Statins and Life Extension - How accurate was that study?

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Statins and Life Extension - How accurate was that study?

Рет қаралды 1,685

Күн бұрын

We often hear that statins only extend the life of patients by a few days. This data must be taken in the context to which it applies: patients at a high risk of dying from cardiovascular disease in the short term.
Nevertheless, I am deeply suspicious of these numbers even in that context as they are presented to us.
In this video I call into question the computations behind these numbers (for example, an average life extension of 22 days for people at high risk who take statins every day for 5-6 years.)
It is important that we use accurate statistics as much as we can, and those of us who are statin-hesitant, (as I am), gain nothing from incorrectly citing such data to support our position.
The Material Presented in this video is used in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: creativecommons...
Citation:
Kristensen ML, Christensen PM, Hallas J. The effect of statins on average survival in randomised trials, an analysis of end point postponement. BMJ Open 2015;5:e007118.
doi:10.1136/bmjopen-2014-007118
This is an open-access video licensed under these same terms
Chapters:
00:00 Intro
00:30 Discussion
01:08 The Paper Being Reviewed
02:08 How they calculated the results
07:42 Problem with units
09:20 Possible Flaw in Calculations
12:54 Correcting the formula
16:19 A flaw we propagate
17:59 Closing Thoughts
References:
The effect of statins on average survival in randomised trials, an analysis of end point postponement
bmjopen.bmj.co...
British Medical Journal, May 2015
[1s] Supplement
bmjopen.bmj.co...
[2] Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels (LIPID Trial)
www.nejm.org/d...
New England Journal of Medicine November, 1998
Photo by Andrea Piacquadio: www.pexels.com...
Video by Oleg Gamulinskii: www.pexels.com...
Video by Tima Miroshnichenko: www.pexels.com...
-------------------------------------
DISCLAIMER: The following presentation and all presentations on this channel are for informational purposes only and should not be used to diagnose or treat any medical condition. Please consult with your personal physician when deciding whether to treat or not treat any condition with pharmaceuticals or by any other treatment or therapy. In particular, never change dosage, stop taking medications, or change a therapy because of something presented in this series without discussing your options with your primary care physician or other health professional.
The author is not a medical professional and is presenting his own story, research, and opinions as they apply to himself, and himself alone.
If you think you may be experiencing a medical emergency, immediately call your doctor or dial 911.
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Пікірлер: 36

@psoneill813 Ай бұрын

I got off statins at the beginning of June. I no longer have the bad muscle pain and tingling I had. I am relieved.

@mystatinfreelife Ай бұрын

Very common experience. I went from being barely able to walk on some days to pain free in a short time.

@psoneill813 Ай бұрын

@@mystatinfreelife Thank you for your videos...they made me realize it and I feel better!

@tallgrass9366 Ай бұрын

I enjoy your considerable effort to bring up dificult topics in statin analysis for our benefit.

@mystatinfreelife Ай бұрын

@@tallgrass9366 Thanks!

@leonfuerst4790 Ай бұрын

Russ, thanks for the video. Remember that we are all born to die. Quality of life and side effects of medicines are also variables.

@mystatinfreelife Ай бұрын

Yes, I hope the message here is seen as be wary of any individual data point and consider all aspects.

@SET12DSP Ай бұрын

Why I take a multi-pronged approach to heart disease not relying on anyone factor. But I do believe that Linus Pauling is one of the smartest men that ever lived in the last 1000yrs to be one of the largest factors in the reversal of my heart disease.....

@JohnA000 Ай бұрын

My father always said, no matter what you do you'll never get out of this world alive.

@SET12DSP Ай бұрын

@leonfuerst4790 no a problem but I rather get out later than sooner!

@tmad-sb6mj Ай бұрын

Some time ago I was reading a definition of 'science', probably by a philosopher of science. A requirement of science is that experimental data should be openly shared, so that other scientists can replicate the experiments and verify results or disprove. By that reason I would submit that much of 'medical science' is not actually science! It has aspects similar to alchemy... 😄

@mystatinfreelife Ай бұрын

@tmad-sb6mj Lack of transparency of the data is one reason why I am suspicious of all the studies.

@worldcitizenra Ай бұрын

This was an interesting exercise. However, it still doesn't change my personal view of risk. I definitely wouldn't take statins to live on average an additional 22 days. But I also would not accept the risk of adverse effects from statins hoping that I will be among the 495 people who take statins for 6.1 years just to live on average an additional 6 months or so. I still don't see that as a sufficient benefit. Especially when I have a higher probability of being in the group of 4,000 people in either group who did not die during the 6.1 year period whether or not they took statins.

@mystatinfreelife Ай бұрын

Thanks for weighing in. I agree, this may not change the equation for many of us. It's too bad we can never know how it will help an individual and we are forced to base our decision on basically our personal values in light of shaky statistics, including the probabilities of a degradation of Quality of Life. I certainly haven't changed my position either.

@JohnA000 Ай бұрын

what about the 70% increased risk of developing diabetes.

@mystatinfreelife Ай бұрын

@@JohnA000 I cover that here to some degree: kzfaq.info/get/bejne/aspjdpaFut_KZ6c.html

@JohnA000 Ай бұрын

@@mystatinfreelife Well I haven't dropped statins yet but I am about to. I just have some concerns about it because I am trying to switch to carnivore.

@mystatinfreelife Ай бұрын

@@JohnA000 I suspect that your doctor will have a fit - on carnivore I suspect your trigs will decrease, and HDL will increase, but so might your LDL. It may be Pattern A (or transform towards that eventually) but most Primary Care Doctors really don't care about that. It's even possible that your Lp(a) may decrease, though that effect may be minor.

@fiddlerJohn Ай бұрын

I remember solving physics problems by first doing a 'unit analysis.' That what you just did. Good job.

@tallgrass9366 Ай бұрын

Please consider doing a podcast with the original authors of the bmj 2015 Study. Your audience i think would like an expanded discussion of some of the key statin studies such as this one. You would be very good as a host of this. And it would benefit the science by keeping key studies "alive".

@cherylking1459 Ай бұрын

I love your review here. Excellent work.

@John-ri1pc Ай бұрын

Another informative video. Thanks Russ.

@davedonnelly5587 Ай бұрын

Intellectual honesty….. what a rare thing. You may be right… You may be wrong…. Being willing to attempt to call BS on something that would confirm your own bias is what science is all about, (and why good science is kinda rare). Kudos.

@vadimesharak726 Ай бұрын

Well, applaud! The same way you can calculate how statins would shorten the lifespan and combine it together. The only question is that there is no data about that. Cherry picking data does not allow to fairly generalize pros and cons

@Dino-wq5sm Ай бұрын

I took atorvastatin and had bad muscle pain in my neck muscle, the next day , I could tell, take low dose it goes away faster, I rather exercise and diet in low carbohydrates , drink water and walk 30 minutes a day for 7 days , It worked for me, I see my numbers going down slowly but surely , especially my LDL and hdl

@mystatinfreelife Ай бұрын

I have found my LDL goes down if I hike for days on end. That's probably my body's appropriate response in that case. I think we really need to gain an understanding of why our cholesterol levels are what they are, instead of defaulting to "higher is bad". I can keep my PCP at bay by simply having my blood tests done after a backpacking trip (10 days or more), but that doesn't rally give me the understanding.. something I'm still trying to figure out.

@dacisky Ай бұрын

You mentioned this,so I want details of damages caused by statins.

@mystatinfreelife Ай бұрын

The details are spread over several videos. I will try gathering them in some coherent fashion into a unified video in the future.

@shawnfallahi5616 Ай бұрын

would you take someone with heart disease off their statin?

@mystatinfreelife Ай бұрын

@shawnfallahi5616 I have no medical training, so I would not advise anyone with (or even without) known heart disease on getting off statins. I can only point out what the studies say, and how strong or weak such studies are. For someone with heart disease the decision is incredibly complex and unfortunately very difficult to get truly unbiased information on. And of course, I have biases too.

@shawnfallahi5616 Ай бұрын

@@mystatinfreelife Understood. thank you for the reply and have a great weekend.

@JMK-vo8pv Ай бұрын

Russ, do you think that STATIN therapy might be contributing to President Biden's cognitive deterioration?

@mystatinfreelife Ай бұрын

It's certainly possibly but entirely speculative and impossible to determine. I wish we had an objective test for such things, but we don't, and aren't likely to have one anytime soon (for anybody.)

@waynetrenton2310 Ай бұрын

I had similar thoughts.