Scientists Gave Human Brain Cells to a Rat. Why?
Рет қаралды 1,508,613
Жыл бұрынScientists transplanted human cerebral organoids ("minibrains") into rats, to better study brain disorders. The neurons grown in vivo looked more like mature human brain cells than those grown in vitro, and they made better models of Timothy syndrome. The human minibrains formed deep connections with the rat brains, received sensory information, and drove the rat's behavior.
Points of Clarification (Q&A based on common comments)
- Why didn't the rat reject the transplant, which frequently happens with organ transplants? /// They used immunocompromised (athymic) rats to avoid the problem of the immune system attacking the transplanted tissue.
- Was the licking behavior really due to optogenetics, or just seeing the blue light? /// A separate group of rats (control group), with a transplant but no optogenetics, also completed the red/blue light water training. They showed no significant difference in licking behavior during red and blue light. This suggests that the differences were really due to optogenetic stimulation of the organoid (not, for example, seeing the light). You can see how the control group did, compared to the optogenetic transplant group, in Figure 5j of the study, link below.
Support the channel: / ihmcurious
More on how minibrains are grown and used, and the issue of organoid consciousness: • Growing "Mini-Brains" ...
On the topic of organoid sentience and playing pong: • Lab-Grown "Mini-Brain"...
Organoid transplant study: www.nature.com/articles/s4158...
Sitcom music by John Bartmann: johnbartmann.com
@derek2593 Жыл бұрын
"Last I remember, I was about to crash my car. When I woke up, I was a rat."
@arcturus4067 Жыл бұрын
Hahaha.... So funny comment 😂
@Retrenorium Жыл бұрын
Crashed intro a truck
@yun-z Жыл бұрын
《that time I was reincarnated as a rat but was trapped in a mad scientist's lab, and the mad scientist turns out to be another rat》
@Kutsushita_yukino Жыл бұрын
Ahh sounds like a light novel title
@ScionStorm1 11 ай бұрын
Typical anime plot.
@bitcoinzoomer9994 11 ай бұрын
Finally, manmade horrors within my comprehension
@ultimaxkom8728 11 ай бұрын
Hurray, just one wrong step away from horrors beyond our mortal comprehension!
@LexyLexer 11 ай бұрын
HA
@Spookspek 11 ай бұрын
Fuck yeah
@quazar-omega 11 ай бұрын
I was looking for this comment, now I can die in peace
@valkeriejones3818 11 ай бұрын
Damn, you beat me to it
@NicolasCermak 4 ай бұрын
Imagine the rat starts squeaking morse code for "They'll never believe you"
@ValenceGG. 2 ай бұрын
Definitely Remy but with human brain
@SWISS-1337 9 ай бұрын
Ah so this is how Remy was born in ratatouille. They placed human neurons into the sensory area of the Rats brain, so that's why he REALLY loved food lol
@MP-vc4nu 3 ай бұрын
They’re training rats to be in US army since they’re cheaper than robotics rn, and cheaper than humans.
@geronimo5537 3 ай бұрын
So the "secret of nimh" was actually a true movie predicted in the past.
@jadehaze7939 3 ай бұрын
Limbic system got legacy reactions like gag reflex
@tordlindgren2123 2 ай бұрын
Yes.
@porterbays 2 ай бұрын
those were american brain cells.
@denissmith7671 Жыл бұрын
-What are we going to do tonight, Brain? -The same thing we do every night, Pinky. Try to take over the world.
@xavierrojas7684 11 ай бұрын
Omg thats why
@blazednlovinit 11 ай бұрын
Damn, you beat me to this by 5 days.
@Meshamu 11 ай бұрын
@@blazednlovinit And you beat me to being beat to making a Pinky and the Brain reference by about 10 hours. Dang it.
@brokenacoustic 11 ай бұрын
*NARF*
@Dodsodalo 11 ай бұрын
@@blazednlovinit You BOTH beat me to it.
@yeahthatpat 10 ай бұрын
I was so busy worrying about AI, I didn’t realize I should be worried about human/animal hybrids.
@Warwipf 9 ай бұрын
Google "organoid intelligence", I'm sure you'll be delighted to hear that the two can be combined!
@heuvelke1065 8 ай бұрын
You failed to realise of you combine that with AI who can control humans or whatever with chip in the brain. Yes, ai still going to be your first worry
@creamythecat8258 7 ай бұрын
They have Rat Neurons integrated into machines as AI now
@Mcflapphypants 7 ай бұрын
Agreed. I think Brain AI interfacing is going to be a HUGE mis-step, but its coming. @huevelke1065
@brucearmstrong5536 6 ай бұрын
Exactly
@Emperor-Quill 3 ай бұрын
Bartholomouse: "What's wrong with Ratthew?" HoRATio: "Not sure, the human took him somewhere and ever since he's been muttering about some cruel god named "taxes"
@ValenceGG. 2 ай бұрын
😂
@wildyato3737 2 ай бұрын
😂😂
@shanearmstrong7197 2 ай бұрын
Great love it -not in heavenor earth does our philosophy?
@necoyouth 9 күн бұрын
Hey...you misspelled Bartholomeow...it's Bartholosqueak👀
@lucycarola 5 күн бұрын
That is way too good. I hope you’re a writer. Sometimes k go on KZfaq just for the comments.😂 Witty as hell!
@horsepowermultimedia 3 ай бұрын
Those scientists are trying to recreate Ratatouille. 💀
@ValenceGG. 2 ай бұрын
Was gonna say that 💀
@KenLinx 2 ай бұрын
More like Rocket Raccoon.
@DoamBot 4 күн бұрын
More like Pinky and the Brain
@sylphienne 11 ай бұрын
Instead of cat girls, scientists first human animal abomination would be Rat girls.
@jaxblonk5127 11 ай бұрын
Cheesed to meet you and have a gouda day.
@HolyApplebutter 11 ай бұрын
Real Skaven let's fucking gooooo!
@canobenitez 11 ай бұрын
count me in
@PSIChris 11 ай бұрын
🤮
@xXIronPeachesXx 11 ай бұрын
Sign me tf up to be a rat girl
@yourgenerickid1109 10 ай бұрын
A rat? I was a rat once. They locked me in a room. A rubber room. A rubber room with scientists. And scientists made me into a rat.
@OnyxtheFolf 3 ай бұрын
jimmy
@FiSH-iSH 3 ай бұрын
did the scientists really turn you into a rat, or did they actually turn the rat into you
@CarlosGordo97 3 ай бұрын
Or were you always a rat and you just didn't realise until those scientists put you in that room?
@absolution6191 3 ай бұрын
A rat? I was a rat once. They locked me in a room. A rubber room. A rubber room with scientists and scientists made me into a rat.
@Wasaby50312 3 ай бұрын
@@absolution6191a rat? I was a rat once
@bananajoe9951 3 ай бұрын
At first I was worried, then they started talking about using rabies. Now I'm terrified.
@tixium3471 3 ай бұрын
yaaay. rabies can now spread by human bites!!
@helenTW 3 ай бұрын
Same, it's gruesome and terrifying
@Payday5 3 ай бұрын
@@tixium3471 we going the walking dead with this one
@PS64Subs 3 ай бұрын
@@Payday5 sheesh, not only walking dead, but the crawl back to a non-rotten version resurrection. that sounds like hell. as Forbidden Siren 2 tells us: Eternal life is endless agony, no human would want to physically go through dying over and over again, even if they're effectively immortal from an age standpoint, as long as your brain remains in some way... you'd survive. also, imagine being right in your mind but your body is so rotten you can't even convey it well physically, and you can't speak, only groan. being a typical zombie but you're not mindless as they are would SUCK until breakthroughs can mentally transplant you elsewhere. also the debate of what would essentially become mass necromancy and weather or not raising the dead/rebirthing them is moral... probably not, unless y'know, you consent.
@leonardoospino3497 3 ай бұрын
It is a modified version of the virus that infect neurons but does not cause dead of the animal because is not that virulent. Because the virus selects a specific group of cells you can trace those cells in this case the human neurons to know how much they integrated into the rat's brain. Basically, it's an overcomplicated version of a coloring book... just with genetically modified human tissue and viruses that's all.
@rockercas 2 ай бұрын
if you give human brain cells to a rat, he will ask for a glass of milk
@steponkusceponas4085 23 күн бұрын
but what if you gave it a cookie?
@NolanPirkl 3 күн бұрын
I laughed out loud
@maksiksq 10 ай бұрын
The rat just got an integrated GPU
@RealValkor Ай бұрын
Lmao made me chuckle ngl
@FleshWizard69420 18 күн бұрын
Hardware upgrade
@DrFumiya 6 күн бұрын
Bro got the intel integrated graphics 💀
@qawamity Жыл бұрын
Call me crazy if you like, but it seems to me that the human tissue in the rat did not control the rat at all. It was integrated into the rat brain. It's like adding a a video capture card to your PC, it doesn't control the computer, it becomes part of it and augments its capabilities. The experiments with blue light demonstrate this integration.
@ahuman4797 11 ай бұрын
yeah, like switching your cpu for a new one haha
@Fasteroid 11 ай бұрын
Since the human tissue was responding to external stimuli, I think comparing it to an I/O device like a mouse is more appropriate. It gave the rat a new sense, which under the correct conditions can be manipulated to influence its behavior.
@Kayachlata 11 ай бұрын
Even in that analogy, the GPU controls video processing. This part of the brain controlled reactions to stimuli and influenced decisions. You could say that it "controlled" those processes and therefore, controlled the rat in some aspects. Take one part of your brain and it does not control you, but merely a part of you, same with this scenario
@qawamity 11 ай бұрын
@@Kayachlata, video capture card, not video card. A capture card is sensory, it isn't a GPU in the regular sense. A GPU is ancillary output processor, a capture card is used to process video (and audio) from an external source (generally for use in livestreams) without bogging down the CPU. Similarly, the human neural tissue in the rat brains was employed in sensory processing. It wasn't involved in decision making or learning, outside of processing input for use by the parts that performed those functions.
@ReatExists 11 ай бұрын
@@Fasteroid giving the rat a mouse
@hannahalexy 9 ай бұрын
These scientists need to chill out. The last time this was succesfully attempted, they created Jerma.
@FleshWizard69420 18 күн бұрын
Jerma
@livenishikireaction 15 күн бұрын
he really is the giant rat that makes all of the rules
@tacobellemployee7819 9 күн бұрын
king of the rats
@nymphmythic454 4 күн бұрын
Jerma the MewTwo of the streaming world
@xSephironx 3 ай бұрын
"To make it more human, we attach it to rats..." Ah yes very human
@Telados 2 ай бұрын
"The design is very human"
@Arabella-bl9zm 2 ай бұрын
@Telados you stole my words lol
@jonintrovertedpotato3866 Ай бұрын
How long would it take to create conscious rats? Big moral doubts, but they are already conscious, dear half-brains.
@jonintrovertedpotato3866 Ай бұрын
@@Telados Sure it is. How long would it take to create conscious rats? Big moral doubts, but they are already conscious, dear half-brains.
@ether158 Ай бұрын
@@jonintrovertedpotato3866 I mean look what we do to each other, I don't rats are getting an exception
@PeppermintSwirl 11 ай бұрын
If we’re not careful, we are gonna have rats who ask “to squeak, or not to squeak?”
@WhyGodby 11 ай бұрын
Big cheese is dead, and we have killed him
@Harsh-tf9he 11 ай бұрын
every rat has the right to obtain their cheese
@Qualicabyss 11 ай бұрын
Brain size probably plays a bigger role in this
@sournois90 11 ай бұрын
some rats are just more superior than others
@thegoodolddays9193 11 ай бұрын
Life, liberty, and the pursuit of cheese.
@heypankajhere1 10 ай бұрын
Legend says this mouse went underground with his 4 turtle apprentices.
@y-i-k-s 3 ай бұрын
It’s the rat from fort night
@Ak2TheSky 3 ай бұрын
@@y-i-k-snah thts the rat from halo: the master chief
@sayansaha155 3 ай бұрын
I swear I can hear tmnt music...
@eliasniwert3680 3 ай бұрын
Knowing science they had to do this with many many more than just one rat
@Idolikethis 3 ай бұрын
The best part about this joke is, it is fun. The worst part, you will see this wherever a video is regarding human/rat science videos
@gneu1527 Ай бұрын
Imagine how bro must feel being conscious as a rat
@FleshWizard69420 18 күн бұрын
Idk but he seems cheesed to meet me
@scaredhvh1 10 күн бұрын
It is like a nightmare
@FirstnameLastname-jd4uq 9 күн бұрын
I don't think consciousness is human exclusive Obviously rats don't have the same cognitive abilities as humans but they seem aware to me
@miufke_ 3 күн бұрын
The rabies part too... Infernal horrors far beyond comprehension
@miufke_ 3 күн бұрын
Not like we should stop tho cause this will lead to insane breakthrough
@soulsbourne 13 күн бұрын
*Modified rabies that specializes on human Brian sounds like the nightmare waiting to leak from a lab*
@kalliaslands9938 Жыл бұрын
In case anyone was wondering this has actually been done in a human. A patient with Parkinson’s had a cell sample taken which was then cultured into dopanergic neurons. The ethics review then gave special permission for the patient to undergo experimental surgery in which these neurons were inserted into his motor cortex. The procedure appeared to lead to a halt in the progression of his Parkinson’s disease but it is hard to tell until this is being tested on a dozens of subjects
@kingpiggins292 Жыл бұрын
Cool
@glenliesegang233 11 ай бұрын
I believe stem cells, modified into not brain cells, were used. Hard to get cells from nigro stratum brain region.
@backseatgamer1808 11 ай бұрын
that's fantastic
@rbanerjee605 11 ай бұрын
I find it difficult to believe it would only be done in one person only if any at all. Unless they were very rich…
@glenliesegang233 11 ай бұрын
@@rbanerjee605 agree, unless the modification of any person's millions of stem cells in their circulating bloodstream ca be multiplied in vitro, chemically modified to becoming neural stem cells, then injected through minimal holes in the skull. More exciting is transcranial infrared stimulation of neuron growth, new findings of trating Parkinson's like riding bicycles- look it up.
@HolyApplebutter 11 ай бұрын
"When I understood the weakness of my flesh, it disgusted me. I craved the strength and certainty of other flesh."
@Skullkid16945 3 ай бұрын
This comment is golden. Maybe this is how humans evolve. Maybe we really are just the neurons and we just infect the brain of another animal and hijack their spiecies.
@doggg4977 3 ай бұрын
@Skullkid16945 it's also a 40k reference
@septicsauce322 3 ай бұрын
@@Skullkid16945 Warhammer 40k Mechanicus teaser trailer. It is where the quote came from. From the moment I understood the weakness of my flesh, it disgusted me. I craved the strength and certainty of steel. I aspired to the purity of the Blessed Machine. Your kind cling to your flesh, as if it will not decay and fail you. One day the crude biomass that you call a temple will wither, and you will beg my kind to save you. But I am already saved, for the Machine is immortal… ...even in death I serve the Omnissiah.
@Dodsodalo 3 ай бұрын
Really while this is a Warhammer 40k reference, you could argue it accidentally is a Cruelty Squad reference.
@Arkimedus 3 ай бұрын
Flesh for the flesh god
@HydroGyro_ 3 ай бұрын
Ethically this is a fucking nightmare
@master_nooing 3 ай бұрын
science without ethics achieves multiple breakthrough very quickly my source? war
@Swaxol 3 ай бұрын
yeah
@Arkimedus 3 ай бұрын
@@master_nooing Depends, sometimes that occurs, other times it becomes pointless cruelty without a real purpose.
@PS64Subs 3 ай бұрын
yeah. i don't really want catgirls or dog people or whatever if it means we're making something suffer for it in return.
@james-2540 3 ай бұрын
@@PS64Subs if it benefits the government or any military group then you'll see it soon enough
@user-pu5br4dp6y 2 ай бұрын
"Man, this is awesome! I've got a whole new way to perceive the world around me an-" "Let's give him rabies."
@mcjunior011 11 ай бұрын
Using rabbies as a marker for differentiating human tissue from rat tissue was genuinely brilliant idea. Rabies is not contiguous for rats, in this case only the human derivated tissue will be infected.
@alexlifeson8946 11 ай бұрын
Until you realize the real reason was to develop an effective rabies virus that's carried by rats but only harmful to humans. Thus, another bio weapon
@suyogdevaiah1114 11 ай бұрын
It can infect a rat tho
@mhitman0385 11 ай бұрын
@@suyogdevaiah1114 highly unliley not to include rabies is a very easily and successfully preventable disease which we have both vaccinated wild animals and humans
@suyogdevaiah1114 11 ай бұрын
@@mhitman0385 yes but once infection progress its all over.
@Sanscripter 11 ай бұрын
Oh that makes sense
@VictorTwo2 11 ай бұрын
Imagine being a rat just living your days in a cage not thinking too much about it and this dude just injects you with grief, misery, future, shame, desolation, joy, hope
@BattleSlayer 11 ай бұрын
Not necessarily they do think about it because if you were in a cage all day you would eventually get depressed human or not.. but it's normal because if your depressed it means your doing something wrong. It's not a disease like people claim
@BattleSlayer 11 ай бұрын
@VictorTwo2
@seandunbar6427 10 ай бұрын
Right except that's not how it works. The brain transplant grew with the rat from birth. It's like they were born with it. Also, those complex emotions don't just come from a little part of our brain. Many of those are conceptual, which require a foundation of language the rat does not have.
@inmyexpression19 3 ай бұрын
Me when I was in jail
@inmyexpression19 3 ай бұрын
@@seandunbar6427so you’re saying, the unconscious must be taught
@thaedleinad 3 ай бұрын
"Dollar store in vitro organoids" Ok, I am taking this one as a song title to my new single.
@lantousaturn6115 9 ай бұрын
"You may live to see man-made horrors beyond your comprehension" -Nikola Tesla
@Spliceozome 11 ай бұрын
I am a neuroscience phd student and I just want to say.I think this channel does a great job explaining the literature
@saberhap2639 11 ай бұрын
you just wanted to brag about your study
@Spliceozome 11 ай бұрын
@@saberhap2639 not trying to! but there's a lot of oversimplistic "serotonin = happiness" stuff out there so its nice to see people who are very careful making videos
@Spliceozome 11 ай бұрын
@Samir Dončić Just an undergraduate degree in bio/psychology/ neuroscience / math depending on what you want to study. Just try to go to a university where you can work in a neuroscience lab as an undergrad, thats the main thing
@ElonMasks 11 ай бұрын
@@Prodigious147Possible pathway is to pursue a Master's degree in Neuroscience or Neurobiology. The program will provide you with a comprehensive understanding of the brain's structure, function, and related areas of research. MSc in Biophysics can also be relevant to studying the brain and its functions, it primarily focuses on the application of physics principles to biological systems. While there may be overlapping areas between biophysics and neuroscience, a dedicated Master's degree in Neuroscience would offer a more specific and comprehensive education in the field
@alteraxia1646 11 ай бұрын
@@saberhap2639 how would you know?
@tristanmisja Жыл бұрын
It makes perfect sense that the human part of the rat's brain acted as if it was originally the rat's. The neurons have been growing with the same conditions and communications as a rat's.
@pustota7254 11 ай бұрын
*the
@tristanmisja 11 ай бұрын
@@pustota7254 Thanks!
@pustota7254 11 ай бұрын
@@tristanmisja no problem.
@spookyweeb5563 11 ай бұрын
except you are(probably) not a neuroscientist and this is likely extremely simplified
@tristanmisja 11 ай бұрын
@@spookyweeb5563 I'm not a neuroscientist (yet), but I've studied the field a lot. Yes, it's somewhat simplified, but that's the gist of it.
@divs7415 7 ай бұрын
That was SO much Information for just 9 mins! I'm genuinely fascinated and impressed by this video🙂
@ValenceGG. 2 ай бұрын
Bro got impressed for IRL Ratatouille 💀💀
@Rin-zn9bo 3 ай бұрын
This was wildly inspiring, thanks for the video
@ValenceGG. 2 ай бұрын
**wildly inspiring** 💀
@SpriteWild 2 ай бұрын
to...to do what?
@pou-c 15 күн бұрын
@@SpriteWild😈
@sandraforeman620 11 ай бұрын
As the owner of a pet rat, I was so impressed at how she understood so many things, and acted in such a smart way, so quickly. I really wouldn't want her to be smarter! The kisses & love she expressed was so far ahead of most.
@RoundShades 11 ай бұрын
It's a curve where rats with satisfied needs and much encouragement embrace positivity and growth of that sort, but humans always think of more and more things to do with more and more gains, to justify taking it away from others and then shrugging off the suffering they cause as a result. Humans are pretty shitty.
@canobenitez 11 ай бұрын
yeah it's better to have retarded pets
@FortWhenTeaThyme 11 ай бұрын
I think most people would be surprised by the intelligence and friendliness of domesticated rats.
@Ariel333666999 11 ай бұрын
DUDE. for a second I read "as the owner of the pet rat[...]" (as in, the rat in the study) And I was like, man, where can I buy modified rats
@fenayev1848 11 ай бұрын
@@Ariel333666999 modded rats 😭
@jasper2621 Жыл бұрын
I like this style of content. A lot of youtube channels turn to overproduced sensationalism when dealing with new technologies/discoveries. Ihm Curious just lays out a summary in a concise, easy-to-understand fashion.
@jacekstankiewicz1594 Жыл бұрын
agree most youtubers who talk about this kind of stuff, are like when you wanted to reach the word mark in high school essays, yes you have a bunch of content, but not much would be said. this channel is better
@dylanfisher6042 Жыл бұрын
sensationalism - what a great word. Too many documentaries nowadays do this in such a way . No offense to American documentaries but this all too common.
@bigsmall246 11 ай бұрын
@@dylanfisher6042 American documentaries are the only ones that use rock music
@NiceDZNintro 11 ай бұрын
@@jacekstankiewicz1594 bro this guy doesn't talk about nothing he just copies text into text-to-speech lmao
@destinpatterson1644 11 ай бұрын
@@NiceDZNintro He very clearly wrote his own script to make it digestible, because I can promise you, no scientific journal would be written like this and I highly doubt he copied and pasted from a website. And that's his real voice
@geronimo5537 3 ай бұрын
So the "secret of nimh" was actually a true movie predicted in the past.
@knarf975 7 күн бұрын
I am a medical doctor myself and I feel very sorry for the torture these poor sociable animal have to undergo. Experiments on animals rarely led to something good.
@ren3171 11 ай бұрын
As a rat implanted with human brain cells I can confirm this is true.
@meowman69420 11 ай бұрын
this comment is funnier because of your profile pic lmao
@nateo200 10 ай бұрын
lol
@justind4615 10 ай бұрын
yes because if it wasnt true you couldnt comment this
@redmadness265 10 ай бұрын
xD
@MusicGuyFK 10 ай бұрын
I do not believe you. I believe you are an ape(homo sapiens specifically) on a computer making a joke. I do not believe you are an actual rat but I could be wrong.
@ecm84ee 10 ай бұрын
That rat has more human braincells then alot of humans on this planet.
@justind4615 10 ай бұрын
lol, nice one
@Dreptilator 10 ай бұрын
its just that he doesnt use twitter
@justind4615 10 ай бұрын
@@Dreptilator uh yes, we need to keep that rat out of twitter
@louislower3724 10 ай бұрын
Acktually that is not possible because the human organisms needs way more braincells to even stay alive. Where is your peer reviewed study?
@grobble7321 10 ай бұрын
@@Dreptilatorno it is the smartest Twitter user
@xbirdshorts5075 3 ай бұрын
The hypocricy in the last bit about weighing out the benefits when they're already implanting something on animals that can't consent 💀like choose one
@marza339 Күн бұрын
Go complain about stupid nonsense elsewhere
@xbirdshorts5075 23 сағат бұрын
@@marza339 i mean you're complaining about someone complaining about something. if that's not the ultimate complaining about stupid nonsense then i don't know what is
@SkratchersOtherWorseChannel 9 ай бұрын
She wanted to find out if he'd still love her.
@natasha6867 10 ай бұрын
"dollar store in vitro organoids" lol if only we could get them at the dollar store. but seriously, i'm a neuroscientist and i didn't know about these types of studies. very cool! and very well and thoroughly explained. thanks!
@tommytheshimigami 10 ай бұрын
It's gain of function research...
@TheEmolano 11 ай бұрын
That's like a hardware upgrade for the rat. The "software" of the rat remain intact and took controll of that extra hardware.
@JavierAlbinarrate 11 ай бұрын
They lack the correct drivers... do you have a ratASM compiler by chance?
@somuchtocook9159 11 ай бұрын
@@JavierAlbinarrate considering that it worked then it was a definite yes
@ferro9929 4 ай бұрын
@@JavierAlbinarrate using LLVM, yes
@bananajoe9951 3 ай бұрын
This reminds me of the book Flowers for Algernon, where they experiment on two patients with down syndrome. One mouse, one human. The experiment works, both subjects display remarkable gains in intelligence, to the point that they are smarter than the average of their species. Unfortunately the therapy it stops working, and we get to read of the mental decline of the human patient. The mouse ends up dying as a result of rapid intellectual decline, it stops eating as a result of depression. The human contemplates suicide as well. Really fucking sad.
@Fuckalope-cm5dk 3 ай бұрын
I dont think it was down syndrome, was it?
@_WilhelmII. 2 ай бұрын
Exactly what I thought when I saw the video's name and thumbnail
@hectornonayurbusiness2631 3 ай бұрын
They were so preoccupied with whether or not they could they never stopped to consider whether they should.
@mjbaricua7403 3 ай бұрын
They always should, cowardice holds back innovation
@just-a-fnf-fan 3 ай бұрын
@@mjbaricua7403and innovation can sometimes be bad, (not always tho)
@ThanosDestroyeryearsago 8 күн бұрын
And they should, Decels are the bane of existence.
@MigraineBuddy420 11 ай бұрын
Ah yes, horrors beyond human comprehension.😊
@fenn_fren 11 ай бұрын
In this case, horrors beyond rat comprehension.
@thebuilder5271 11 ай бұрын
@@fenn_frenonly until the rats gain human intelligence 💀
@Angel-ng2gz 11 ай бұрын
This shit is actually terrifying because they could become self aware
@IVeryMuchHateYouTubeHandles 11 ай бұрын
NPC🥶🥶🥶
@vibinjesus 11 ай бұрын
@@IVeryMuchHateKZfaqHandles you sound more like an npc than anyone else here
@m0zzar353 9 күн бұрын
they should do a test to see if rats with human cells are better at solving puzzles than a normal rat.
@justmyopinion192 3 ай бұрын
Very interesting video, thank you for sharing ❤
@christianpiedra1514 11 ай бұрын
I’d be okay running a social experiment with a group of normal rats and a group of humanoid rats. It would be interesting to see what would happen… for science of course.
@canobenitez 11 ай бұрын
how long until the military wants their rat army division
@Funtermore 11 ай бұрын
Probably segregation among rats
@veryangryduckpl2122 11 ай бұрын
@@Funtermore Finally, proof that segregation and racism is normal even among animals!
@Michael-du2fv 11 ай бұрын
The rats with human brains would enslave the normal rats and force them to start building step pyramids. Then the entire study is classified and all scientists suddenly die in accidents.
@Angel-ng2gz 11 ай бұрын
Bad idea imagine a war with self aware rats
@Vitorruy1 Жыл бұрын
no clickbait, just a good explanation. Love it.
@Countertistic 11 ай бұрын
Literally dont know what 95% of the words he saying means...
@kiyo211 3 ай бұрын
@@Countertisticme too but at least I can get the idea
@adrianandaverdevega8320 5 ай бұрын
Great content!!
@koushikkumarghosh5887 2 ай бұрын
Fantastic video 😃
@metamind095 11 ай бұрын
Its incredible how you packed this all together in an easily consumable science clip. Keep it up!
@br9809 11 ай бұрын
Because they were so preoccupied with whether or not they could, they didn't stop to think if they should.
@GalacticNovaOverlord 11 ай бұрын
Nah, they should. The issue comes in 100 years when someone tries to create super soldiers
@reachthesingularity 9 ай бұрын
That is a very strong response from the rat. I can only imagine how strong the drive to drink the water is when the light is activated.
@tempy-tq3ix 2 ай бұрын
wonderful im living the monologue portion of the prequel to Rodent Uprising
@VimmiiPOV Жыл бұрын
We are on the timeline of genetically engineered catgirls aren't we?
@FrostyHandled Жыл бұрын
"poetry is the usage of language to push thought in the direction of important, yet neglected ideas"
@davib8963 11 ай бұрын
@@FrostyHandled In the twilight of a daring dream, Where science touches the extreme, In feline minds, humans play, To mingle minds in a peculiar ballet. Once a kitten, soft and small, Now carries thoughts that hold us all, In her eyes, a universe unfolds, As a saga, unlike any, it beholds. Through felinity, with a soft purr, Bearing wisdom, in her fur, In her mind, stars and cells combine, A testament to a design, so divine. A mouse she chases, yet contemplates, In her dreams, mankind she imitates, Beneath the moon's silvery gleam, In her, our essence does dream. In her pounce, philosophy's dance, In her purr, an enlightened trance, Through whiskers, flows the human tide, A testament to the world inside. What once was myth, now stands true, As humans glimpse a feline view, In a creature, cute and small, Echoes the universe, and enthralls us all.
@derpherp1810 11 ай бұрын
We are in the Timeline of Secret of NIMH which if that's case ultimately has very little effect on our day to day lives.
@weltschmerzistofthaufig2440 11 ай бұрын
@@davib8963 This sounds a lot like a stanzaic poem written by ChatGPT, but if it’s not, then that’s pretty good poetry!
@davib8963 11 ай бұрын
@@derpherp1810 Ever read 'Fast Times at Fairmount High'?
@mickmickymick6927 Жыл бұрын
I'm glad your here to guide us through the eldritch horrors to come.
@helicalactual Күн бұрын
I find it very interesting the way that you can do differentials on the cells. Given the growth of a system with more of one chemical or hormone or amino acid versus another system , and how all of the systems interact resulting in chaos theory expressing a completely different application
@zebonautsmith1541 9 ай бұрын
The brain was thinking: "help; get me out of this rat!"
@statelyelms 10 ай бұрын
I love the hint of humour while very educationally explaining this brain stuff. I also really appreciate how you go around the comments, answering questions and clarifying things very kindly. What a nice channel!
@danielvanstaden8247 Жыл бұрын
I really love your videos. I was first recommended your video about neurons playing pong a few months back, and then recently I was watching a lot of videos about psychedelics which is when I saw your video about that (which I absolutely loved, I learned so many things I didn't know about before). I decided to check your channel out and that's when I realised that I'd seen one of your videos before. I was then very pleasantly surprised that both of these had come from the same person and that you had much more quality content too. You are truly underrated, and I wonder what crazy things you'll be talking about in a year from now 😁
@AbdulSoomro-kj5lt Ай бұрын
Make more videos my bro: this channel has so much potential
@GraveXSensei 6 ай бұрын
Master Splinter, Lezz Goo !!! 🔥🔥🔥
@fattyMcGee97 11 ай бұрын
I’ve had many pet rats over the years and I can tell you that I don’t doubt they are self aware without any medical intervention. I’ve watched them display having a sense of self. I’ve noticed this through watching them play into “oh hey, I know I’m cute so I don’t have to work as hard as my brother for treats”, or “damn I’m getting fat and the humans are calling me fat, time to work out and lose weight”. One of my rats absolutely understood that we were calling him fat and he took it upon himself to run on his wheel to lose weight. He even turned down treats and ate a bit less of his healthy food than he used to. A few months later and he was actually in pretty good shape and had a lot more energy. Rats aren’t stupid creatures. I’ve seen rats unscrew jars to get to snacks, open sliding cupboard doors to get into where I kept the snacks, work as a team to try and pull the meal worm box up the side of the cage. They’re very clever little animals and it’s part of why I adore them honestly. I’m not against research like this. I think it’s fascinating and the rats appear to be unharmed. I just think that people need to know that rats probably are self aware.
@123youbia 11 ай бұрын
I don't think it's to be self aware. If anything it's pattern learning, if you called them fat and gave no treats to then makes them run on the wheel (somehow) then they'd understand that they have to run on the wheel to get a treat
@fattyMcGee97 11 ай бұрын
@@123youbia No, you misunderstand, I didn't incentivise them to run on the wheel with treats. I didn't change my behaviour at all and they started turning down treats in favour of their healthier food. It was their own choice.
@123youbia 11 ай бұрын
@@fattyMcGee97 Ok I see, but still they are just very clever then not self aware
@Pulpo_Pol 11 ай бұрын
@@123youbia Humans will just go far and beyond to blind themselves about how intelligent some animals truly are.
@madman7544 11 ай бұрын
@@Pulpo_PolThey'll also go as far to blindly seek meanings in uncomplicated things. (Example: sign language gorilla Koko)
@eduardobalbino8486 10 ай бұрын
What an EXTREMELY well made video and presentation, damn! I don't know how much time it took you, but if this effort went into literature reviews of other areas it would exponentially increase both public reach and onboarding/motivating undergrads. Thank you so much for the inspiration (and knowledge, of course!)
@SaraMorgan-ym6ue 7 ай бұрын
so to find human brains cell just use rabies sounds dangerous to me
@tnyers4535 3 сағат бұрын
This is the type of thing you tell when you want to destroy a conversation.
@someguycalledCh0wdah 4 күн бұрын
I remember headlines like 20 years ago like "Scientists Put Human Brain Cells In Lab Animals" and Fox News yelling about it for like three days at one point but I always wondered what was really going on with that and now I know!
@Saturnius 3 күн бұрын
What do those morons not scream about? This stuff is going to help hundreds of thousands of children and adults with debilitating diseases that otherwise would entail a lifetime of suffering. But no, my sky daddy didnt approve this or what do the rat feel?
@AVX512 Жыл бұрын
It would be interesting to figure out _how_ the cells decide which chemicals signal what information
@leagueaddict8357 11 ай бұрын
Not really mostly the same or very similar compounds, lookalike compounds are known as poison as the brain or budy will use them incorrectly, which is why people sometimes get very sick or worst when eating or drinking the wrong plants whether by accident or not.
@thatpandaz6094 11 ай бұрын
@@leagueaddict8357hile the brain uses mostly the same chemicals all over they have different jobs. The chemicals themselves don't do anything, it's the receptors response to that chemical that makes a reaction. So when taking drugs for example it's not that the compounds looks similar to one in the brain (which is the case most the time) It's just how well it fits into that receptor in different parts of the brain and more importantly if it can pass the blood brain barrier
@leagueaddict8357 11 ай бұрын
@@thatpandaz6094 You are spreading misinformation
@thatpandaz6094 11 ай бұрын
@@leagueaddict8357 Educate me
@geckoo9190 7 ай бұрын
I think that they could do that because the chemical signals are very similars, those hormones should have been developed way back in the evolutionary scale and didn't change much.
@gilgabro420 11 ай бұрын
Could we expand human brains like that? I'd be down.
@Wyi-the-rogue 11 ай бұрын
Big brain time
@winklerdinkler-hh7km 11 ай бұрын
Bro getting a new cpu
@Tea_N_Crumpets 11 ай бұрын
Don’t think so, sadly. Intelligence usually isn’t completely related to brain size or even body/brain ratio, but more by a combination of several factors, particularly by the average time it takes for parts of the brain to communicate (the time that it takes, on average, for a signal to travel from one neuron to the other in the brain, or sort of the neural density). This is why elephants aren’t as intelligent as humans, despite having much larger brains. Their physically larger brains are optimized to handle the massive amount of input from their huge body, and to control that body to keep it running and moving, but the large total neuron count required to do that makes the brain too large to perform a lot of higher-level processing. Think of it as: human brain is akin to a top-of-the-line gaming PC, while a larger brain (like an elephant’s) is like a big server in a server farm. The server might have more total power than the gaming PC, but they’re not comparable because the gaming PC is more optimized for performing singular, complex tasks while the server is meant to process massive amounts of relatively simple tasks. Or at least, that’s how it is as far as I know.
@gilgabro420 11 ай бұрын
@@Tea_N_Crumpets well the correlation is 0.3 to 0.4. I totally think that increasing the brain of a person would mean higher intelligence. Bigger animals obviously need more brain mass overall. Well you also have to consider that human brains are much more complex. I mean i get it, woman and man have about the same intelligence despite man having much bigger brains but guys are also bigger on averrage. There is of obviously a lot of other factors but I'd say that you have higher intelligence if your brain is bigger if everything else is equall. You would for instance be more inteligent than your twin if extend your brain and your twin didn't. Well that all hinges on similar performance of the implant and your main brain but I think it could work in the future. There is also the issue that brain development takes decades... :,D I think it could work though. but I would never subject myself to that till it is probably tested. I definitely think this is more promising than neuralink.
@BattleSlayer 11 ай бұрын
@@Tea_N_CrumpetsYea we evolved from monkeys with bigger brains but they weren't as smart as we are now. Funny how we survived the 99 precent extinction life is truly insane
@NEONetior 3 ай бұрын
Imagine walking back to your lab and the rat greets you with "Hello Doctor."
@Tai182 Ай бұрын
"Your scientists were so preoccupied with whether or not they could... they didn't stop think if they should."
@philguer4802 Жыл бұрын
Kinda scary, the idea they can just grow mini brains and experiment on them.
@petevenuti7355 Жыл бұрын
Have you seen the thought emporium channel he's working on it! Anybody with the inclination to learn,(and keep good sterile technique), and a conservative few thousand dollars for reagents & growth medium and incubator can at home! The thought emporium channel calls their incubator meatcubator😜
@Biedropegaz Жыл бұрын
and at the end infect them witbrabies virus...madness, not science
@danielhicks1824 11 ай бұрын
They're very mini, to be fair.
@effervescentrelief 11 ай бұрын
They need to put the human cells into the communication part of the brain and see what happens. In fact, due it to multiples and maybe they will start to communicate in more advanced ways. I should say I find this research highly intriguing as well as disturbing.
@motivatedpotato6604 11 ай бұрын
Yeah, i wonder if they could put the human cells on both brain modules, cerebellum and the celebral cortex. So, the rat brain is ingrown with human neurons from every side. And how that would affect their choice making and adaptability
@tetsmon 10 ай бұрын
My guess is that it wouldn't affect their communication in any significant way. Human brain cells aren't any more "advanced" than rat brain fells, it's just that more of our brain is dedicated to communication. to get more advanced communication between rats, we would need to somehow promote growth in that specific portion of their brain. But also, I feel like it would have a similar end result as Planet of the Apes
@NotSoCrazyNinja 10 ай бұрын
@@tetsmon Genetic engineering to the rescue! I'm sure what you suggest can be done, but should it be done? I say absolutely!
@cj.wijtmans 10 ай бұрын
Incorrect. Human neurons are not the same as a rats. The fuck are you smoking?
@trappedkitty5335 3 ай бұрын
Those globs with optical sensors will haunt my nightmares.
@garyr7027 4 ай бұрын
Discovery channel had a documentary in the mid 90's claiming scientist grew a human ear on a mouses back, even showed a video clip of it walking around. I wouldn't have believed it if I didn't see it for myself.
@talumbachitaya4567 3 ай бұрын
🥲🤢🤮
@PerilousXPrep Жыл бұрын
I just found your channel. New sub! I really enjoyed your manner of communicating fringe science in an informative and engaging way.
@chromyl_chloride Жыл бұрын
only 150 comments with a video as well made as this? AND the creator replies to questions with answers? amazing! subscribed.
@ScootLogix 3 ай бұрын
It's begun. Pinky and the Brain is no longer just a cartoon...
@bradfordlangston836 3 ай бұрын
This is why I love neuroscience
@SorakaOTP462 11 ай бұрын
Imagine you wake up as a rat and you have no way to communicate with scientists telling them that you're self-aware and you're actually a human being.
@emmioglukant 11 ай бұрын
I can tell you like 10 things that you can do to communicate that
@SorakaOTP462 11 ай бұрын
@@emmioglukant They'll interpret those things as rat having rabies or something.
@emmioglukant 11 ай бұрын
I'll give you one nugget, moisture the glass panel holding you and with your fingers write "Ligma" Edit: oh, found a better one, try writing "Jo Mama", and below that draw some nûdês
@SorakaOTP462 11 ай бұрын
@@emmioglukant that could work but first thing that would come to scientist's mind is that some human wrote it when he sees it.
@emmioglukant 11 ай бұрын
@@SorakaOTP462 bruh you can just write when someones nearby, and I'm not even going to get into what things you can do with only your body to grab their attention, and communicate that you are a human
@nyantacoplayz7493 6 күн бұрын
Rat existential dread sounds neat
@qwertykeyboard5901 3 ай бұрын
Ugh. Thats fucking horrifying. I can't even imagine the mental shenanigans that would ensue.
@avivsharon819 Жыл бұрын
A great approach to presenting scientific papers!
@cameroonemperor755 Жыл бұрын
Absolutely amazing video as always
@mariaslough5038 Жыл бұрын
stole my comment argagrh
@arthurjeremypearson 3 ай бұрын
These special features on my rats of NIMH special edition DVD are pretty freaking wild
@danielavanilla4331 6 ай бұрын
The animal evolution Dreamworks theory becoming more than just a dream fr fr 🔥
@pseudonymousgarbage8 11 ай бұрын
I wonder if it would be possible for the human brain tissue to somehow improve the rats mental abilities. Like a co-processor that can learn quicker and help the rat solve problems?
@dltr4730 11 ай бұрын
I think you would run out of space in the skull before achieving significant results that way, but if it isn't too cruel to crack some bones into the right position I would love to see how this could progress (I mean, I think this is how you get Mojo jojo, but c'mon)
@ICECAPPEDSKY 10 ай бұрын
@@dltr4730 honestly you are probably better off using a larger animal like a dog for that purpose
@DogDogGodFog 10 ай бұрын
@@dltr4730 I don't think physically expanding a skull is possible. Okay well. In babies it may technically be possible, because the skull is not fully fused yet...
@Pincsi01 10 ай бұрын
Assuming human brain tissue is any better
@sanguillotine 10 ай бұрын
@@DogDogGodFogyes, but that’s a human specific thing, humans are born with unfused skull plates so that they can fit through the narrower birth canals of their mothers. This is not the case with other mammals.
@user255 Жыл бұрын
You know when the rat brain is overtaken by human brain cells when they start to declare wars and are deeply interested in money and shiny objects.
@Flahtort Жыл бұрын
Skavens
@batatanna Жыл бұрын
Nah that only happens when they're put into a perfect (dys)utopian society made to answer all their needs until they eventually collapse onto each other and go insane.
@Borgilian Жыл бұрын
Oh, so basically they become rat-faced (((talmudic little hats)))?
@justanotherguyful 11 ай бұрын
You just described Israel
@user255 11 ай бұрын
@@justanotherguyful _"You know when humans have overtaken Israel, when they start to declare wars and are deeply interested in money and shiny objects."_ Yeah, the cancer is everywhere. No need to mention any specific country.
@EchoYoutube 2 күн бұрын
So you're telling me, the first animal I'll ever be able to have an actual conversation with.. is gonna be a rat. *Not complaining.*
@288theabe 9 ай бұрын
“Dollar store in-vitro neurons” 🤣🤣🤣🤣🤣
@JustinHallPlus 11 ай бұрын
Unpopular opinion: regular rats are already self aware, so you can't make new "self aware" rats.
@mo-s- 11 ай бұрын
based
@danielboone8256 11 ай бұрын
Is there any evidence rats can think about themselves, their thoughts (if they have them), or reflect at all?
@zazzyboy8592 11 ай бұрын
@@danielboone8256yes it’s called not thinking you are special because you are human. Mammals for the most part are extremely smart and aware creatures
@danielboone8256 11 ай бұрын
@@zazzyboy8592 That’s more of a claim than evidence. I could also say that that theory leads to the conclusion that animals are moral agents (assuming you accept the premise that humans are morals agents and the premise that any consciously self-aware person is a moral agent), which contradicts our intuition and experience. So, what evidence do you have for the belief that animals are self-aware?
@DarthVaderfr 11 ай бұрын
@@danielboone8256 well they are aware in the sense that, they react to the environment and are able to learn, It's difficult to say how aware they are
@britwadsworth3047 Жыл бұрын
Love the high quality content keep it up!
@Azyraasr 9 ай бұрын
The rat woke up and became as smart as a human
@pablovaldes2397 9 ай бұрын
awesome video
@conwaytwitty8634 11 ай бұрын
This show is genuinely funny. I got the giggles learning about human/rat brains fused together.
@godladio3723 10 ай бұрын
Honestly, if I can one day work alongside with a rat that has a human brain in it, I’d not only be ecstatic I’d also be extremely intrigued
@flameburst5585 10 ай бұрын
Days later: the rat sues you for harassment
@Smokkedandslammed 3 ай бұрын
I mean....are some of these people out here actually smarter than a rat?
@wlday_ Ай бұрын
i want to give a rat a human brain it be like "whats up bro"
@Brindlebrother 3 ай бұрын
When you get a random itch under your nose, that is a scientist tickling your rat-brain counterpart
@showyourself9796 Жыл бұрын
Wow, that's fascinating! I truly wish that one day I could work on research like this one . Thank you for the wonderful video . I am glad I found your channel .
@chijiokemadubuko9004 11 ай бұрын
So you are basically showing yourself?
@showyourself9796 11 ай бұрын
@@chijiokemadubuko9004I chose this name during a difficult period of my life when I wanted to change myself, and it helped a lil. It's like a small reminder for me to show who I am and not be afraid to speak about my passions and what I enjoy doing.
@showyourself9796 11 ай бұрын
@@chijiokemadubuko9004 I dont really know what you mean by showing myself , but I can say that I try to express my dream and my feelings . It's fun :))
@chijiokemadubuko9004 11 ай бұрын
@@showyourself9796 I think it's cool and all. Just made the joke to make you laugh.
@showyourself9796 11 ай бұрын
@@chijiokemadubuko9004 It's ok . It was fun xD Maybe I was overthinking a bit
@catpoke9557 11 ай бұрын
This is something out pf a horror movie. Imagine having a piece of brain that doesn't belong in your head and then it starts GROWING in your actual brain until it starts to change how you behave. This feels scarier than a parasite controlling you because it's harder to notice and it feels more.. malicious. Like it feels like the brain itself is choosing to take over consciously even though it obviously isn't
@ariesleo7396 11 ай бұрын
It’s more like someone giving you an extra eye, it’s not controlling you, but it’s giving you extra senses.
@catpoke9557 11 ай бұрын
@@ariesleo7396 I'm talking about a hypothetical scenario in which it does take control, I should've specified
@Quetzalcoatl_Feathered_Serpent 11 ай бұрын
Since the Brain isn't itself sentient and grows with the animal, it pretty much becomes part of that creature. If however you have a sentient brain that is more complex enough to do decision making and can overtake its host brain then yes that could be potentially malicious. Although in order for that to work said brain needs to already be adapted to its host or at least biologically be able to live in a environment similar to its host brain.
@themarlboromandalorian 11 ай бұрын
Eh... More like getting a RAM upgrade.
@conorflinn600 11 ай бұрын
@@Quetzalcoatl_Feathered_Serpent Made me think of some of the tyranids from warhammer that have 2 brains one about as intelligent as a hungry cow with a cannon on it's back with a brain that aims and fires it occasionally having to tell it to move
Ihm Curious
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