T cell Development

Рет қаралды 39,221

Maureen Richards Immunology & Microbiology

Күн бұрын

Пікірлер: 28

@maxgosselin62 4 жыл бұрын

"you will have time to digest this" Me looking at this video 2 days before the test, having not studied at all: "ha, no"

@danimari516 Жыл бұрын

My dental school immunology professor could learn a thing or 200 from you. Thank you for clarifying this concept (and B cell development) for me after hours of rewatching my professor's lectures!!

@WeijieYao1994 4 жыл бұрын

why do i pay 1000$ for a teacher that don't teach and you're free

@victoranosike2621 3 жыл бұрын

Exactly

@angiemillermusic1 2 жыл бұрын

love ur channel! made me genuinely interested in the immune system. (instead of just learning it for class!)

@delilahjones6496 Жыл бұрын

I do believe in regards to positive selection that it is not the affinity of self-MHC recognition that determines cell fate, but whether or not the peptide bound to MHC is recognized with better affinity by the TCR and it's co-receptor CD4 or CD8. So, if a peptide is presented by MHC II and the developing thymocyte TCR and CD4 co-receptor recognize this peptide with the right affinity, then it becomes a CD4+ T cell. Correct me if I'm wrong, that's just what I read recently that it's a combination of all these factors and the co-receptor affinity is important in positive selection.

@sanjib_75 Жыл бұрын

You really are an amazing teacher. Thank you for making these videos.

@mariammusri5640 3 жыл бұрын

Thank you SO SO much, you really helped me understand this, you're amazing!!!

@antoniomele436 4 жыл бұрын

Thank you! This was very helpful

@panyuanlim1116 4 жыл бұрын

Thanks You made my microbiology exam

@maureenrichardsimmunologym9632 4 жыл бұрын

It's my pleasure

@latifahahmad5348 3 жыл бұрын

you're saving my grade!

@WhyNot-si4pj 4 жыл бұрын

20:00 "Positive selection" takes place through the interaction between DP lymphocytes & self MHC molecules ! I've 2 questions : first , Is it dendritic cells that present both MHC I & MHC II self molecules ? second , Why does CD8 WEAKLY recognizes MHC molecules in +ve selections & self antigens in -ve selection ?

@JacobSchomer 5 ай бұрын

Because you want the immune response to the mhc molecule and antigen combination and not too strongly to the MHC itself

@rumesahashmi2775 3 жыл бұрын

very helpful

@saraha.3860 2 жыл бұрын

Thank u so much

@sn-7754 4 жыл бұрын

Nice video mam,I have 1 doubut allelic exclusion occur during t-cell development like B cell?

@maureenrichardsimmunologym9632 4 жыл бұрын

Hi Darshit, thanks for watching! This is something that has been the focus of study for a number of years. When I last looked, it appears that both T cells and B cells engage in allelic exclusion. This is how the "unsuccessful" chromosome avoids expressing an antigen receptor that is different from the "successful chromosome. This way we can be sure that T cells and B cells only have 1 antigen specificity. If you have data that says otherwise I would be very interested in it!

@WhyNot-si4pj 4 жыл бұрын

In B cells allelic exclusion takes place AFTER (DJ) gene segment rearrangement of the Ig heavy chain in the EARLY progenitor B cell line i.e : starting from the LATE progenitor B cell line ! In T cells the (DJ) gene segment rearrangement of the beta chain - corresponding to the Ig heavy chain - takes place during the DN2 cell line ! Do we have evidence of allelic exclusion starting from the DN3 cell line ??????