It is the third entry in the Marvel's Spider-Man series, acting as a sequel to Marvel's Spider-Man (2018) and a follow-up to Marvel's Spider-Man: Miles Morales (2020), with Peter Parker and Miles Morales struggling to navigate the next steps in their personal lives while combatting an assortment of villains, including a private militia led by mercenary Sergei Kravinoff, and the extraterrestrial Venom symbiote, which bonds with Parker and threatens to destroy his personal relationships.