The Effects of Forced Exercise on Parkinson's Motor and Non-Motor Symptoms

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The Effects of Forced Exercise on Parkinson's Motor and Non-Motor Symptoms

Рет қаралды 53,740

Davis Phinney Foundation for Parkinson's

Күн бұрын

Пікірлер: 47

@BURTBROWN Жыл бұрын

Many thanks for this.... I live in a small town with few connections to others with Parkinson's. Haven't figured out why I have it and have been a big health nut for decades. Ldopa seemed to do me little good but increased L-tyrosine (1500mg daily) and/or phenalalnine (1000 mg daily) DOES decrease my relatively small tremors quite a bit. Only diagnosed about 18 months ago. Smell: My dad lost his smell fairly early on and in his later 70's began to have some small tremors (he was a watchmaker and needed extreme precision). I never suspected Parkinson's - he never had any major shaking, falling, etc.. I noted your comment on not noticing body odor like I used to - extremely interesting. That maybe happening to me though I use deodorant every few days, even if I don't, I seem to have lost that ability to smell body odor and that frightens me! LOL!!! I'll correct that part. Mississippi and Atlanta have similar climates and I try to walk at least every other day, but it's cold and rainy in the winter and during mid summer gets extremely hot and muggy. Those times I have difficulty walking but may change to a stationary bike or treadmill so I can do those indoors. Caffeine, even slight amounts, can set off shaking. Years ago I noticed caffeine could set of instant rages in me for very little reason. Now I take about 25 mg from a pill to help me wake up - but within 30 minutes, the small trembling will start - sometimes a small amount and sometimes enough to make it difficult to put in my contacts. One other thing I'll bring up is I am hypothyroid. I take about 260 mg desiccated thyroid a day plus iodine. I have no idea if that has any connection to Parkinson's but it certainly helps keep my limbs from getting cold, etc.. It has made my receding eyebrows regrow to fullness, hair all over my body (especially legs) regrow and seemingly the thinning spot on my scalp. No one in my family that I know of has had Parkinson's but a number of us suffer from depression. I've taken Zoloft for many years and mention it because it might have side effects I am not familiar with that could affect the brain and dopamine receptors. The dopamine, serotonin and related brain receptors might have some part in the receptors being affected by side effects. I've never been on drugs, smoked, rarely drink. I do have Hypoglycemic condition diagnosed back in the mid-80's and get very sleepy after sugar or lots of carbohydrates. Sorry, I started this out as just a thank you for the video and felt some of these symptoms and factors might connect with other patients in clearing up these Parkinson's problems..... Many thanks!!!!!!

@davisphinneyfdn Жыл бұрын

Thank you for sharing your situation, Burt. I think everyone really appreciates seeing themselves in others and being able to connect on various aspects of their journey. I'm glad you found us and hope you'll join us morre often.

@BURTBROWN Жыл бұрын

@@davisphinneyfdn Just hoping something connects, whatever it might be, drug side effects, imbalance of amino acids, whatever!!! Many thanks for the reply - Not necessary to reply to this one!!!!

@milesberghan8450 2 жыл бұрын

Great presentation very informative thank you

@SouLightness 2 жыл бұрын

I dance to african drums, indian drums, latin rythms etc...it improves my symptoms a lot. Perhaps the rythm is a manner of "enforcing"exercise

@realparkinsonslisaryan Жыл бұрын

I often see it's other health issues my clients are dealing with that cause them more trouble than their PD. We exercise online 2x/week. They range in age and in degree of PD. One was told his PD is benign after 6 years of working out. He's one happy 74 year old!

@davisphinneyfdn Жыл бұрын

Yes, that's often the case. Exercise is medicine!

@antondelacruz9362 Жыл бұрын

Funny thing is when i walk on a narrow raised platform, like a bar or a raised sidewalk curb, i lose balance easily, but if i walk across while doing eskrima motions with a sword, i dont lose my balance. Normally youd expect the opposite.

@ggswindow 2 жыл бұрын

love his sense of humor...

@julesj5853 2 жыл бұрын

My grandpa has gone downhill quickly with carbidopa-levadopa and always feels better before he takes it. When he takes it he has more falls and instability!

@johntomecek718 3 жыл бұрын

Seeing slides would help especially handwriting results pre and post

@khuwahwin4644 3 жыл бұрын

Thank you .very informative.

@johnswallow1550 4 жыл бұрын

This is not good he keeps talking about charts that are not showing on my screen!

@Taranto98 3 жыл бұрын

i agree and I am a huge fan of this work and the doctor

@rhondadevore267 Жыл бұрын

I agree

@Gkuljian 11 ай бұрын

I was really excited about this when I made the connection that Davis was riding the hell out his bike. Now I don't know what to think. I will definitely continue exercising.

@davisphinneyfdn 11 ай бұрын

Thanks for your message! Keep up the exercise! (And Davis does still ride the hell out of his bike!)

@michaelthompson501 2 жыл бұрын

Great talk!

@rawnoob2143 3 жыл бұрын

the slides alluded to at the 1:28 mark are not present on the davis phinney foundation website

@bestmomever1347 4 жыл бұрын

It is medicine! Forced or not .

@grahamheywood4426 4 жыл бұрын

Very interesting. Thank you

@vonshango6311 2 жыл бұрын

13:35 off DBS before ride had strong tremors, after 4hr ride had none. 16:48 initial study 2007... 19:45 assisted lower body cycling 80-90rpm (65-85% of optimal heartrate) saw incidental upper body/sensory changes ex improved handwriting. 22:40 and olfaction resurrected. 24:32 if we see these changes in upper areas and other functions of the body from assisted lower body cycling, then it must be change something in the brain.

@mkkrupp2462 3 жыл бұрын

The deliberate creation of a disabling condition in a non human species and the administration of electric shocks is morally questionable. Couldn’t these trials have been directly done on Parkinson’s patients without the need for animal experimentation first?

@antondelacruz9362 Жыл бұрын

Thats a lot more morally questionable.

@meduffer 4 жыл бұрын

Fascinating. Thanks for presenting this study.

@taylorgirltoo1 2 жыл бұрын

@darlenevonderlieth888 Жыл бұрын

😢I work with heavy feed bags hay bales and 60 dairy goats here alone my husband died and I have Parkinsons I force myself to work and walk really far too sometimes I have to run sometimes I have a pic of an animal off the floor I have to give shots vaccines😅 that being female I might be weaker than a man lifting these things been taking care of my goats and sheep for 19 years😅 alone😅 I don't know how long I've had it I was just diagnosed last year I am on a low dosage of levodopa very interested in some clinical trials I live in live oak

@davisphinneyfdn 11 ай бұрын

Wow! You're busy! It's great to keep active! Visit www.clinicaltrials.gov/ and www.michaeljfox.org/trial-finder to search for clinical trials. Also, check with the nearest movement disorder center to see what trials may be ongoing near you!

@KetovoreAnita 2 жыл бұрын

Thank you for such a positive and informative talk. Have you noticed any improvements if people change their diets eg to Mediterranean or Keto?

@raywesolowski667 2 жыл бұрын

e-Trike?

@laiwahlee2938 3 жыл бұрын

Exercise is medicine

@FlaschDJ 2 ай бұрын

What a terrible choice: “forced” couldn’t be more different than “assisted” or “augmented” or “helping hand”. And shocking mice into running is NOT akin to what’s going on with humans (tandem bike or motor). Please explain why you call it “forced”. What a confusing choice of terms. Yet, I’m advocate of Dr. Alberts and pedaling for Parkinson’s- but this confusing name, ”forced exercise” pisses me off, frankly.

@davisphinneyfdn 2 ай бұрын

Thanks for your comment. Your observation is not lost on us. The term is complicated. One significant part of the reason we--the Davis Phinney Foundation--use the term forced in the title and other material related to this video is that this is how Dr. Alberts discusses the topic. As you note, Dr. Alberts' research was partially grounded on animal-based research. One of Dr. Alberts' early papers discusses the relationship between animal-based forced exercise and related research in humans here: journals.lww.com/acsm-essr/fulltext/2011/10000/it_is_not_about_the_bike,_it_is_about_the.3.aspx A quote from this article: "In fact, a recent meta-analysis concluded that there was insufficient evidence to support or refute the effectiveness of exercise therapy for patients with PD (25). We hypothesize that the apparent contradictory results between human and animal experiments are due to differences in the exercise paradigms used. The human experiments utilized voluntary exercise (VE), whereas forced exercise (FE) was used in animals." We suspect--but are not certain--that the Dr. Alberts' choice to use the term "forced exercise" in discussing this research derives largely from wanting to differentiate between exercise in other research--which involved VE--and the exercise used in research by Dr. Alberts'. In other words, the term "forced exercise" may be used in this video and the research it describes because the term grounds the research in an alternative line of scientific reasoning. All that said, again, you are right to point out that the term is not without flaw.

@FlaschDJ 2 ай бұрын

@@davisphinneyfdn Thank you for helping me understand - by explaining how we got “stuck” with the unhelpful term “forced exercise” (FE). I need to understand what Dr. Alberts means by FE. I understand that shocking mice “forces” them to keep exercising. Clear. ……… In the tandem-bike situations, it seems like the (weaker) person, in the back, rides with higher RPMs or “rate” (than he’s capable of alone) due to the power of the stronger rider up front. (They share one chain. They’ll have the same RPMs. To summarize: The person in the back achieves a faster (more beneficial) pedaling rate due the person in the front. He is “caused” to pedal faster. I suppose you could say he was “forced” to pedal faster, especially if, like the mouse, he didn’t want to. Turning to humans from mice, it seems like all uses of “FE” pertain (only) to pedaling rate!! In this biking usage, the rider is “made to” (“forced to”, yuch) pedal faster. Some may think I’m being picky but I’m not. The difference between understanding and not understanding could impact the progression of my (probable) disablement. Sometimes having the most descriptive words is vital. “In FE biking, the rider is caused to pedal faster by an assistive motor or human. The benefits of faster pedaling couldn’t otherwise occur.

@FlaschDJ 2 ай бұрын

@@davisphinneyfdn Forced-exercise means: “made to” pedal faster by an external power-source (or force)

@brianjohnston2897 Жыл бұрын

Thank you so much. I have a 74yo Norwegian friend with Parkinsons that I will start this type of programme with together with supplements of Lions Mane Mushroom, Co Enzyme Q10 + PQQ, sauna use and Red Light Therapy (aka PhotoBioModulation)Terrific presentation thanks so much. Brian Birmingham UK