Studying sleep and consciousness with TMS EEG

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Why does consciousness fade during non-REM sleep?
This is a puzzling question, explains neurophysiologist Marcello Massimini, because the brain does not “shut down” when we fall asleep. Rather, neurons can show comparable firing rates, albeit with different patterns of synchrony from what is seen in wakefulness. Here, Massimini explains how he and his colleagues applied TMS to subjects while they were awake, and after they fell into unconscious sleep, while simultaneously recording the EEG. With this "perturb-and-measure" approach they tested the hypothesis that the two states differ in terms of levels and patterns of connectivity - predictions made by the Integrated Information Theory of consciousness. It’s a technical tour-de-force, with strikingly clear results.
For more info/content, please visit: postlab.psych.wisc.edu/cog-ne...
Relevant papers:
Massimini, M., Ferrarelli, F., Huber, R., Esser, S. K., Singh, H., & Tononi, G. (2005). Breakdown of cortical effective connectivity during sleep. Science, 309(5744), 2228-2232.
Ferrarelli, F., Massimini, M., Sarasso, S., Casali, A., Riedner, B. A., Angelini, G., ... & Pearce, R. A. (2010). Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proceedings of the National Academy of Sciences, 107(6), 2681-2686.

Пікірлер: 8

@Ronayne015 4 жыл бұрын

Maybe a future analysis could include a deep meditation group. Perhaps the influx of perceptions and limbic reactions to sensation during wakefulness pre-load the neural network with complex (de)polarisations, thus prohibiting a uniform "neural sonar" response as shown during unconsciousness.

@KrisAmos 4 жыл бұрын

I wonder how this would look if an H-coil was used and BOLD measures we taken. What difference would we see in wake vs REM sleep participants at subcortical sites, especially compared to non-rem sleep?

@bennguyen1313 2 жыл бұрын

Any thoughts on consumer grade TMS/tDCS/tES devices that attempt to *INDUCE* sleep? NeoRhythm, Muse S (Gen 2) Hapbee , Cove, NuCalm, EarthPulse v6.0 Sleep on Command System, SEDONA Pro PLUS+

@joywong23 Жыл бұрын

Thanks for the details important secret, is that consciousness restore during dreaming? No consciousness in sleep without dream?

@shanthakadam1960 3 жыл бұрын

Sir Beautiful sleep is very complex mechanism I think. Only one thing I understood is that neurons communicate with sensory organs during day but it won't at night. What makes them to cut down this communication is what am I interested in. Plz do videos on sleep and its process. Why cell need rest but not the neurons?