The Nebula and CuriosityStream deal is at an incredibly good price right now - $11.59 is an insanely good deal they are doing for Memorial Day! It won't be this cheap for very long so get in on it while the gettins good!

Epic, I will try this

It took 100 years after its discovery to realize the powers of this jellyfish. It might take another 100 years to implement the beneficial aspects of this.

7:26 "And a bit like the plastic bits at the end of our shoelaces..." They're called aglets, there's an entire song about them.

"The slight inconvenience of death." Great line. I'm really enjoying your content. In depth, very well written, great narrative voice.

I love this channel so much, I started studying biology this semester and we just covered hydrozoa but in a way less interesring way. Its amazing how you can make the exact same topic that much more interesting

It's hard to believe jellyfish and octopuses are from this planet. Evolution in the ocean seems to be so much more advanced than it is on land.

God I love real science You guys have actually taught me a lot

I think there's an overlooked aspect of the regression -- the polyp becomes multiple adults. This isn't one adult reverting to childhood and growing up again to refresh itself. This is an adult reproducing in a way that consumes itself. In an organism, over any given period of time, each cell has a chance of malfunctioning. Over time, these malfunctions accumulate until they threaten the life of the overall organism. In reproduction, a small number of cells are used to start a new organism. Fewer cells, fewer chances for malfunctions, lower chance of enough malfunctions accumulating to prevent the offspring from reaching maturity. If you sample enough conceptions that the number of starting cells is equal in number to the cells of an adult, you will be able to witness the chance malfunctions in the form of birth defects and nonviable larvae/fetuses/etc. But plenty of offspring did not experience those malfunctions, allowing the species to continue. In this regression-based reproduction, there may be a far greater number of old cells which will contribute to each new organism, meaning more defunct cells to start with and thus a reduced viability of each offspring. I'm interested to see if research has been done regarding that.

6:21 Senescence is not cell death. On the contrary. It is living cells deteriorating in function and ceasing of cell division. They're rather accurately called "zombie cells" because they are indeed still active, just dysfunctional. They're still however releasing proinflammatory mediator chemicals, etc. (The so-called SASP, senescence-associated secretory phenotype).

It doesn't just roll back into a 'baby', it essentially turns back into a fetus. It's hard to consider this "immortality", it's arguably the same organism but once the babies spawn from the polyp it's certainly not the same individual. In a human, a process that could take us back that far would wipe clean all of the memories and scars that define a person's identity. You, as an individual human person, would slowly die as your brain shrunk and congealed into a mass of cells with no capacity for cognition. The resulting person(s) would essentially be a clone of the original. As she pointed out, that's not the purpose of the research, I'm just quibbling about how these creatures are commonly referred to as immortal. The research into telomeres could result in some kind of Lazarus treatment, but as pointed out in the video, in humans this would likely not result in us de-aging to such an extent. Most likely it would only "stop the clock" at our current age, but it could also potentially allow us to (very slowly) reverse the negative effects of aging to have the bone, neuron, and muscle resilience of a 30 year old.

I remember watching a documentary about a scientist in Japan that was obsessed with them, and how they may be the key for immortality in humans or much longer lifespans.

The alien creatures we share this planet with never ceases to blow my mind!

“Plastic bits on our shoelaces” Looks like somebody has never watched phineas and ferb

Hopefully one day we may be able to use something similar as a local treatment to fix a severed spine or other damaged tissues.

They literally go "reject maturity, return to polyp"

When literal eternal life isn't even the coolest thing you can do: sending yourself back in time is. Unbelievable creature.

Now in 2022: You know your Jellyfish is imortal😂 Plastic in the ocean be like: ah i don't think so....you didn't see me coming.

You should do a video on the naked mole rat. It’s the only mammal that they’ve discovered that doesn’t age. They’ve also found that lobsters also don’t age. Maybe with a combination of Crisper CAS -9 and these animals we can find a way of extending human life.

Inspiring science, extraordinary editing and perfect narration! Just right, to watch with a cup of tea.

I would love to do this, presuming these are light sensitive, split the groups into two tanks (or one per jelly), and flash lights red for a tested timeframe (say a day- so it's not too long or short), then some of the jellyfish a pinch to trigger it going back to polyp. The other is a control group of course. Then keep repeating this to see if the jellyfish starts reverting based on seeing the red light.

your layout for all your videos are amazing. You explain a little bit, then explain further with strong vocabulary and high res pics and good editing. Nice videos.

So wouldn’t part of the key to unlocking this code be how does the jellyfish harness/control the enzymes that protect and reproduce telomeres?

I've always been interested in the immortal jellyfish.

It is always a treat when this channel produces new videos! Please keep them coming.

Not only microRNA and telomere elongation, but gene silencing by chromatin condensation is very important in the aging process (probably causes the Second one). We need to shed more light on how the process works.

I love your channel! so detailed! keep up this good work.

I really appreciate this series because there are not many cool biology related videos on this platform with this high quality

I'm obsessed with your channel. I love learning about different animals, especially aquatic animals.

Did you know the has avocado we eat technically comes from one single tree! This is true for a lot of stuff, you can find examples of negligible senescence everywhere but it's much less common in vertebrates.

Other animals: Oh no I'm gonna die 😢 Immortal Jellyfish: Ctrl + Z

Imagine existing like this for eternity, just existing, not knowing your in water..just existing in this environment…true hell

I would love to see a vocab list at the end btw, some might find it annoying, but I feel like I’d be able to remember more if the videos had this feature

Imagine how amazingly stellar the leap to immortality will (hopefully) be in the future of our species. Learning about this little creature is truly inspiring!

Amazing video! Excellent narration, fact finding and explanation on one of the most amazing animals on earth no doubt thank you.

I feel as though my lifetime's worth of sci-fi stories have come to life lately...

Wow, absolutely stunning information and as always perfectly made video. Thank you

Wow this is so intriguing! Nature truly is such a wonderful thing 💕

What an incredible creature!

I appreciate the shopped photos/locally filmed footage and editing instead of stock footage

Amazing, as always. Thank you!

i think the most interesting thing that could happen is life not being extended at all even if we physically retain our more youthful looks for longer so we just end up with 80 year Olds looking like 30 and 40 year olds.

I literally learned more about biology right here than in my biology lessons. I like this channel

I love that you have the references!!!!! I actually want to read more about this

*Grim reaper shows up* Jellyfish: I'm bout to ruin this mans whole career

Real Science literally became my science class

Your voice is just perfect for these kind of videos

Absolutely amazing content. Greetings from Brazil!

It's crazy to think about how nature has all of the answers to our greatest questions. Or will eventually figure it out.

I wonder if in the future we will find a way to synthesize telemorase and use it as a treatment to extend our lifespan

Im excited to see what potential this knowledge and AI can produce for the human experience! What a time to be alive!!!

I love this channel so much. Thank you!

When you think you can't get surprised anymore...

Who came here after Miles told you about the immortal jellyfish?

I heard a theory once that we lost the ability to regenerate telomeres as a defense against cancer (cancer cells can regenerate telomeres), is this jellyfish any more likely to get cancer?

Amazing video, gotta love this channel!

Thanks these vids are so well explained 👌

Could this form of regeneration be considered a type of cloning- seeing as you end up with more, genetically identical (I assume) jellies?

3:44 this is the generalized life cycle for scyphozoan jellies ("true jellyfish"), not for the hydrozoans, which Turritopsis belongs to. Turritopsis medusae develop as buds on the stalks of the polyp colony, and then detach as young medusae which resemble smaller versions of the mature medusae. They don't strobilate, i.e., divide via transverse divisions along the stalk of the polyp like is shown here, and they do not have an ephyra-like appearance as young medusae-the term "ephyra" is only used to describe young scyphozoan medusae.

Really awesome and promising field of research!

Absolutely fascinating

Truly fascinating 🎐

imagine it gets a lifetime prison amount

I love all your videos and watch them every week.

Fantastic presentation. Very interesting and informative.

So we can use the jellyfishes telomerase to repair our telomeres? maybe we could have some kind of telomerase injections to boost telomere repairs

Fascinating! Nice content and presentation. This seems like a shortcut around nature's genetic blender though, and could lead to dead ends in the paths of evolution.

Cyst and polyp is something else in the medical world 😂😂

the writing in this episode was impeccable

I would almost like the idea of immortality, if the universe itself he'll or our solar system and galaxy weren't going to die themselves and come to an end. It all seems pointless then. So maybe just a way to slow down aging, some sort of nanotechnology that can be created on a micro level to keep the telomeres elongated will work better for us.

Brb, let me crawl back in my mom's womb

I love the way you say “Jellyfish”. It makes me feel younger.

Great post my friend. Very fascinating abilities !! 🤩

I'm curious, could we use telomerase in some way to reverse damage to our own telomers?

Tbh , as a Zoology student i learnt more about animals from this channel than my textbooks lol😆

i found some of the lines so funny! like the shoelace tip, lunch with no content etc etc!

Thanks for such an incredible video

Your videos have such amazing production quality. It is always well presented and is a treat for curious folks. Keep up the good work. +1

When adulting gets hard..

Yes! Her voice is everything!

This type of knowledge is absolutely groundbreaking and fascinating! what a beautiful video presentation of the information!

Im convinced jellyfish aren’t from earth cause this is incredible

“Can’t eat your lunch until you find something good to watch” been there 😅

Love it!!!!! Thanks for sharing!

Scientists discover that living cells are machines and life is intelligently designed. It shouldnt have taken them so long.

Real Science lapel pins 🥺👉👈

I love your work!

Thank you for this!

How does a jellyfish taste like when cooked and eaten?

Despite the economic downturn,I'm so happy☺️. I have been earning $90,000 returns from my $7,000 investment every 14days.

Great lecture Thanks!

Another really well done video :)

Effective and intriguing presentation

The best and coolest animal ability. Deserve highest recognition among all animal

Real Science, please make a video on the insane biology of the Eel!!

For more information about the Buteyko method you can read the following 2 articles: - Kazarinov V.A. (1990) "The biochemical basis of KP Buteyko's theory of the diseases of deep respiration" - V.K. Buteyko, M.M. Buteyko (2005) “The Buteyko theory about a key role of breathing for human health: scientific introduction to the Buteyko therapy for experts”

Truly an amazing organism

Narrarator really knows how to advertise. I need something to binge watch

5:05 - 9:05 the arpeggios in the background here were so pretty they kept distracting me from the actual video

one thing about the telomere repair,, we do have telomerase naturally in our bodies, it's just that their production and function and restricted. this is because if our cells were constantly repairing themselves and replicating and never died, we'd just start growing and growing and growing until we couldn't sustain enough energy to keep our metabolism functioning. in fact, one of the key mutations that causes cancer changes the restrictions of telomerase, which makes tumor cells essentially immune to time.