Understand PSA Doubling Time | Ask a Prostate Expert, Mark Scholz, MD

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4 жыл бұрын

PCRI's CEO, Alex Scholz, asks Executive Director, Mark Scholz, MD about the significance of PSA velocity (that is, the rate of PSA change over time) in screening, monitoring, and predicting the behavior of prostate cancer.
2:36 How do you calculate the PSA doubling time?
3:28 What is the significance of doubling time in relapsed or advanced prostate cancer?
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To learn more about prostate cancer visit www.pcri.org
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's KZfaq channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
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Пікірлер: 63

@karlkascha1261 4 жыл бұрын

I can't believe that there aren't more people watching these very informative videos. Thank you for the great unbiased information.

@JerryEgge 2 жыл бұрын

Thanks so much for addressing PSA doubling time. I recently had surgery. Lymph testing found one lymph node with cancer. My first PSA test said my PSA level was undetectable. I’m going to mentor my PSA level every three months for the next two years. I’m hopefully that I can avoid hormone therapy and radiation. All of you interviews have been so helpful!

@user-ez4ds1zm3f 3 жыл бұрын

Very informative, straight to the point while taking into consideration all kind of cases. This deserves far more views imo.

@rolandr9289 4 жыл бұрын

What a wonderful insight. Thank you

@harrygarimd4396 2 жыл бұрын

Very informative and thank you for that!

@antonvanveen8824 3 жыл бұрын

you all ROCK!

@antoinettequashie8838 3 жыл бұрын

Thank you so much Dr.Scholtz and your daughter; the questions are always very important and the answers most informative.My husband and I also enjoyed the annual conferences.

@mikemir121 4 жыл бұрын

Thanks again :)

@BigZWD 5 ай бұрын

After 20 rounds of radiation treatment 60GY 2 6X, PSA dropped from before treatment 14.1 to after completion and 3 weeks later PSA was 0.04. 6 weeks later dropped to 0.19. 6 weeks later tick up to 0.59. 6 weeks later it had skyrocketed to 3.02. At that moment, made an appointment to see my urologist. About 3 weeks later when we met it was 4.25. He immediately scheduled a pelvic CT scan and a skeleton imaging scan, plus scheduled me to meet with an oncologist. Took the pelvic soft tissue scan, nothing was visible. Met with the oncologist, he immediately canceled the skeleton scan and scheduled me a PMSA SCAN. He said that would be better and more accurate if it has metastasis. 😢 Not what my options are once text are completed. Oncologist just said lets just wait first for the results. Scheduled for January 31st, that was the earliest I could get in. NOTE: I was the 2nd patient he referred for this scan. Just became available at the hospital I been going to for 6 years. He specializes in metastasis patients and a type of hemoglobin type expert. Not sure what do or look towards

@KDean22 10 күн бұрын

YOU ARE BEING CONNED. CORRUPT HEARTLESS DOCTORS

@edburke8361 2 жыл бұрын

What is the base starting PSA level to compute the doubling time in one who has had treatment, radiation and hormone therapy. Mine is now undetectable after 2.5 years. Gleason 9.

@ovhome6841 Жыл бұрын

So if on AS for G6 and PSA has stayed basically the same in 1yrs time is that a sign of no change & less likely there is any aggressive higher Gleason elsewhere in the prostate?

@davecooke7868 Жыл бұрын

My PSA is 9 went down to 8.2 two months later . My dr wanted to do a biopsy when it was 9 then when I asked for another test it went to 8.2 so he said let’s monitor it and another test in April. Hoping it goes down a lot. The reason for the Urologist was I woke up and couldn’t pee finally went to hospital where they put a catheter in, as soon as I was relieved I asked them to take catheter out and haven’t been back since, that was four months ago and peeing just fine. Still wake up at night at least twice but that’s because I drink liquids until 11 or 12 at night . I’m 69 y/o and have an enlarged prostate which may be the reason for the high score. I have cut salt and sugar out completely which may of been the reason I couldn’t pee. The flow is coming back to normal and I eat more greens and fruits cut down on red meat which seems to help

@tomslick2058 10 ай бұрын

Go straight to biopsy is ridiculous. Where do you live? A MRI should be done. Then if any liesons are present a Biopsy should be done. You undoubtedly have BHP. But a mri is warranted. Find a new urologist .

@Kepss1222 Жыл бұрын

My father's psa levels went from 5. 3 to 14.9 in about 2 months. Could he have cancer?

@steinshaw2490 4 жыл бұрын

Well, that explains the Doctors excitement when I went from undetectable in Aug, to 2.7 the end of April. then 3.2 a few weeks later. Scans so far haven't shown anything... He asked if I had pain, no, and no real symptoms... Requested a PSMA scan getting an aximum scan in a couple weeks. sigh.

@imxploring 4 жыл бұрын

Depends on your initial treatment. I opted for removal and went to zero PSA. Two and a half years later PSA reappeared and was slowly increasing. Had the Aximum scan that didn't pick up anything. At the 4 year mark after an MRI and Bone scan (both negative) I opted for radiation (8 weeks) of the prostate bed. Completed that a month ago. Next PSA in three weeks. Staying ahead of the curve is the plan!

@ThePCRI 3 жыл бұрын

Hello, our prostate cancer helpline may be able to help with your question. Please feel free to contact us here: pcri.org/helpline

@imxploring 3 жыл бұрын

Follow up.... PSA after 8 weeks of radiation back to zero!!! I guess they hit the right spot.... life goes on and I continue to monitor my PSA on a regular basis.

@steinshaw2490 3 жыл бұрын

@@imxploring Awesome. My second PSA test was a month after the first and it almost doubled from 2.7 to 5.0. I wanted the PSMA scan but was offered an axumin scan and it was not approved. I started ADT right away as I did not want to wait. Glad to say my last PSA was down to 1.8 so the ADT and now the generic of Zytiga is working! good luck!!!

@imxploring 3 жыл бұрын

@@steinshaw2490 That's great.... I didn't opt for ADT at the same time as the RT as my doctor had indicated the most likely area of PC reoccurrence, after all the testing was negative, was the prostate bed. I was concerned about side effects and over treating. Better to catch it early and treat it before it reaches the level of being detectable and spreads elsewhere. (Organs/Bones) When dealing with PC you play the odds to some degree... and use the treatments to manage PC if a compete cure isn't obtained as you continue your battle. ADT might be the next tool I have to pull out of the armory should that PSA reappear and treatment is once again needed to beat it back.

@Artbycarrie Жыл бұрын

Psa 4.1 four weeks later 7.2.

@nickfunk5804 8 ай бұрын

Is doubling times (post prostatectomy and radiotherapy) accurate at very low PSA values such as 0.02 ng/dl to 0.06 ng/dl after 3 years?

@RH-xd3nx 3 ай бұрын

Great question!!!

@jlo537 2 жыл бұрын

After Prostectomy PSA was .014 6 months later .191 and now three months later .225 I am 48 seeing my doctor in a few weeks my question do I need to be worried?

@ThePCRI 2 жыл бұрын

J P, Unlike most cancers, a prostate cancer relapse is usually very manageable and possibly even still curable. Feel free to get into contact with our free helpline if you have any questions. You can find our contact information here: pcri.org/helpline Here is our playlist on relapsed prostate cancer if you are interested: kzfaq.info/sun/PLHj3V3RB2V-jS8JJviFVLi_Bu9dLyIfa4 And be sure to check out our videos on the PSMA PET scan. Those are becoming more widely available and can detect the location of a recurrence with a PSA as low as 0.2 in some cases. There is a GA-68 PSMA PET scan which is available at some academic institutions like UCLA, UCSF, Cornell, etc., and there is also a commercial version (F18 DCFPyL PSMA PET) that is more widespread and works just as well. Here is the website that shows the current locations of the commercial version scans: www.pylarify.com/ordering-and-reimbursement

@jackjackson7577 3 жыл бұрын

PSA 10 one week 4 weeks later it is 14. I have never had treatment.

@MariamAhmed-sb8kz Жыл бұрын

Do you have any issue? Did you get it checked?

@KDean22 10 күн бұрын

RELAX. DON'T BE CONNED

@raymaglalang4584 2 жыл бұрын

I have been reading in the internet regarding SUGAR from fruits are source of energy food to cancer cells. Is this true?

@ThePCRI 2 жыл бұрын

Here is a video we have on the topic: kzfaq.info/get/bejne/sN2mesVpva2ooZs.html

@lindakinnie487 3 жыл бұрын

My husband has been ill for 4 months or more, fatigued, his psa is 43.5 and keeps rising. He had a biopies recently but nothing found although mri said highly suspicious for cancer. We dont know who to turn to , his uroligist is not concerned about it. Should we be? All his other blood tests have been ok as he went in emergency 3 times recently, he feelslike hes dying he says. Help please!

@ThePCRI 3 жыл бұрын

Hello, our prostate cancer helpline may be able to help with your question. Please feel free to contact us here: pcri.org/helpline

@robolm8059 2 жыл бұрын

Hey there Linda how did it go with your husband?

@KDean22 10 күн бұрын

MY PSA IS 240 . YES 240 FIR 2 YEARS. NOT WORRIED

@tommaloney8874 3 жыл бұрын

Doubling Time in days = (T1 - T0) * ln|2|/ln|PSA1/PSA0| The difference in days * 0.69315 / the natural logarithm of ( new PSA divided by previous PSA)

@bojanreljic8310 Ай бұрын

What if between 2 measurements the psa doubles and the next measurement does not

@ThePCRI Ай бұрын

Hello, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline

@sherwinS_13 4 жыл бұрын

My PSA on 07//11/19 was 2.96 and then on 06/22/20 it's 4.39...should I be worried...should I get a biopsy(which my doctor is wanting to do)...I've never had an biopsy done before. I'm 49 years old....I weight 151ish and in very good shape(compared to weight and height ratio. What should I do???

@ThePCRI 3 жыл бұрын

Hello, our prostate cancer helpline may be able to help with your question. Please feel free to contact us here: pcri.org/helpline

@anthonynattoo1935 2 жыл бұрын

Within the last year my PSA went from 3.75 to 6.2 after 6 months. I had a a digital test which my Dr said was very normal but he recommended a biopsy due to the rapid doubling of the PSA. I did a biopsy which came out normal. I later read that at age 70 a PSA of 6.2 can be very normal. I regret taking the PSA because it's very invasive and showed tinctures of blood and tiny tissues in my urine for 3 weeks. If you are 70 and the digital test is normal don't worry so much. Do another PSA and digital before any biopsy

@MariamAhmed-sb8kz Жыл бұрын

@@anthonynattoo1935 are you okay now? Can i contact you pls if you can share some details

@anthonynattoo1935 Жыл бұрын

@@MariamAhmed-sb8kz I am fine nothing of any abnormality, just the regular 70yr old routine. I rise only once per night to urinate, but I drink natural juices, green tea or water late into the night.

@MariamAhmed-sb8kz Жыл бұрын

@@anthonynattoo1935 if i may ask do you have prostate cancer?

@BlackIronRob Жыл бұрын

My PSA has gone from 1.1 to 2.85 in a years time. For 2 years it has remained steady between.08 and 1.5. I’m a little alarmed at the doubling time as I am only 49.

@MariamAhmed-sb8kz Жыл бұрын

Did you show to a doctor? What do they say

@mactheslovac8673 6 ай бұрын

Mine went from 3.8 to 6.3 in 8 weeks hopefully it's from inflammation

@sidneyparker201 3 жыл бұрын

I've got an elevated psa whch I've had for many years without taking any action. The doubling time has been 7 years (from psa of 10 to 20). Why is this not a relevant factor as Dr. Scholz states in this video.

@MariamAhmed-sb8kz Жыл бұрын

Did you get a biopsy done?

@sidneyparker201 Жыл бұрын

@@MariamAhmed-sb8kz Yes, I did get a biopsy and an MRI as well. It turned out that I had a lesion of 2 cm with a gleason score of 7 (mostly 3+4) so I had a seed implant combined with radiation treatments. My PSA now is very close to 0.....

@MariamAhmed-sb8kz Жыл бұрын

@@sidneyparker201 is that cancer

@sidneyparker201 Жыл бұрын

@@MariamAhmed-sb8kz Yes, it was cancer but it's been "nuked" with combination radiation treatments

@tomslick2058 10 ай бұрын

@@sidneyparker201over 10 is something that is a strong indicator.

@frankshort7265 3 жыл бұрын

How to contact PCRI for advice? Is there an email that can be used?

@ThePCRI 3 жыл бұрын

Yes, all of our contact information is here: pcri.org/helpline

@ALI051683 4 жыл бұрын

My Dad after 1st ADT, his psa got to the point of 0.1, then after 2.5months just yesterday its 1.4. His doctor said its still below 4 so still doesn't need another ADT shot. Should I worry about his psa increment or just agree with the doctor ?

@ThePCRI 3 жыл бұрын

Hello, our prostate cancer helpline may be able to help with your question. Please feel free to contact us here: pcri.org/helpline

@jackhsu5685 Жыл бұрын

@@ThePCRI My Gleason 9 cancer was treated with EBRT, brachytherapy, and 24 months of hormon therapy. My PSA was undetectable afterwards for about 14 months. The last three levels (two months apart) have been .06, .11, and .15. Is this indicative of aggressive cancer doubling? Thank you

@aliterogasolini6401 6 ай бұрын

Should You be concerned with a doubling time of 10% per year over the last 6 years. That’s 6 no/ml in 2017 to 10 no/ml in 2023 evenly spaced out over 6 years.