Rheumatoid Arthritis Pathophysiology (signs and symptoms)

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8 жыл бұрын

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@_ahab2012 5 жыл бұрын

-Macrophages start by releasing cytokines, TNF-alpha , IL-1 , IL-6 that lead to inflammation. - cytokines stimulate fibroblasts (synoviocytes) , which results in activation, and proliferation. - Synoviocytes will stimulate RankL expression, which will lead to the stimulation of osteoclasts with the aid of cytokines. Which will lead to bone erosion . - Proliferation of fibroblasts also result in creating proteases, which leads to cartilage breakdown (degradation), cartliges also secrete proteases. - When the fibroblasta are activated, they can travel from joint to joint, and this is how you get symmetrical arthritis. (Like in right and left hands). - T-cells, (immunity cells) which are thoroughly present in the synovium are resposible for promoting inflammation by secreting IL-17 (cytokine) which promotes macrophage activity so it....etc. - They also help in expression of RankL that .....etc. - Plasma cells are responsible for inflammation too. Through cytokines and antibodies. - Neutrophils in the synovial fluid also contribute to inflammation because they release proteases and active oxygen species which will affect in bone and cartilage erosion. - Immune complexes (antibodies) which are a feature of rheumatoid arthritis , they bind to one another and promote inflammation - Angiogenesis is affected by increasing the vascular pemeability by cytokines which will result in migration of all these cells into the joint. - Rheumatoid arthritis also affects other organs due to increased inflammatory cytokines , skin: nodule formation, liver: anemia, cardiovascular diseases: stroke, myocardial infarction. - Rheumatoid arthritis occurrence has unknown reasons but there are theories that suggest that genetics, smoking, and specific bacteria ( porphyromonas gingivalis) that are present pre RA are responsible for the appearance of the disease, these can lead to modifications in body’s antigens, which will make them seem foreign to the immune cells leading to an immune response, or by injury that leads to inflammation, and then lead to antigen modification. this is the first step of the pathogenesis of Rheumatoid arthritis..

@elena.derm1 8 жыл бұрын

You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!!

@MrZalada 7 жыл бұрын

AHAHAHAH Pethana!!

@elena.derm1 7 жыл бұрын

***** με ποιο πραγμα ακριβως?

@elena.derm1 7 жыл бұрын

***** ποια συνωνυμια? :P

@MrZalada 7 жыл бұрын

Εχω μια συμφοιτητρια Elena KK κι ημουν σιγουρος οτι ηταν αυτη.

@elena.derm1 7 жыл бұрын

***** ααα οκ

@ammerrstf838 6 жыл бұрын

I've nearly finished the pathology book and read articles but still felt like I hadn't grasped the entire pathophysiology behind some diseases, including RA. Thanks for this Amazing overview

@LWalks64 3 жыл бұрын

Brilliant. I have had RA for 24 years and also a medical professional. People with RA know all too well the agony and frustration of living with this multifaceted disease that some may minimize into almost a trivial process. I appreciate your video as it eludes to anything but that. Thank you for your thorough explanation and demonstration.

@ushasehgal2816 Жыл бұрын

Very nice video but what is the treatment of this Arthritus

@ENFPerspectives Жыл бұрын

People can see how it moves the bones, criples amd deteriorates them. How could they not think its anything but extremely painful?

@praveenarao2582 Жыл бұрын

Thank you 👍

@dropdeaddown69 11 ай бұрын

How are you at present? How you managed your RA? What kind of treatment you went through? Can you plz lemme know I would be grateful for that .

@MadradiRudy Ай бұрын

Cupping therapy in your hand can help

@lengde16 6 жыл бұрын

You're a very important man for a Med student, from anywhere in the world, with a very unique gift of drawing and conversing. Please take care of yourself :) And just as always, awesome work!

@rittenbrake1613 5 жыл бұрын

😂😂😂😂😂” please take care of yourself “

@savankate7239 3 жыл бұрын

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@azimhashim1709 2 жыл бұрын

All Thanks 🙏🏿 To #drode on KZfaq were I was able to Cure my Rheumatoid arthritis problem completely with Herbal medicine

@Melike-hi7qt Жыл бұрын

how u doing now mate

@RenegadeRanga 7 жыл бұрын

Awesome video which I will have to re watch numerous times.

@ViolinMD 2 жыл бұрын

Great video Armando!!

@belovedchaos1 6 жыл бұрын

This makes a lot of sense... both from testing and symptoms to reasons for swelling. Much appreciated!

@majaber1 Жыл бұрын

" You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!! " I couldnt have said it better than below comment...thank you Armando, your the absolute best at making medicine understandable.

@LatFlare 5 жыл бұрын

Well-explained with beautiful, easy-to-understand illustrations. Thank you!

@randayousif8887 8 жыл бұрын

OMG 😮 I have an exam about RA tomorrow and your explanation helps me alot thank very much sir!

@BunnyNevermore 7 жыл бұрын

u helped me when I took anatomy & again then with physiology & once again, here ur helping me to understand exactly what is happening with my hands/joints as I have recently been diagnosed w/RA. thank you so very much!

@Happy-healthy-holistic 3 жыл бұрын

Allopathy can’t cure you. And overtime you will be made to depend on immune suppressants, then comes the complications of the medicine, then surgery and you will be ultimately exhausted of hospital visits! Start on traditional or alternative medicine, follow a healthy food and lifestyle. I was earlier diagnosed as having rheumatoid arthritis, SLE. Now, I got my RA test become negative with homoeopathy. Rheumatologist and an Orthopedician were completely surprised as according to allopathy, once RA factor becomes positive, it will remain so forever. I too was surprised and enquired the lab to recheck if there was some mistake, they gave the sample to another lab and I got the same negative result. I have been on homoeopathy for many years. Take care. I’m still on crutches but improving over time. Much better than 5 years back. And that pain which was there every second even at rest has turned out to be almost nil at rest... but still have it while moving and is tolerable. My movements were greatly restricted to the extent that someone should help to even turn around in bed but now I can do it myself and from past 1 month, though a little difficult I am able to get up myself and go to toilet with the crutches. I had severe digestion problems too that I always vomited some of what I ate every time but now... there is almost no vomiting but still have belches. Hoping to return to complete normalcy soon. I am not on any other medication. Wish you get well soon.

@lEmiliee 6 жыл бұрын

First year medical school here ; You just saved my life. A M A Z I N G video and thank you soooo much :)

@TransformChantel 7 жыл бұрын

This is beautiful! I understand RA so much more better now. Thank you soooooooooo much!

@aayatprasad8111 5 жыл бұрын

Be blessed sir!! We medicos owe you for providing such beautiful explanation n pics to memorize!! 😇

@nadimsheikh 4 жыл бұрын

I have never come across a better teacher all my life

@mrsamandabernier 3 жыл бұрын

I think this might be my favourite video on KZfaq, wow. Thanks.

@MrPrincebass99 4 жыл бұрын

Clear and simple explanation of a complex disease. Well done!

@rickfearn3663 2 жыл бұрын

Exceptional clarity. Images and words provide a clarity not possible with other pedagogies.

@lvdigitalart883 Жыл бұрын

You have no idea how much this just helped me!! Thank you for this absolutely beautiful presentation.

@IHaveMagicPowers 3 жыл бұрын

This made so much more sense to me in the context of bringing together immune and inflammatory responses. Thank you!!

@saidgd8744 7 жыл бұрын

Wow, just wow, thanks dude, you're awesome, you helped me so much for my med school work, greetings from Mexico

@promybari-hassan2982 6 жыл бұрын

This video was seriously the best!! Everything was explained simply!

@1015SaturdayNight 7 жыл бұрын

I only have some basic nursing knowledge and this is so easy for me to understand - you're an excellent teacher. I have this disease myself. Thanks for this video!

@donkeybenjamin 7 жыл бұрын

Excellent!!! It is really a very clear presentation. THANKS VERY MUCH.

@Azufer13792 8 жыл бұрын

Thanks, the video is awesome (and even clearer than many medical textbooks)!

@jakedejesa2173 3 жыл бұрын

I was tasked to discuss the pathophysiology of RA and I couldn't understand a thing. This helped me to thoroughly understand it. Thanks, mate!

@jingshen2165 5 жыл бұрын

Very impressive and easy to understand the whole picture of Rheumatoid arthritis. Thanks!

@halimcremer 4 жыл бұрын

thank you for this video, i just spent 5 hours reading review papers and text books trying to understand it and you did it so beautifully in 15 minutes. Thank you - you are amazing.

@arpita_ae9 4 жыл бұрын

Same here l was searching about the pathogenesis in different books and in internet but yes i finally understand it after watching this video. Sry for my bad english

@tastedpurple1492 4 жыл бұрын

same! I dont have a biology background until undergraduate but this video is soooo well made and easy to understand

@azimhashim1709 2 жыл бұрын

All Thanks 🙏🏿 To #drode on KZfaq were I was able to Cure my Rheumatoid arthritis problem completely with Herbal medicine

@aya-hh7db 10 ай бұрын

your lectures are life saving. thank you for your time!!

@franciscacuffy7136 4 жыл бұрын

You are an Awesome teacher, never understood my doctor, but I learned a lot listening. I have the swan neck. My doc told me I had a permanent hitch hiker thumb. I understood now what she was talking about. Thank up for helping me understand this disease. May God bless you always

@sofianetamine3060 7 жыл бұрын

fabulous explanation

@asmaagoda3925 Жыл бұрын

Excellent,simple illustration . Thank you

@ArthritisLife Жыл бұрын

So so helpful, thank you for this detailed and visually appealing explanation!

@proffezur 8 жыл бұрын

excellent, as usual

@ChewdaGum21 7 жыл бұрын

Zu Nobi

@marwamokhtar8469 4 жыл бұрын

Thanks alot for this brilliant and concise presentation , It takes much effort and time .

@vidyabijo6925 7 жыл бұрын

best video!!!!!! concise precise, covering everything except treatment and lab inv... pls make a second video to cover those parts tooo

@lisahowland144 3 жыл бұрын

wow what a superb vid! Easy to understand with great drawings. Much appreciated

@Abreutie 6 жыл бұрын

Thank you very much ! I'm listening to you from France, I have understood all of the video, it was really clear thanks !

@linkeongkimfunctionalfoodn2576 4 жыл бұрын

Fantastic work and easily understood! Thanks a lot.

@vibhamallikarjun 7 жыл бұрын

You are just amazing!! Thank you so much for making it so easy!😊

@shannonhendrix9520 2 жыл бұрын

This disease is so hard to understand and explain. Thank you for the very detailed breakdown!

@judithjara7584 6 жыл бұрын

Excellent explanation as always!

@divyaduggal5950 6 жыл бұрын

Beautifully explained!!!

@abdullahalimaykac4098 4 жыл бұрын

You are so valuable man bro I m watching this video in Turkey and normally my English is not so good you speak fast but I can understand nearly everythink actually you explain perfect please dont stop that send video

@user-kr5ed5rv7d 6 жыл бұрын

what a wonderful explanation. thanks again from Yemen Aden.

@kasunekneligoda2354 7 жыл бұрын

This was just awesome! Great clip :)

@desertfox8583 3 жыл бұрын

Great video. Really helps me with my studies.

@saifsharayah951 8 жыл бұрын

Armando Thank you so much !!

@sarahrtseidel Жыл бұрын

Amazing video and linking of the markers -> tissue -> symptoms!

@SaiwanMaerufSaiwanbio 7 жыл бұрын

Thanks for great video! , I hope you will prepare same video on Seronegative rheumatoid arthritis, and difference between seronegative and seropositive RA in immunological response .

@hanchybananchy 3 жыл бұрын

Really great explanation and summary! Thanks :)

@dextercardel5895 7 жыл бұрын

very well said sir! thank you for the nutritive information.

@yashvyas9979 7 жыл бұрын

what a video... awesome sir great explanation..!!!! thank you..!!!!👌👌

@ahmetcadrc5480 6 ай бұрын

Thanks for the work put in

@jessmfox 6 жыл бұрын

Your videos are incredibly useful. Thank you so much :)

@songokutan 7 жыл бұрын

Great video, your explanations are pretty nice!

@enikofulop794 7 ай бұрын

I saw this video so many times. No it's much more clear.. Thank you. ❤🎉😊

@pamparompa630 8 жыл бұрын

thanks for all of the information. love your videos please make more

@fei_studio_ 2 жыл бұрын

What a great informative video, thanks for sharing!

@MasinaTai86 6 жыл бұрын

Bravo!! Coming from a non medical student! Idk what T alphas, etc are but I'll rewatch this video until I've looked up all the terminology. I enjoyed your video although ofc I didn't understand everything, I could tell it was excellent explanation at least and got the gist (did have to look up a few definitions ofc).

@hamzamuhammadgm4749 3 жыл бұрын

Great sir .. I really like your explanation and way of teaching

@wonderjodocus 6 жыл бұрын

This video has helped me a lot. Thanks

@ishikawshalyab.a.d2768 5 жыл бұрын

Thank you so much it is really helpful. I got lot of ideas from that video, for my review article.❤️❤️

@madhumithra1962 5 жыл бұрын

Thank you, an awesome explanation with drawings

@AhmadSmairat 8 жыл бұрын

you are doing a great job. as usual, Thx a lot

@shkokurda2098 5 жыл бұрын

dude. weldone.you are realy realy amazing in presentation.despite the simplified coherent,conclusive information,your voice tones is too natural and not push on yourself thus makes listener relax and enjoy. thank you very much.

@umaanand4864 5 жыл бұрын

Very nice lecture on the path physiology of R A. Very easy to understand. Thanks.I have R A for 20 years. Your lecture explains lot of my questions .Thanks.

@naziahaidar762 2 жыл бұрын

How is life with RA?? How do you perform ur daily activities??

@gohiljayrajsinh-ju6pk 5 жыл бұрын

Thanks for this video will helping to study . Thankyou so much

@khushbuverma1539 5 жыл бұрын

I can relate everything as I'm experiencing the same thanks fr explaining..

@nmarvlonam9908 6 жыл бұрын

Thank you for your amazing videos doctor

@aathmikagovindh733 6 жыл бұрын

Thanks a lot this will help me in my upcoming individual presentation

@MammaCass 8 жыл бұрын

have you got such a dedicated video to the complication in rheumatoid disease when it affects the lungs, I've just been diagnosed with Ra interstitial lung disease

@christianemelki9413 7 жыл бұрын

what a champion!!! great video

@saravananpalanimuthu8793 6 жыл бұрын

Excellent video! Thanks a lot!!!

@charlesmunyoro633 6 жыл бұрын

Wow. Great video. Thanks a million

@vereda61 7 жыл бұрын

Great video. Thank you!

@hapilee5844 Жыл бұрын

I have RD and I thank you for a concise video that helped me understand my dis~ease😢

@pastor.petertnagarajurehob700 7 жыл бұрын

Exelant explanation very Good information for RA patients

@gooddoctor3286 8 жыл бұрын

great explanations!!!

@KristopherWilliams_tahmson 3 жыл бұрын

Excellent video! I have RA and am also coincidentally taking pathophysiology next semester. What a great opportunity to learn about my disorder while also preparing for the depth of pathophys May I ask what textbook you’re using for this information?

@Kim-ix6yv Жыл бұрын

Excellent video, thank you so much

@sergiopina3485 6 жыл бұрын

This is the best video ever! I love u

@olivergood1999 Жыл бұрын

great video, thanks for the help!

@tharahassan3316 7 жыл бұрын

that is great keep it up god bless you

@vinaypharmacist5838 6 жыл бұрын

i don`t have any word to say about your way of delivery, content ,,,,,, but i would like to say awesome.... thanks a lot........ plz update more videos for helping us