Great suggestion! The main problem I see with rewiring analysis is, that it mainly makes sense to do, if you have actual condition-specific networks. By that I mean networks in which the edges themselves relate to conditions so that actual rewiring takes place. Unfortunately, most of the networks that people refer to as "condition-specific networks" in fact only have conditional data for the nodes. You are thus looking at a networks, for example from STRING, which are the same global network filtered down purely based on the expression of the nodes. For such datasets, I am not convinced that rewiring analysis makes much sense, since you are in fact looking at nodes coming and going (and taking edges with them), so it is debatable if the network as such is being rewired.

@@larsjuhljensen Thank you so much for your reply.