You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!!

You're a very important man for a Med student, from anywhere in the world, with a very unique gift of drawing and conversing. Please take care of yourself :) And just as always, awesome work!

I've nearly finished the pathology book and read articles but still felt like I hadn't grasped the entire pathophysiology behind some diseases, including RA. Thanks for this Amazing overview

Brilliant. I have had RA for 24 years and also a medical professional. People with RA know all too well the agony and frustration of living with this multifaceted disease that some may minimize into almost a trivial process. I appreciate your video as it eludes to anything but that. Thank you for your thorough explanation and demonstration.

Awesome video which I will have to re watch numerous times.

OMG 😮 I have an exam about RA tomorrow and your explanation helps me alot thank very much sir!

Well-explained with beautiful, easy-to-understand illustrations. Thank you!

This makes a lot of sense... both from testing and symptoms to reasons for swelling. Much appreciated!

Great video Armando!!

Be blessed sir!! We medicos owe you for providing such beautiful explanation n pics to memorize!! 😇

u helped me when I took anatomy & again then with physiology & once again, here ur helping me to understand exactly what is happening with my hands/joints as I have recently been diagnosed w/RA. thank you so very much!

First year medical school here ; You just saved my life. A M A Z I N G video and thank you soooo much :)

You have no idea how much this just helped me!! Thank you for this absolutely beautiful presentation.

" You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!! " I couldnt have said it better than below comment...thank you Armando, your the absolute best at making medicine understandable.

Wow, just wow, thanks dude, you're awesome, you helped me so much for my med school work, greetings from Mexico

-Macrophages start by releasing cytokines, TNF-alpha , IL-1 , IL-6 that lead to inflammation. - cytokines stimulate fibroblasts (synoviocytes) , which results in activation, and proliferation. - Synoviocytes will stimulate RankL expression, which will lead to the stimulation of osteoclasts with the aid of cytokines. Which will lead to bone erosion . - Proliferation of fibroblasts also result in creating proteases, which leads to cartilage breakdown (degradation), cartliges also secrete proteases. - When the fibroblasta are activated, they can travel from joint to joint, and this is how you get symmetrical arthritis. (Like in right and left hands). - T-cells, (immunity cells) which are thoroughly present in the synovium are resposible for promoting inflammation by secreting IL-17 (cytokine) which promotes macrophage activity so it....etc. - They also help in expression of RankL that .....etc. - Plasma cells are responsible for inflammation too. Through cytokines and antibodies. - Neutrophils in the synovial fluid also contribute to inflammation because they release proteases and active oxygen species which will affect in bone and cartilage erosion. - Immune complexes (antibodies) which are a feature of rheumatoid arthritis , they bind to one another and promote inflammation - Angiogenesis is affected by increasing the vascular pemeability by cytokines which will result in migration of all these cells into the joint. - Rheumatoid arthritis also affects other organs due to increased inflammatory cytokines , skin: nodule formation, liver: anemia, cardiovascular diseases: stroke, myocardial infarction. - Rheumatoid arthritis occurrence has unknown reasons but there are theories that suggest that genetics, smoking, and specific bacteria ( porphyromonas gingivalis) that are present pre RA are responsible for the appearance of the disease, these can lead to modifications in body’s antigens, which will make them seem foreign to the immune cells leading to an immune response, or by injury that leads to inflammation, and then lead to antigen modification. this is the first step of the pathogenesis of Rheumatoid arthritis..

I think this might be my favourite video on KZfaq, wow. Thanks.

Exceptional clarity. Images and words provide a clarity not possible with other pedagogies.

I only have some basic nursing knowledge and this is so easy for me to understand - you're an excellent teacher. I have this disease myself. Thanks for this video!

This made so much more sense to me in the context of bringing together immune and inflammatory responses. Thank you!!

This video was seriously the best!! Everything was explained simply!

Clear and simple explanation of a complex disease. Well done!

Thanks, the video is awesome (and even clearer than many medical textbooks)!

I was tasked to discuss the pathophysiology of RA and I couldn't understand a thing. This helped me to thoroughly understand it. Thanks, mate!

This is beautiful! I understand RA so much more better now. Thank you soooooooooo much!

Very impressive and easy to understand the whole picture of Rheumatoid arthritis. Thanks!

Excellent!!! It is really a very clear presentation. THANKS VERY MUCH.

best video!!!!!! concise precise, covering everything except treatment and lab inv... pls make a second video to cover those parts tooo

You are an Awesome teacher, never understood my doctor, but I learned a lot listening. I have the swan neck. My doc told me I had a permanent hitch hiker thumb. I understood now what she was talking about. Thank up for helping me understand this disease. May God bless you always

Bravo!! Coming from a non medical student! Idk what T alphas, etc are but I'll rewatch this video until I've looked up all the terminology. I enjoyed your video although ofc I didn't understand everything, I could tell it was excellent explanation at least and got the gist (did have to look up a few definitions ofc).

I have never come across a better teacher all my life

thank you for this video, i just spent 5 hours reading review papers and text books trying to understand it and you did it so beautifully in 15 minutes. Thank you - you are amazing.

Excellent,simple illustration . Thank you

your lectures are life saving. thank you for your time!!

wow what a superb vid! Easy to understand with great drawings. Much appreciated

Thank you very much ! I'm listening to you from France, I have understood all of the video, it was really clear thanks !

Thanks alot for this brilliant and concise presentation , It takes much effort and time .

This disease is so hard to understand and explain. Thank you for the very detailed breakdown!

You are so valuable man bro I m watching this video in Turkey and normally my English is not so good you speak fast but I can understand nearly everythink actually you explain perfect please dont stop that send video

Thanks for great video! , I hope you will prepare same video on Seronegative rheumatoid arthritis, and difference between seronegative and seropositive RA in immunological response .

dude. weldone.you are realy realy amazing in presentation.despite the simplified coherent,conclusive information,your voice tones is too natural and not push on yourself thus makes listener relax and enjoy. thank you very much.

So so helpful, thank you for this detailed and visually appealing explanation!

Amazing video and linking of the markers -> tissue -> symptoms!

You are just amazing!! Thank you so much for making it so easy!😊

Thank you so much it is really helpful. I got lot of ideas from that video, for my review article.❤️❤️

Excellent video! I have RA and am also coincidentally taking pathophysiology next semester. What a great opportunity to learn about my disorder while also preparing for the depth of pathophys May I ask what textbook you’re using for this information?

I saw this video so many times. No it's much more clear.. Thank you. ❤🎉😊

what a wonderful explanation. thanks again from Yemen Aden.

This was just awesome! Great clip :)

Your videos are incredibly useful. Thank you so much :)

fabulous explanation

thanks for all of the information. love your videos please make more

very well said sir! thank you for the nutritive information.

i don`t have any word to say about your way of delivery, content ,,,,,, but i would like to say awesome.... thanks a lot........ plz update more videos for helping us

Fantastic work and easily understood! Thanks a lot.

Hi Armando, I really enjoy your work. I would like to see your references at the end of the video. Thanks!

Really great explanation and summary! Thanks :)

Great video. Really helps me with my studies.

Great sir .. I really like your explanation and way of teaching

what a video... awesome sir great explanation..!!!! thank you..!!!!👌👌

Very nice lecture on the path physiology of R A. Very easy to understand. Thanks.I have R A for 20 years. Your lecture explains lot of my questions .Thanks.

Excellent explanation as always!

What a great informative video, thanks for sharing!

Great video, your explanations are pretty nice!

wow thanks so much for this brilliant explanation of how RA is triggered and develops.

Thanks a lot this will help me in my upcoming individual presentation

Thank you, an awesome explanation with drawings

you are doing a great job. as usual, Thx a lot

I have RD and I thank you for a concise video that helped me understand my dis~ease😢

Beautifully explained!!!

Armando Thank you so much !!

excellent, as usual

I can relate everything as I'm experiencing the same thanks fr explaining..

Thanks for this video will helping to study . Thankyou so much

Thanks for such an amazing video.. U made my life easy 😍

This video has helped me a lot. Thanks

Thanks for making use of all of these great abilities in order to help people I think about the great efforts make to accomplish this organized smart work Please continue this great work

Exelant explanation very Good information for RA patients

what a champion!!! great video

Thank you for your amazing videos doctor

Wow. Great video. Thanks a million

Ur explaination is best est of all. After a lot of struggle I found it. 😍

Brilliant teacher wish you best of luck sir

Love your videos thanks a lot for helping ❤️

This is the best video ever! I love u

Great video. Thank you!

absolutely wonderful as always - nice preparation for my exam this afternoon. Always a joy to watch these videos. So clear and informative.

Simple and goodexplanation. What about the treatment? Pls help as I have started suffering from it.

excellent work like always. can you please mention the books you consult for you videos.

Thanks for the work put in

Wow im speechless! This is amazing :) it helped so much!

Excellent video, thank you so much

Excellent video! Thanks a lot!!!

u r amazing.. u cleaned all the mess of my mind..thnx a lot.

great video, thanks for the help!

your drawing skills are so good!

Brilliant : ) Thank you soo much!

you have made an extraordinary job describing RA. Now, what hope is there for those who suffer with this terrible disea?

Very helpful thank you! Do you have a pdf version of your whiteboard drawing?

You're amazing! Thank you :D