A wonderful spoof of disaster films, The Big Bus is about the world's first nuclear-powered bus - a 75-ton monster on 32 enormous wheels - and its maiden journey from New York to Denver. Jockeying the world's greatest bus, of course, is the world's greatest bus driver. His co-pilot is given to sudden blackouts and has a penchant for driving on the shoulder of the road. A pair of evil-doers vow to destroy the bus at the outset, thus providing lots of hilarious suspense.