee11 жыл бұрын
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@rosapiie12 жыл бұрын
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@yellowtough10 жыл бұрын
Thx doctor!
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Thank you!
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@MsDellydell12 жыл бұрын
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@renhartung11 жыл бұрын
Yes, the Ca++ entering the axon terminal activates motor proteins involved with exocytosis of the neurotransmitter. If you want the details on how this works take a look at the wikipedia page on exocytosis.
@sakanablesakanable11 жыл бұрын
tHANK YOU SO MUCH...
@ludaludamartini276611 жыл бұрын
Thanks!
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@nuuuyuyui11 жыл бұрын
Thank you :) It was very helpful :D
@yaseenme_4 жыл бұрын
9:23 for the rundown
@myambition23135 жыл бұрын
nice explanation. Thank you
@SixxFootThree11 жыл бұрын
I'm heading over to Wikipedia now. Thank you sir !
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@AngieAPoku7 жыл бұрын
wow! a very nice video
@Pinkbun1712 жыл бұрын
I'm taking A & P in my third year in high school, and I gotta say this stuff is confusing! But thanks for explaining!
@renhartung11 жыл бұрын
There is not really a relationship between Parkinson's disease and the neuromuscular junction. The tremors are actually initiated up in the brain where the actual problem appears to be. The only relationship to the neuromuscular junction is that motor areas of the brain are sending signals to those junctions leading to the tremors that the person experiences, but those signals appear to be due to an imbalance of neurotransmitters happening in those motor areas rather than at the junctions.
@formosawest10 жыл бұрын
great video. would have liked a more thorough explanation... of course this is only partially complete/true. As this process differs slightly in cardiomyocytes vs skeletal muscle cells.. i was hoping for a description of cardio-selectivity in Calcium channel blockers, versus non-cardioselective dihydropyridines... and specifically how the excitation-coupling process differs in these two places... One is calcium induced calcium release at ryanodine channels (as is shown here) and the other is mechanical induced ryanodine channel calcium release. ...id like to know more about that please.. if you get a chance to expand on this topic. Andrew
@umerbinshabir65615 жыл бұрын
Who is watching it in 2018
@SixxFootThree11 жыл бұрын
Dr. Hartung, after watching this video segment i'm guessing that Tetanus would also prohibit the breakdown of AcetylCholine in the Synaptic Cleft i.e. similar to your nerve gas example.
@renhartung11 жыл бұрын
Yes, as I understand noradrenaline is another word for norepinephrine and vise versa :)
@renhartung11 жыл бұрын
There is no direct relationship between ACh and Ca++ that I am aware of. Take a look at my other video on the sliding filament theory to see where Ca++ comes into play in skeletal muscle contraction. You are correct about smooth muscle. For smooth muscle Ca++ comes into the cells from the outside during contraction. There is also other differences between skeletal muscle and smooth muscle contraction.
@AliJ2311 жыл бұрын
I thought the right speaker in my headphones was broken. :/ Thanks though it was very helpful!
@renhartung11 жыл бұрын
Nope, actually tetanus has its effects by a different mechanism. It damages motor neurons that send inhibitory signals affecting muscle contraction. Without the inhibitory signals muscles tend to stay contracted. Wikipedia has a good page on tetanus. Take a look if you have time.
@yaseenme_4 жыл бұрын
nice vid
@marcelasafarova462511 жыл бұрын
I like this video, it´s really helpful, but there is one thing I don´t understand and I can´t find how it works. What happend when Ca++ comes into axon, how it is possible that it starts exocytosis ?
@renhartung11 жыл бұрын
Thank you. I was not aware of this. I looked up a few papers on it and it looks like the majority of fibers innervating eccrine sweat glands do use ACh. A good review can be found... Shebasaki, M. et al. Neural control and mechanisms of eccrine sweating during heat stress and exercise. American Physiological Society. 2006. PMID: 16614366
@JackhammerNOR11 жыл бұрын
Hello! Is it possible to make a video of the t-tubule system? I heard you mention it in a video, but I can't find it explained.
@MissShenava12 жыл бұрын
There are mitochondria present in the synaptic cleft, why are mitochondria essential for for the transmission of impulses across the cleft for muscular contraction? Thanks
@shuFFlerIam11 жыл бұрын
Where did the Ca++ in the motor neuron part come from? Thanks
@jackieee16111 жыл бұрын
Is norepinephrine the same as noradrenaline?
@CamilaChannel9 жыл бұрын
Awesome thank you! I have one question.. which way does sodium and potassium rushes in and out? And how much of each?
@renhartung9 жыл бұрын
Sodium rushes into the cell and potassium rushes out, there is no specific amount though. It's more about the charge changes that their movement creates. Take a look at videos that cover membrane potentials (resting potential and action potentials) to get a better idea of the importance of these ions.
@CamilaChannel9 жыл бұрын
Thank you so much! Yes I was getting the resting and action potentials mixed up!
@siraat-e-ishq7 жыл бұрын
How equilibrium potential of any particular ion achieved? Why the resting membrane potential is much close to Ex to Na ??
@titislukita11 жыл бұрын
is there relationship between the neuromuscular junction with Parkinson's sufferers who experience tremors?
@Tpainkiller2113 жыл бұрын
I thought the 90mv is the resting potential for nonexcitable cells..according to guyton's book the resting potential for excitable cells is about 70mv.
@25zsams11 жыл бұрын
I have learned that acetylcholine is a parasympathetic neurotransmitter. then how come in this case, it stimulates contraction, which is sympathetic response? I am assuming that the muscle you drew is not a skeletal muscle. I m probably wrong, so... thanks!