Targeting Aging Ep3 - Rapamycin Benefits, Side Effects & Doses

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Targeting Aging Ep3 - Rapamycin Benefits, Side Effects & Doses | Professor Matt Kaeberlein Interview

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Күн бұрын

Professor Kaeberlein talks about rapamycin, what are the benefits that it has shown, some of the side effects and myths around them and what doses he is using in the Dog Aging Project.
Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He is currently leading The Dog Aging project, a large multi-year trial to study the aging of companion dogs in a normal environment. He has published nearly 200 papers in top scientific journals and has been recognized by several prestigious awards, including a Breakthroughs in Gerontology Award, and most recent GSA’s 2020 Robert W. Kleemeier Award
Professor Kaeberlein at University of Washington depts.washington.edu/mbwc/abo...
Dog Aging Project. dogagingproject.zendesk.com/h...
#DogAgingProject #rapamycin #Healthspan

Пікірлер: 55

@susanc.2482 3 жыл бұрын

Thank you for another great interview!

@dlhanson51 3 жыл бұрын

Another great video! I have bern taking Rapamycin at 6mg/week most weeks ( I skip after a FMD week). I enhance the effectiveness by eating a grapefruit 30 minutes before swallowing the Rapamycin tablets. Zero side effects.

@RickLindstrom 3 жыл бұрын

Feel free to ignore these questions if they are too nosy or personal, but this is the first comment I've seen from someone saying they take rapamycin. Was this prescribed by a dr (and what kind of dr) for a specific aliment, or as a longevity supplement, or did you choose to take it yourself as a longevity supplement? What country are you in? How long have you been taking it? What is your approximate age and how has that impacted you decision to take it? By comparison I believe David Sinclair takes resveratrol, NMN, and metformin, but not rapamycin. I believe Peter Attia previously took metformin but stopped. (I'm was just searching and he might actually be taking rapamycin now, which I was not aware of.)

@dlhanson51 3 жыл бұрын

@@RickLindstrom No problem answering. Not prescribed. I chose myself to take Rapamycin as a longevity supplement after reading many published papers, Dr. Green's clinical observations, and informal discussions online with people including a few MD's who take it themselves. I am a few months short of 70 years. My view is the benefit for at least older individuals is positive. Known side effects are mostly non existent. Questions exist about long term usage and dosing do exist. Tests on humans so far indicate that immunity is enhanced at low and intermittent doses. (Number one issue from people who haven't done their research is to automatically and incorrectly assume that immunity would be harmed at any dose.)

@dlhanson51 3 жыл бұрын

@@RickLindstrom A good way to start learning about rapamycin is read papers by Mikhail Blagosklonny.

@DonLeatham 3 жыл бұрын

Thanks for your informative comments. Are you able to measure any effects of the Rapamycin for you personally? Effects on blood labs? Glucose? Triglycerides?

@ModernHealthspan 3 жыл бұрын

Hi David, thanks for sharing. It is really interesting to hear from someone who is taking rapamycin. Can I ask how long you have been taking it?

@Leoninmiami Жыл бұрын

thanks you so much!!

@MsElaine122 2 жыл бұрын

Dr Green's latest is 20mg Rapa / every 2 weeks. Prior protocol was 6mg once per week. NOT 3x per week. Need the 1/2 life to trickle down to zero per Green. We need more tests re benefit / doseing / frequency.

@SteveHazel 2 жыл бұрын

oh - just found this. it's GREAT :)

@rapamycinnews 2 жыл бұрын

Just to add another comment - I've been using rapamycin for over two years now. More energy, aches and pains have largely gone away. The side effects I've noticed are occasional small skin rashes, and once a canker sore that went away after 3 days.

@V.Hansen 2 жыл бұрын

How is it possible to acquire Rapamycin?

@lokeshmayannagowda8336 2 жыл бұрын

My triglycerides tend to raise post rapamycin dose.

@Edovic13 Жыл бұрын

@@V.Hansen indiaMart It is sold as Sirolimus.

@someguy1169 Жыл бұрын

What's your dosing regimen currently? Age and weight too if you don't mind.

@rapamycinnews Жыл бұрын

@@someguy1169 I take 8mg to 10mg per week, 164lbs, age 59

@howardmiller5411 3 жыл бұрын

Thank you and most interesting!

@ModernHealthspan 3 жыл бұрын

Hi Howard, thanks!

@abrahamnorthhampton3327 3 жыл бұрын

Another enlightening segment. Given that Rapamycin is an antibiotic, I'll wait for more information before seeking to add it to my regimen, but I will be waiting eagerly. It seems quite promising. Also an interesting insight into the mTorc1 vs mTorc2 discussion. This is the first time I heard from anyone in the field that suppression of mTorc2 might not be a bad thing. Lots to learn. Thank you for bringing so much interesting and insightful material to us.

@ModernHealthspan 3 жыл бұрын

Hi Abraham, thanks for the comment. Yes, I found that was really interesting as well. Especially as he described rapamycin as a "very safe drug" which is not the impression I have got from other sources. Hopefully the dog trial will provide more clarity on this.

@romari2706 2 жыл бұрын

Rapamycin is an antifungal. It originally was produced by bacteria to fight off fungi in Easter Island.

@ronm6585 3 жыл бұрын

Thank you.

@ModernHealthspan 3 жыл бұрын

Hi Ron. Thank you!

@americanladybug3354 2 жыл бұрын

I'm interested the in the studies uc Davis is doing with cats in using rapamycin to reverse heart disease. I believe ncsu is also doing a clinical study. From what I've read a combination of rapamycin and metformin is the best treatment. Metformin promotes AMPK and the combination of both seem to guard against insulin resistance. Very exciting!

@elliottrubenstein1746 2 жыл бұрын

You are looking younger. Keep it up.

@250txc Жыл бұрын

CIGS were marketed as good also back in the 50s ...

@paulwolf3302 2 жыл бұрын

Great interview. The key info for me is at 17:45, where Dr Kaeberlein says he suspects Rapamycin works by reducing age-related inflammation, particularly inflammation caused by senescent cells. We already know other ways to reduce inflammation and kill senescent cells, that don't require prescription drugs and are better understood. My favorite one is fisetin. Quercetin is also anti inflammatory, and NMN may be as well. So I will leave rapamycin for the dogs and mice for now.

@robertdeskoski9783 2 жыл бұрын

@Grim Reaper: Exactly. It's one study with the ITP but damn, I was disappointed.

@arturosidransky2866 Жыл бұрын

Hydrogen by tabs into water also decreases TNF tumor necrosis factor and IL-6 that drive inflamation

@marcosta183 Жыл бұрын

What about combining Rapamycin with Metformin? It seems, after new studies, that one drug compensates the side effects of the other, considering the correct dosages...

@iainhutchinson345 Жыл бұрын

For anti ageing what should be the dosage?

@bobcocampo Жыл бұрын

Any update after 2 years?

@ankur0682 3 жыл бұрын

Very informative. What's your take on Rapamycin Richard?

@ModernHealthspan 3 жыл бұрын

Hi Ankur thanks for the question. I have not tried it so I have no direct experience. I think Prof Kaeberlein's view is very interesting as it was different from the prevailing view of Drs Kennedy and Sabatini who both viewed the long term effects as being negative. He also pointed out the negative side effects could because of the large doses used in organ transplant patients. He also said it was a "very safe drug". It is good to hear different opinions even it means that there is no clear answer!

@rapamycinnews 2 жыл бұрын

@@ModernHealthspan Richard, one thing to note - both Drs. Kennedy and Sabatini are involved with startup companies working on other MTOR inhibitors, so they have a financial interest in focusing on the negative side effects seen with rapamycin at the very high doses of rapamycin used in Cancer and Organ Transplant patients - as high as 40mg to 90mg per day. This contrasts to the minimal side effects we see in dosing of 5mg to 20mg per week that are used in anti-aging.

@julioalmeida4645 3 жыл бұрын

Im talking to my anti-aging doctor to try to get a cycle of rapamycin that dodges the effects

@mrpmac 2 жыл бұрын

Or just buy some online. Rapacan.

@user-lg4cv1dj6k Жыл бұрын

@@mrpmacwhere?

@Renku07 2 жыл бұрын

Does anyone know where can rapamycin be purchased? I looked at Amazon, and I had no response for rapamycin. Thanks.

@MrJacks1959 2 жыл бұрын

As it requires a prescription you won't be able to find it on Amazon.. There are a few people who have commented on other related videos where they purchased it..

@Fizzypopization Жыл бұрын

You can get it via healthspan (online pharmacy).

@arturosidransky2866 Жыл бұрын

give me your email and I will send you contact .

@GodDieux 3 жыл бұрын

just started using it this week at low dose.... once a week. I wanted to get a feel for it and so far so good. metformin just did not agree with me, although I do enjoy resveratrol nmn tmg .... I may add grapefruit juice next week to get that 350% boost.

@marianamaia9917 2 жыл бұрын

Can you answer me a question? How old did you started taking rapamycin? Do you continue taking Trans-resveratrol? Metformin wasn't good? I'm considering taking rapamycin and I already take resveratrol.

@bobcocampo Жыл бұрын

Test in prisoners in the Philippines