Specific (Adaptive) Immunity | Humoral and Cell-Mediated Responses

Рет қаралды 89,888

Күн бұрын

CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram.
This is how our bodies learn to identify a new pathogen and develop immunity to that pathogen in the future.
🔬For all my science videos and other resources, check out: www.justinmsiebert.com
💻 My youtube channel: / siebertscience
0:00 Introduction
0:48 A Wild Pathogen Appears!
2:11 Phagocytosis and Presenting the Antigen
3:27 T-Helper Cells
4:29 Humoral Response (B-Cells and Antibodies!)
7:07 Cell-Mediated Response (Killer T-Cells!)
9:18 Recap
11:13 More bad acting...
_____
Image used:
“6VSB spike protein SARS-CoV-2 monomer in homotrimer” commons.wikimedia.org/wiki/Fi..., 5-HT2AR, CC0, via Wikimedia Commons

Пікірлер: 137

@halqthedarktemplar Жыл бұрын

To add a bit to the cell-mediated response for people reading the comments, the infected cell presents the antigen via the MHC-I (instead of the MHC-II of the APC cells) and the T-killer lymphocyte uses the CD8 receptor for that antigen

@naylacalvin2507 3 ай бұрын

Thank you it was actually helpful

@user-wx8kv8ty3o Ай бұрын

Fantastic lecture and comments.

@zizojaezekeom3565 14 күн бұрын

But T8 lymphocytes need T4 lymphocytes so how did T4 lymphocytes get activated if they don't recognize CMH1

@Charles-uk6ur 6 күн бұрын

@@zizojaezekeom3565 well the macrophage has MHii that presents the antigen,the MHii and is recognised by cd4.while the affected cell has MH i that it presents the antigen with and is recognised by cd8 in short macrophage MHii - cd4 affected cell MHi - cd8

@fimpero994 16 күн бұрын

I've been trying to get my head around this topic for months now and I stumbled across this video, ive never heard it explained so well and so precisely yet in a way so easy to understand. You're an extraordinary teacher, THANKS!

@charlespolino 14 күн бұрын

Can't begin to express how excited I am to have come across your channel! 60 slides all explained in one amazing video, and everything just clicked in my head. Thanks Siebert!!

@chefmittens3056 Жыл бұрын

This was insanely precise. I love that you follow such a linear path for something involving a lot of steps at once. Seriously thank you thank you thank you. I've watched a lot of good videos on immunity but yours was the only one to truly make it fully understandable.

@SiebertScience Жыл бұрын

Thanks so much for the kind words! Glad you found it helpful.

@user-hv6ow1tu6x 10 ай бұрын

Yes, this is so true thank you😊

@flygirlkc 2 жыл бұрын

Thank you for the "clear as glass" explanation!

@SiebertScience 2 жыл бұрын

You're welcome!

@heatherkrn5200 Жыл бұрын

This is the most helpful video I have seen on the interaction within the adaptive immune system. Thank you for such a clear explanation

@TiaDimi Жыл бұрын

I have been researching this topic over the past week for an assignment, struggling to find anything as clear and helpful as this video by a mile. This video literally feels like the best video on the whole internet for explaining B cell and T cell functions and specific immune responses in general. The detail is perfect, the whole video flows. Thank you so much, I really appreciate your work!

@darianleduc 7 ай бұрын

Thank you so much! Adding the etymology of the cell and biochem names is super helpful

@puneet1173 2 жыл бұрын

Thank you so much. I have spent hours looking for videos to help me on this topic and now you have made it crystal clear in my head. Please continue to make more videos they help so much

@SiebertScience 2 жыл бұрын

Aw, thank you for the comment! Glad it was helpful!

@SyenPie 8 ай бұрын

EXACTLY. This was by far the best video I've found on this topic, presented in such a CLEAR and organized way! This man truly has a gift for teaching.

@zygridollero5479 Жыл бұрын

Thank you so much for doing this! I was having a hard time reading about this topic on my own. It made so much sense :D

@bonner9900 3 ай бұрын

The best and clearest presentation !

@arnabray3662 2 жыл бұрын

Thank you so much for such amazing explanation. Definitely gonna nail this topic tomorrow

@marthaschurr7827 8 ай бұрын

Great video, and such beautiful visuals

@chrissvitreoushumour 7 ай бұрын

awesome explanation. you connected the processes of cell-mediated and humoral immunity really well

@annguy5563 3 ай бұрын

This is so amazing, you explain what my 3 hours lectures couldn't in 10 minutes.

@jenniferthomas6592 9 ай бұрын

This was super helpful! Thank you!

@mondelwane8592 9 ай бұрын

I wish you were making videos 4 years ago, my goodness man you are a life saver

@jennyrios9535 Жыл бұрын

Reviewing my Physiology notes to take my TEAS exam. I looked through so many videos that were either too complex or too simple. This was perfect! Loved the artwork and the clean separation of processes. Thank you!!!

@SiebertScience Жыл бұрын

You're welcome! I'm glad you found it helpful. Yeah, it's hard to find resources at the right level for a lot of this stuff.

@user-wx8kv8ty3o Ай бұрын

Fantastic lecture and comments

@hollyweselowski7442 2 жыл бұрын

thorough and helpful, im an NP student and this was SUPER helpful !

@tiffany6376 2 жыл бұрын

I got frustrated learning about immune system, but your video is truly a big help for me to understand it better. Hopefully u will continue making new videos cause I gonna be a big fan of your

@SiebertScience 2 жыл бұрын

Glad it helped! I plan to keep making more videos!

@v.2435 Жыл бұрын

This is so concise, Thank a lot Prof. !!!

@laurenbaron6820 2 жыл бұрын

Thank you so much! Very helpful video. Love the pictures made it much more clear :)

@SiebertScience 2 жыл бұрын

You're welcome!

@sagaranilkumar8619 Жыл бұрын

Oh thanku so much for that wonderful class helped me to understand the topic very much... plz keep going and post more videos..

@jo_lenin8990 2 ай бұрын

Super cool video. Thank you so much. You make it straight forward, interesting and deep at the same time. Best doctor here!

@pulkitverma8104 Жыл бұрын

Brother one of the finest video on this topic.....you got my respect 👍🏻🤝🏻

@hamzaha.al-quaid2441 2 жыл бұрын

Really awesome big picture video. Thank you🙏🧬

@ratanraj743 3 жыл бұрын

You are wonderful ... clear and crisp ... wish youtube present u to the needful learners in the manner how our cells present the antigens for betterment of body :)

@SiebertScience 3 жыл бұрын

Thanks! I hope KZfaq listens to your advice, haha! :)

@sandyable Жыл бұрын

so far your videos have been very helpful:) thank you for making it easier for us. although I didn't believe you were sick :x

@samanthaagneslumapas8479 Жыл бұрын

Big help 🎉 thank you!

@taylorguarino1555 7 ай бұрын

Thank you so much for this amazing video

@NappyZoeRebel 2 ай бұрын

Great video!!!

@TheTiss1982 3 ай бұрын

This man needs a medal for this breakdown! I’m passing this exam! Talk about confidence he just gave me

@akeminnocentosagie5901 11 ай бұрын

You have definitely help and educate me so so much with your videos. You are the best with the You analyses and make it look very simple to understand. Thank u so much.

@carlapaperdoll Ай бұрын

Bless you! Please continue doing what you're doing! You're an angel

@karl_fischer Жыл бұрын

I have a class test in 4 hours and now I am fully confident that I'll ace that! Thank you.

@celinaleal7692 Ай бұрын

Love your videos! I'm doing biomed and some concepts I just cant' understand until you explain it. Also, omg I love Cells at Work too!!

@jonnymercy4528 2 ай бұрын

best guide ever!

@TP-mv6en Жыл бұрын

This is a great video thanks so much for making it

@user-pc6or2qi2m Жыл бұрын

thanks heaps for this video!

@sookieseestruth7573 4 ай бұрын

This was the bomb. Thank you

@sarahlee3100 6 ай бұрын

Please continue making these videos. Once I learned about your channel, I can't stop watching them to learn more! Very concise and easy to digest diagrams (they are also very cute) Thank you so much

@SiebertScience 5 ай бұрын

You're welcome! I plan to keep making them!

@lamarjr001 Жыл бұрын

You’re the best!!🏆🔥

@carolinew1616 8 ай бұрын

THANK YOU! 🎉🎉

@khalidabdulfattahmutwally9286 7 ай бұрын

Extremely beautiful and beneficial. I love that so much.. please continue

@emersongill8501 4 ай бұрын

I'm a very visual learner and the way you drew it all out and separated the different processes! thank you for finally helping my brain understand this topic :) If I get an A on my exam today I can thank you!!

@SiebertScience 4 ай бұрын

Glad the videos were helpful. Let me know how you did on your exam!

@kimmagri181 2 жыл бұрын

Very helpful ! Thank you so much :)

@SiebertScience 2 жыл бұрын

You're welcome!

@alperbulut1267 8 ай бұрын

i didnt had a problem with focusing on your lecture. That's rare for me thank you for the video

@user-nw4sp1bp5v 9 ай бұрын

Nursing student here! Thank you so much for these videos!! You are a hero!

@dejamin876 11 ай бұрын

Many thanks very good video

@ddamme05 Жыл бұрын

I'm not a Bio major but this is probably the best video explaining anything ever. Helps me understand research I'll have to read for my extra-credit assignment. Thanks!

@SiebertScience Жыл бұрын

Best video explaining anything ever??? What a great compliment! I appreciate it!

@rajabumlaluko2897 7 ай бұрын

I found it more helpful and easy to understand

@mulukenm268 4 ай бұрын

What an attractive and genius way of presenting!! Please continue doing it for other parts of pathology and physiology. You made the subject matter very edible 😀😀😀

@SiebertScience 4 ай бұрын

Thanks! I plan to keep making videos 👍🏼

@stephaniemiller5165 2 ай бұрын

I Spent a week trying to figure this out and u explained it in a few minutes. You are truly a teacher indeed. Can you couple this with the Mac 1 and two? Omg you are good. I have hope now of passing this section of the exam tomorrow!

@Jarh9999 Жыл бұрын

thank you sooooooooo much this clicks so well now

@SiebertScience Жыл бұрын

You're welcome! Glad it helped!

@cbri1621 10 ай бұрын

Your videos have single handedly taught me all of the systems that we need to know for the MCAT! I never took anatomy as its not required for us and when I started studying I had regrets on not taking it, but man your videos on the immune system, digestive, respiratory, circulatory and kidneys have literally taught me everything!!! Your videos are so well put together and so easy to follow I hope KZfaq pays you a million dollars a year for your services :) Question about the immune system: So what is the difference between MHC-II and MHC-I? Are MHC-II's only present on macrophages? Seriously thank you x 1000 and I hope to use your videos throughout medical school once I make it there :)

@vectorie6195 2 жыл бұрын

Thank you so much

@AnaMishu 2 ай бұрын

I always watch your videos before reading a textbook bc most of the time textbook seems very complicated, then I do my quizz assignment with ease

@JessicaDejesus60 Жыл бұрын

wow thank you so much!!

@milliecroft1200 2 ай бұрын

I dont think ive ever commented on a youtube video in my life, but this was so helpful i almost did a backflip out of joy, thanks !!!!!

@yhwhspirit 11 күн бұрын

I thank God for helping me find this channel 🙏🙏 immunology best explanation ❤

@mohammedshamboul3145 11 ай бұрын

Thank you You are good medical teacher I watch in youtube

@evamaryanti800 4 ай бұрын

Not so convincing coughing, but the lecture was amazinggggg. Thanks!

@SiebertScience 4 ай бұрын

So you’re saying I shouldn’t quit KZfaq to become an actor??? ;)

@gellerhockey1213 Жыл бұрын

Thank you!!!!

@HamedAlqahtani Жыл бұрын

thank you so much

@allround8771 3 жыл бұрын

I've been watching a couple of videos on the Immune System and I could easily admit that you're the Phil Jackson of Immunology. Well, Phil Jackson with a touch of DiCaprio (nice fake acting lol). You've mastered the act of transferring knowledge. Thank you!!!

@SiebertScience 3 жыл бұрын

Hey, my students tell me my acting is improving! But they’re probably just being nice... Thanks for the comment!

@ethancraeynest4183 10 ай бұрын

very clear and specific video, just hoped you would take about the types of interferones and the "component system" too. This would have helped to be even more complete. Maybe talking about the NK-cells too but overall very very good video

@martashenker 8 ай бұрын

NK cells are part of the innate immune system, that's why they are not being discussed here

@croys8608 3 ай бұрын

Thank you,

@eman.hasann3335 7 ай бұрын

U r one of the best youtuberrrr❤❤❤❤❤❤❤

@osamaelessawy4796 7 ай бұрын

thank you

@mollygrigg7005 2 ай бұрын

I watched the lymphatic system video and now this … and I want to watch the blood one next. For the very first time I’m finding human body systems fascinating. Never had such a great teacher before. I might have gone into medicine if I had had videos like this in my younger life! Now I’m going to use them to teach my kids!

@SiebertScience 2 ай бұрын

Aw, thanks for the kind words! Best of luck with homeschooling anatomy this year!

@Heh18287 19 күн бұрын

thanks you for this AMAZING explanation, and you should definitely be an actor😂

@elle3947 2 жыл бұрын

Took me so long to understand until this short video , so clear :) thanks

@user-ck8qz6yb6n Жыл бұрын

100% perfect🤞👏👏clear and understandable ♥️

@SiebertScience Жыл бұрын

Thanks so much!

@victormulenga4690 2 жыл бұрын

wonderful and help tutorial, I like it

@SiebertScience 2 жыл бұрын

Thanks for the comment!

@MdR15 Жыл бұрын

Just Excellent💯💯

@SiebertScience Жыл бұрын

Thank you 🙌

@eman.hasann3335 7 ай бұрын

Thank uuuuuuuuu❤❤❤❤❤❤❤❤

@ilaly8347 15 күн бұрын

You’re literally the best!!! I don’t know why you don’t do biochemistry😭

@SiebertScience 15 күн бұрын

I’d love to do biochemistry someday. But this isn’t my job…I do all this stuff in my spare time, so I’m pretty limited in how much content I can make.

@grrrrr219 2 жыл бұрын

hataraku saibou in the background! It's a good show focusing on body immunology ! 😄

@SiebertScience 2 жыл бұрын

I was hoping some people would notice that! Great show!

@mangajunction8762 Жыл бұрын

This is good ✨

@SiebertScience Жыл бұрын

Thanks!

@aggelikinakou_ 2 жыл бұрын

oh my god, thank you so much for this video, immunology is driving me crazy

@cortneyellyn3233 14 күн бұрын

When you're taking a 6 week online accelerated A&P 2 class before nursing school starts-- you're freaking out and then you find Siebert Science. I may pass now. THANK YOU. lol

@shalulubelle1 6 күн бұрын

same lol

@cortneyellyn3233 14 күн бұрын

Do you have a video on Hypersensitivity Reactions?

@Ahmad_Fawaz Жыл бұрын

Can you make vd about the non-specific?

@medianayaseen1610 Жыл бұрын

I have a question regarding the B cell maturing in the bone marrow i read in multiple sources that it start’s developing in the bone marrow but continues in the spleen to final maturation but i also read it matures in the bone marrow so can you tell me which is true?

@Yo_Thenics Жыл бұрын

What about MHC 1 that present the antigen for T cytotoxic?

@JarodKientz 3 жыл бұрын

I like the Cells at Work easter egg.

@SiebertScience 3 жыл бұрын

Yeah, I just discovered the show last week! So good!

@prernapatil6458 Жыл бұрын

can you just clear a doubt ? How can cells retain specific memory of any pathogen in spite of having average life span?

@karl_fischer 11 ай бұрын

they keep dividing into new cells and passing on the information.

@trinityg8511 5 ай бұрын

the best video to explain this. I really wanted a clear cut, step by step demonstration and this is incredibly helpful. thankyou!

@teresap8428 7 ай бұрын

The intelligence of our body

@VennelaReddy-fj3st Ай бұрын

this guy made my life a lot easier

@triggeredbiology4726 7 ай бұрын

This is for class 12??

@bili4591 Жыл бұрын

The problem is, everybody start to modify the truth at the moment of the cross between innate and adaptive immunity so I can’t know what is real or not real ... - The T helper cell learn the shape of the antigen presented by the APC and goes on ? OR - The T helper cell have already learn a antigen specificity at the birth and goes on only if himself and the APC match ?

@justgremoryy2148 23 күн бұрын

Cells At Work!! i love that anime!

@andreasvanbrusselen3802 Жыл бұрын

Goat

@alvinsun2346 Жыл бұрын

very helpful, especially when you have a teacher that doesnt do her job

@SiebertScience Жыл бұрын

Thanks! Glad you found it helpful. Yeah, a bad teacher makes it tough, but as a student you have to find what works for you! (such as finding KZfaq videos)

@haley3730 9 ай бұрын

APC: the body’s way of wearing the blood of our enemies 😂 Those cells literally decapitate the invader and WEAR it’s body to alert other cells!! How cool is that!!!

@szxnv Жыл бұрын

goated

@samanthadebruin1467 2 жыл бұрын

would Humoral mediated immunity be how we build immunity through vaccines???????///

@SiebertScience 2 жыл бұрын

There are several different mechanisms for different types of vaccines, but understand this type of immunity is kind of the first step in understanding how those work.

@johnyannelli2480 7 ай бұрын

I would be very careful if you listen to this and use it to learn immunology. It is oversimplified. For example, CD4 does not define specificity nor does it recognize antigenic proteins. This is mis-leading. Be careful.

@SiebertScience 5 ай бұрын

Thanks for pointing this out! I added a correction in the description: "CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram."