The Puzzle Comes Together - Why Dysfunctional Metabolism Might Explain Long Covid

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The Puzzle Comes Together - Why Dysfunctional Metabolism Might Explain Long Covid

Рет қаралды 47,250

Күн бұрын

In this film I talk again to Dr Ade Wentzel, who has co-authored a new paper looking at the metabolic dysfunction present in Long Covid, and how it is connected to just about everything else, from endothelial dysfunction, to platelet activation and microclotting, dysautonomia, mast cell activation and even erectile dysfunction.
There’s a reason no-one’s cracked it until now, and it’s because it’s bloody complicated. So this film will get a little granular at times - I’m afraid it’s kind of impossible to explain it without breaking it down to the nuts and bolts.
* Please do talk to your doctor first if you have any concerns about taking any new supplements or medications of any kind. *
* Note on the dosages slide, Cholecalciferol should be 10mcg, Quercetin dose should be in mg not mcg *
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The Long Covid Handbook (Oct 2022), by Gez Medinger and Professor Danny Altmann and published by Penguin Books is now available in paperback, ebook and audiobook. A singular resource that brings together everything patients, clinicians and academics have learnt about the condition since early 2020, as well as lessons from sufferers and researchers of ME/CFS and other chronic conditions. It offers world leading expert advice on understanding, managing and treating Long Covid. The Long Covid Handbook is available from the following links:
US: a.co/d/0gvkJCU
UK: amzn.eu/d/9KjurGb
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CONTENTS:
0:00 Introduction
1:42 Developments in last 12 myths
2:34 The New Paper
3:53 Connection to Microclotting
9:11 Endotheliitis
10:25 Venous O2 sats & anaerobic metabolism
15:00 What Evidence is there?
17:02 Link to Dysautonomia & POTS
19:47 The 3D puzzle of LC
24:19 The Role of Connective Tissue
26:01 Viral Persistence
29:27 How to Treat?
32:00 What's wrong with Nicotinamide?
34:40 Ideal Research Project
36:58 Conclusion
REFERENCES:
The Biology of Long Covid (Dr Wentzel's first paper):
• The Biology of Long Co...
Study on efficacy of Niacin in Long Covid:
• First Effective Treatm...

Пікірлер: 748

@sagemeline 2 жыл бұрын

Absolutely spot on with the exhaustion. it isn't just tiredness; it's a near-total loss of ability: everything just stops working, and rest does not help until it passes. I'm currently fighting to keep my job (and therefore insurance) through all of this.

@violetasuarezcapri4258 2 жыл бұрын

THIS channel should be a go-to for the NHS.

@luckyluc7412 2 жыл бұрын

You’re so right about the word fatigue not really describing what we go through. It’s more like the body shutting down. If you’re well and tired you still have good cognition and can function even after no sleep. With a LC crash all function goes.

@bethalpert5999 2 жыл бұрын

No truer words have ever been spoken. People who dont have LC have literally No Idea what this fatigue feels like.

@harryjohnthorburn8006 2 жыл бұрын

Yes, this is more than a word "fatigue". I can't function any when it comes to shut down my body, all day I can't function even my Brain can't function

@NiokaDynamicLaser 2 жыл бұрын

I want to scream every time I hear myself say “I’m so tired!”, “I’m so very exhausted”, “I’m so weak and have no strength .” because I hear how hallow the words ring compared to how it really feels, the burning hard muscles, joints on fire, chest tight and painful like I’m having a heart attack because to move a limb or try to turn myself , attempt to stand, the 30 ft trip to the bathroom feels like I’m dying, because the feeling of being covered in heavy bags of sand the size of hefty bags weighs on me every day. Fatigue. What a joke. I’ve long said there needs to be a more adequate word for this torture! God, please let there be enough interest now, with all the medical/scientist/wealthy people/celebrities having Long Covid to not ignore post viral illnesses any longer and figure this out, Finally!!! There ARE bio markers and tests that can be done to definitely diagnose Me/CFS, Fibro, Lyme, and more, they are just so expensive they are only used in research. So what we get if we have devoted our lives to raising a family and a community/Church/schools? I tell you what, SSI, $841 a month, if you are lucky. So along with your physics misery you get to worry every day at an ultra high stress level, that if you have ME/CFS is just as bad as physical exertion, so it drives you down even further! By no means am I ever allowed to rest without heavy financial worries, no way can I afford comforting measures, or things to take to try that have helped those with money, like clean, organic food, vitamins/herbs/supplements, and help in the home. It is a disgrace on our country that the disabled are left out, when it comes to deciding where to allocate funds, human connections and help, or even trying to bring current the woefully out of date laws and rules, that haven’t changed since Nixon enacted them. Disgraceful.

@Kteeee Жыл бұрын

Exactly right. It’s way more than being tired. My brain literally stops working and that’s coupled with tingling, vibrating, cold spots, weird visual issues, light sensitivity, sound sensitivity, the list goes on. All I wanna do is lay in my bed with the blinds down.

@adonnaprice9676 Жыл бұрын

Why not water board the bat lady, make the witch squeal..

@drmanishdas5010 2 жыл бұрын

Thankyou so much, Gez. There is a doctor, Dr Cyanthia Li. Very inspiring for the Long Covid community. She was bed ridden for 3 years with dysautotomia and fibromyalgia. Then she decided to slowly beat her illness and recovered, a wonderful journey of slow healing (the rest and digest mode) about which she wrote in her book- The Brave New Medicine. I have read the book. I Wish you interview her once. It will be extremely inspiring for the Long Covid community.

@charlotteandersson6944 2 жыл бұрын

Heathy food, no suger, no alcohol, extra vitamins, meditation, smoothies, walks, yoga/stretching, resting, set goals, ask for help with household/shopping and try to accept the situation. I'm 13 months not able to work but getting better every month.

@timc2010 2 жыл бұрын

Another great video - So amazing to see progress being made, driven forward by people like Dr Wentzel who throw themselves into the problem for the benefit of us all.

@originalrecipedan 2 жыл бұрын

Thank you for all of your amazing work, Gez! I can't tell you how much these videos mean to us. It's such a lonely struggle fighting this disease. Seeing the latest research provides some hope.

@allTheRobs 2 жыл бұрын

Gez. You are a modern day hero. Thank you for sticking with this!

@dusktropic 2 жыл бұрын

Watching this and getting my pieces of the puzzle somewhat sorted out made this 55 year old man cry. I have been on the nicotinic acid protocol since christmas 2020 and it have helped me combat this to a 80% win. Thank you from the bottom of my heart Gez and Ade.

@RUNDMC1 2 жыл бұрын

So glad to hear it’s made a difference for you 😊 And nothing wrong with being a grown man crying - I do it all the time!

@browneyedgirlFL67 2 жыл бұрын

@DuskTropic how long was it in the Niacin before you felt improvement? Which protocol are you following? And what dose care you currently on? Thanks

@dusktropic 2 жыл бұрын

@@browneyedgirlFL67 It took about two weeks before I felt any improvement. The effect builds up over time. I am on 500 mg/day (nicotinic acid)

@dusktropic 2 жыл бұрын

@@maadjgumar5166 No it is a B-vitamin. B3

@markstaud 2 жыл бұрын

Do you use Flushing or Non-Flushing (What Brand are you using?)?

@nakana149 2 жыл бұрын

Gez you've been fantastic from the get go with your videos! Thank you for all you do as I'm sure making the videos takes its toll. It's so wonderful and hopeful to see Long Covid dots getting connected by the amazing researchers around the world. It makes me feel hopeful that we'll pull out of this and heal our bodies.

@RUNDMC1 2 жыл бұрын

Thank you Nicole!

@bell4textu973 2 жыл бұрын

Thank you for making more films about this subject Gez. Your work are deeply appreciated and extremely important.

@RUNDMC1 2 жыл бұрын

Thank you!

@MichelleRevs 2 жыл бұрын

Thank you so much again for all the work you have put into exploring long covid. I am so grateful.

@katrinakrulla290 2 жыл бұрын

Gez, Another amazing video! Makes me wish I saved my AP biology book. Now I remember why us HS science nerds used to say "may all your phosphorilations be chemiosmotic... thank you for all your hard work to research this, document it and disseminate the information. I think it is amazing that you had the energy and motivation to be able to share so much valuable information. Watching your earlier videos, it is encouraging to see how much you have improved health wise.

@RUNDMC1 2 жыл бұрын

Thank you Katrina! Best of luck to you in your recovery :)

@EasyEcoLifeWithKaren 2 жыл бұрын

Another corker! You are real star.Thank you for shining a light on the emerging optimism of understanding our debilitating condition

@blukatzen 2 жыл бұрын

I listened to your videos for over a year now, they've helped me pull out of long haul cv. What worked for me was a low histamine approach alongside anti parasitical herbs since I could not get Iv. Prescribed to me. It made such an initial improvement. Then I juiced a lot last Spring. It have me the vigor and strength to pull out more. With vitamin, mineral and herbs, ginger, etc. I pushed upwards and further along. I'm awaiting cataract surgery as they have grown in quickly. Hoping to return to work soon after that. I had list my husband at the end of 2019,had a stroke in my sleep a week after he died, and then got my initial covid in March of 2020. It wS horrid, blood clots everywhere. Now I watch my diet and get plenty of rest. I take my health seriously, always have. Want to enjoy my Senior years

@RUNDMC1 2 жыл бұрын

So glad to hear you’re doing better!

@blukatzen 2 жыл бұрын

@RUN-DMC / Gez Medinger thank you for your videos. I attribute my health to your information. Please continue to help us please. Ty.

@deniseh32033 2 жыл бұрын

I have done similar. I did the protocol as soon as I saw it. Tried to get as low histamine intake as possible. Was lucky to get Iv last August 21. Acute symptoms like chest pains, sore throat headaches, palpitations etc. Disappeared on day 3 of the FLCCC protocol. Still had brain fog, tiredness not fatigue, now managing building up my physical strength and lung capacity, and work capacity but making progress every day. I wish you well, sounds like you had a hard time but are determined to get well and happy. Best wishes.

@turkdouglas 2 жыл бұрын

Thank you Gez, thanks so much . To hear such positivity from the doctor is enormously helpful. Nearly two years for me and I sometimes give up hope. This has helped a lot , thank you again.

@RUNDMC1 2 жыл бұрын

My pleasure Stuart!

@wendylorimer5663 2 жыл бұрын

@@RUNDMC1 Don't give up hope, taking the Nicotinic acid, and the rest, has made all the difference to me. I'm not quite 100% better but I'm close.

@attiladanko6379 2 жыл бұрын

Thank you for the brilliant 3D analogy@@RUNDMC1

@tbrant8064 2 жыл бұрын

@@wendylorimer5663 Did you start showing improvement within days or several weeks?

@emmacourtney7515 2 жыл бұрын

@@wendylorimer5663 out of interest where did you get the nicotinic acid from? Which brand? Thanks! ☺️

@tanyaclarke268 2 жыл бұрын

Thanks Gez as usual for another great post. Dr Wentzel is a superstar , just into year 3 now and he is the go to guy for my inspiration to just keep on keeping on despite everything. It is the hardest thing ever to get through. So many views and comments on here now, he deserves to be a GIF I think !

@RUNDMC1 2 жыл бұрын

Thank you Tanya!

@Patrick-bu5vy 2 жыл бұрын

Thanks for the great discussion - it gives us hope knowing this important work is being done in the trenches. And it's also great that people like yourself are wrestling with the bigger picture to see how it all fits together. I think the process of 'joining the dots' between micro and macro is the often overlooked aspect that will ultimately reap the most benefits for long haulers. Thanks again.

@loradorado 2 жыл бұрын

You are an amazing person Gez! As a biologist, this video overlaps with some of the things I figured out on my own. But I certainly didn't figure them all out! The transcript is a godsend! Thank you so much for making that available. I read Dr Terry Wahls book, The Wahls Protocol, as I felt that a lot of my long covid symptoms resembled MS. In her book she recommends consuming organ meats on a regular basis. I have been taking them in pill form for 6 months, in addition to the other things in the stack you recommend. And I think the desiccated organs helped me improve. I'm going to study this chart and see what I can do to fine tune my recovery. BTW, I also take ivermectin once a month. I noted the biggest improvement in my long covid symptoms when I followed the FLCCC guidance for long covid which includes ivermectin. In any case, I am light years away from where I was when I started listening to your videos. I am so much improved, thanks to you. 🤗😘💕👍🤠

@RUNDMC1 2 жыл бұрын

So glad you’re doing better Laura, and thanks for the support!

@sandrapeterson2691 2 жыл бұрын

I have a had good luck with ivermectin as well thanks for tip of taking once month is that the one day dose or are you repeating the five day dose?

@myhealthobs5290 2 жыл бұрын

Fantastic!!!!! episode. I've wondered about this from the first time I heard Rob Phairs mitochondrial dysfunction. This puts a lot of things together

@teddybearroosevelt1847 11 ай бұрын

Really amazing work by dr. Wentzel and colleagues. I read the paper and I’m very much surprised that it’s gotten very few citations over the past couple of years. All the things that are happening in the body and this helps make a bit of sense as to the super complicated nature of the illness. Especially given how little is known about the pathogenesis of ME and mechanisms later on in the disease, there are some very useful things in this theory that I have not come across before.

@Tabitha_K 2 жыл бұрын

Your videos are excellent, Gez. So well researched and informative!

@RUNDMC1 2 жыл бұрын

Thank you Cathy!

@maricogan2903 2 жыл бұрын

RUNDMC, I have not seen your videos in months and I am subscribed. So happy to see you again.

@RUNDMC1 2 жыл бұрын

Thanks Mari!

@lesliec8069 2 жыл бұрын

Thank you Gez and Dr. Wenzel! The pieces of the jigsaw puzzle are starting to come together. Those dogs need to stop eating the pieces that fall to the floor! I look forward to sharing this article with others. Thank you for all the hard work you have put in with learning all of the meaning and the need for a 3-D whole person approach. (Pieces also occur in the U.S.A.).

@RUNDMC1 2 жыл бұрын

Thank you Leslie!

@melaniekanz3543 2 жыл бұрын

When I got sick in early March 2020 and started to have Long Covid symptoms, I spoke to my doctor about my antiphospholipid syndrome possibly being involved with what was going on with me. She completely dismissed me as she didn’t even believe I had ever had Covid because I had “no cough”. She sent me home with a lorazepam prescription for anxiety! 😵‍💫 So you can imagine how far my jaw dropped around 16:30 into this video. I’m going to send a link for this to my (new) doctor. I kicked the old doctor to curb after she told me all my symptoms were in my head. Thank you for validating what I’ve always believed to be true!

@NiokaDynamicLaser 2 жыл бұрын

I know exactly what you mean! Sometimes I think I should be wearing the doctor’s credentials and they should go back to school. 🤦🏻‍♀️

@doloresdemar2347 2 жыл бұрын

Good for you!!! 👍👍👍💯

@susanwright1999 2 жыл бұрын

I'm beginning to wonder if Doctor's are being told to dismiss as many as poy.

@doloresdemar2347 2 жыл бұрын

@@susanwright1999 it's really sad if most are chalking it up to anxiety!!! 😤😞

@doloresdemar2347 2 жыл бұрын

@@susanwright1999 you may be right about that!!!

@elwayen20 Жыл бұрын

Great informative video Gez! Thanks to Dr. Wentzel as well for his insights!

@annasvensson5684 2 жыл бұрын

Thank you for making these videos!! Very interesting information today.

@RUNDMC1 2 жыл бұрын

Thanks Anna!

@carolenmarch7445 2 жыл бұрын

This is brilliant Gez, so well produced, documented and lucidly explained. Soooo much easier to get a handle on than his pre - print! Dr Wentzel is amazing. I hope his wife forgives him for spending the last year in the lab/with hospital patients, trying to crack the dysfunctional metabolism of LC. 😀His unstoppable enthusiasm and contagious positivity will, I'm sure, deliver on finding effective treatment protocols for LC patients in the near future. NHS, please listen.

@RUNDMC1 2 жыл бұрын

Thank you Carol, you’re right this is top class stuff!

@garyrobinson8213 2 жыл бұрын

Another good one, thanks for putting this together.

@RUNDMC1 2 жыл бұрын

Thanks Gary!

@HuzarFilms 2 жыл бұрын

Great video Gez, really hope we’re getting closer to a brighter future. 🙏

@RUNDMC1 2 жыл бұрын

Me too!

@tanjamannhart4665 2 жыл бұрын

Thank you Gez an Dr. Wentzel! This was one of the most encouraging films! The biochemistry is quite complicated but i look extremely forward to the publication! I believe the good thing with LC is it will have positive impact on medicine and how we approach certain diseases. Very very thankful for what you do!

@RUNDMC1 2 жыл бұрын

Thank you Tanja!

@Johannes-wj5ri 2 жыл бұрын

Really great interview Gez many thanks. As an NHS Consultant with LC I totally agree the system not set up for a multisystem disease as no dept takes real responsibility. Hopefully getting that message out will lead to better things

@JustME-ft4di 2 жыл бұрын

Hope will help those of us with ME from other viruses as well.

@adewentzel2580 2 жыл бұрын

Always here to help.

@RUNDMC1 2 жыл бұрын

I hope so too!

@margaretowens2793 2 жыл бұрын

Thanks again Gez for all your hard work. I’ve been taking this stack since this video was released. My only symptoms are brain fog, crushing fatigue and understandable depression. I really wanted to avoid antidepressants so started taking 5HTP 3 days ago. Also I had heard that a teaspoon of food grade Epsom salts in water was helpful. I’ve had no fatigue for 2 days and just wanted to share that in case it might help someone else.

@caregiver1865 Жыл бұрын

😊

@ashleyjones4030 2 жыл бұрын

I’ve been taking this stack for almost 3 weeks and feel like I’ve broken the back of my fatigue issue which was my worst symptom, thanks for getting this out there Dr wentzel and gez!

@chloebelle4923 6 ай бұрын

Great news! How are you doing now?

@barbarasaunders2160 2 жыл бұрын

@0:14 fatigue is not the word. Regular COVID fatigue had me feeling like gravity was pulling on my body where I could barely sit up. The pain and ‘fatigue’ was like nothing I’ve felt before. As much as I knew not to lay around, I had zero energy to even sit up. It was unbelievable.

@flagmichael 2 жыл бұрын

That is a good point: "chronic fatigue" sounds like "I will clean the basement next week" to those of us who are not ME/CFS sufferers. I didn't have much of a clue until I saw YT videos about people who now required two hours to dress themselves. What really struck me was how many of them had been remarkably athletic before this, particularly the number of runners and marathoners in the Community of the Damned. If not for those videos and particularly this channel I too would probably think it is just a nuisance. Take a day off, get some sleep, and be ready for action the next day. I predict when the pandemic part of COVID is settled and the world tries to get back to normal the public will become aware of the extent of Long Covid... sort of like suddenly noticing the house is infested with crocodiles. Until then there will be madness like "Omicron parties."

@Miss-Hellcat666 2 жыл бұрын

@@flagmichael I just want to say thank you for taking the time to learn about the illness and what it's truly like for us. So many just trot along with their misconceptions and make the world a much worse place. People like you are the ones who will make a positive change for everyone🖤

@cbskwkdnslwhanznamdm2849 2 жыл бұрын

Exactly. I feel like I have flu levels of fatigue, over a year. There is no option to push through it. It is not like a healthy fatigue at all.

@gabrielarangel8644 2 жыл бұрын

You are amazing Gez!!! Thank you so much for all the work you do! And Thank You Dr. Wentzel!

@RUNDMC1 2 жыл бұрын

Thank you Gabriela!

@katewright492 2 жыл бұрын

You're looking healthier Gez! Hope you're feeling better too. I was wondering if you would consider making a video summarising what you've learnt from all of your conversations with experts and the research you've done? I'm sure I'm not the only one who struggles to keep up with it all. It might also be a useful resource to share with our doctors (unless this resource already exists somewhere else?). My GP says we don't know anything about long covid yet and I'm looking for the best way to show him that that isn't true!

@RUNDMC1 2 жыл бұрын

I’ll have something to talk about on this front soon!

@margaretskinner1416 2 жыл бұрын

@@RUNDMC1Llook forward to it. Thanks for doing what you do so well.

@EEiVit 6 ай бұрын

It would be great! In that way we understand better and the doctors as well. They keep on dismissing my daughter and giving her antidepressants what she hasn't taken. My daughter has been suffering from this long Covid fatigue etc. for more than a year. She has been diagnosed with insulin resistance and we hope the diet and supplements work.

@caroliner2029 2 жыл бұрын

Fantastic discussion Gez, thank you.

@tonyrabone4668 2 жыл бұрын

Probably the best video on the subject I've found, along with your mast cell interview. Nice one.

@RUNDMC1 2 жыл бұрын

Thanks Tony!

@tonyrabone4668 2 жыл бұрын

@@RUNDMC1 Gez how are you doing now? Did you get any benefit from Dr Wentzel's protocol? I think I am starting to. I think the niacin helps as well as the reduction in exertion.

@savethatyt5640 2 жыл бұрын

Thanks for the video, I’m 19 years old male and been suffering for 8 months. And I mean daily suffering. I want to give up but your videos keep my flame alive. I really believe we will have a cure soon and answers. Thank you so much! Btw I’m completely housebound it sucks.

@steve0ne11 2 жыл бұрын

Don’t give up. This problem will be solved. There are simply too many of us to be ignored. Take it day by day and never be afraid to comment just like you did when times get rough. You are not alone.

@AlbaLynxQueen 2 жыл бұрын

So sorry to hear this. I am 7 months in. It sucks.

@RUNDMC1 2 жыл бұрын

So sorry to hear this - keep pacing! And try Niacin :)

@OJ-sr6bg 2 жыл бұрын

@@AlbaLynxQueen same here

@loisvaughan8651 2 жыл бұрын

Dearest one I am soon to be 71 in March and have endured these long haulers symptoms since may of 2020 if I can do this at 70 boy then you can too dearest one ☝️ Self love is self care pacing with patience helps ALOT meditation daily before getting out of bed Which I know can take hours A lot of researching helps because Knowing what’s happening to you and also knowing that you NOT alone Is everything I personally find journaling and drawing illustrations It’s all sitting creating something And soaking hot baths for hours This all Works for me Lots of supplements also And eating healthy But You should do what makesYOU HAPPY 😃 Gaming always worked for my son Jupiter when he was sick as a child Because happiness brings healing 🤗Lotsa Love ❤️ 🧝🏻‍♀️Lotus 👩‍🎨

@comicbossone2411 2 жыл бұрын

Hi Gez, thank you for doing these videos. Please don’t stop! Lol My tachycardia/pots seems to be improving slowly. Thanks I’m large part to you. Genuinely thought I had no joy in life ahead of me for months but slowly seem to be getting better. OTC antihistamines, Bvits, Vit C and Iron seem to be improving things… that and gradually undertaking more. Thank you so much.

@RUNDMC1 2 жыл бұрын

Take it easy and try to build as much joy into your life as you can :)

@carmella88 Жыл бұрын

How are you doing i have tachycardia and pots too

@comicbossone2411 Жыл бұрын

@@carmella88 the tachycardia which was confirmed as Pots has gone. Took 8 months.

@carmella88 Жыл бұрын

@@comicbossone2411 this gives me so much hope. Did u do anything to make it go away or just on its own

@carmella88 Жыл бұрын

@@comicbossone2411 i see in your comment now what you took .. what antihistamine did you take

@Shellsnfeathers 2 жыл бұрын

Thanks again for the great information Gez.

@FPproductionz 2 жыл бұрын

Gez, this is awesome to have an update like this come out. Some of us in a long covid Discord have been discussing the emerging trials with BC007 out of Germany. Could you make a video on this/with people from Germany? There's tons of interest in the drug among long haulers, but it's likely to be years before those of us outside of Germany (and people with milder symptoms like myself) can get access. Hoping creating more awareness through channels like your own might help. I should note, niacinamide seemed to cure me for the most part. I'm still dealing with some numbness in my extremities when I run and light PEM, but I'm otherwise doing great.

@RUNDMC1 2 жыл бұрын

Hi Dan - trying to set something up with Berlin Cures, leave it with me

@MyMateGeorge 2 жыл бұрын

How much niacin were you taking? Flush/non-flush?

@rupinderh01 2 жыл бұрын

@@MyMateGeorge flush is better, I would start off low then build up, I can't remember dose I think Gez talks about dose in previous vids

@FPproductionz 2 жыл бұрын

@@MyMateGeorge non-flush; started out with ~25mg, and basically micro-dosed that throughout the day in ~25mg doses (whenever I felt brain foggy/tired), taking in upwards of 300mg 2-3 months from my 2nd bout with covid. But, as the video suggests, taking the flush variant is better.

@MyMateGeorge 2 жыл бұрын

@@FPproductionz Thanks, Dan!

@MH-zg5yw 2 жыл бұрын

I was in the ICU with COVID in December 2020. To date, I am still experiencing post covid symptoms. The fatigue is terrible. I wake up and can feel close to how I did pre-covid then two hours later I will feel extreme fatigue where I have to lay down. I was a long time runner of over 30 years and can't even run anymore. walking is a chore. Thank you for your informative video.

@sixpackbinky 2 жыл бұрын

I had Covid in Dec 2020 also and still experiencing severe fatigue and sometimes weakness.

@shaft657 Жыл бұрын

How are u now?

@andocobo 2 жыл бұрын

I’ve had cfs since 1995, got covid in March 2020 - everything is so much worse now. It really does seem like covid dramatically worsened whatever was already wrong to begin with. I agree with the doc, I think covid and cfs probably have the exact same underlying mechanism

@theancientsancients1769 2 жыл бұрын

Me too. But sunshine vitamin D3 and K2 and Longvida Tumeric , hyaluronic acid did help. I noticed this virus hates fresh air too. Try Airnergy device , rent one and see if you feel better or hyperbaric oxygen therapy

@mikehale7393 2 жыл бұрын

Diabetics can manage their blood sugar levels much better by going Keto or Carnivore than by injecting synthetic Insulin because the root cause is the cells in the body becoming insulin resistant. When your eating low carbs and healthy saturated animal fats you can reverse insulin resistance and your body will gradually switch from burning carbohydrates to burning fat, the medical experts who present on the KZfaq “Carbs Down Under” channel are calling dementia type 3 diabetes as it’s due to inflammation caused by insulin resistance.

@TheBushRanger. 2 жыл бұрын

Hope for a jongy?

@TechnologyForFunVideos 2 жыл бұрын

Thanks Gez, a very positive interview (albeit quite difficult to keep up with the terminology!) It all stacks up for sure. One this Dr. Wentzel said in passing was that he had found a mechanism to explain the tinnitus that many long-haulers suffer. Can you point me to where I can find this? Thanks! Keep up the great work and get better yourself.

@ms-jl6dl 2 жыл бұрын

FLCCC

@scripturethroughancienteye1509 2 жыл бұрын

The interruption to explain some of the cellular processes and vocabulary was helpful. I did not know that this condition was associated with ED. Since having LC, I have gone to have my testosterone checked over this problem. Quite informative interview.

@mikehale7393 2 жыл бұрын

If your Testosterone is low have your cholesterol level checked as well, if it’s low one of its many functions is in the production of Testosterone try going keto or carnivore and see if this helps.

@scripturethroughancienteye1509 2 жыл бұрын

@@mikehale7393 Thank you for this. My testosterone dropped about 80 points since having Long Covid, from about 340 to 260. The endocrinologist didn't seem to think the testosterone was the problem. My cholesterol is still in the upper end of the reference range.

@mikehale7393 2 жыл бұрын

Remember your endocrinologist is only experiances in one 2D layer of the 3D model of your motabalism, we literaly are what we eat 90% of our DNA is in the gut biom.

@nabarg75 2 жыл бұрын

With so many of us experiencing constant and sometimes debilitating tinnitus, I was curious if this has been addressed in any of your interviews? I can press on the nerve bundle behind my ear and it almost goes away. It makes me want to dig into my skull there and pull out the nerve bundle, lol! Just kidding, I wouldn't do that. It is the one thing that is constant and I can't get rid of completely. Thank you for all you do, this channel has been so enlightening and helpful.

@BlackCountryJo 2 жыл бұрын

Thank you for your videos it’s been a bit of a life line to see research is going on.

@ireneoosting5907 2 жыл бұрын

Great video, thank you so much for this!!

@RUNDMC1 2 жыл бұрын

Thank you Irene!

@joecanti5944 2 жыл бұрын

Interesting, thank you. This ties into a paper by Matsuyama suggesting that positive feedback between pai-1 and stat3 is responsible for many of the symptoms in acute covid. Pai-1 and hmgb1 act as DAMPs and activate tlr4 which triggers innate activation and cytokine release, and stat3 hyperactivation leads to fibrosis and lymphocytopenia. It feeds back on itself and perhaps becomes chronic. Quinolinic acid/kna, at least in animal models, stimulate pai-1.. and pai-1 is already raised in many metabolic conditions such as insulin resistance...and tlr4 activation stimulates the kynurenine pathway as a homeostatic adaptation in response to infection, especially lps mediated. Would be interesting to see if people noticed improvement with tlr4 inhibition. Hops has an anti-inflammatory effect via this pathway.

@adonnaprice9676 Жыл бұрын

Chew or drink?

@miskaknapek 2 жыл бұрын

Many many thanks for this. Really great knowledge, that we don't get through public health. Thanks for being a bit of an angel of necessary knowledge. Greetings from Berlin!

@RUNDMC1 2 жыл бұрын

Thank you Miska!

@zaxjunk7703 2 жыл бұрын

Thank you! This goes far to help me understand and will likely convince a few doctors that this is NOT "all in your head." !!!

@evansforsyth8993 2 жыл бұрын

Thank you so much. This video has been a life-changer for me! The trick was to be really slow and cautious with the Vitamin B, Nicotinic Acid. (This form of Vitamin B seems to be the most important single component.) I am at 50mg/day to keep it at a level where the "flushing" is very occasional and very minor. My Karma tells me that, for seniors, flushing eventually tears us down. Combined with one to two hours of napping, not letting my heart rate go over 95, and never pushing past the point of exhaustion--physically I have improved from a 3/10 to a 6 or 7/10 after about 6 weeks on the regimen. (Memory isn't great, but at least it isnt shutting down anymore!) Again, thanks! Evans

@richardmock3198 2 жыл бұрын

Glad I dodged the tinnitus and erectile dysfunction symptoms 🤨 great work from the doctor again 😁👍 thanks fellas.

@RUNDMC1 2 жыл бұрын

Haha. Thanks Richard!

@baldwina3 2 жыл бұрын

Thank you so much Gez! Your videos have been so helpful to me over these last, long 22 months. This video in particular was of great interest to me as I have hypermobile Ehlers Danlos, Sjogrens, Lupus and Fibromyalgia. All of these conditions were well under control, in remission until I got covid which caused a horrible autoimmune response that brought them all roaring back with a vengeance. In addition, I've now been diagnosed post covid with hyperadrenergic POTS and MCAS. So your question about the involvement of connective tissue really hit home as I've also seen numerous people in my long covid group now being dx'd with hEDS. I can't wait for Dr W's paper to be published. Thank you for helping to put all the puzzle pieces together for us!

@RUNDMC1 2 жыл бұрын

So sorry to hear you’ve been suffering so much - like you say this really does start to put it together. Wishing you the best in your recovery.

@baldwina3 2 жыл бұрын

@@RUNDMC1 Thank you ❤️

@myhealthobs5290 2 жыл бұрын

Those collagen genes seem to be heavily over represented in me/cfs too.

@JocelynTee 2 жыл бұрын

Thank you so much Gez! I’ve just discovered your videos (way too late in the game but nonetheless incredibly helpful) and I love how easily you explain everything and interact with these amazing doctors. With approval of my many doctors, I’m going to start this protocol. I’m sorry if this question has already been answered, but is there less effectiveness to taking “flush-free niacin” with inositol hexaniacinate rather than just niacin? I know that Dr. Wentzel explained the flush is important for the NAD enzyme, so I’m wondering if I should just take that? Thank you so much! I greatly appreciate what you do! 🙏🏼

@RUNDMC1 2 жыл бұрын

Hi Jocelyn, thanks for the comment! The flushing variety does seem to be more effective so if you can tolerate it it’s worth having. If you don’t tolerate it then non-flush will still be OK :)

@gustavdesnica9753 2 жыл бұрын

My story, 35 years old. I had dizziness for 2-3 months. Weakness and tingling in the left leg and vision problems. Extreme insomnia that still lasts as well as episodes of moderate anxiety. I did an MRI/MRA. Everything is ok about the brain. There is hope for all of us.

@user-hv8jw1fx7x 2 жыл бұрын

You feel better now?

@lewisparkes1597 2 жыл бұрын

Thank you Gez for all you’re doing regarding long covid and all those suffering (a year now for me)! It sometimes feels like there’s little chance or hope of getting over this. However seeing these videos and pathways to what will hopefully be a full recovery is brilliant. Can I ask if regular drops in blood sugar/ hypoglycaemia is also linked to long covid?

@RUNDMC1 2 жыл бұрын

Yes I’ve heard people report this but it’s not super common

@lewisparkes1597 2 жыл бұрын

@@RUNDMC1 Ah ok. I have that going on as well but never high blood sugar. Kind of hoping it’s linked rather than a separate issue. Thanks for your reply.

@lily2062 2 жыл бұрын

Another super informative video thank you so much Gez. I’m just wondering if you’re aware how long Dr Wentzel prescribes the stack for ? Thank you :)

@9yetis 2 жыл бұрын

Gez, your efforts are priceless! Thank you so much for your videos. I'm 12 months with LC now and i would like to know how do you feel after your "experiment in the Alps". Are you probing with more 'sport'? Greetings from Spain ❤️

@RUNDMC1 2 жыл бұрын

Feeling good post trip to the alps. Considering some more gentle activity!

@eileenhartman8290 2 жыл бұрын

Hi Gaz. Thank goodness for you. I have been ill for over 40 years, with M.E, and gut problems. I had a hysterectomy, then got Epstien Barr. I have battled for all that time with ill health. I have tried every diet, therapy, supplement, and seen every Doctor possible. Then 7 years ago I had breast cancer. I had surgery and radiotherapy. I then ended up with Fibromyalgia. Then 4 years ago I started having bloating cramps and so I. I went to Harley street. Had several tests. I was diagnosed with sibo. And other things. I had Antibiotics twice. Only got worse. Started loosing weight. My G I doctor told me it was IBS. I was sent for a CT scan and a pet Scan. It shows I have breast cancer back, but this time it's spread to both my lungs. I'm not going through treatment again. But on my last hospital visit I got Covid. Now more than 3 months down the line I have long Covid. I watched DR Tina Peers. I beleave I have, Mast Cell Activation Syndrome. I have become allergic to almost every thing that goes into my stomach. I feel so ill all the time now since Covid. My muscles ache all the time, and I'm struggling to eat any thing. My gut us he'll. And I'm totally exhausted all the time. At the moment I have just started Low dose Neltrexon for Cancer. I don't know how I can get to see Doctor Peers. I beleave I may have had this all my 40 years I have been ill. I'm 72 now. And have lost most of my life. Getting no where with GPS. In the UK. I haven't found any one to help me. I have no quality if life. It's not worth living. My words get jumbled up. So sorry for mistakes. Can you offer any advice please. Eileen.

@RUNDMC1 2 жыл бұрын

I’m so sorry to hear this Eileen. It’s not really my place to offer advice over and above your doctors, but I would say this one thing: be kind to yourself. Wishing you the very best.

@vickielewis3848 11 ай бұрын

Highly informative and thought provoking discussion. Quality listening. Learn and teach. Thank you. 🔜👊🇺🇲

@MrEdkirby 2 жыл бұрын

Fascinating stuff Gez. Have taken a bit of a break from the Niacin but maybe its time to revisit my old flushing friend...

@RUNDMC1 2 жыл бұрын

I would do Edward!

@Trev_Draws 2 жыл бұрын

Another great and optimistic film. I’d better get back on the Niacin!

@RUNDMC1 2 жыл бұрын

Indeed!

@carlibeardsley1326 2 жыл бұрын

Thanks from NYC for all you do.

@isadorasegura9314 2 жыл бұрын

Thank you Gez again for such an amazing piece of work! I want to find out whether this protocol is recommended for people who's blood pressure fluctuates. Some of the supplements can increase or decrease. Also do we need to be monitored by a GP? I'm so sorry if you have answered before, I can't seem to find anything. I had high blood pressure with third jab and don't want to make myself ill. Many thanks and I'm sure I speak from all of us in the community - truly application for the work you have done for us!!! In deep gratitude :-)

@RUNDMC1 2 жыл бұрын

Hi Isadora, if you have any concerns at all best talk to your GP first. Generally speaking this is a safe stack though! Just be careful with the niacin flush.

@thomasfinlon6386 Жыл бұрын

Thank you so much for sharing this info. Having the flushing kind of niacin gave me relief for the first time in weeks after just a few doses. It felt like my skin was tingling with hot sauce fire for a minute but then was like the cloak of fatigue lifted and I had so much more mental clarity. I’m not feeling anywhere near 100% but felt like I went from feeling 10% to 50% with this one change alone. Thank you!

@RUNDMC1 Жыл бұрын

Great to hear it Thomas!

@kenttwomey 2 жыл бұрын

How can we find his paper? My doctors apparently don’t like videos. This doctor is spot on. My daughter has pots/long covid since dec 2020. Keep the intel rolling. Awesome job.

@ivo2 2 жыл бұрын

I was waiting for this video from hmm forever! Please post more often some tips, ideas... I benefit a lot from those, already feeling almost no fatigue taking all the supplements, and following the diet and advices... :) But my immunity is still low...

@swalexander6218 2 жыл бұрын

Thank you very much for this video. Dr. Wentzel laid out a perfect puzzle of possibilities. The problem is, not even specialists would agree to test for these indicators. May I ask Dr. Wentzel if he investigated phytanic acid, x-linked "VLCFA" (very long chain fatty acids) as another indicator or even as a marker?

@harryboby7563 2 жыл бұрын

Hi Gez, Thanks so much for your content as usual! I feel very grateful that I am at the point now where I feel largely back to normal after 16 months, I can exercise again without any serious repercussions and can live a pretty normal life. However, I still generally feel a bit foggy and lack energy and just don't feel quite 100%. I wondered if you had any insights into your experience with aphresis - I've been offered a slot and am debating whether it would benefit me and my symptoms. Would love to hear any insights from you or anyone else with experience!

@deethompson3592 2 жыл бұрын

Thank you as always for all your hard work . I must admit this particular podcast was hard for me to take in whether that's my covid brain or just me - probably just me 🙄👩🏼🐾👍

@gracemonk5873 2 жыл бұрын

Don't worry I was pushing through the brain fog to keep up too!

@RUNDMC1 2 жыл бұрын

It’s properly hardcore - I only got my head round it on about the third time of watching it back during the edit!

@deethompson3592 2 жыл бұрын

@@gracemonk5873 I genuinely thought it was just me - Thank you 🙏

@deethompson3592 2 жыл бұрын

@@RUNDMC1 - Thank you Gez for helping me feel better 🙏I was having flash backs to my school days 🤓

@Feirin332 2 жыл бұрын

I don't have much brain fog anymore and it was mostly Greek to me too

@zzberman9283 2 жыл бұрын

Gez, thank you for another great discussion and discovery on Long Covid. Dr Wenzel is brilliant and motivated and I’m excited to share his findings with my functional md so more healing can begin. This video was better than a box of chocolates for Valentine’s Day 💕💕💕. Coming from a chocoholic, that’s a significant complement 😉. By the way, you look wonderful! Are you following this protocol? Let me know what’s working for you in a DM if you’re comfortable. Best wishes, Gez. You’re a light in the darkness for many. Thank you for your work and commitment to our recovery.

@RUNDMC1 2 жыл бұрын

Thank you ZZ! Yes I’m following this protocol.

@mike_zander 2 жыл бұрын

This video is amazing! Can't thank you enough for this info..It's hard to find the micro doses in the protocol though! For instance, I could only find one company selling quercetin anhydrous (Nootropics Depot) and they're 500 mg.

@RUNDMC1 2 жыл бұрын

@@mike_zander Quercetin dose should be in mg!

@JocelynTee 2 жыл бұрын

Gez, I was also wondering about these dosages. It’s difficult to find these dosages for these supplements. Is there any leeway to dosage amounts or is it quite strict? I know Dr. Wentzel explains that high doses of quercetin and resveratrol led to nasty side effects. Is there any other wiggle room here? Thank you! 🙏🏼

@dimarie9466 11 ай бұрын

Thank you for your research and hard work. I suffer from a condition called Multiple Chemical Sensitivity and some of it's symptoms seem to coincide with Long Covid symptoms. I am hoping in your search for understanding and a cure of Long Covid that you may be able to provide relief for so many of us that suffer with MCS. It is a completely debilitating, isolating, and life devastating disease with a multitude of horrific symptoms that come on when exposed to any level of chemicals. Personally one of my symptoms is chronic severe vertigo which makes life miserable and intolerable when it's bad. I do hope you can provide relief for many more people than Long Covid patients and will be following your work excitedly!

@venuslatte1522 2 жыл бұрын

Fascinating! Thank you!

@helenlaurenson8017 2 жыл бұрын

Apologies if this has already been asked. If - as Dr Wentzel said in your previous video - one can expect to recover in about 1 - 2 weeks on the treatment stack, assuming that the problem mainly concerns NAD and not myopathy - how long would one stay on the treatment thereafter? Thanks for another great video, Gez.

@nickmac6859 2 жыл бұрын

Yes am thinking the same thing Helen. Thanks for posting. Is an expensive stack to purchase. Am just about to start and interested in how long I should continue if my symptoms improve. Adding another thank you for the videos Gez and all the hard work you are putting into collating this research. For the first time I feel hopeful.

@leannatimmerman9922 2 жыл бұрын

Excellent and brilliant. Thank you, thank you, thank you!

@RUNDMC1 2 жыл бұрын

Thanks Leanna!

@norav5971 2 жыл бұрын

Thank you Gez for all your work! Could you let me know if you follow the low GI diet ? I am following a low histamine diet since the beginning and don't know if I have to change that?

@helenstergius 9 ай бұрын

Looking for a link to this paper, but my search hasn't turned it up yet - only his first paper. Has it been published yet? Thanks.

@ThreeFineWonders 2 жыл бұрын

Fascinating and inspiring. Thanks Gez

@RUNDMC1 2 жыл бұрын

Thank you!

@pawelmatuszewski1919 2 жыл бұрын

Hi Gez! Thank you so much for another great video! With regards to the protocol you kindly shared with viewers do you know if this is something you can simply get off amazon or H&B or you need GP to prescribe these?

@RUNDMC1 2 жыл бұрын

Most of these you can just get without prescription

@Laura-xw7mr 2 жыл бұрын

Someone mentioned there's a transcript for this? If so, please let me know and post it (or a link) in the description. Thanks so much!

@jsmcclellan 2 жыл бұрын

Great work, as usual, Gez! BTW, did you suffer any symptoms after your ski trip?

@RUNDMC1 2 жыл бұрын

No - ski trip was extremely positive!

@jsmcclellan 2 жыл бұрын

@@RUNDMC1 that’s great to hear!

@user-mb7lo7ef2n 2 жыл бұрын

Doing some great work Gez, thanks for that! I have some questions about the dosage of some supplements. Some speaks for itself, but others are not that clear for me (and my brainfog) The quercetine is a lot less than the 'first stack' where 3x 500mg was prescribed. Is this due to the fact that now is spoken about quercetine anhydrous? I am now using di-hydrate The methylcobalamin I find the most is about 1000mcg, that's way too much in this case? Where does AAC at selenium and zinc stands for? The dosages of selenium I find the most in supplements are about 100mcg, so a dosage will be 10-30 pills? I think I am overlooking some details..

@SimmoSD 2 жыл бұрын

Thanks for the great LC research & treatment videos Gez, really helpful for us long haulers! I’ve just watched the FLCCC video on LC & was wondering if you’d discussed their iRecover treatment protocol with Dr Ade Wentzel, if so any thoughts?

@barringtonsmythe3464 11 ай бұрын

Gez I am new to your channel and can't thank you enough

@RUNDMC1 11 ай бұрын

Total pleasure!

@susanwoodward7485 2 жыл бұрын

As someone who has experienced varying frequencies and intensities of cfs/me since having mono in 1968, the absolutely disabling exhaustion I have been experiencing with long-coved since initially having covid in October of 2020, is in a class by itself. I have just begun self-medication with Truniagen under the data-supported hypotheses that nad+ is depleted by covid-19, as well as in cfs/me, and chronic kidney disease, which I have had for 20 years, and autoimmune connective disease diagnose 25 years ago.. Pray this will improve nad+ production, and utilization, and Sirt 1 activation..

@svdrummer805 5 ай бұрын

Hey I have similar medical issues. Did you find some relief and if so what helped ?

@andocobo 2 жыл бұрын

It sounds like Mestinon should help with POTS according to this theory - interestingly Mestinon has been found to be helpful for many people with POTS. Mestinon is a cholinesterase inhibitor, it increases the amount of acetylcholine at the synaptic junction.

@skylerwittman3146 2 жыл бұрын

Thanks so much for the info! Keeping up hope to get my body/life back. Would a B-Complex vitamin work? Or would it be better to get them all individually?

@luckyluc7412 2 жыл бұрын

Really appreciate what you’re doing for the LC community. Are you aware of Raymond Perrin and the Perrin Technique? he’s doing a study on this technique for long covid, might be worth checking out.

@RUNDMC1 2 жыл бұрын

Yes, aware of it and some people report good results!

@anthonyminniti17 2 жыл бұрын

I started this protocol and instantly felt better. Thank you so much Gez!

@cherilamay3449 2 жыл бұрын

Gez, thank you for yet another chunk of useful information and *hope*! I see you have a name check in The New York Times, shared the link here for you earlier but it's disappeared, possibly into your spam. Congrats on hitting the big time! I am writing another rap about my nearly two - year (and counting) Long Covid experience. I would love to mention you, along with others who have held a torch for us, and helped to keep us alive! If this is okay, how is your name pronounced? Does it rhyme with "singer", as in someone who sings? Or "singer" as in someone who slightly burns things? Or something else? Thank you again. 🙂

@ianseaweed 2 жыл бұрын

Fascinating, thanks Gez

@RUNDMC1 2 жыл бұрын

Thanks Ian!

@arjayfuentes2271 2 жыл бұрын

Interesting. Regarding the protocol, I was wondering, do you need to take the supplements in separate? or is it okay to have a supplements that have lets say vitamin b complex with vitamin b1, b6 and b12. I'm confuse of how to take or buy all these supplements specially those with low dosage mcg in the protocol

@RUNDMC1 2 жыл бұрын

I don’t think it makes too much difference, but if you want to spread them out across the day that’s fine too

@minituremarvels 2 жыл бұрын

Thank you so much for all these videos, the work you are doing is so important. I'm really grateful for all your efforts. Been taking niacin for a while and had some good results, but realized my dose is a bit low. Will try the full stack soon. I am also looking at doing a prolonged fast, in the hope that autophagy up-regulation and immune system might benefit. Have you or any of the experts you've met looked into this at all? Anyone had positive results with fasting?

@RUNDMC1 2 жыл бұрын

Personally I’ve not tried fasting but I have heard of people reporting positive improvement with it

@minituremarvels 2 жыл бұрын

@@RUNDMC1 Many thanks for the reply. I'm going to do an N=1 on myself and see how I get on. Will post results in comments!

@bretthoehn404 2 жыл бұрын

I was trying to find the video where you mention alpha stim. I'm curious which one it is and if you believe it helps.

@victorianalin5885 2 жыл бұрын

I’ve worked up slowly to 2 x 50mg Niacin p/day with the rest of the stack and honestly I feel like it’s helping, less exhausted, can do more physical work without getting totally wiped out and less circulation problems in my legs which was the worst 🙏🏽 Have you felt a difference Gez and what’s the optimal daily dose theoretically? Has Dr Wentzel’s preprint been published? Why isn’t there more media coverage about his work???

@mistymango 2 жыл бұрын

Thanks so much Gez for making this video for us. I would love to try this protocol. But if I try any vitamin pill even a humble Vit C I get palpitations, chills and my body shakes uncontrollably. Am I right in thinking this is Mast cell activation?