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The molecular machinery that keeps bacteria on course

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Chemistry World

Chemistry World

Күн бұрын

Many bacteria use a whip-like 'flagellum' to move around their environment - away from danger and towards food. New research reveals the molecular machinery behind bacteria's ability to rapidly change direction.
Read more at www.chemistryw...

Пікірлер: 126
@joanzone4930
@joanzone4930 3 ай бұрын
imagine solving this unbelievably cool structure and the press puts this music over it
@tomasfrybert
@tomasfrybert 3 ай бұрын
I was looking for this comment
@yikebendan
@yikebendan 3 ай бұрын
carousel, I think this is the link between the two things
@It.s-just-me
@It.s-just-me 3 ай бұрын
I think it's supposed to go with the merry-go-round resemblance of the mechanism.
@joanzone4930
@joanzone4930 3 ай бұрын
Ah yes... *woosh*. It's even oriented to look like a carousel. I thought it was just randomly chosen stock music. @@It.s-just-me
@kwebis3014
@kwebis3014 2 ай бұрын
The press lol
@chexo3
@chexo3 3 ай бұрын
Oh my god it’s literally just a fucking microscopic gear
@hirofox85
@hirofox85 3 ай бұрын
Some scientist will be working on a transmission in no time. "Today on Tiny Gear!"
@seniorbob2180
@seniorbob2180 3 ай бұрын
Ya, at the sub-cellular level, it's all nanotechnology, dude, seriously. It's crazy. Biochemistry is wild.
@Tremor244
@Tremor244 2 ай бұрын
there is also the intercellular signaling via motor proteins literally walking on two legs along a microtubule, shits crazy
@vociferonheraldofthewinter2284
@vociferonheraldofthewinter2284 25 күн бұрын
What's really insane is that it's got a transmission for when it needs more torque and it can even go in reverse. And it's literally powered by protons. There's a TON of crap like this. The sliding clamp made my jaw hit the floor. Mechanical pumps, copy machines (with the ability to reverse and correct errors), and a no-$hit power plant. I can't believe that we've actually achieved the ability to see living cells on a molecular level in my lifetime - and found very clearly engineered, precision workshops manned and operated by a plethora of specialist robots. If we keep improving our ability to see, I hope they find the instructions and the warrantee. Mine is quite banged up and barely operational. I probably missed that I'm supposed to lubricate a few parts and the rust is building up on the gears. I keep taking it to various mechanics, but I'm starting to doubt that they know what they're doing.
@seniorbob2180
@seniorbob2180 25 күн бұрын
@@vociferonheraldofthewinter2284 The instruction manual exists, it's just mired in a pile of $hit. A guy had to die a couple thousand years ago to get a better version to us. Apparently everyone who came before him came only to kill, steal and destroy. Gee, it's hard to find good help. But he came so that we may have life and have it to the full. Sounds like an upgrade to me.
@AmryL
@AmryL 3 ай бұрын
Today the algorithm blessed me with this knowledge.
@LFTRnow
@LFTRnow 3 ай бұрын
This rotation looks exactly like the ATP manufacturing system (from ADP and another phosphate). I just recently saw this vid (lUrEewYLIQg) by Clockwork, showing a rotating mechanism essentially assembling ATP and the rotation being caused by H+ ion concentration and repulsion. Fascinating. Would love to see a longer version of this flagellum motor vid. Maybe Chemistry World might want to colab with someone, perhaps Clockwork, perhaps even Kurtgestat?
@CJBurkey
@CJBurkey 3 ай бұрын
I saw the paper a week or so ago, so when youtube showed me that video you mentioned (today!), I was like "3 years ago??, didn't that just come out?" and now here I am on this video
@espanadorada7962
@espanadorada7962 3 ай бұрын
Important difference is the static portion that makes up a lot of ATP synthase and ensures correct direction of rotation. Only a chunk of ATP synthase actually moves
@alex.g7317
@alex.g7317 3 ай бұрын
Did you just say Kurtzgezagt?
@Gelatinocyte2
@Gelatinocyte2 3 ай бұрын
I'm more of a WEHI/Drew Berry kind of guy.
@theexchipmunk
@theexchipmunk Ай бұрын
Not sure about the exact structure, but the Mot A/B looks indeed a lot like the H plus Motor that powers ATP synthesis. And works of the same principle. If there is indeed structural similaritys or if the genes coding both are related it would give a path for the part that powers the molecular gear.
@br3nto
@br3nto 3 ай бұрын
I love how RNA leads to the creation of 3D structures which can then do useful things and further combine into more useful things. It’s like a 3D Turing machine but where the output has physical functionality so is infinitely more useful. It’s like the ultimate programming language and computer combined into a single complex process. It’s stunning.
@RoboArc
@RoboArc 3 ай бұрын
What controls the structures being put in the right place ans formed at the correct time. I know it's physics, but is there a protein for that ?
@Gelatinocyte2
@Gelatinocyte2 3 ай бұрын
RNA themselves can also form into 3D structures, examples: ribosomes, tRNA and spliceosomes.
@Gelatinocyte2
@Gelatinocyte2 3 ай бұрын
@@RoboArc there are many different proteins for that. The ones I can think of are Chaperonins and the Signal Recognition Particle (which is a protein-RNA macromolecule).
@FutureAIDev2015
@FutureAIDev2015 3 ай бұрын
Interesting, the way that mechanical switch protein changes the direction of the output while keeping the direction of the input the same reminds me of how a car transmission can switch from a forward gear to a reverse gear.
@georgeofhamilton
@georgeofhamilton 3 ай бұрын
Does this mean there are more wheels than doors?
@leoshork
@leoshork 3 ай бұрын
Let me introduce you to: bacteria porins
@ericvandenavond8748
@ericvandenavond8748 3 ай бұрын
Unfortunately, you must also take into consideration the many "ports" that permit the diffusion of certain molecules through the cell membrane.
@jatigre1
@jatigre1 3 ай бұрын
Gotta give credit to all those engineers trillions of years ago, in a galaxy far, far away...
@crisleightning6158
@crisleightning6158 3 ай бұрын
But then what engineered the engineers?
@jatigre1
@jatigre1 3 ай бұрын
@@crisleightning6158 I'm what you call an atheist, and I know we're all immortal spiritual beings, we're older than the physical universe, so we came first. kzfaq.info/get/bejne/mqt7a5xe07bdhWg.html
@rabidL3M0NS
@rabidL3M0NS 3 ай бұрын
Midichlorians are the powerhouse of the force
@lukemeck
@lukemeck 3 ай бұрын
Boy, if only we had proof or an explanation as to how life began... 😒 🤔 oh wait, we do 😮
@zat5176
@zat5176 3 ай бұрын
Huh?
@moistmike4150
@moistmike4150 3 ай бұрын
I find it amazing that it all this highly-refined, seemingly purpose-built, nano-level structure all just happened by random accident.
@podcastwithpastorjesse9367
@podcastwithpastorjesse9367 2 ай бұрын
Do you believe that or are you being sarcastic ?
@AdrianOkay
@AdrianOkay 2 ай бұрын
Have you seen what computers are able to achieve by brute force and random chance?
@GuardianSoulkeeper
@GuardianSoulkeeper 27 күн бұрын
And selective pressure. Kind of an important feature that no one seems to mention.
@PushyPawn
@PushyPawn 3 ай бұрын
I *knew* I heard something squeaking while trying to get to sleep.
@sephirothcloud3953
@sephirothcloud3953 3 ай бұрын
We didn't invented anything, we just remembered how we are made
@hirofox85
@hirofox85 3 ай бұрын
This stuff blows my mind. Molecular machines are so amazing.
@kriegjaeger
@kriegjaeger 3 ай бұрын
What's remarkable to me is people cannot deny intelligent design in this, but reject the designer.
@yikebendan
@yikebendan 3 ай бұрын
If you cannot accept miracles that are not designed, you must accept the miracle of the existence of a designer. Doesn't the existence of the designer of such miracles need to explain its origin? Isn't its existence ingenious? Isn't it the result of wisdom? Then there must be a designer above the designer. Unless wisdom comes out of thin air. This assumption is even more bizarre than the ingenuity of life coming from billions of years of evolution.
@moistmike4150
@moistmike4150 3 ай бұрын
@@yikebendan Blah, blah, blah... and in summation, There Is No God. In other news, we'll be praying for you.
@seniorbob2180
@seniorbob2180 3 ай бұрын
"Unless you people see signs and wonders, you will never believe" -Christ It's just the way we are, don't blame them.
@kriegjaeger
@kriegjaeger 3 ай бұрын
@@yikebendan The creator isn't subject to the rules of his creation. God exists before time, before matter, in the same way a person might start a computer program, your existience isn't reliant on the program running and your program runs with the rules you've designed. When the program closes, you still are just as you were before it began. It's far simpler than the idea of complexity arranging itself from chaos, which we never observe.
@mirfan-2020
@mirfan-2020 Ай бұрын
Prove it​@@kriegjaeger
@ashrocks8443
@ashrocks8443 3 ай бұрын
I am interested in understanding how they have negotiated with the rear earth metal holding countries for continuous supply for the sake of creating permanent magnets to ensure efficient locomotion, it is also important for us to know how they could have stayed profitable for so many years, and I presume they might have made a killing in earning carbon credits
@kma3647
@kma3647 3 ай бұрын
Interesting visual. The music overlay was obnoxious and too loud. I did learn something, but this was unwatchable with the sound on.
@doridore1234
@doridore1234 3 ай бұрын
AHHHHHAHAHAHAHAHAHHAHAHAAAAHH
@taukid421
@taukid421 3 ай бұрын
What's up with the off-brand circus music?
@Gelatinocyte2
@Gelatinocyte2 3 ай бұрын
Because it's like a merry go round. Get it? (Yeah, it's stupid.)
@roystonlodge
@roystonlodge 3 ай бұрын
Where are the axles for these wheels?
@vaakdemandante8772
@vaakdemandante8772 3 ай бұрын
there are none - it's an inner wheel, more like a ball bearing assembly than a wheel on an axel. The "axel" is pointing outwards and it's the flagellum that is being spun by this nano-motor.
@Gelatinocyte2
@Gelatinocyte2 3 ай бұрын
It basically just "floats" in the membrane. The flagellum whip itself is the axle.
@seniorbob2180
@seniorbob2180 3 ай бұрын
@@Gelatinocyte2 anchored in the membrane. It wouldn't surprise me if there were other trans-membrane proteins involved.
@user-di7tg7qf6u
@user-di7tg7qf6u 2 ай бұрын
I keep replaying this for the song
@stephman02
@stephman02 Ай бұрын
If every living thing we know is made from / by these molecular machines, do these machines ‘evolve’ as well or have they remained the same since the first cell millions of years ago ? Did dinosaur cells have the same molecular machines ? Or did dinosaur molecular machines look different and evolve to the become the ones that exist today ? It seems that the machines or ‘code language’ Is the same , but the commands / coding produces different living things ?
@existereOracle
@existereOracle 3 ай бұрын
this is how i get around btw
@ricardocalderon9823
@ricardocalderon9823 3 ай бұрын
Hmm but what is turning motA/B? Very interesting. I believe nature knows mechanics better than us so if we study nature we can innovate our technology too.
@misteral9045
@misteral9045 3 ай бұрын
The ATP reaction within the mitochondria.
@roycrippen9617
@roycrippen9617 3 ай бұрын
​@@misteral9045The powerhouse of the cell?
@lemonade2706
@lemonade2706 3 ай бұрын
Hmm... Now do it 😂
@subwaytoiletgaming762
@subwaytoiletgaming762 3 ай бұрын
@@misteral9045wdym, respiration?
@FutureAIDev2015
@FutureAIDev2015 3 ай бұрын
I think the motA/motB complex is powered by a proton gradient similar to what powers the ATP synthase.
@RoboArc
@RoboArc 3 ай бұрын
How in the fck does this get assembled ?
@vaakdemandante8772
@vaakdemandante8772 3 ай бұрын
yep, it has to be assembled by even more interesting machinery than the nano-motor itself. The DNA/RNA sequence is the key. Mind that it's being produced en masse because it's part of many species of bacteria. By the numbers it has to be THE MOST common engine on the whole planet.
@RoboArc
@RoboArc 3 ай бұрын
@vaakdemandante8772 what chemical is being monitored by the protein for timing ? Like it has to have a clock ?
@Chad-Giga.
@Chad-Giga. 3 ай бұрын
Somebody is on that mota
@vaakdemandante8772
@vaakdemandante8772 3 ай бұрын
Is the exact DNA/RNA sequence for producing this mechanism known already? If not, it should be a priority to discover it because it opens the doors to biological nano-machines.
@Gelatinocyte2
@Gelatinocyte2 3 ай бұрын
It already is. I suggest looking at databases such as the Protein Data Bank.
@juangil384
@juangil384 16 күн бұрын
Plenty of stolen content
@nomnomnom5732
@nomnomnom5732 2 ай бұрын
🤣
@Jonas-Seiler
@Jonas-Seiler 3 ай бұрын
idk honestly seems fake
@goldmaskfiend
@goldmaskfiend 3 ай бұрын
Obey the ancient biomachinery
@tl5429
@tl5429 3 ай бұрын
​@@goldmaskfiendFor the flesh may be weak but always persistent
@wdwadindwatri
@wdwadindwatri 3 ай бұрын
you seem fake XD why not google or check or just go into the profile and turn on the braions? are the influencers only crappy people you belive in?
@martinsimeonov1563
@martinsimeonov1563 3 ай бұрын
Meh that's pretty strong instead. Compared to its size its like having it made out of HAIR. Trust me its like steel compared to the size of the entity​@@tl5429
@misteral9045
@misteral9045 3 ай бұрын
It does?
@abumarabumar7489
@abumarabumar7489 3 ай бұрын
Blessed is Allah, the best of creators!
@wdwadindwatri
@wdwadindwatri 3 ай бұрын
are you normal? It's emergent evolution, not made up god who allows killing and promotes terrorism and self glorification after suicide... Religion is for people who constantly need to live in fear of unknown, and don't want to learn about world...
@williamchamberlain2263
@williamchamberlain2263 3 ай бұрын
I'm not sure you realise, but your phrasing means that you acknowledge that there are other creators, which I think counts as blasphemy in most forms of monotheism
@miloelite
@miloelite 3 ай бұрын
Yes but Allah is still the best of them.
@BigGod7ODSubscribeBecauseYes
@BigGod7ODSubscribeBecauseYes 3 ай бұрын
🦖
@Dumb-Comment
@Dumb-Comment 3 ай бұрын
@@miloelite so allah's creation is the best you're implying? so you're bascially racist?
@luketracey3269
@luketracey3269 3 ай бұрын
You can see diagrams of this in the voynich manuscript at Yale . It's a medical school I heard . Shame they're clearly incompetent.
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