The Realities of Gene Editing with CRISPR I NOVA I PBS

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NOVA PBS Official

NOVA PBS Official

Күн бұрын

CRISPR gene-editing technology is advancing quickly. What can it do now-and in the future?
The revolutionary gene-editing tool known as CRISPR can alter, add, and remove genes from the human genome. The implications are immense: It could help eliminate illnesses like sickle cell disease and muscular dystrophy, and could even allow us to alter the genes of future generations of humans, leading to so-called designer babies. But will this ever really happen?
Medical journalist and pediatrician Alok Patel investigates the current state of CRISPR-starting with a bull calf named Cosmo. Patel discovers how scientists edited Cosmo’s genome so he would produce more male offspring, and what that means for humans. In conversation with scientists, artists, and ethicists, Patel explores what kind of gene editing is actually possible right now-and what we should be thinking about when we consider manipulating human traits and, ultimately, the human experience.
PRODUCTION CREDITS:
Hosted by Dr. Alok Patel
WRITTEN, PRODUCED AND DIRECTED BY
Caitlin Saks
EDITED BY
Robert Kirwan
ASSISTANT EDITOR
Jay Colamaria
CAMERA
Arlo Pérez
UC DAVIS FIELD DIRECTOR / CAMERA
Zachary Fink
ASSOCIATE PRODUCERS
Ana Aceves
Christina Monnen
Arlo Pérez
Jay Colamaria
PRODUCTION ASSISTANT
Lorena Lyon
INTERNS
Jessie Hendricks
Samuel Lipsey
AMERICAN SIGN LANGUAGE / ENGLISH INTERPRETER
Adam Bartley
ANIMATION
Edgeworx Studios
ADDITIONAL ANIMATION
2K-12 Studios
Mitch Butler
MUSIC
APM
ONLINE EDITOR AND COLORIST
David Bigelow
AUDIO MIX
Chris Anderson
ARCHIVAL MATERIAL
AP Archive
Broad Institute of MIT and Harvard
Getty Images
He Jiankui Lab / CC BY
Penn Medicine
Pond 5
Storyblocks
SPECIAL THANKS
Mike Baylis -- Assisted in the set up of a remote interview, at no cost.
Isaac Plant -- Reviewed script and graphics for scientific accuracy, at no cost.
Elizabeth Delgado -- Reviewed script and graphics for scientific accuracy, at no cost.
Dr. Samira Kiani -- Reviewed script and graphics for scientific accuracy, at no cost.
Dr. Kim Thornton -- Interviewed but did not include in the final film, at no cost.
Participants:
Françoise Baylis
Teresa Blankmeyer Burke
Karmella Haynes
Xavier LaPlante
David Liu
Bret McNabb
Liana Novoa
Alok Patel
Ariana Pelaez
Brianna Sapienza
Niaz Uddin
Alison Van Eenennaam
Image credit: (DNA helix)
© WGBH Educational Foundation

Пікірлер: 573
@briankraemer8139
@briankraemer8139 3 жыл бұрын
People arguing that deafness or blindness or other disabilities makes them "special" and therefore we should let them raise their children, and their children's children, in this "special" way is ridiculous.
@jp290
@jp290 3 жыл бұрын
What do you think we should do
@JoeVirella
@JoeVirella 3 жыл бұрын
Yeah that didn’t sound right to me. Do I need the deaf’s community’s go-ahead if I want to edit out deafness from my child?
@fedorbutochnikow5312
@fedorbutochnikow5312 3 жыл бұрын
@@JoeVirella yeah that snipper of video surprised me too. what does the deaf community has to do with parents' decision to help their future children...
@JoeVirella
@JoeVirella 3 жыл бұрын
@@fedorbutochnikow5312 Exactly!
@epgui
@epgui 3 жыл бұрын
I think the bigger point (which could have been made clearer or better) was that in selecting "who gets to decide" we need to be mindful of existing social inequities. ie.: the process needs to be inclusive, culturally sensitive, etc. An easier objection can be imagined if you consider that old rich white men will probably be the first people to be able to afford genetic treatments, and that marginalized groups will have little say over who gets access.
@riasharma3927
@riasharma3927 3 жыл бұрын
I love how he looks young and old at the same time.
@HonestOne
@HonestOne 15 күн бұрын
Non edited and the new cave men
@toshiboyig
@toshiboyig 3 жыл бұрын
Watching this high af, was not prepared to see a man more than elbow deep in a cow. Still very interesting documentary
@telman222
@telman222 3 жыл бұрын
The apparatus used to immobilize the female cow is referred to as the "rape rack" as that is what is being done.
@vafixer8885
@vafixer8885 3 жыл бұрын
@@telman222 sounds useful, wonder if i can buy one on amazon
@kojimapromeatspin
@kojimapromeatspin 3 жыл бұрын
I was eating :(
@jodajoda2863
@jodajoda2863 3 жыл бұрын
Currently high af, thank you for the warning. I was not prepared to see a man elbow deep in a cow, but now I am.
@PeteBogg
@PeteBogg 3 жыл бұрын
It's all BS anyway!
@albeit1
@albeit1 3 жыл бұрын
Regarding objections to correcting deafness, any individual that wants to hear should have the right to hear. The objections of others are irrelevant. People don’t have to be or stay a certain way to make you feel better.
@quotebrainiac2593
@quotebrainiac2593 3 жыл бұрын
Don't be eating while watching this. I learned this the hard way...
@marisabeltran3084
@marisabeltran3084 3 жыл бұрын
If some humans can remember old English, medieval history, etc, I'm sure deaf culture will not be forgotten even if everyone in the world could hear.
@shadfurman
@shadfurman 3 жыл бұрын
A persons value doesn't come from their traits. Deaf person isn't valuable because they're deaf, it's because they're human and people value people. A disability isn't a negative thing, but it's called a disability (in the real world ignoring the politically correct eugenics of ideas) because it is, the absence of an ability. The reason that gene was probably picked for testing is due to its simplicity. She doesn't own the deaf community, she can only speak for herself. Consulting the deaf community only reveals the opinions of those consulted, there is no such thing as a deaf community with all the same opinions. This is a regressive tribalist idea. I have 3 siblings with a genetic abnormality that causes dystrophy because both parents are carriers of that abnormality that puts a stop codone that prevents proper formation of dysferlin. A protein necessary for cell healing. Luckily, the type they have isn't life threatening, but it does mean their arms and legs will get progressively weaker for the rest of their life. They don't feel like their value as human beings is inextricably linked to their disability, and would be horrified of research into treatments was limited because others that are insecure about their self worth didn't want to allow the option for others. I'm quite sure many deaf people feel the same way, and that lady doesn't represent them. The reason I'm watching this video is to better understand the science necessary to treat my siblings disability, and perhaps one day contribute to the possible set of treatments or perhaps even a cure.
@zocava90
@zocava90 3 жыл бұрын
Have you watched the documentary Human Nature on Netflix? It talks about the potential to treat a lot of disabilities and diseases including muscular dystrophy. It only shows it on a list of research papers but CRISPR is being researched for its potential in everything.
@alexhutchins6161
@alexhutchins6161 3 жыл бұрын
I wish you and your family luck hopefully they can be cured soon.
@3DPhD1
@3DPhD1 3 жыл бұрын
I think, first, we should redefine 'disability' as 'differently-abled." As the deaf woman said, understanding the richness in one's differences, evolving our mindsets, would make me more comfortable about the ethics of CRISPR technology. Making more male cows is not a far stretch from making the world one ethnicity, is it?
@SandmansPhotography
@SandmansPhotography 3 жыл бұрын
@@3DPhD1 IMO it is up to the human's choice, regarding the deaf woman remarks, no one is pointing a gun to all the deaf people and making sure no one "suffers" from that anymore. I understand that new characteristics, in those humans what possess lack of 1 of their senses, will appear, and in the mist some are probably an evolution regarding human traits, psychology, etc. But, again, IMO I believe it's the choice of the individual that matters. There are many conflicting thoughts about this technology, and religion is also one of the big forces of denial that will most likely delay the possibilities of this tech.
@albeit1
@albeit1 3 жыл бұрын
@@3DPhD1 if we can accept people who are differently abled, so can deaf people. Even when a person decides to change their abilities. It’s up to the individual, not people who have an agenda for others to fulfill.
@user-gs9jg4dp9r
@user-gs9jg4dp9r 3 жыл бұрын
The world is literally getting ready to be divided between natural born humans and genetically tampered mutants. This is like watching an x-men prequel.
@basedchad6035
@basedchad6035 3 жыл бұрын
yeah thats kinda bad. It whould be cool if adults could be engineered. Than everyone whould be a mutant and all is good
@kepnjem
@kepnjem 3 жыл бұрын
It's called "playing God"
@TehVulpez
@TehVulpez 2 жыл бұрын
Finally, furries are going to become real
@terrorbilly1
@terrorbilly1 2 жыл бұрын
@@kepnjem No, it's called: evolution. Whether natural, or artificial - this is the way forward.
@roxxydesign4424
@roxxydesign4424 2 жыл бұрын
Yesssss
@andyklapper8484
@andyklapper8484 3 жыл бұрын
The moral issue here isn't with fixing broken people before they are born, and yes, being deaf is broken. The moral issue is that rich are likely to gain access to this technology well before everybody else. Not only do they have the means of paying for it when it isn't covered by insurance or the government, but they have the means to travel to a country that allows it if their home country does not. There is a lot of talk about privilege these days, but after wealth the most important privileges are health, intelligence, height and being attractive - all things that babies of the rich will have well before the rest of us, and restricting access will only help create our Gattaca future.
@kulveersehra1674
@kulveersehra1674 3 жыл бұрын
Rich people have access to a lot of other things that the average person does not, what is your point?
@tosha6013
@tosha6013 3 жыл бұрын
@@kulveersehra1674 “a lot of other things” are nothing compare to this
@PeteBogg
@PeteBogg 3 жыл бұрын
Height?
@sadiea4381
@sadiea4381 3 жыл бұрын
Like now you mean?
@theactivecoconut6077
@theactivecoconut6077 3 жыл бұрын
Rich people and their kids are already generally generally, smarter, and more attractive. I don't think it's right to think that just because there are unequal opportunities then nobody can have the opportunity. Cars could only be afforded by rich people in the past. Same with computers, phones, types of medicine, etc... imagine if people decide to not let these innovations be released to the public because only rich people could afford it.
@juliusreischauer345
@juliusreischauer345 3 жыл бұрын
This is inevitable. It will be used to cure disease at first. Then it will be used to improve ourselves. Of course this capability is immensely powerful. We have to learn to use it carefully and wisely to maximize good in the world.
@eatlaughandstupid4430
@eatlaughandstupid4430 3 жыл бұрын
a global indian...cast system...
@dianamccandless7094
@dianamccandless7094 3 жыл бұрын
What could possibly go wrong?
@coopersmith4333
@coopersmith4333 3 жыл бұрын
Nah I’m sure the elitists are going crazy with it right now
@KingCalb
@KingCalb 3 жыл бұрын
Like the Days of Noah. Gene editing and then the flood came
@milhouse14
@milhouse14 3 жыл бұрын
@@KingCalb Fairy tales are not valid arguments
@Nando85ec
@Nando85ec 3 жыл бұрын
I hope there is a team workimg on mental illnesses, there are so many lifes being wasted and people don't care at all. Some are just left to their luck living in the streets. In the best cases they live in families but are not productive and therefore can't have a fulfilling life. Someone please do something about it!!
@fedorbutochnikow5312
@fedorbutochnikow5312 3 жыл бұрын
what a good point. everybody is focused on better performance but no word on the current abysmal state of mental affairs.
@Susieq26754
@Susieq26754 2 жыл бұрын
If you need help maybe someone can help you. Mental illness isn't something to be ashamed of. If you have enough self esteem you could get off your couch and live a productive life. I just know it. Buck up buttercup.
@midassnap9028
@midassnap9028 3 жыл бұрын
I would have never thought that deaf people would not want deafness eradicated.
@fedorbutochnikow5312
@fedorbutochnikow5312 3 жыл бұрын
it's like the cancer support groups where so people with cancer feel so sentimentally belong that they don't want the cancer to end.
@HardKore5250
@HardKore5250 3 жыл бұрын
They believe deffects are cause of god 🤣🤦🏻‍♂️
@TimeTheory2099
@TimeTheory2099 3 жыл бұрын
Thanks PBS Nova 👍 I'm sure several nations militarys are already on this.
@brendanwood1540
@brendanwood1540 3 жыл бұрын
It's been around since at least the 80's. Project Coast in South Africa; gene splicing and recombination. 1998 patents on Corona parts or genetic clippings. 2003 Patent on the whole virus by chimera researchers at CDC. Exported to Wuhan center for virology in 2014 after NIH cut funding in american facilities. Now they are just selling a kit that can only mess with bacteria. But what can this technology do? In Project Coast they were making pathogens produce more deadly toxins by clipping parts and isolating genes. They also refined and purified certain toxins using the same technology. It's really not comforting that it's not heavily regulated. I find these presentations to be heavily sanitized.
@user-yj2ow9zi4j
@user-yj2ow9zi4j 3 жыл бұрын
Wait, but this means that you can add or disable the SRY gene, resulting in the rewind of the sex organs which then will develop into female if it's disabled and into male if it's added. Does this mean that there is a cure for fender dysphoria?
@rds7696
@rds7696 3 жыл бұрын
I think this is only for embryos, but it may be possible in the future, who knows.
@Succumbed2Rum
@Succumbed2Rum 3 жыл бұрын
This is an amazing breakthrough that will better the lives of many. Disappointing NOVA gives an extreme view of it. The deaf families deciding to give their children the gift of hearing should be applauded, not vilified. Deafness is a disability, it doesn't mean deaf people are "less than" in any way but to be able to make someone's life easier, experience more of the world, especially a child, is a gift. My 2 c.
@crackseller321
@crackseller321 3 жыл бұрын
I love these people. The game changing types. Much love and respect.
@russbrownnewsscalping7661
@russbrownnewsscalping7661 Жыл бұрын
fool
@zachdorian925
@zachdorian925 2 жыл бұрын
I know a woman that did gene editing to save her kids eyesight. He didnt get a copy of the RHE65 gene or something like that I honestly forgot what specific gene it was but he was ultimately loosing his eyesight and was supposed to go completely blind. He was already reading and writing in Braille and the insurance company said gene testing and editing wasn't going to benefit him so she paid out of pocket. When I found her she said it was 4 years since his genetic procedure and he is able to live a normal life! I didn't give him 20/20 vision but it saved his eyesight and now he can live a normal life without reading and writing in Braille!!
@russbrownnewsscalping7661
@russbrownnewsscalping7661 Жыл бұрын
stop lying
@ayushtank_2307
@ayushtank_2307 10 ай бұрын
I don't think that's true
@bradwoods371
@bradwoods371 3 жыл бұрын
15:50 ok but if you’ve got two parents who are deaf who don’t want their children to be born deaf, who is anyone to tell them “no! you have to have deaf kids!!!”
@riasharma3927
@riasharma3927 3 жыл бұрын
yess happy that someone said it.
@nameberry220
@nameberry220 3 жыл бұрын
Is it ethical if they want to modify their child to be born deaf?
@JuanIII
@JuanIII 3 жыл бұрын
Deaf children are more likely to die due to preventable accidents and are at a greatly increased risk for traffic accidents in older age, not to mention just getting hit by a car because they didn't hear it. Just because a person's kid is born to someone doesn't mean their kid wants to be deaf. Who are they to decide for their children they should be more likely to get hit by a damn car or in a traffic accident later in life? If she had a child with better reasoning ability than is suggested by the degree she somehow acquired, they would resent her for a long damn time.
@JuanIII
@JuanIII 3 жыл бұрын
A person's child isn't that person's property.
@basedchad6035
@basedchad6035 3 жыл бұрын
@@JuanIII Everyone clear minded should see that deafness isnt a good trait. No explanation needed
@yourfriend3054
@yourfriend3054 2 жыл бұрын
I hope this is available soon, to advance society and quality of life
@christopherorosz795
@christopherorosz795 3 жыл бұрын
Would it be possible to genetically modify a tree to increase its rate of converting carbon dioxide into oxygen? Would it be possible to genetically modify a organism to convert carbon into oxygen at a fast rate by inserting genes of another organism that does so on the planet?
@piglin469
@piglin469 2 жыл бұрын
WELL yes its plausible but at the moment not yet here
@chem101studygroup4
@chem101studygroup4 Жыл бұрын
Yes absolutely, rubisco modification. There’s a paper out on it now. They swapped an arecheobacteria’s rubisco genes into a plant and they think it has a much faster metabolism.
@themad_scientist2139
@themad_scientist2139 3 жыл бұрын
does anybody know what the name of the kit is called? or have a link to it thanks
@kaleesiking239
@kaleesiking239 2 жыл бұрын
Yes I do know the name of the kit
@kaleesiking239
@kaleesiking239 2 жыл бұрын
Its called crispr
@Joaocruz30
@Joaocruz30 3 жыл бұрын
Love you by masking the reality of Nova...
@Meleeman011
@Meleeman011 3 жыл бұрын
if the tools to edit genes are availible from the internet. human gene editing is probably already happening
@tgmwright
@tgmwright 3 жыл бұрын
"If they're changing your DNA, like, they could change completely how someone will... look" - an artist, circa 2020 Clearly someone who grasps the gravity of the situation.
@alexhutchins6161
@alexhutchins6161 3 жыл бұрын
Wpuld people who design humans like that be considered artists?
@bigfatstupidfish2397
@bigfatstupidfish2397 3 жыл бұрын
That would be cool
@Borderlands808
@Borderlands808 3 жыл бұрын
They can already alter most physical characteristics. What I want is wings to fly or ability to breath under water. Lol
@alexhutchins6161
@alexhutchins6161 3 жыл бұрын
@@Borderlands808 flying is going to be dificult. We dont. ATurally have tje right body shape for it. The question is how much would they need to change rignt? Tho i would do the same for wings that work as long is it doesnt change my physical form to much. I want eyes that can see suuuuuuuuper far and see in ultraviolet ect. But it seems cybernetics would do that better.
@Borderlands808
@Borderlands808 2 жыл бұрын
@Ahehx Cjejc gills?
@SapphoKore
@SapphoKore 2 жыл бұрын
I hope that the options of editing bacteria available to the public are pretty limited I mean what if someone creates like some super freak bacteria? And who wants to do that? I mean it hasn't happened yet apparently ...but i mean.... im confused
@chris2444
@chris2444 3 жыл бұрын
This is incredibly smart. I research sexual development conditions' genetics myself and I never thought that inducing SRY-translocation De la Chapelle Syndrome in livestock could change our world. Something known with human De la Chapelle Syndrome is that patients are still smaller than genotypically male counterparts. These genetically modified XX phenotypically male cattle may produce more beef on average than phenotypically female cattle, but they may still be less than XY males. Perhaps increasing the potency of the cattle's androgen reception gene may make up for that.
@jothepro1013
@jothepro1013 3 жыл бұрын
well, i have about 5k invested in the genomics/crispr sector. Lets hope it makes me rich this decade
@Gerdaldfighterkid
@Gerdaldfighterkid 3 жыл бұрын
In what exactly
@jothepro1013
@jothepro1013 3 жыл бұрын
@@Gerdaldfighterkid CRSP ARKG
@SnowboardCharlie
@SnowboardCharlie 3 жыл бұрын
I've made more than 4x since March... Happy to support such a technology. CRSP EDIT and NTLA
@jothepro1013
@jothepro1013 3 жыл бұрын
@@SnowboardCharlie hell yea, I first invested in about June and am almost up 4x which equates to 36k profit. Its mind blowing knowing I have this much money considering I'm 16
@SnowboardCharlie
@SnowboardCharlie 3 жыл бұрын
@@jothepro1013 dug me out of the hole I put myself in when I started investing at that age lol. Glad you picked a good one early
@easternwind4435
@easternwind4435 3 жыл бұрын
The deaf people who reject gene editing shouldn't be included in the decision of deaf people who whish to loose their disability. This is just sick.
@kenkclam
@kenkclam 3 жыл бұрын
The scary thing with germline editing or so called designer baby, is that whatever gene you edit, the gene is going to be passed on to future offsprings, into the human gene pools. You can never take that back.
@fouadmas5413
@fouadmas5413 Жыл бұрын
Good point, I wonder if the 2021 MRNA gene technology shots have this capability?
@russbrownnewsscalping7661
@russbrownnewsscalping7661 Жыл бұрын
its a hoax
@TophinatorStreams
@TophinatorStreams 3 жыл бұрын
I heard that if research was supported and advanced enough, genome editing could/would cut out ADHD! I would give anything to get rid of this lifelong disease. This disease (ADHD) is not what makes me “special” and has only prevented me from doing what I love. And doing what I love is what makes me special. I don’t need life set to Hard Mode. And I hope one day (when I have children), I can get my baby edited to rid this affliction from my genetic line forever. Plus, no diabetes or HIV? Yes, please!
@joel-uw2lg
@joel-uw2lg 2 жыл бұрын
Respectable
@whoneverknow9588
@whoneverknow9588 3 жыл бұрын
In the year 2000, the scientist at MIT cloned a Guar inside of an ordinary Jersey Cow, because cows are incubators. Most types of animals can be Cloned inside of Cows. The name given for the First Cow incubated animal by MIT was ........... Noah
@drew4021
@drew4021 3 жыл бұрын
I'm an optimist so I think this is wonderful! Genetic disease -of which there are many -will be a thing of the past. Most people live their lives unexposed to this -it's almost hidden away but for the people that suffer with these debilitating medical conditions it can be quite disheartening. It's easy to sit on your high horse and worry about things like "designer babies" I say let the science perfect first and let these people -the ones with disabilities decide how it should proceed.
@HermitKing731
@HermitKing731 2 жыл бұрын
im hoping crispr will be able to change my asexuality. that would be a dream come true for me. but theres very litle hance anything will be able to change my orientation. so i guess i will have to go to my grave as a freak.
@1000REMBOY
@1000REMBOY 2 жыл бұрын
@@HermitKing731 don't say that about yourself. You don't have to base your worth on society's expectation of you. If it was a self deprecating joke then my mistake for assuming. But I'm not worried about the science behind this technology half as much as I am about the social implications if this tech were to go mainstream.
@HermitKing731
@HermitKing731 2 жыл бұрын
@@1000REMBOY all i want is for my asexuality to be cured. thats all. i dont care about moral implications. i dont want to be asexual. i hate it. and this has nothing to do with society expectation of me.
@HermitKing731
@HermitKing731 2 жыл бұрын
@@1000REMBOY i know what i want to do with my life. i want to become a scientest and find out why people are asexual and aromantic and find a way to change it. because i will not stand for this injustice that has been done to me. i will not tolerate having been born aro ace. i want to fall in love. i want to feel lust for woman. i dont want to be a cold dead robot. this isnt faire. but im not going to die an asexual aromantic freak of nature. because i will dedicate my life work to destroying this error of evolution. and dont you dare tell me it cant be done. anything can be done with science.
@1000REMBOY
@1000REMBOY 2 жыл бұрын
@@HermitKing731 you may be right but nothing is ever worth putting yourself down over. Going around thinking that you're a freak of nature just because you were born a certain way isn't healthy. The worst sins of humanity were committed in the name of lust. Lust brought me financial hardship that I'm still paying the consequences for. It sucks that you can't enjoy the things you were meant to as a human. It's not right that it's hard to find love. But you aren't any less of a person because of it. My uncle lost his sexual abilities from prostate cancer. So I've seen what it does to a man. I could never begin to understand that pain. And I hope you fulfill your dream. But don't forget who you are along the way. You probably disagree with everything I just said but one day you might remember these words and I hope they serve you well in that moment.
@sudiptasarkar9262
@sudiptasarkar9262 2 жыл бұрын
How to contact Dr Patel? Want to contact him for my son.
@Player3.
@Player3. 2 жыл бұрын
I just hope CRISPR is used SOLELY for the health and well being of humanity, with the intention of only making others whole again and giving people second chances. The moment we start dipping into, “we’ll I want my son to have blues eyes, broad shoulders, etc,” or any other vanity reason, we need to take a step back. Idc if it’s my religious background or morals which present that concern. It’s a real and serious concern. We all know what humanity can do with just a little bit of power. For example, what’s plutonium more know for? Assisting in space exploration or cultivating weapons of mass destruction? Just some food for thought.
@e.v.k.3632
@e.v.k.3632 3 жыл бұрын
Really good video 👍
@0230Raveena
@0230Raveena 3 жыл бұрын
Please Change people's tendencies to use the word "LIKE"
@destyon9966
@destyon9966 3 жыл бұрын
No
@marisabeltran3084
@marisabeltran3084 3 жыл бұрын
Where do I sign up, I want a super-smart baby that can take care of me economically after 12 years... Also save the world.
@LDuke-pc7kq
@LDuke-pc7kq 3 жыл бұрын
High IQs can be used for evil and greed just as much as good; moral of the story: maybe we should evolve in Empathy as a species before 'playing God' with the future of the human race....
@susanwoodward7485
@susanwoodward7485 3 жыл бұрын
Whenever I read an article about some new CRISPR experiment, I marvel that epigenetics is apparently never considered - the proven fallacy that the "genome is everything" is still alive and well. Tremendously disturbing - the ultimate book of matches given to a child in a fireworks factory.
@johnhughes2124
@johnhughes2124 3 жыл бұрын
We can (with Crisper casX) turn on and off the epigenome
@susanwoodward7485
@susanwoodward7485 3 жыл бұрын
@@johnhughes2124 Wow, thank you for this. Can you suggest best lit links from your perspective. Just pulled up an article from Cell Research by Yang and Patel and this: blog.addgene.org/crispr-101-editing-the-epigenome to get me started. My apologies for not being up to speed.
@russbrownnewsscalping7661
@russbrownnewsscalping7661 Жыл бұрын
stop being so gullible
@alucardsomer
@alucardsomer Жыл бұрын
Could this help with Huntingtons?
@carlosericmontoya
@carlosericmontoya 3 жыл бұрын
Researching stocks - how the freak did I end up seeing this! I forgot why I clicked on the link ...
@PeteBogg
@PeteBogg 3 жыл бұрын
Synchronicity?
@jothepro1013
@jothepro1013 3 жыл бұрын
CRSP AND ARKG TO THE MOON
@jayjohn9680
@jayjohn9680 3 жыл бұрын
Wait I watched a ted talks speaker that said you couldnt crisper bacteria
@vortexfx420
@vortexfx420 3 жыл бұрын
it's your body and babies. You do YOU. F the Govt
@Danuxsy
@Danuxsy 3 жыл бұрын
but is it moral to have children if you know that they will inherit a genetic disease?
@devait4752
@devait4752 3 жыл бұрын
@@Danuxsy yes
@briankraemer8139
@briankraemer8139 3 жыл бұрын
Every time I stopped watching this video to go to the bathroom or make some breakfast, when I come back to it, it starts again at the beginning and I have to try to find my place where I was before. I've never had this happen with thousands of other videos. Is there anyway you can set up this video, and all your future videos, in such a way that it starts right where I left off when I come back to it. To be clear, I didn't close the window or close the video. I simply hit "pause" and left for awhile. I did open other folders and read other things, but it seems to me it should be waiting patiently at the same location in the program as when I left it. Thank you! :)
@jcstang8952
@jcstang8952 3 жыл бұрын
Gene editing for sex, that's dangerous, even for cows. You could wipe out beef permanently.
@kaleesiking239
@kaleesiking239 2 жыл бұрын
They done it on chicken too they are fatherless chickens. Hopefully they marked it gmo!
@BenkaiDebussy
@BenkaiDebussy 7 ай бұрын
I feel like the applications of stuff like this will be limited to conditions with clear and obvious genetic causes, but many things influenced by genetics are very poorly understood just due to the profoundly complex interactions between genes and other genes/environment. Like if tasked with "using genetic engineering to make smarter people," we'd have no idea how to do this.
@alexandercle
@alexandercle 3 жыл бұрын
And therefore, according to the ancient Chinese wisdom, what are the five most critical knowledge, power, richness, and wisdom that every individual could and should possess? altc, Paideia Academy-Society
@marisabeltran3084
@marisabeltran3084 3 жыл бұрын
What about muscle dystrophy? 16:31
@midassnap9028
@midassnap9028 3 жыл бұрын
You know what my job isn't so bad. 5:43
@Dustrick
@Dustrick 3 жыл бұрын
I'm in my 30's and I can't remember when but as a child I read in a magazine about designer babies and thought it was so weird.
@Silvertestrun
@Silvertestrun Жыл бұрын
Ty
@samtawil861
@samtawil861 2 жыл бұрын
who can help with gene editing to human ?
@a0um
@a0um 3 жыл бұрын
15:46 The deaf were invited to the conversation! They just didn’t hear! Ok, that was a bad joke. [The whole part about treating deafness starts at 14:15] I don’t think anyone said deaf people will be forced to get their hearing back, did they? Having a technology that gives the option is only good, isn’t it?! Happy deaf people will keep their privileged lifestyle. Unhappy deaf people will have a technology to recover their hearing. Considering all the bullshit and nonsense being thrown about, and how soundtracks are exploited for emotional hijacking I wish sometimes to be deaf as well. But I’m general I prefer to have the option to choose whether I want my ears open or not.
@robertfoertsch
@robertfoertsch 3 жыл бұрын
Added To My AI Research Library Sharing Through The TRUTH Network...
@robertfoertsch
@robertfoertsch 3 жыл бұрын
kzfaq.info/sun/PLG7EoBMUD1JwbD5-MQpFRGvadGWtf-4yD
@jesuscano6697
@jesuscano6697 10 ай бұрын
It’s a double edge sword because the only way to perfect the practice is by trial and error and obviously it’s a big impact considering the losses , but everyday we are gambling with an unwanted gene expression or a defect within our genome so it just depends how you look at it … eventually we all want desired traits if we want to surpass the speed from its normal natural selection process
@uchutsukitotaiyonomegami469
@uchutsukitotaiyonomegami469 Ай бұрын
I get people who want nothing to do with gene editing, etc. Choice is important and im for that. What im not for is others telling individuals what to do and how to live their lives. Thats a trait of religous evangalist/zealots, a trait i'd prefer to edit out of existence. In the pursuit of science, exploration, and human advancement, we will NEED things like CRISPR and VIRAL PHAGES to survive and thrive in the years to come, ezpecially if we are going to make it to becoming a TYPE 1 civilization and decreasing our chances of extinction.
@jawbrace
@jawbrace 3 жыл бұрын
In this week's episode of What Could Possibly Go Wrong ...
@treemanzoneskullyajan711
@treemanzoneskullyajan711 2 жыл бұрын
I tried cutting my hair with some protein powder and it didn't work
@SKiLLsSoLoN
@SKiLLsSoLoN 3 жыл бұрын
Wissenschaft :)
@eatdirtnetwork
@eatdirtnetwork 3 жыл бұрын
New?! This has been out since 2016 ...
@Agent-Astro
@Agent-Astro 3 жыл бұрын
Yeah but they are still testing it
@johnmontez1228
@johnmontez1228 3 жыл бұрын
《Agent Astro》zfn’s are a little bit farther ahead than crispr itself
@JessicaOrban3606
@JessicaOrban3606 3 жыл бұрын
We see issues with GMO food, why would we do that to our babies?
@nekora_core9666
@nekora_core9666 3 жыл бұрын
I REALLY REALLY hope this becomes successful! I don't wanna be TRANS or Diabetic anymore 😭 If people deem it immoral despite it being safe, I will never forgive humanity. I should have the right to my body, my life and my happiness.
@flagwashere
@flagwashere 2 жыл бұрын
it is immoral. The human experience must live on, no matter how bad it may be.
@thearamsay9578
@thearamsay9578 3 жыл бұрын
If I could, I would want a combination of gene editing and the Dion quintuplets. I mean, five daughters, Jean edited it for sweet disposition gentle this position and things like that. I have read sci-fi stories about children being genetically modified to be super soldiers or super intellect, and I’ve even read one story where they were fatal virus carriers. So far though, I have not read a sci-fi story featuring five little daughters engineered for sugar and spice and all things nice. That’s the kind of thing I would be interested in.
@BigChant88
@BigChant88 3 жыл бұрын
So the genetically modified cattle will look similar the all natural cow but in reality it's not. The genetically modified fruits and vegetables we eat look very similar to natural ones however the genetic makeup has been altered, they do not have the nutrients and vitamins that are essential to our health , most tend to be small in comparison to natural not to mention the taste is even different We are only beginning to see the negative affects and do not know what the full consequences will be .
@erdnati
@erdnati 3 жыл бұрын
So.. if we humans are nothing but mammals in the animalistic sense and certain sexes at the animal level are more suited for different purposes, why is it so hard to believe that men and women were are and can never be equal?
@logantidwell7698
@logantidwell7698 3 жыл бұрын
Okay, designer babies, cool. But what about those of us already born? According to my (probably inadequate) internet research, it may be possible to edit the genes of adults. Make them stronger, faster, give them better sight, that kind of stuff. That is extremely interesting to me
@logantidwell7698
@logantidwell7698 3 жыл бұрын
@lolbit well, put me on the waiting list
@logantidwell7698
@logantidwell7698 3 жыл бұрын
@lolbit I'm 18 now, so 37
@logantidwell7698
@logantidwell7698 3 жыл бұрын
@lolbit well this is becoming more serious than expected. The answer to the service thing is yes, I've actually been strongly considering joining the national guard. Sticking to the realms of possible powers, I'd want basically what wolverine has. Super strength, endurance, maybe even enhanced sense's like smell
@logantidwell7698
@logantidwell7698 3 жыл бұрын
@lolbit well, I definitely have some opinions about how things are done in government, and I've had some interest in investigation in the past. If I could do something about those problems, I certainly would like to. I suppose other powers I'd like is enhanced intelligence, perhaps night vision if that were possible. I guess there aren't many powers I wouldn't be interested, although I think some would suit me more. What exactly are the limits of what people like you can do? (Once you have the proper technology, I mean)
@logantidwell7698
@logantidwell7698 3 жыл бұрын
@lolbit well, I think that's about all I can think of on the power front, short flying, Spidey sense's, wall climbing (all of which don't seem very possible to me)
@aBigBadWolf
@aBigBadWolf 3 жыл бұрын
Why do you ask artists?! What a random show.
@Algormortis9
@Algormortis9 3 жыл бұрын
It's getting at the idea that this needs to be a two-way conversation, with the scientific community AND with everyone, including "random" artists, and the disabled community, and your neighbor, and your grocery store workers.. That the human genome is something we all share. The program also hinted at characteristics of intellect / creativity being part of our DNA, and the question of how much we really want to mess with that, or what kind of divides that could create among us. To me it's an impactful and intentional narrative, not something random.
@absoluteunit3885
@absoluteunit3885 3 жыл бұрын
@@Algormortis9 Well nice explanation , but I want to answer the question of "if we want to mess with that"(the intellect/crativity or the overall appearance of someone), the thing is that for the first time in history we might be able to manipulate things speed up evolution and even expand it, why we should let things in luck ,why we shouldn't try to enchance ourselves become smarter more beautuful or end mankinds worst disease, aging.And who is responsible to take such decision , the decision to create an utopia or to continue living in a world full with death jealously and misery.
@texasbob2528
@texasbob2528 2 жыл бұрын
When did PBS become the spokesperson for big Beef?
@nathanielcradle-yourrichfriend
@nathanielcradle-yourrichfriend 3 жыл бұрын
This was very informative......now throw those damn shoes away 💩 👟. By the way, when she said “PRIME TIME” I thought it was Cathy W. for a moment.
@wiggiag
@wiggiag 3 жыл бұрын
Wonder how well this works on coronaviruses?
@sadiea4381
@sadiea4381 3 жыл бұрын
It won't do a thing for a virus...but it will be amazing when it begins working on people. Like as soon as its in the body. Think twice.
@jcstang8952
@jcstang8952 3 жыл бұрын
the people behind crispr made the virus. Connect the dots.
@jawbrace
@jawbrace 3 жыл бұрын
Opening the door to Pandora's Lab
@cruzmoreno2798
@cruzmoreno2798 3 жыл бұрын
Is this a good stock to invest in?
@darrowallgood6353
@darrowallgood6353 3 жыл бұрын
I’d say so
@EnclaveHater07
@EnclaveHater07 3 жыл бұрын
You should invest in Joe
@charliesrandomthings5457
@charliesrandomthings5457 2 жыл бұрын
7:27 very quiet cat
@sergeyzelvenskiy5126
@sergeyzelvenskiy5126 3 жыл бұрын
There are different ways of knowing 🙄
@WhiteLakotaMan777
@WhiteLakotaMan777 2 жыл бұрын
What's wrong with preventing disabilities?
@shagituz
@shagituz 3 жыл бұрын
If deafness really isn't worth throwing away competitive self-interest will render it remain
@lollsazz
@lollsazz 3 жыл бұрын
I don't quite understand why CRISPR is said to be very unreliable. When we worked with it, we combined CRISPR with a transposable element that inserted itself in a very specific place. We had to sequence the vectors - make sure the gene hadn't inserted themselves in a weird place, but otherwise, the experiment went well. I wish I had chosen the first Master's assignment I was offered - would've worked with modifying fish using CRISPR then. BTW: I wouldn't trust a medical doctor to have good knowledge about gene editing - they learn waaaaay too little about genes.
@jongricafort4
@jongricafort4 3 жыл бұрын
what if the inserted synthetic genes is Draco DNA, is that a possibility?
@popeyegordon
@popeyegordon 3 жыл бұрын
@PRGASC The most primitive inexact CRISPR efforts are far more accurate than the most precise GMO creations. GMOs take an average of 13 years to get approved, CRISPR doesn't even need such approval and is bypassing GMO restriction laws. After CRISPR there will be something even better. Crop science is not static.
@matthewgeraci3938
@matthewgeraci3938 3 жыл бұрын
So what I’m hearing is invest in crisper
@seno7904
@seno7904 Жыл бұрын
Bro I just relised we can solve world hunger by making people able to photosynthesis and filter water
@sergiomonfrin2269
@sergiomonfrin2269 3 жыл бұрын
Esperando aqui uma tecnologia que traduza o inglês para o português diretamente :/
@emilianomarquez1629
@emilianomarquez1629 3 жыл бұрын
¿? Já existe, chama-se google translate.
@mohammedshujamirzabeg5044
@mohammedshujamirzabeg5044 Жыл бұрын
can CRISPR edit to the 1year old baby?
@zachdorian925
@zachdorian925 2 жыл бұрын
Look at unnatural selection on Netflix! It's honestly amazing
@coffeepot3123
@coffeepot3123 2 жыл бұрын
If they manage to cure cancer and dementia this would be amazing.
@Susieq26754
@Susieq26754 2 жыл бұрын
Cure cancer one day and the next you find out you have polio or hepatitis. You cannot snip dna and expect not to destroy chromosomes.
@Chris-fh3qv
@Chris-fh3qv Жыл бұрын
@@Susieq26754 That is literally not how it works. Cancer is an over-replication of cells, all you would be doing is setting back normal functionality. By saying stop over replicating. That's all.
@MrCeddie1
@MrCeddie1 3 жыл бұрын
Gene 🧬 editing = Gene 🧬 creation
@xxACIDVIRUSxx
@xxACIDVIRUSxx 2 жыл бұрын
At 6:05 “…doesn’t seem to bother the mama cow so much” that’s because the mama cow is getting some free action!
@tiffanyalberti2029
@tiffanyalberti2029 2 ай бұрын
3 of my blood relatives died in less than a year. 98 percent of my family is dead. I lost my father to kidney disease. My mom to Alzheimers. My uncle to a heart attack. My family has a long list of sicknesses and illnesses. One day my families medical history is going to come to take me out as well. I am so close to being the last surviving member of my family. If my parents genetically engineered me and their parents engineered them then this would not be happening to me. I was born in 1980. No such thing as genetic engineering then. Maybe it's not that bad.
@swalexander6218
@swalexander6218 3 жыл бұрын
Science should concentrate on disabilities such as ALS, MS, high phytanic acid ALD (x-linked), Tetrahydrobiopterin (gs224), psoriasis and, and, and.
@lillyanab
@lillyanab 3 жыл бұрын
I don't like the idea able change characteristics, I think this just increase higher expectations in society what the perfect standards a human should be
@chltmdwp
@chltmdwp 3 жыл бұрын
Why are all cows covered with flies? Is this normal?
@danielebrparish4271
@danielebrparish4271 3 жыл бұрын
Yes. It's also noticeable in the wild. Close ups of bears and lions usually reveal lots of flies. Did you notice all the poop on the side of the cow? Flies love poop and cattle produce big piles of it every day. They don't bathe so when they get dirty they stay that way until the next big rain. What I found strange is that they didn't hose off the cow's rear before going in and again when the cow defecated on the man he didn't wash it off before going in. I would think that thrusting a poop covered arm into an animal's vagina would cause a lot of infection. Regarding the flies some ranchers have a cylinder that is filled with an insecticide that is wrapped in burlap and the burlap hangs down so it touches the cow as she passes beneath it. They hang the contraption at the entrance to the barn in order to reduce the amount of flies. The good news is that flies are mostly a summer problem.
@fedorbutochnikow5312
@fedorbutochnikow5312 3 жыл бұрын
what a cocky dude. off putting!
@johnnyblack946
@johnnyblack946 3 жыл бұрын
Can whe cure alopecy with Crisper!?
@albeit1
@albeit1 3 жыл бұрын
People who think they can keep this technology from being used by noble discussions about hearing everybody’s input, well, that’s pretty naive. The first person to figure out how to boost IQ using this technology will decide this issue.
@joshuapotts7634
@joshuapotts7634 3 жыл бұрын
What if...the governments of the world collaborate a plan to render most of the existing human population sterile (or dead) via a pandemic/vaccine scandal while being distracted by political turmoil? Just a thought.
@petergunn9603
@petergunn9603 2 жыл бұрын
Could CRISPR be used to scramble not repairing the mitochondrial DNA of cancer cells to cure cancer? Essentially starving the cancer cell.
@LDuke-pc7kq
@LDuke-pc7kq 3 жыл бұрын
Don't think it's a very good idea playing with bacteria in an age of super strains....😪
@motorolaandroid5688
@motorolaandroid5688 3 жыл бұрын
This reminds me of Nassim Taleb's "CARPENTER FALLACY" In his Precautionary Paper he warns against using "experts" in biology to get tail risks of GMOs, gene editing, etc., even if they aren't shills. Just as a carpenter is not the one to use to compute probabilities of tail payoffs at a roulette table.
@huberhg
@huberhg 3 жыл бұрын
The Carpenter Fallacy Risk managers skeptical of the understanding of risk of biological processes, such as GMOs, by the experts are sometimes asked "are you a biologist?" But nobody asks a probabilist dealing with roulette sequences if he is a carpenter. To understand the gambler’s ruin problem by roulette betting, we know to ask a probabilist, not a carpenter. No amount of expertise in carpentry can replace rigor in understanding the properties of long sequences of small probability bets. Likewise, no amount of expertise in the details of biological processes can be a substitute for probabilistic rigor. The context for evaluating risk is the extent of knowledge or lack of knowledge. Thus, when considering GMO risks, a key question is what is the extent to which we know the impacts of genetic changes in organisms. Claims that geneticists know these consequences as a basis for GMOs do not recognize either that their knowledge is not complete in its own domain nor is genetics complete as a body of knowledge. Geneticists do not know the developmental, physiological, medical, cognitive and environmental consequences of genetic changes in organisms. Indeed, most of these are not part of their training or competency. Neither are they trained in recognizing the impact of the limitations of knowledge on risk. Some advocates dismiss the very existence of risk due to the role of scientific knowledge in GMOs... I highly recommend the full article, the Precautionary Principle www.fooledbyrandomness.com/pp2.pdf
@PatNeedhamUSA
@PatNeedhamUSA 3 жыл бұрын
I picked the wrong video to watch while eating breakfast
@nothingspecial98
@nothingspecial98 2 жыл бұрын
Can't believe some idiots are fighting for the right to be deaf...you win, keep it.
@limabravo6065
@limabravo6065 Жыл бұрын
Curing disease, birth defects, blindness, deafness, cognitive impairments, are all good things and should be pursued. Altering genes for cosmetic reasons, like making your kid taller, have a certain color of eyes, or increasing physical strength, should be prohibited before its even possible. And things like deafness or blindness are disabilities whether that woman or those like her think so, and the idea that she would subject another generation to endure that disability, seems less like "oh look at our beautiful culture" and more like misery loving company. I was born color blind and it's prohibited me from being able to do certain things and had their been a way to identify and fix that while I was developing and my folks didn't do it because we come from a long line of people who can't differentiate colors, to say id be pissed would vastly understate how I'd have reacted
@TheQUBANQT
@TheQUBANQT 2 жыл бұрын
I’ve been investing in CSPR for a year +/-. I’m a big fan of Jennifer’s work. Supporting female scientists in a male dominated field is important to me. The science itself has amazing possibilities. I see a bright future.
@russbrownnewsscalping7661
@russbrownnewsscalping7661 Жыл бұрын
mr gullible
@soufmaro502
@soufmaro502 2 жыл бұрын
when they get to the point where they either can remove black or white skin color/gen with that that will catch interests
@prilep5
@prilep5 3 жыл бұрын
First plants then animals and after 30-50 years perfecting the technology - humans
@Machiavelli2pc
@Machiavelli2pc 3 жыл бұрын
Even sooner I’d wager within 5 years easy.
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