MDMA synthesis in 3 steps & how it could help PTSD therapy (educational)

MDMA synthesis in 3 steps & how it could help PTSD therapy (educational) | Chemistry & Science

Рет қаралды 164,712

Күн бұрын

🧠 Did you know that MDMA-assisted therapy was recently proven to be highly effective for people with severe PTSD? In this video, we will break down MDMA's history and discovery, synthetic approaches from the literature - including a kilo-scale process route - and clinical data from a Phase 3 study investigating MDMA's therapeutic benefit.
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* Note, some slides spell safrole as saffrole
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00:00 MDMA might have valuable therapeutic potential
00:37 Uncontrolled drug use is dangerous!!!
00:53 History and discovery of MDMA
02:26 Organic synthesis and chemical reactions: Safrole, piperonal, GMP synthesis
05:43 PTSD burden of disease and unmet need
07:08 Clinical trial design and results
09:48 Short-term MDMA safety seems acceptable - still, long-term or regular use is discouraged!
10:53 Outlook on potential FDA approval
Disclaimer - This channel does not provide medical advice!
No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on KZfaq.
Key references:
- Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA (ACS Omega 2022, 7, 900−907)
- MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study (Nature Medicine 2021, 27, 1025)
- The origin of MDMA (‘Ecstasy’) - separating the facts from the myth (Die Pharmazie 2006, 61, 966)
Some recommended books on organic synthesis:
- Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
- Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
- Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
- Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
- Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
- Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

Пікірлер: 153

@totalsynthesis Жыл бұрын

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@user-ru7im4kz2g Жыл бұрын

New treatment discovered

@Callummullans Жыл бұрын

I took MDMA when I was around 18, I suffered childhood trauma and at the time I would say I felt more stunted than anything and MDMA taught me love in a whole other way like I was loved unconditionally and I knew it in every fibre of myself. Big release into life and a massive step towards my authentic self in a way I could never have imagined. One of the best decisions I could have made as it ended up being an integral stage of development for me that I would have just missed out on entirely without this freeing experience.

@maktiki Жыл бұрын

That is exaclt why MDMA can work in a therapy session. Because of your new point of view (unconditional love for self and others) you can speak about problems openly with a therapist. Extacy is the wrong name it should have been named MPT or Empathy

@Callummullans Жыл бұрын

@@maktiki I like that a lot, Empathy is the perfect word for it. It’s empathy in its purest and most unobstructed form. What does MPT stand for?

@drswaqqinscheckingin7210 Жыл бұрын

@@Callummullans just like how people say xtc to refer to ecstasy you could say mpt as shorthand for empathy

@EddieTheH Жыл бұрын

I was a victim of paroxetine, thanks for mentioning it. We should never let that be forgotten.

@Pootie_Tang Жыл бұрын

paroxetine ìs just an antidepressant, what are you talking about. It may not be suited for you, of course, but to say you are a victim... pff :-))) :-/

@sigmamale4147 Жыл бұрын

@@Pootie_Tang ssri's can have lasting side effects like sexual dysfunction, idk if he's talking about that but they suck

@l0lan00b3 Жыл бұрын

@@Pootie_Tang of being sold on a medicine that had improper safety testing and reporting which led to a 3billion dollar lawsuit. Its in the video

@keelo-byte 10 ай бұрын

First synthesis can avoid bromine in first step by reacting catechol with diiodomethane in dmso over a brass powder catalyst... allegedly.

@stevengill1736 Жыл бұрын

I remember bck in the late 70s when a paper company started offering 1,3-benzodioxole as a potential feedstock (catechol being a byproduct at that time of paper production). Those of us with dirty minds foresaw a couple synthetic routes utilizing it. However, in those days piperonal, safrole, and even MDP-2-P were readily available, so why bother? It wouldn't surprise me if the route from 1,3-benzodioxole was already in use by cartel chemists somewhere...

@kategoss5454 3 ай бұрын

I really appreciate you stressing the importance of the clinical therapeutic setting. I have had experiences with people on MDMA in a few different social situations and I can say for sure that the wrong setting can be devastating for vulnerable or traumatised people, and the right people in the right place can be extremely valuable. Thanks for this fun & informative video!

@zizu1911 Жыл бұрын

Great video! Was especially interesting as I did a research project investigating psilocybin's viability for treating depression. It's nice to see psychedelics clinical potential getting more attention!

@sepro5135 Жыл бұрын

Great stuff!

@sepro5135 Жыл бұрын

@@cyro44 well, MDMA is not psilocybin and the idea behind treating depression or things like PTSD with psychedelics is not continuous use, but rather once a year or just once, as the effect it’s supposed to have is based on altering the brains structure and not on manipulation the hormones or blocking receptors like ssri‘s do, which is highly temporary

@gregjackson4117 Ай бұрын

My friend Catherine was one of the publishers of the paper you sited in this synthesis. She is one of the most intelligent people I have ever met.

@Therealogtroub 9 ай бұрын

Very Interesting, I wish I had people with similar interests to explore.

@ironfeatherstudio4476 Жыл бұрын

The very sad thing is... X is super helpful for drug addicts, 'who are typically suffering from abuse' but,yet is illegal. Sad😢

@Thundralight Жыл бұрын

I think it could also be helpful for treating disorders such as psychopathy and narcissism as MDMA is also sometimes referred to as the empathy drug. I would like to hear your thoughts on this. Has there been any research on using it for these conditions? It is unfortunate that when the government bans a drug and places it on a list of scheduled drugs it makes it difficult for researchers to obtain approval and funding to conduct studies which could benefit people.

@nickbonsavage2586 Жыл бұрын

Wow, excellent video. Very interesting. Thank you for making this video

@tx.hardhead2546 Жыл бұрын

I remember in about 1986 when I lived in San Antonio we used to go to teen clubs and they sold it in test tubes for like 3 dollars a tube. It had a dye or something in it that made it look sick under the black-light lighting of the club. They also sold nitrous oxide in balloons, but that's not really relevant. MDMA was legal then and was making lots of news treating marital problems. It was really touted as the next big thing in couples counseling, then overnight it until went poof and turned into a schedule whatever drug..

@davidreed3021 Жыл бұрын

Nitrous oxide is currently in stage II clinical trials as a therapy for treatment-resistant depression. Basically the person would go in and be fed it for a couple of hours, and the therapeutic effect was significant and lasted for several weeks. Another drug that has a similar mechanism of action, Ketamine, is already used for this, (run a search for ' depression ketamine infusion') and so I suppose it shouldn't really be that surprising that it seems to work.

@tx.hardhead2546 Жыл бұрын

@@davidreed3021 I was reading about that the other day, and I really am glad the attitude is starting to ease on using these methods. I'm 47, and my whole life I have watched these drugs being demonized and banned because of their potential for abuse without being explored for their potential for treatment of mental health. This has also seemed to me a big mistake, to dismiss a drug as illicit and to ban it because some people might experiment with it to get high. Just yesterday I had to talk my son-in-law down "off the ledge" or suicidal urges because of marital problems. I asked him what they are doing to help him, what if any medicines the doctor was using because his thought patterns were obviously not normal. He said he had started Zoloft recently and sirens went off immediately in my head. My brother committed suicide when he was prescribed it, and I asked him didn't the doctor warn you about the side effects? How the shit amplifies suicidal thoughts and tendencies in the early stages of treatment? He said they hadn't mentioned that to him, never. I was fukn shocked that they had sent him out without even a thought of warning him of this so he could be prepared for these extreme mood swings! They were probably afraid he was say no thanks and his doctor might not get his cut for pushing this IMO completely dangerous drug that I feel has already caused more harm than good and had even helped my brother end his life. To conclude my ramble, any drug that has potential to successfully treat depression should be explored regardless of its abuse factor. I am glad the old hardliners are dying off and its refreshing to see the attitudes of my generation finally coming into practice. Maybe it'll bring better options instead of the ones that are helping to kill many people that trusted it because of limited choices.

@user-p6-3561 Жыл бұрын

Incredible video

@sea-ferring Жыл бұрын

Great video. Hopefully the law enforcement lobby will not derail this kind of research. There are so many groups that exist because of the war on drugs and they will do absolutely anything to continue their funding.

@dondobbs9302 Жыл бұрын

From what I've read; if that Saffrole is coming from Sassafras oil, it could be the equivalent of a "blood diamond." Ancient canopy trees being cut down in places like Cambodia and the oil steamed out of the roots on site and smuggled out + a few potential fire fights along the way. Sounds really "cuddly and huggy" doesn't it?

@dondobbs9302 Жыл бұрын

Yeah; starting at 13:00 in this video, seems like there's another, even more potent precursor source than even the Sassafras tree. kzfaq.info/get/bejne/pJagZZqKqtybqX0.html

@Wowthatscrazybro Жыл бұрын

great video.

@lukassorowka2672 Жыл бұрын

My FBI Agent watching over me rn: 👁️👄👁️

@knivesnico8775 Жыл бұрын

wonderful! may the psychology field get new tools

@user-ru7im4kz2g Жыл бұрын

I wouldn't support psychology as they are not even professionals. I trust myself and self-medication with time fixes everything.

@knivesnico8775 Жыл бұрын

@@user-ru7im4kz2g Ok. Ok hippie.

@bruceolga3644 Жыл бұрын

Ewe huemans should be aware that loot is abstracted with a tool...

@Love369A Жыл бұрын

Thank you :)

@andrewgiv 7 ай бұрын

Look up uncle fester, hate to say it, but meth manufacturing. That book has a few chapters that cover mda and MDMA. I found them very interesting. Science is very cool. Organic chemistry is even more interesting

@cvspvr Жыл бұрын

man, i just want there to be more research done on reducing mdma tolerance and the ~loss of magic~. mdma was the first drug i ever tried and my first time was still the most beautiful drug experience i've ever had. unfortunately, i've never even come close to replicating that, even after waiting a year between doses

@reedoburrito7456 Жыл бұрын

Did you take the same batch each time? Maybe its your dose.

@Huey_Freeman357 Жыл бұрын

Not all E is created equal.

@cvspvr Жыл бұрын

@@reedoburrito7456 no, but i don't think the dose was that different. i've tried both higher and lower doses than my first time, and while they felt more or less stimulating than my first time, they never felt as happy

@reedoburrito7456 Жыл бұрын

@@cvspvr theres alot of fake molly out there.

@cvspvr Жыл бұрын

@@reedoburrito7456 i always reagent test any drugs that i get

@teiskovich Жыл бұрын

Shulgin published it in PIHKAL, not TIHKAL as you mentioned

@totalsynthesis Жыл бұрын

I just threw in a random picture, but youre correct! Thanks

@grantwelstead6809 Жыл бұрын

In 1998/99 Shulgin came to UK to help Micheal Collins in his 2cb/ DOB trial... 1997 Collins was arrested... First 2cb / DOB Manufacturing conviction... He got 7 years...

@randomroughneck1030 Ай бұрын

now you should make the obvious sequel of how to synthesize 2cb since shulgin said to always take mdma and 2cb together

@unairodriguez4446 Жыл бұрын

Good video

@Aimee88-c8o Жыл бұрын

i have that paper on the gmp synthesis

@Beatdown.Babylon Жыл бұрын

I like how you sound like Pedro from Napoleon Dynamite... But an intuitive chemist.

@zorintoto1167 11 ай бұрын

Will there not be a substitute to oil in the synth. It's annoying that we are still bound to it 😢 . Even the MAPS guys confirmed they had to use it

@carlpanzram7081 Жыл бұрын

Damn. If I'd be more intelligent and adventurous I'd attempt making it. I wish there would be a reliable source for clean MDMA, because honestly I don't see why it's illegal at all.

@yeetyeet7070 Жыл бұрын

Where Hamilton at? ehehhe

@billallen6109 Жыл бұрын

He just had that chemist on his podcast recently. Would be cool if this channels makes it on there as well

@ZBB0001 Жыл бұрын

That was the first thing I thought, and then Rick Doblin. I'll make sure they at least get it, if they haven't already.

@transatlanticsilkcottonfabrics Жыл бұрын

Alexander Shulgin and his wife Ann . All the way. Vice has gone down hill.

@bigredinfinity3126 Жыл бұрын

For some reason I dislike him especially after the frog incident

@latefid 15 күн бұрын

Welcome to the list

@DOCB-op1qc 7 ай бұрын

- Nicolaou; Classics in Total Synthesis 1-3 is this really a trilogy or just updated editions?? seems like you could just pick 1 if your on a budge??

@totalsynthesis 7 ай бұрын

Thats indeed a trilogy, all different content. But it depends what you are looking for and what your level of chemistry knowledge is. There is nice focus on history and context in the 1st one in particular. Let me know your situation and I can weigh in if it makes sense

@ironfeatherstudio4476 Жыл бұрын

Was PIHKAL right?

@bigredinfinity3126 Жыл бұрын

Is this the same guy from the book Total synthesis from strike?

@fatman9644 Жыл бұрын

About the reduction of the nitro compound (4:00), isnt it an oxidation? I mean the carbon has an oxidation state of +I before the reaction to the ketone and +II after it, doesnt it? I thought a reduction of a nitro compound would yield a primary amine. Explain it please.

@totalsynthesis Жыл бұрын

Isnt it double bond reduction followed by Nef reaction (nitro->ketone)?

@fatman9644 Жыл бұрын

@@totalsynthesis Oh I didnt know the reaction mechanism and assumed its done in one reaction, but you are right. However, eventhough it is first reduced, its later oxidize to the ketone (in the nef reaction) or am I getting it wrong?

@potumnn Жыл бұрын

Here we go again 😩

@stevethomson8193 Жыл бұрын

What is known about the biological differences for the two enantiomers? And is there a reported asymmetry synthesis?

@totalsynthesis Жыл бұрын

Unclear in humans - actually there is a first clinical study ongoing: clinicaltrials.gov/ct2/show/NCT05277636 Preclinical research indicates that S-MDMA mainly releases dopamine, norepinephrine, serotonin, and oxytocin while R-MDMA may act more directly on 5-HT2A receptors and release prolactin. Animal studies also indicate that the two enantiomers act synergistically to produce the subjective effects of MDMA and that S-MDMA is mainly responsible for psychostimulation while R-MDMA may have fewer adverse effects and have greater prosocial effects. However, acute effects of S- and R-MDMA have never been validly examined in a human study.

@cvspvr Жыл бұрын

shulgin said that the best effects come from a 1:1 mixture of the enantiomers, which is unlike most other phenethylamines where the best effects come from primarily 1 enantiomer

@Gxvin 3 ай бұрын

Stuff like this should be taught in schools in my opinion. This is incredible life changing knowledge, and you are a saint for providing it. It SHOULD be more widely available and talked about, because of the (for lack of a better word) raging drug culture in America that glorifies the use of drugs like these in a terrible manor. BLESS YOUR SOUL

@ironfeatherstudio4476 Жыл бұрын

Safroil is very temp sense

@therideneverends1697 Жыл бұрын

What im interested in seeing is this produceing data in regaurds to neurotoxicity, because so far all we have is rat studys showing that a 4 day cycle of 4 dosages per day results in serotonergic neurotoxicity more severe than would be observed with high dose prolonged methamphetamine use, (most studies on the matter are on users over 500MG a day, however the likely point of toxicity is surely lower. However low dose prolonged methamphetamine use (dosages of up to 15 MG up to twice a day) for ADHD does not show neurotoxicity and Amphetamine and D amphetamine only show neurotoxicity at dosages in rats at dosages equivalent to 800MG in a 150 pound adult that may have been the result of overheating more than the substance itself. (the rats that did not experience hyperthermia did not exhibit straital dopamine receptor nore serotonin receptor damage) So Based on other examples in the amphetamine class presumably theres a safe level of use that avoids those risks, but those risks are also proportional to the serotonin affinity of the individual molecule, So im curious to see if brain scans are being done on the trials participants to investigate the matter, Is it that the 80-125 MG in a single sitting simply does not produce toxicity, or is it that the level of toxicity is too low to have an actual perceptible effect to the individual? If anyones got any data to show on the matter by all means send it because ive been on the hunt and have so far had no luck

@kshitijkumar5629 Жыл бұрын

I have doubts, in henri reaction, is a carbanion formed alpha of no2 group and something like aldol reaction? In reducing No2, why Fe, HCl is used and where oxygen comes from? Can we reduce no2 by h2/pd then use Hno2 to remove 1 degree amine and alcohol so formed can be oxidised by PCC?

@totalsynthesis Жыл бұрын

Yes to Henri reaction (you can check mechanism). The second one is a Nef reaction (has a more complicated mechanism but you can also find it on google). Oxygen comes from hydrolysis with water which is also added to the reaction (I usually only write key reagents and not all reaction conditions)

@totalsynthesis Жыл бұрын

Here is another example: www.orgsyn.org/demo.aspx?prep=CV4P0573

@hamable1995 4 ай бұрын

ferb i know what we are doing today!

@swenic Жыл бұрын

I thought the reason MDMA is used in therapeutic trials instead of MDA was due to some kind of confusion regarding what ecstasy is. In my admittedly experimental and non-scientific experience MDMA is a bit of a roller coaster and I advice against this, in particular if someone already is emotionally unbalanced. MDA on the other hand is more along the lines of peaceful loving bliss without the bendy roller coaster and therefore seems much more suitable for trials. (not to mention Vitamin D combined with K2 and Omegas but maybe it is naive to assume basic deficiencies are not addressed in these trials ?)

@maktiki Жыл бұрын

The "rollercoaster" is only when the dose is above a certain degree. for example very low dose was described by Shulgin as a Martini light/alcohol without calories

@swenic Жыл бұрын

I see. Thank you. Btw, non-coloric alcohol does not exist, it would be like alcohol without alcohol. Here's to that 🥂 whatever it means

@SetTheCurve 4 ай бұрын

Maybe the brain damage caused by mdma is a necessary factor in the clinical efficacy for depression and ptsd. Like chemical shock therapy

@lolnyanterts Жыл бұрын

Wonder how long until this video is purged

@guravi4295 Жыл бұрын

yeah.. proven against PTSD... tell that to the doctors they still live in 1990 as far as meds are concerned.

@daviddowns7552 Жыл бұрын

im not sure if this has anything on sassafras mda from 70s or not. i really dont think it could.

@francislutz8027 Жыл бұрын

I'm not sure you understand chemistry. If a molecule is made in the 70s or the 2020s it's still the exact same molecule, regardless of the synthesis. If it was a different chemical it would be called such, and if it was the same chemical with an altered structure it would be an analog

@DOCB-op1qc Жыл бұрын

3:19 what is a double Snh2 reaction?? i cant even find a definition of what that is????

@totalsynthesis Жыл бұрын

Just a SN2 followed by another SN2

@senso5793 Жыл бұрын

he MIGHT be ken carson

@everythingexplained3226 Жыл бұрын

heres one for the algo

@auli5786 Жыл бұрын

Is there an easy way to get the precursors? For medicinal purposes of course

@zorintoto1167 Жыл бұрын

Saffrole is a controlled substance

@totalsynthesis Жыл бұрын

Nope - will not comment on sourcing 🤓

@yungshromp2165 Жыл бұрын

The best (and only) way (in Minecraft) would probably be to contact a manufacturer in China directly by encrypted email (in grand theft auto 5) for medicinal purposes of course

@knivesnico8775 Жыл бұрын

uhrmmm, thats friggin illegal???

@user-p6-3561 Жыл бұрын

Based

@_juraj_ Жыл бұрын

Combination with mild 4-ho-tryptamine dose, it can get even better, as it induces a lot of neuroplasticity.

@michaelboehle1161 Жыл бұрын

5-HTP I take daily with .1g mdma.. best anti depressant I've ever had❤

@reedoburrito7456 Жыл бұрын

@Michael Boehle you take 5htp amd mdma at the same time?

@_juraj_ Жыл бұрын

@@reedoburrito7456 5htp is precursor, so you won't be running on empty.

@reedoburrito7456 Жыл бұрын

@@_juraj_ that is a very dangerous combination

@reedoburrito7456 Жыл бұрын

@Juro Dobrík but if you take 5htp befor and after mdma then thats okay

@mrhoffman_ Жыл бұрын

Oregon🌲 Measure 110

@MandrakeFernflower Жыл бұрын

jesse!

@thomasgarbe8354 3 ай бұрын

nice chemistry, but I consider LSD the non plus ultra

@user-p6-3561 Жыл бұрын

10:27 Ok based

@salodip3480 18 күн бұрын

Please do a video on ketamine

@totalsynthesis 16 күн бұрын

I will at some point!

@mrgenetor Жыл бұрын

*Alexander Shulgin has entered the chat*

@Wavy_Gravy 17 күн бұрын

If you've untreated ADHD/Autism, don't mess with M, unless under a medical environment. It's super addictive, being normal for a bit, lol.

@victorprokop9343 Жыл бұрын

time to make jack3d

@cvspvr Жыл бұрын

time to make gorilla mind rush

@ironfeatherstudio4476 Жыл бұрын

Start bitter almond oil easy

@koukouzee2923 Жыл бұрын

That's for benzaldehyde no ?

@bdnugget Жыл бұрын

Based. I have some old shitty videos where I made 2C-B and the phtalimide protected version. Naughty chemistry is best chemistry

@scottiusnevious5143 Жыл бұрын

Psilocybin is a better alternative. Just saying.

@JelMain 8 ай бұрын

This video is dishonest, as it fails to state the research and its limitations at the outset. For the last four years, Rick Doblin and Michael Mithoeffer's MAPS Project in Los Angeles have been engaged in research in the area, under FDA supervision. Their method uses a single low-dose MDMA tolerance test, which if it does NOT trigger any addictive reaction, is followed by a SINGLE full-dose MDMA therapy, which is in the form of a therapist-guided drain of the reflex. Other therapies do similar things, although they're not effective with a subject who has aphantasia, the inability to hold the trauma trigger in the mind's eye. Effectively, something traumatic happens. Ideally, the subject shakes, physically, and that deprograms the memory. If they do not, beta-phase sleep embeds it in the amygdala as a trigger and a reflex response. If it happens again, a pre-filter in the basal ganglia, specifically the periaqueductal grey, sends a message through the limbic system straight to the motor cortex. Generally known as the fight-or-flight response (to which freeze and flop have been added), the Innate Alarm System goes nowhere near the cognitive cortex, and can cause PTSD when we judge the consequences. To reprogram this, we have a subconscious system which can drain the reflex response if engaged with the trigger in mind. To do so, the subject drops into a cognitively-suppressed state, which can be in any form, meditation, mindfulness, shamanic, mantra, psychotropic (of which this is one: the lead researcher prefers psilocybin), hypnotic, shibari subspace, Reiki/healer, all different names for the same thing, and the therapist monitors the progress. I've found it leaves a cracking headache four hours later, which can be resolved by using Reiki to fill the void with meridian power, so now I get reassurance when it triggers. The latter is unorthodox.

@lorriecarrel9962 Жыл бұрын

The synthesis may as well be a alien language lol

@richarddodd2782 16 күн бұрын

welcome to the government watch list

@electronium6378 Жыл бұрын

me and the boys selling caffeine mixed with bzp or pma at the music festival

@terlinguabay 3 ай бұрын

Theraputics of MDMA were common knowledge in the '80s.

@davidreed3021 Жыл бұрын

MDMA is functionally indistinguishable from methamphetamine (Desoxyn) and amphetamine (adderall, vyvanse, dexedrine, etc.), the latter of which is already used off-label for treatment-resistant depression. These medications directly attack the reward system and are highly addictive. In fact, there is currently a nationwide shortage of stimulants, and many clinicians are having to switch patients onto other medications like ritalin. So like everything in medicine its a question of cost/benefit. Medications like this would generally only be considered in the event the patient was not responsive to less-invasive treatments.

@festerwalter Жыл бұрын

Source other than safrole are very low yield and not pratical

@max3eey Жыл бұрын

@justfor8550 Ай бұрын

Some PTSD is just well-earned guilt for crimes committed.

@swampdog1592 17 күн бұрын

TRUE

@dinmorsamushimushi 4 ай бұрын

Where is the paper from 2022? The synthesis of mdma

@gimme0dis0junk0mail 3 ай бұрын

a caution: look at a picture of a neuron after chronic MDMA use - it ends up looking like a frayed piece of rope. I would love to see this drug legalized for my hospice patients, however. And if I am of sufficient capacity when my own terminal diagnosis comes down, I will be adding this to my own med list

@cvspvr Жыл бұрын

kilo-scale. now this... this does put a smile on my face

@penisdadlover98 Жыл бұрын

I've never seen so many ads in an 11 minute video 🙄 educational lol, more like click bait monetary production. All of this information is available for free online idk do better

@zorintoto1167 Жыл бұрын

You don't have to watch it

@young-stove Жыл бұрын

watch on a computer, install ad blockers, and seek education outside of youtube rather than expecting to be spoon fed information by other people who put in the work. Do better.

@totalsynthesis Жыл бұрын

My friend I'm making

@davidfetter Жыл бұрын

@@totalsynthesis *You're* not making money on these videos, but rest assured that KZfaq is doing so.

@lolnyanterts Жыл бұрын

Buddy, there is too much PII I found from you.