This is why James is the best out there, great content in his videos, and he does a outstanding job of explaining the exercises in his exercise videos, Im 64, and he's one of the reasons I switched to training with resistance bands, thank you again James.

This is the best thing I've seen on youtube. MUCH respect.

This has to be one of the most thorough explanations of testosterone, estrogen, Anavar and supplements I've ever seen!

OMG. So glad I found this video. By far, the best vid I've seen for TRT chemistry analysis and monitoring. Very knowledgeable Dr, very easy to follow along. Plane English. Thank you so much!!

Fantastic conversation with a fantastic, ethical and informative doctor. Well done to you both.

This is amazing interview. So calm. So straight forward.

110% great content here. Thank you for taking the time to do this!

Great interview with so many questions I had, just prior to my appointment at the VA clinic. Thanks Dr Osborne & James

Bro, this content was next level stuff! Keep asking the right questions! I’ve seen other Doctor’s YT videos and so far none of them have gone this deep on the subject. Thanks for the good content.

Love the videos man. Extremely informative. Thanks for the great content.

Best explanariam about TRT I ever listened.

Love the video and information! Can't wait for the next video!

Doc is very insightful & informative, some the best info I've heard on the Hrt & or Trt subject matter!!

I’ve watched a lot of videos on this and this by far was my fav. Thank you!

I have watched SO many videos on the topic and this is hands down THE BEST of them [others are not even close].

Age 49, been on TRT for over 10 years. One thing not talked about is other meds you may be taking and how they may affect Test. If you are on any kind of anti anxiety or anti depressant you may not get the full affect of test as those meds can affect libido, sexual performance and energy levels. Also, I've noticed TRT being way more beneficial for those that lift weights or exercise as that is when you really notice the difference. Not sure if it is worth taking if you just want for libido and/or other health benefits as it is hard to maintain a steady balance of hormone levels without the ups and downs. You also have to keep an eye on RBC's and Hematocrit levels.

Great information 👍 what an interview 👏 thank you for your content.

Great info! Cleared up a few tiny things I was confused about thank you

THANK YOU!! amazing video, I looked everywhere for this type of information

Best explanation hands down. Well done Dr. Osborne.

A lot of answered questions. Thank you!

Thank u and Dr Osborn for sharing this. Gotta have a deeper talk with my Dr and probably find a specialist in this.Wish I lived closer.

Very interesting video. I'm 55j old and training from my 15j 5 days a week. I never used anything. Now, I am willing to know how to maximize my T levels on a natural way to be the best version of myself. Can you make a topic of that some time. It would really help me. Thanks for all the great videos

Thank you. Informative, particularly for me about the supplements.

Amazing, amazing video, thank you!!

Excellent information.

Killer video James! Thanks.

Great video!! Very informative and helpful, thank you!

What a great video. Thanks

This video is pure gold

Best video I have seen on trt, thanks for that.

Thank you so much for this video!!! I learned so much! 👍👍👍

Great content.

Great interview!

So much awesome information, thanks mate!

Great vid, very informative.Thanks

Excellent and very informative video! Thank you guys kindly for bringing this information to the public!

Great "inside perspective!" Thanks guys

Interesting information... thanks ❤

This is the best video I’ve seen on the TRT subject in the 8 months I’ve been on it. I’m working on nailing down the right dosage. I think 200 mg a week may be a bit much for me. Thank you for all the information!

Very helpful

Without a doubt, the most insightful deep dive on male hormones out there

Thank you gentlemen

Such a informative video james.. appreciated 🤜🤛

Great interview

Great video!

great conversation

James this is second time commenting you are a great influence was 290 now 217 best shape of my life came up with routine using alot of your advice trying to make it to golden gloves in April hope it gets me threw first week matches. Thx again sir!

Very informative

Thanks for the video. Very interesting information that deserves to be viewed several times to capture it all.

So much knowledge...thank you for this UL .👍🇸🇪

This was super insightful. Some of it still went over my head, but the key takeaway for me is that I need to have a deeper talk with my doctor at my next wellness check about my bloodwork. It's something we usually gloss over but I'll be 43 soon and feel like I've been experiencing changes that I've not been able to put my finger on.

Bro great vid!

Thank you so much for putting this piece of content out. I just turned 40 and have been feeling a drop in energy and libido over the last 2 years. Got tested two weeks ago, and although my total test was 617, my SHBG was was 86 and my free was 6.7! I start 200mg of cyp/week next week and I am beyond stoked. The funny thing is that I still compete in BJJ, surf regularly (2 hour sessions), and stay ripped. People don’t realize that you may look great on the outside but feel like total crap under the hood.

Great video. Just wondering if Doc has ever dealt with an patients that have a mutation in AR gene, leading to androgen insensitivity syndrome? There would definitely be some sort of genetic component to your question about receptors…

this is awesome info.. thank you so much

Great video sir!

Great video. I'm 46yo, and just started my hormone replacement therapy under my doctor's guidance. For reference, my total T was 320, free T was only 4.6ng/dl, SHBG was good at 30, and my available t was only 100 ng/dl. My doctor started me on gel, but I plan to do test cyp at 200mg/week starting next month.

Great Educational Video my friend. I wish all youtubers would follow suit 👍🏼👍🏼

Wow! Well done guys! Only wish we had doctors like Dr Brett in Canada!

Nice video. Good questions.

my shbg is 56.6, ordered 5mg boron straight away, thanks :D

Great video man 👏💪✅️

Fantastic!

Wow..great information,..thank you

Great video and great questions, but it would be even better if you asked him about what is an optimal free testosterone range like you asked him about total T in previous video!) Thanks a lot guys!👍🏻

I’ll be 55 in June and I’ve been increasing my lifting everyday.I haven’t waked up with erecting for a long time.I don’t smoke or drink.I’m not a diabetic. I’m skinny fat. I eat 4 organic eggs everyday with avocado. With Greek yogurt and organic blueberries. I’ve been trying to get my V shaped look back.

Thanks for this vid James I’ve been thinking about getting my T checked so timing is right on

Perfect complement to my current book: Testosterone by Carole Hooven - THX James, this trustworthy insides are rare

Love the video thank u

Thank you for a super informative Q&A with Dr Brett. I have just got my blood test results and the exact scenario highlighted in this video is me. I'm 53, healthy, in good physical shape, I have Total T = 713 (great) but Free T = 7.55 due to SHBG at 90. So Nettle Root Extract and Milk Thistle are my supplements to see if I can lower this and increase my T levels. TRT is off the table until my SHBG is lower and I get some free T pumping, hopefully this will help with my clarity.

James you are my fitness idol. I'm in my 30s so not quite at the level of needing to worry about TRT but such great information in this video and very candid. Gonna give stinging nettle a try for a few months and see if I notice a difference. Thanks for the years of great content.

Great video. So, I am prescribed with 8% testosterone cream but I am scared because of preexisting gyno. Should I take high zinc with cream without AI for start ?

Great video ❤

You found a shirt with sleeves. Honestly, you look good. Nice job.

James, on the Saw Palmetto...I didn't see/hear a dosage suggestion. Do we have a low starting point on that? Great video by the way...answered a bunch of questions I had.

You know it works

Is there anyway to get a list of doctors around the country that you would recommend. Can’t seem to find one who is good in dc, va, or md.

I've been on TRT for 2 years, and I'm in my early 30s. So this was a ton of helpful information for something I'll probably be on for the rest of my life.

I have been on an all natural BOOSTER for about nine months now, just got mt T levels checked a month ago and I have a total T level of 1060 ng/dl and a free test level of 17.5 ng/dl. Im 55 years old. The product is called Aphro D. Great product and no side effects

Is there any type of list for specific companies or places you recommend in different cities/states. I’m in Las Vegas if you have a recommendation on where to go to start etc?

Great vid James thanks again. I got a T test from my physician and the test only shows total T and Free T. If somebody has a low total T number and "normal" free T. Do you think its possible for the doc to make a sound medical decision without SHBG and Albumin #'s?

I was so worried about going on TRT, I'm 50, had blood work done in november 2022, test level came back low 301, forced myself back in the gym since i had balloned up to 420lbs from my inshape weight of 245lbs, was still tired abnormally weak, like I struggled with 175lbs on the bench, but before I gained all this weight, i could still bench over 300lbs, so now I just had my bloodwork done again and now my test is 199! wtf. So my dr has me seeing a urologist next month, I pretty much know I need test. My previous test levels prior to the weight gain was 989, that was when I was 44. So I'm hoping TRT works for me.

I never comment on vids, but I'm getting desperate. In 2 months I'll be 40. Always have dealt with depression and not able to keep weight on until a few years ago. Now I have fatty tissue in my chest that is basically like an adolescent girl. For a couple years I used muscle shirts to descise it, but now I'm so depressed and am giving into the fact that I don't have the energy, or even desire 90% of the time, to try an work it out. I've never gone to doctors much and don't know my levels, but I can only think I must have low T. My testicles have nearly disappeared, and I have no sex drive, even though I had always had a very very active sexdrive. I just went through a relationship with a woman that is SO beautiful and was very sexually active only to be completely disfunctional. I'm a fairly tough guy at heart. Will do absolutely anything I must no matter what the danger is to take care of my family, but just feel like crying all the time. Who can I see and where do I need to go to get help? As a man, I am ashamed of how I feel and act. I want to be a man that will take care of my sons and daughter, but I'm so lost right now... I hope this actually reaches someone that can help and not just be a stupid comment for everyone to critisize..

Do I need a specific doctor for this or would any primary doctor be qualified!

Having high testosterone levels is extremely important, especially in this day and age. Most men today have suboptimal levels of testosterone - a lot less than their fathers or grandfathers had just 30-50 years ago. There are various reasons for this. One factor that is oftentimes neglected is endocrine disruptors in our environment (i.e. xenoestrogens, BPA, phthalates, triclosan, etc), phytoestrogens in food (i.e. soy, which is in almost ALL processed foods), and hypothyroidism (subclinical or autoimmune Hashimoto's disease). There are many ways to increase testosterone levels naturally. Diet, supplements, and lifestyle changes can make a tremendous difference in boosting testosterone, DHT, growth hormone (GH), IGF-1, and other anabolic hormones. Sleeping before 11 p.m. works wonders for your endocrine/hormonal health. Including more cholesterol in your diet which is a precursor to all steroid hormones helps as well - red meat (beef, lamb, bison etc), seafood, eggs, full-fat dairy, organ meats (offal), and saturated fats in general (even plant-based sources, such as coconut fat/oil, cocoa butter, etc). Weightlifting, especially multi-joint exercises, such as deadlifts and squats, have been shown in various studies to increase testosterone, IGF-1, and GH levels. Tribulus Terrestris is a famous supplement that offers short-term benefits, but doesn't address the root cause of low testosterone. No one has a 'Tribulus deficiency'. Concerning supplements, the big 3 are 1) Magnesium, 2) Vitamin D3, and 3) Zinc. Choose a magnesium formula that contains many forms of magnesium as every form carries unique benefits compared to others. Concerning vitamin D, go for a product that is sourced from animal-based sources to maximize bioavailability. Do not use more than 5,000 IU per serving as over the 5,000 IU mark there are malabsorption issues. Break the dose into 2 or 3 servings throughout the day, depending on when you consume a high-fat meal. Vitamin D is a fat-soluble vitamin that requires fat to be efficiently absorbed in the intestines. When it comes to zinc, use zinc picolinate 30 - 40 mg per day taken with a fat-containing meal as zinc picolinate is partially fat-soluble. A nice read on increasing T levels naturally through weightlifting, nutrition, and supplements is 'Vintage Physique' by George Kelly. Old-School bodybuilding diets were very rich in testosterone-precursor compounds, such as cholesterol, saturated fats, monounsaturated fats, zinc, magnesium, vitamin D, B complex vitamins, vitamin E, selenium, boron, iodine, etc. This is one of the reasons why Оld-Schооl bоdybuilders looked like real-life superheroes. If you combine high T with regular weightlifting, the results are compounded (1+1=3). Testosterone also makes you stronger in the gym and more explosive athletically.

I have used Testosterone over the past 10 years. In the last 2 years I have not used any. Feeling flat and low did bloods and was diagnosed with secondary hypogonadism. The problem is when I started with test enanthate 250mg once a month I experienced severe bloating and a very uncomfortable gut. As soon as I'm done eating I would get very uncomfortable and need ed to use the loo. Moved over to test cypionate, 50mg once a week. Same result. It's almost as though I can't tolerate it internally. I have chatted to my endocrinologist and few other well versed people however nobody seems to understand why or how this happens. Any feedback would be highly appreciated.....🙏

They do not discuss the effects on hemocrit and hemoglobin. Not all people respond the same but I was TRT for a year and my hemoglobin and hemcrit levels went through the roof. Just know if you have this issue you are signing up for regular blood donations to keep those in check.

Are the pills 💊 you get in the health section any good? Ive taken T-male for example

Im 45 and my Testosterone has dropped by 360 pts in the last 7 yrs. I was at 890 now at 530 and they have started me on T cream twice a day. I have also started Sermorline once a day at bed. My liver function was very good but my main concern is my estrodial number is at 13.9 and my DHEA was the lowest she said she’d ever seen at 75.9. I will also be supplementing DHEA. Should I be taking something to keep my estrodial numbers down or do they need to increase? I have been taking finasteride for 20 yrs do to hair loss in the family. I am a little concerned that my hair loss will increased by the Test therapy.. I should note my Free T is 93.2. Any recommendations are greatly appreciated

how does one start the process on TRT? looking for a guide to get me through.

I just got tested. Im 62 and my total test was 17.9 or 516 NG. Wondering what the doctor will say

Can anyone recommend a good clinic which will review other bio markers as well as test levels and prescribe remotely?

Great interview 👍. Where can I find a testosterone practitioner in Canada 🇨🇦? Anyone out there know of one in the Toronto area? Thanks

I wanna know which one to get

Is it true that fruit can be good for reducing SHBG?

Are testosterone supplement tablets bought at GNC stores worth while to take? I have been taking them for 60 days now.

What can you take to increase SHBG ? On TrT and my SHBG is at 10 . Never taken anything other then TRT and HCG . Thanx in advance

Hi do I see an endocrinologist for my trt dialing in. Or is it just a primary care physician. I. Considering strongly on starting this year. Hard to stay in shape with metabolic syndrome.

My doctor put me on bioidentical testosterone troches. 50 mg twice a day and 50 mg Dhea. What do you think about this? Been on this for 6 weeks now. The only thing that l have noticed is that my libido is some what better. I am 60