The Science behind Spironolactone

The Science behind Spironolactone | Dr Davin Lim

Рет қаралды 21,142

Жыл бұрын

Big thankyou to my colleague, Eshini, for helping me out with this video!
Find her on instagram - @dr.esh.perera
What is the science behind spironolactone?
Spironolactone is an anti-male hormone (anti-androgen) medication. It blocks the male hormone receptor and reduces the level of the male hormones, testosterone and DHEAS. This tablet was first used as a diuretic (“fluid tablet”) effect and increases urine production. This medication lowers blood pressure and reduces fluid retention.
Spironolactone is an oral medication & not a cream because androgens (the target for spironolactone) is found circulating in the bloodstream.
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What skin conditions can be treated with spironolactone?
Hormonal acne: It’s the impact spironolactone has on the hormones that give it its acne fighting reputation. That’s because it blocks the effect that androgens have on oil glands. This medication is an alternative to Accutane or Oratane.
Hair loss in women: Due to its impact on hormone regulation, the drug has recently been prescribed for women experiencing hair loss, also known as androgenic alopecia.
Excessive unwanted hair: On the other hand excessive hair known as hirsutism, commonly seen in PCOS can be treated with spironolactone.
Oily skin: can also be effectively treated with this medication. Most patients only require a very small dose of between 50 to 75 mg.
To see if you are a good candidate for this medication, book in with one of the medical dermatologists @cutis_dermatology.
*Disclaimer: I am a procedural dermatologist, I do not treat medical conditions such as hair loss, acne or other conditions that require prescriptions/tablets.

Пікірлер: 85

@DontEven-AsIf-Whatever Жыл бұрын

I believe the best thing to do that doctors are not doing or anybody who can prescribe that type of drug or birth control... Is having a blood panel done before, during and after any sort of treatment with any drugs?. This is to see where someone's depletion of a specific vitamin or a deficiency in their blood and also where their hormones are sitting so that the proper treatment can be given at the proper dosage because it's not a one size fits off. That's the problem that we have with a lot of these doctors prescribing these drugs is that they do not do the pre -testing before prescribing.

@dianesanford1290 Жыл бұрын

My dermatologist prescribed this medication for me and it has been unbelievable! Cleared my painful acne that I could not get rid of around my chin. My face has been totally clear for 2 years now. Best medication!

@beautyishername2023 Жыл бұрын

Hello, are u still taking it? Asking because sometimes when medications are stopped, the problem may come back. Thanks

@stu.dent-ASMR Жыл бұрын

Can I ask your dose?! I’ve been on spiro for 3 years and barely a change I’ve seen!

@emilyx2043 Жыл бұрын

Are you still taking it? X

@lavenderbex 10 ай бұрын

Any side effects?

@stu.dent-ASMR 9 ай бұрын

@@lavenderbex the worst side effect (and I mean horrendous for me) is that it’s a diuretic and it makes your urine production intensely increase. Which can also be a good side effect, bc you have ZERO bloating whatsoever. But the amount of times I pee in a day makes it really hard to work, travel or even sit in my classes for the full hr. I’m constantly peeing. When I travel I have to go off of it bc that’s how much of an inconvenience it is- I would say every 30 minutes I have to pee. Sometimes I can stretch it to an hr. Everyone is different and maybe some aren’t affected in the same way- but for me this is my only and absolutely worst side effect 😩

@shannonnero Жыл бұрын

Spiro really improved my skin in my 20s unfortunately I had to stop taking it completely because it really exacerbated my anxiety and I started having panic attacks. I was so sad about it because I didn’t really get to enjoy having the clearest skin for the first time because my mental state was so bad at the time. It stayed clear for a little bit but the acne returned unfortunately, not as bad though :( Another side effect which is common was no matter how much water I drank I was always so thirsty and had to pee all the time - that was annoying 😅 The good thing though is it leaves your system fast and is safe to take long term so it’s worth a shot before you have to consider something stronger like accutane.

@justsayin397 Жыл бұрын

The best treatment for cystic acne for females, Accutane not as good as Spiroloctane … nothing worked for me long term until I tried Spiroloctane. 100 mg a day for years .. no side effects apart from beautiful skin

@justsayin397 Жыл бұрын

@@AH--173 I noticed the texture of my skin change within a week. It was less oily. I stopped getting any spots after 3 months. Not one spot for the whole time I was on Spiro and I had no side effects at all……

@justsayin397 Жыл бұрын

@@AH--173 I was on it for about 10 years and I was in my early forties by then so I wanted to see if I had grown out of acne . So when I stopped I didn’t get any spots like I used to but my skin was not as glowy when I came off it. It can only be prescribed in the uk by a dermatologist and as my skin was more or less fine by then I didn’t go back in it. If I had any problems again I would go straight back on it.

@justsayin397 Жыл бұрын

@@AH--173 the best of luck to you I hope you have a good derm who listens and understands. uncooperative skin can really eat away at your self esteem. You don’t have to put up with it 👍

@Farhad-jr5pj 8 ай бұрын

It is safe for men??

@ellamaria354 5 ай бұрын

@@justsayin397what do you think about cancer from it?

@lemenik Жыл бұрын

Great content as usual!! Thank you so much!!

@weighttrain1965 Жыл бұрын

I have a dental patient, 20-ish college student taking spironolactone. Her mouth is extremely dry and she has multiple areas of gum line decalcification. I think this is from increased water loss. My fear is she will experience rampant root surface decay which can lead to tooth loss

@MChristina Жыл бұрын

can this be fixed with increased water intake?

@NedouxSews Жыл бұрын

Brilliant information, Thank you so much!

@afsheen4952 Жыл бұрын

Much needed video, Dr. Lim now when I'm dealing with hormonal acne and hair loss in my late 30s from the last 3 years. Wish you and Dr. Eshini were based in Sydney 🙁

@emgbluedelta5628 Жыл бұрын

Can you make a video talking more about treatments for hairloss? Scarring alopecia, frontal fibrosing alopecia etc…TIA!

@Skihelenb Жыл бұрын

Thank you for sharing this information! I hope more people learn about and find Spironolactone! I suffered with horrific acne until I started my Spironolactone journey. I started with 25mg and the dose was increased every three months until I reached the 150 mark. At 150mg my period came every other week 😢 so after speaking with my Derm we reduced the dose down to 125mg and all is well. I am so grateful for this medication and for your channel! Thank you!

@arielugalde9793 Жыл бұрын

Hey im starting it , does the brand matter ?

@fannyasilberman7373 Жыл бұрын

Thank you for your video on this! Do you breakout more than usual in the first month when you first start spironolactone? Or just slowly better each month?

@lexi6115 Жыл бұрын

I was on this with birth control and still had extremely heavy bleeding. Changed my birth control from COC to one with drosperinone and now on my second month I’m extremely heavy bleeding again. Could this mean my acne isn’t hormonal or something else is going on?

@raddgreat01 Жыл бұрын

What is medicine tablet for men with 36yrs old acne ?

@da4441 Жыл бұрын

Should post menopausal women use Spironolactone for hair loss? Or should they use Dutasteride or Finasteride for post menopausal women with female pattern hair loss?

@jalyngraham6090 Жыл бұрын

If someone had low-normal kidney function would this medication potentially be appropriate?

@marissagurney5285 Жыл бұрын

I take this because I have PCOS but I’ve had a pulmonary embolism and therefore can’t be on the Pill anymore. This is the first time in three years that my face has not been a total oil slick, and I can actually wear make up.

@mcadamson Жыл бұрын

Have you gain weight from it?

@jenm1948 Жыл бұрын

Hi Doctors stumbled in your youtube, new subbie here.Thankful for your video especially from medical professionals view. I’ve been on Spiro for about 4 years now due to my hormonal type cystic acne and to control my mild hypertension. My question is can I stay with it for lifetime as it also controls my BP? Is/are there any long term study/ies about usage of Spiro in regards to cancer? I have strong family history of breast and other type of cancer in the family. Thanks in advance.

@salma_techie Жыл бұрын

why is my comment deleted thou?

@poojadhanure2399 Жыл бұрын

Hello dr pooja here i m from india Facing acne from last 8 years dr suggested me to take aldactone 100 mg i m taking it from last 2 months but it is making me extremely tired fatigue feeling dizzy fainting etc my weight has been reduced by 4 kg .. but acne has been reduced so well this is the only tablet that have worked for me . I really want to continue the medicine but sideeffects are bothering me so much what should i do now plz help me out?

@da4441 Жыл бұрын

Is dry mouth a possible side effect of spironolactone?

@samarae 10 ай бұрын

Also is it safe to take this medicine while on glutathione drip and oral?

@labombaqueen5654 3 ай бұрын

is there any available for men?

@universe25.x Жыл бұрын

It doesn’t help me 😢😢😢

@manpreetghuman6160 Ай бұрын

Can we use aldecton and isotretoin together

@spensiv_gta2841 Жыл бұрын

Is this med good for teenagers?

@Chris-xf6mc Жыл бұрын

Hello sir can you make video on grey hair causes in treatment in early age like in mid 20s. Like for me i have got lots of grey hair on head and beard too. Nobody in my family got grey hair in so early age . I have never used any gels dyes on hair . Please make a video on this topic

@Chris-xf6mc Жыл бұрын

Hello sir can you make video on grey hair causes in treatment in early age . Like for me i have got lots of grey hair on head and beard too. Nobody in my family got grey hair in so early age . I have never used any gels dyes on hair . Please make a video on this topic

@sooopeachie Жыл бұрын

Male and female patients can use Wenlevi, a topical version of spironolactone that works very well for acne without those awful side effects.

@anithavuttaradi5628 Жыл бұрын

My daughter has very less chest and has hair loss and some time acne more andeven has irregular periods also Can i give Spirinolactone to her She is 25years suggest me

@memoonasaeed4408 Жыл бұрын

If someone has normal lab results of serum testosterone and start taking it for acne, will it lower the values of testosterone on lab results too?

@przemkowaliszewski3290 3 ай бұрын

No. Spironolactone inhibits in a non-specfic way androgen receptors. By doing this, Spironolactone inhibits influence of Testosteron and its active metabolite, DHT.

@dennisguilder1 Жыл бұрын

How about a video on topical sirolimus for kprf

@maryhoover4176 Жыл бұрын

My Dr gave me Spironolactone for ovarian cysts. I didn't hear you mention that. Would that be right?

@mcadamson Жыл бұрын

Have you gained weight?

@user-mb9jx5tx9y Жыл бұрын

I’d never go on this medication again. Worst headaches everrrr. Not even accutane gave me this symptom

@dakotahallen654 Жыл бұрын

The period thing is SOOOO annoying Every two weeks

@thoidamliunewmai7916 3 ай бұрын

Can spironolactone worsen malasma???

@katielouise2855 2 ай бұрын

has anyone ever had kidney stones on this medication? It helps me so much but i was getting reoccurring stones so I came off it but now my acne is coming back :(

@bacsilaser Жыл бұрын

Please check PCOS in women with hocmonal acne

@seunshaw5107 Жыл бұрын

What’s the best brand of spironolactone to use?

@maureenbaker7516 Жыл бұрын

It is prescribed by your doctor

@KiranKumarBokkesam Жыл бұрын

Wow she's gorgeous ❤

@yogaqueen515 10 ай бұрын

Struggling with monthly hormonal painful acne with puss which appearing on a chin mostly and my scalp gets so oily during ovulation and luteral phases. I have a sensitive skin , fiancea 15% for three months did nothing and the gel still burning the skin . I switched to Differin + benzoyl peroxide treatment again atm. Tempting to go get prescribed spironolactone. Will it reduce the oiliness of the scalp? 🙏 thank u

@Tennababy 7 ай бұрын

Spiron affects excessive oil production yes

@keving690 Жыл бұрын

Since this affects male hormones, does this have any sexual side effects?

@Da-uo6xu 7 ай бұрын

Not sure if it’s too late…..but it lowers testosterone levels. It’s actually used by transgenders as a T blocker.

@markczarny7088 Ай бұрын

Causes hyperkalemi for mr very dangerous been hospitalised on 25 mg

@Fboy2284 10 ай бұрын

New subscriber ❤

@Nathaniel-Heavyfoot Жыл бұрын

Nothing helps the people who actually have serious acne issues.

@arsal09 Жыл бұрын

well i as a male have been using small dose (25mg) spirono for mild heart failure due to valve disease... i now have man boobs !

@mariama2970 Жыл бұрын

🤭🤣

@jicalzad 10 ай бұрын

Spirinolactone safe for an 18-yr old?

@przemkowaliszewski3290 3 ай бұрын

Yes. If kidneys have a normal function, nothing bad ought to happen

@Mohammedmed7 Жыл бұрын

New Subscriber.

@samarae 10 ай бұрын

Can i get pregnant while on this medication?

@ellieabel1543 5 ай бұрын

No you shouldn’t. It can potentially cause birth defects

@Farhad-jr5pj 8 ай бұрын

It is safe for men?

@lashaniquep7746 3 ай бұрын

@islamic3409 Жыл бұрын

Can taking collagen supplements prevent deep acne scarring like ice pick scars? What can be applied to a fresh new ice pick scar to increase collagen in that area?

@da4441 Жыл бұрын

Too much collagen response can cause a scar.

@ericarona8599 7 ай бұрын

Cancel ❌ Spiro can cause midsection weight gain and it's tough to get rid of.

@wildlifepk 10 ай бұрын

This medicine is worst, I took this for 3 months but had to stop cause it was causing severe breast pain and weight gain, when I stopped taking this my periods didn't came it's been 3 months now, I have PCOS but my periods were normal only had issue of hirsutism.

@WhiteVaille Жыл бұрын

Meanwhile, me on 300mg/day. 😳

@WhiteVaille Жыл бұрын

(the joke is that I'm a trans woman in the US, thus taking spiro specifically for its off-label anti-androgenic effects, lol. god, though, i wish we'd stop using spiro for this. supposedly GnRH agonists are much better suited, but far more expensive.)

@universe25.x Жыл бұрын

I’ve been taking spironolactone for 8 months already(50mg) then 100mg and I still break out like crazy :(

@Chris-xf6mc Жыл бұрын

@da4441 Жыл бұрын

Premature gray hair is genetic. It can skip a generation. Maybe one of your grandparents had it? I got premature white hair in late teens snd 20's. Parents and siblings did not. But fraternal grandmother had premature white hair.