Leah4sci.com/a... presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism
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In this video, you’ll learn how to protect the acidic proton of an alcohol from strongly basic reagents like alkynide ions and Grignard reagents by forming the trimethyl silyl ether using TMS-Cl. You’ll see a detailed breakdown of the reaction and mechanism of the alcohol protecting group - TMSO and learn how to deprotect the alcohol with the use of tetrabutyl ammonium fluoride - TBAF.
↪ Links & Resources Mentioned In This Video ↩
▸Alcohol Reactions Series + Cheat Sheet Leah4sci.com/A...
▸Acetals and Ketals in Organic Chemistry Leah4sci.com/A...
▸Grignard Reaction and Mechanism Leah4sci.com/G...
▸Polar and Nonpolar Covalent Bonding • Ionic, Polar Covalent ...
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⏱ In this video:
[0:29] Why Protecting Groups are Used
[1:43] Ethers as Protecting Groups
[2:46] Structure of TMS
[3:06] Structure of TBAF
[3:32] Protecting Group Full Reaction and Mechanism
[5:37] Simplified Reaction and Mechanism
[7:30] Another Practice Example
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