You know you're high at home watching this. We both know.

"The endocannabinoid system responds to singing and dancing." This makes me wonder about ancient cultures, Native Americans, and their harmony with plants and nature. Methinks humans need more connection to the plant world to live a happy and fulfilling life!

I can say with confidence after 7 years of smoking that when I go without weed I DO INDEED become more irritable, easily stressed, less positive and just overall don’t feel very good until I give my body time to upregulate my receptors again. Dude, this lady isn’t “bashing weed” or saying its bad she is simply clarifying the potential negatives along with the positives by allowing the viewers to see the WHOLE picture on cannabis use, short term AND long term. “FDA brain washer” not even close bro 😂😂😂 those people run wild for sure but this lady just spitting facts. 🤷🏽‍♂️

As a medical student, I could only dream of having a professor explain medical conceps in such an understandable way

The power of the endocannabinoid system and how it relates to all relevant health systems is amazing. We have to convince medical schools to teach this system to the doctors of the future. It’s the reason why I created a whole education video series around CBD. Just make sure you do your homework and know what to look for in a high quality and safe product. Great talk.

It has worked miracles for my uncles who, 3, have MS. Myself for addiction to opiates, clean over six years now, and more importantly attacking the root issue, ptsd. It’s helped me with my issues when needed as well. now, it is amazing to see the positive view by the population, which is long over due. I cannot believe we are finally seeing the gov appreciate their citizens wish, hopefully legitimate. Now If only they would finish the idea of removing it from S1.

Good concise talk. I am not pot user but strong supporter of decriminalization and appreciate good unbiased information... knowledge is power.

I may or may not have experienced some cognitive dissonance while viewing this presentation.

endocannabinoid has been a study for a long time, and there is a good reason why people are now becoming interested in it. There is a lot of good benefits on using it.

Re: Dependence and a down regulation of the endocannabinoid system. I use cannabis to regulate my emotions and deal with stress. For 42 years, I didn’t need to do this. When I turned 43, my underlying depression became impossible to manage on my own without meds. SSRI’s didn’t work for me. I didn’t like how numb they made me. Cannabis puts me right back on track though. Could it be that age, stress, or genetics makes some people’s endocanniboid system malfunction? And in this case wouldn’t cannabis be seen as a reasonable solution? Like any other medication? And it’s not synthetic?

For just over 20 years I had been taking Paxil and Klonopin daily so I could function dealing with C-PTSD for about 3 years I was on Oxycontin for arthritis pain. One of my doctor visits I was asked if I would be willing to give cannabis a try, I did not think it would help all that much I have smoked it many times before. I studied it got my card and now I do not use any prescriptions, just cannabis and it is doing me wonders. Losing the side effects alone from prescriptions was fantastic. With that said I found this talk very interesting but if a person is living in a constant state of fight, fight, or flight (used fight twice on purpose) would THC be the perfect key? Not only did she dismiss CBD she did not mention all the other cannabinoids and terpenes, cannabis is far from being all about THC and CBD but people are stuck there.

Thank you for the value of your time I wish people could see more truth in cannabis can treat cancer related illnesses.

Thank you. Wise words. All the best to you.

She did a great explanation on the endocannabinoid system but when she talked about cannabis THC i felt like she wasn't as confident as before

really appreciate her delivery of thought.

This was not only interesting to get an idea of the very unknown ECS, but also why the "face your fear" approach to anxiety for many might be the correct approach if it truly learns how to compensate for the stress over time and make it a far less mentally challenging experience for people

She lost me at the 9:30 mark. "For CBD we still have a lot of questions about how it works." So, I guess were just going to dismiss the 20+ years of studies done by the Israeli doctors that discovered the ECS...ok then!

After stopping smoking weed I feel like this actually makes a lot of sense for me in particular

Thanks for this clear breakdown of the ECS. Would love to hear the talk re: CBD that you said would be an entire other talk. The information out there is extremely confusing and limited re: how CBD actually interacts with our ECS. In turn, there is a lot of misinformation being shared everywhere by all kinds of publishers and companies.

Incredibly informative. Great job.

The levels of stress people experience overwhelms the endocannabinoid system. That's why we have so much inflammation and stress-related diseases. Why don't doctors talk this negatively about Xanax, or Valium, or Klonopin, or any of the drugs prescribed for depression and anxiety? I've known several people whose lives were totally disrupted by these drugs.

THC replaces anandamide and disturbs it's natural production. Anandamide seems rather important for managing mental illnesses. Which is why it makes Schizophrenia worse. Cannabidiol almost has opposite effect. And is all around a good guy molecule. Also exercising on THC is probably a good idea and easier than you might think. It would like having a runner's high before you run.

Great elegant talk! For me the gist is this: Honeymoon with weed legalization is over and now we should figure out what this stuff really does to our bodies. So basically we are in a middle of a massive social experiment. And as ever since runs behind the giant Cannabis industry.

She explains it so eloquently. Definitely one of the better TED talks I’ve seen.

This was very helpful, thank you

Awesome lecture!! Love It!!

But she would have dinner and a bottle of wine or a few beers without a second thought. Why is alcohol which has no medicinal value and is processed and causes illness and deaths be allowed but we are denied cannabis which saves lives? This is twisted. Money money money. Money matters more than lives. Money rules.

Cannabis has been around for years and used in this country for hundreds of years. This sounded more like a Pharmaceutical talk for drugs not the plant and its well founded medicinal benefits. Granted research is scant here in the US but we have been funding Israel for years and they have tons of research on cannabis benefits as well as Spain!

Thanks for a great educational talk. I learned a lot.

This video reminds me that a medical dispensary recently opened less than 2 blocks from my house and I have no medical card and no buds... :(

🔵 THANK YOU for this content 💪💪💪

As many of the popular comments under that video pointed out, there are DEEP PROBLEMS, and DEEPER PROBLEMS, associated with respect to anyone actually 'employed' in established systems. Generally speaking, people deliberately do NOT recognize their own surrounding keys and locks.

She TOTALLY left out the Terpenes and Flavonoids that are important in the "entourage effect"....her lecture is woefully incomplete at best. Grade D

Now I can finally explain the psychoactive reaction! It's basically just you timing and dosing it wrongly! As a healthy person it can lead to wonderfull things but in case something is wrong the overcharging can pinpoint the problems which then have to be resolved with a perfect combo of THC and CBD. If only the pharma industry would have never stopped the researches early 1900's many of my family members would be still alive. Thanks for your work Dr. Ruth Ross you saved so many people and hopefully make them aware of the pharmaceutical scam THEY are trying to pull through the last 100 years 🙏🙏🙏🙏

This is brilliant! I'm a second-year medical student, and we get to write a 5000 word literature review on a topic of our choice - mine is the upcoming use and opportunities for use of cannabinoids in medicine. Some of the information you've given here is going to be invaluable in setting a foundation for my literature scavenge. I'm not sure if Dr Ross will actually be reading these comments, but, if you are, thank you!

Cbd oil helps me. That's all I care about.

This talk is actually not about the effects of cannabis but about the isolated effects of THC. Her views here about the effects of THC on the endocannabinoid system may be very interesting to the pharmaceutical industry, but to those of us wanting to understand the effect of THC when You use the plant naturally it is almost irrelevant.

Very Educational, thank you!

Great presentation. Thank you. These are very insightful findings. I'd like to see studies that compare medications/herbal interventions with lifestyle support changes that enhance the body's ability to self-sooth and self-regulate such as exercises or stimulating pressure points. Comparing it between no intervention and medication/herbal intervention doesn't give an accurate depiction of our choices. If we discount the help our own body provides for us when given the opportunity, we set ourselves up for dependences and further complications.

The hardest task for a TED- speaker is to separate the real valuable facts and knowledge, from the manipulated information and fake news... If you watch this one carefully, you will realize what I'm talking about...

amazing tedx talks

And yes, the downstream effects of receptors and of cell permeability is very important. Second messengers are the future of understanding neurochemistry. It does get a little crazy when you're trying to understand receptorivity, cellular permarability (as in ionophores), second messengers, neuro-anatomy, and how all that relates to behavior.

This presentation is all over the place! She is either high or needs to be.

It is very interesting to hear this..., but I live in Europe and here THC is not allowed. So we have very good Quality from CBD and this is so helpful for People, without intoxicant or psychological change...! For me would not possible to become healthy without it! I love it!

She told the story, the insight was good, she gave it a shot, it was ok!

I been exercising massively for last 6 months. I had a operation and almost lost my left hand. They said it depends on my health. After 6 months of it I have so much energy people think I'm on drugs. I think it's the endocannabinoid system.

When I stopped taking an SSRI, it threw me into the worst depression, because my natural serotonin production had been horribly down regulated. Nicotine has a similar effect in how powerfully it down regulates serotonin. That's why people struggle to such a degree quitting smoking. Nicotine is very addictive. Quitting SSRIs was a nightmare that ended in a hospital emergency room. THC doesn't do anything like that. It doesn't down regulate to the same extent in most people; so it's not considered very addictive. It's my personal belief that I have never produced enough endocanabanoids. Microdoses of medical marijuana have helped me tremendously over a long period of time. Moreover I skip days with no ill effects.

So helpful!!!

Anyone who uses any kind of cannabis please come forward and help with this research! Simple!

9:05 , THC is not actually in cannabis plant. THC is an oxidized / decarboxylated form of THC-a ( carbon active THC/ acidic form ) which exists on living cannabis plant as glandular resin located in the trichome of the flowering cannabis plant. when the plant completely matures into fruition, it dies and dries and the carboxylic acids then melt away from the molecule exposing the active forms of the compounds ( Hi Grazing nature !) ... that exposed compound molecule form is the active version of the compound ( THC) .

The serotonin down-regulation by SSRI antidepressants results in a range of symptoms on discontinuation much more dramatic than THC discontinuation.

I've smoked my entire life. Not as much as some but I was a daily user for sure. At about 50 I cut back quite a lot and enjoyed not being high all the time which was refreshing. I'm a shy person by nature and weed made it worse which probably closed some doors. Regrets? No , I raised four great kids , quit alcohol , which would have and should have killed me , so all in all pot didn't ruin my life but I'm sure it changed it. I started having anxiety when I smoked (when the weed we grew exceeded twenty percent , lol ) so I pretty much quit. No withdrawls or issues there. Now at almost 63 I microdose a puff or two no and then. I told my kids , don't try pot! You might like it.

Cannabis has been used for thousands of years (probably 10.000+ even) and the only ones complaining about it are the ones that ISN`T using it.. what´s up with that ey ;/? Also, what you call "dependence" I call "preference", as in; "I prefer to feel free enough to choose to take a delicious (imo) health-supplement if I feel like it, aslong as it doesn´t harm anyone."

There should be research into why cannabis is helping me with physical therapy.

Interesting in that she postulates that Cannabis affects the endocannabinoid system by chance, saying it is a question of probability only. I'm not so sure.

Here's your data: in America, for instance, tens of millions of people have been consuming THC on a regular basis since the mid-1960's. This group is certainly large enough to draw scientific conclusions from. Such as, there isn't a single negative health effect that can be identified within this group that doesn't exist in the whole population. There's been no increase in schizophrenia as a percentage of population. Cancer, diabetes, stroke and heart disease are in no way elevated in this group. Conversely, we know for a fact that tobacco, fast food, soft drinks and Republicans actually kill people on a regular basis, all in their own way. With tobacco, our response has finally reached a proportional level. With fast food, soft drinks and Republicans, we are firmly in denial. The attack on marijuana began back during the Depression. A decade later, Congress held a hearing on marijuana, wherein a doctor from the AMA testified that he could see no harmful effect from using marijuana. Rather, it made people calmer. One of the Congressman replied "doctor, if you don't have anything to say to help us, why don't you just go home?" That's America. We make up our mind about something and the persecution begins. So, while this video was interesting, Dr. Ross' conclusion that more data is needed, simply ignores the overwhelming data that exists.

So what’s the alternative pharmacy drugs. I’ll stick with cannibus

"Fun Facts" 6:21 Singing and Dancing - ie art activities - activate the endocannabaninoid system. As one of the first plants cultivated by humans and disseminated along the silk trail it has been studied for millenia and its effects and positive and negative qualities documented.

I want to know more about this. Are there any updates on the topic since then? Thanks in advance

Oh yeah, and I have to add this:. my thing is behavioral neurochemistry, and my specific thing was always 5HT metabolism. Particularly 5HT2A.

I was hitting my bowl as I watched this 😆😆😆

12:05 any link to studies for this ?

I was tired and almost had a stroke reading the title at first glance

And, of course, cannabinoids are known to suppress glutamatergic activity in the hippocampus. Meaning that cannabinoids can suppress, or bring to the surface (in a beneficial way), salient memories.

Thats why we smoke the whole flower and not try to isolate thc

How can you keep talking on endocannabinoid system without talking about ANANDAMIDE..

The psychosis question is for me related with what the environment do to the person. Facing THC is like being interrogated: you have to be prepared.

Was going to down vote because this was nothing new and not the best presentation, BUT the down votes are exactly 420 so let's keep them that way

I use (ok am addicted to) snuff tobacco (no longer smoke, use cannabis & alcohol) & I think tobacco must have some kind similar cannabinoidic effect, though milder? It's effect flutters between calmness and anxiety, depending like she says on what's going on, i.e. time, situation etc. I think smoking is similar also. Hoping to quit snuff soon so my system will have to become normalised. I expect it will be difficult.

If you didn't know her amazing accomplishments she would gladly go over them with you.

The fact that there’s 420 dislikes on this. Well played stoners, well played. 😂

What Dr. Ross said about it causing some psychosis made sense because there are people that can't handle it for sure. But juxtaposed against alcohol and opioids you can say cannabis is safe in my opinion. We are on the cusp of THC infused food and drink going legal in October 2019 so it will be interesting to see what happens. A lot of people simply can not inhale without coughing so bad they decide right there cannabis doesn't work. Be interesting to see what they say the first time they get stoned later this year. There should have been more about CBD and what role it plays hopefully the good doctor can do another Ted Talk.

Context makes the poison, as with any drug. Personally, I find cannabis to be quite useful to help me gain an appreciation for things I might normally find stressful. Especially with excercise, learning new ideas or practicing skills, all of which I can find quite tiring and frustrating, cannabis helps me focus on thr task. What's nice about this is that I can still train grit sober, which counteracts a lot of the stressors elsewhere. That being said, she is right that cannabis is not always completely benign. Some of the worst anxiety episodes I've had have been while I'm high, and can last for days after I clear up. Still, I am aware of the situations which cue them and have been getting better at avoiding those cues. The dependency issue is also quite real, and I have taken fasts from cannabis on a number of occasions to mitigate it, but it still can be very sticky if I'm not careful. Still, I think that with the right practices and knowledge, the benefits can easily outweigh the risks for me. I'll be interested to see what else they learn in the future

Sounds like a great medication. How long will it be before you can patient it and make it into a tablet ?

It is also about dosage, quantity, frequency, set and setting...

She said cannabis is not the reason we have an ECS. But I don’t believe in coincidences lol

To me marijuana makes me feel bad but that's cuz of medications I already take but to some people it does help them

I liked the initial explanation of the endocannabinoid but when she was talking about using Cannabis it seemed like her presentation was more skewed to present the drawbacks and downside of Cannabis. She only briefly said that it may help with some symptoms and then quickly added that it may relieve some symptoms in the short term but make them worse in the long run and followed that by saying that scientists are developing medicines to target the endocannabinoid system. Hmmm... pharmaceutical companies can make lots of money off of medications.

Big pharma wants to create long term customers. These substances may threaten their bottom line hence the suppression

Congrats

I think the important thing here is that we need to do more studies.

Such excellent explanation, but leaving the topic on a negative note I though. Little emphasis on the benefits. Great overall

I’d love to add some of this into my documentary I’m making as part of my uni course work. Could the owner of this please message me.

im regulating my receptors now

13:15 - THC is a non selective weak agonist with Low binding affinity... ECS still works fine with THC present

The understanding of , the where and how used , the side effects or affects the entire intake of the hole being before ie. Other drugs that are still in the body producing effect that affects the metabolism of the hole of the plant . What of the carbon monoxide produce when burnt or vaporized, when inhaled bonds with the erythrocyte platelets impairing oxygen use , absorption and distribution, so many variables. But the plant does work.

Did I just get this, weed makes part of my brain system stop working? Doesn't that makes one dumber? I quit weed!

Yea it all fits so nicely with the theory that plants grow in the same dirt god grew U.S. from funny how that’s is though considering how many people don’t believe

I'm impressed by how reluctant are people to accept facts, just because they confront or contradict their personal believes. People would rather select just bits of information and dismiss the truth just because it looks unpleasant or confronts them in a personal level.

How long does cbd block the faah enzyme?

I plan on mixing THC concentrate with CBD CBG and CBN distillate I'm not sure if it will have any effect seeing how I am going to mix them all together

Is it a separate body system like digestive system and neurological system?

4:29 - predicted there are way more EC receptors , 300 cannabinoid receptors is the prediction , each being toggled by intracellular/extracellular ligands / lipids

100% impossible to become physically dependent on THC. Mentally addicted yes, much the same as one can become addicted to water or air.

I am a duffus, a social failure. I am not allowed to know these things. Yet, I am a HUMAN SUPER-COMPUTER. I studied these things for fun.

I've even smoking for years now, but I micro dose off of concentrate oils. I usually take a puff or two and I'm good for around 3 hours. Everything in moderation is good, even opiates.

16:24 so long term study on alzheimers, parkinson and epilepsy. Also compare with MCT oil or with coconut oil and without

The runners high is thought to be due to annandemide in recent times which is a endogenously produced cannabinoid. So runners are stoners teehee

Of course this Ted talk goes into THC and weed, rather than the Scottish woman immune to fear, anxiety and pain.

We absolutely love cannabis education! THANK YOU!