Great question! Do you mean plug the guitar into the audio in on the PC? And use the audio out to plug into powered speakers or an amp? You'd be using the in-built audio, which will be pretty cheap generic stuff and not designed for high quality audio work like an audio interface is, and won't have ASIO drivers. You can certainly physically do it. But you'll probably have horrendous sound quality, if you can get it to work at all. Also, depending on which amp sim you're using it might not actually let you select the on-board audio for input/output. Finally, I would imagine that latency would make it borderline unusable (the time between playing a note and hearing it come out of the amp sim). Wonder if I should make a video about this and actually try it on camera, and see to what extent I can get it to work...

@@homemusiccreator I mean, audio interface for guitar input over USB, but instead of headphones or speakers connected to said interface, can the PC sound card just be used as an output for the result as you play? I ask as my desk is already over crammed, and my PC is already plugged into my home stereo so it would be very convenient if I could use the FX and what not provided by an amp sim, but hear the output without needing headphones or a seperate set of speakers.

@@gelfie2208 As long as your guitar is connected to the computer you can use whatever speaker/headset/output to your liking. As long as it is compatible with your computer that is of course. The guitar interface only captures the signal from the guitar, which then goes into the program (Amplifier/Effects simulator), from there you can choose your output to be to any Audio device connected to your PC. TLDR; No you don't need to connect it to the Audio interface

@@shade4718 Can't tell about Mac, but on PC, if you choose to output audio other than the supplied audio driver of the interface(ASIO etc) you will get a very perceivable and annoying latency issue. For OP's application, assuming he has a PC, he may be able to connect any kind of speaker to monitor the sound but to get best results in terms of Round Trip Latency or RTL, it has to be connected to the audio interface's output only and not the PC's 3.5mm or motherboard's audio output. There are some other factors involved with the use of a laptop as an amp+fx modeller, that I hoped this video was going to cover, but left out mostly with few sentences, when he was talking about powered speakers and levels. Topics like setting the DAW buffer size for the interface to get better latency, gain staging to get proper level from the guitar till the front of the interface and amp sim, MIDI pedals to switch effects or rigs/parameters, power amps to drive passive cabs/speakers, impedance matching with DI boxes, Line Isolators etc. For a live rig involving a laptop, I suggest you to watch a rig rundown of the band called Tesseract, where their bassist Amos Wiliams breezed over it. There's another youtuber called JMK Music, he talks about other impedance related stuff involving amp modelling pedals, which in fact can be replaced by laptops with a suitable interface and DI boxes. Expect rabbit holes.

@@shade4718 Ahh, awesome, thank you