In this video, Dr. Hanna Kim and Dr. Megan Curran present on second-line treatments and their side effects. Second-line treatments refer to medications administered after the initial phase of medications. These treatments are employed when a patient cannot tolerate the initial medications or when the disease remains active. These treatments may be considered alternative or add-on therapies, with the aim of achieving remission by either supplementing or replacing the initial medications.
0:00 Introduction
0:14 Overview
0:25 Quick Review
9:42 Mycophenolate: Side Effects
12:54 Mycophenolate: Contraindication
13:12 Cyclosporine (CSA): Basics
14:37 Cyclosporine: Side Effects
16:30 Tacrolimus (FK506, Prograf): Basics
18:04 Azathioprine: Side Effects
26:58 Experimental Non-Drug Treatments
33:35 Rituximab in Myositis (RIM) Study
34:22 RIM Study - Main Findings
37:25 Rituximab: After the RIM Study?
38:15 Rituximab Side Effects
40:34 Abatacept (Orencia) Side Effects
40:51 Outline
41:31 TNF Inhibitors
42:51 TNF Inhibitor Side Effects
44:17 Tocilizumab (Actemra)
44:59 Tocilizumab Side Effects
45:34 Anakinra (Kineret)
49:07 Cannabinoids
50:37 Questions