I've always said that they'll find a cure for aging about the time I'm 80 and I'll have to live forever as an 80 year old man.

I've seen what dementia does to people, it robbed my grandmother, grandfather, and great-aunt of their minds in their old age. It's an utterly horrible fate for everyone involved, so if anti-aging tech can prevent or even reverse it, it would be the single biggest boon for human dignity in the history of mankind. No one deserves to be reduced to a shell of their former self like that.

Mortality has been a subject that has put me in great sadness many times. The idea that "experiencing" will end someday, and just the realization that the fact that we "experience" in the first place is so complex and so unexplicable... It makes me feel very fragile if that makes sense.

You hit the nail on the end with your closing speech. I'm getting tired of those selfish people not worrying about the future because of "not living long enough to see it". It kinda shows you that these people literally screwed future generations and would rather Kamikaze themselves than face the consequences of what they did.

I'm 48 at 46 I was diagnosed with stage 4a cancer. Physically I feel about 90 and mentally about 12. Can't help the cancer but the way I live with it. I'm not dying from it I'm living with it. Only way to go. #hereforagoodtimenotalongtime

I think what Sinclair's lab is doing is, hands down, one of the most fascinating stuff out there. The fact they managed to rejuvenate an old mouse to become a "teenager" is just astonishing. As I remember exactly, they had two mice of the same age. Then they olden one mouse(gray falling out hair, no energy, losing vision) measured it's results on a treadmill, and then rejuvenated it back to being young and measured again. I remember Sinclair said this "new young" mouse ran so long on a treadmill that their testing program stopped measuring because they didn't expect any mouse to run that long :) They also managed to tumorize an eye of a mouse(I think) and then cure it back to full health. Yeah, next 20 or 30 years looks quite promising, if we manage not to kill ourselves in nuclear war that looms on the horizon..

It's taken me 50 years to shed the fears installed by my parents, and the world. I feel I'm just starting life after decades of mental illness.

This is actually precisely what I'm working on! Already have some human data to show a decrease in the age of individuals DNA with a specific protocol!! Sinclair has definitely done some great research

Aging means two things to me: 1- INJURIES from long ago come back to remind me they happened. 2- GRAVITY really starts to be an obstacle.

35 yr old man: "Age reversal is unnatural!" 75 yr old man: "How's that age reversal thing going?"

CGP gray had a really good video on the psychological barrier you referred to as "aging Stockholm syndrome". People that say aging gives life meaning have a perverse definition for the meaning of life. No one would say to the Grim Reaper "Hey could you cripple my son so the time he spent before being crippled is more meaningful"? Yet that's basically what people seem to think with regard to aging

I think it's interesting how people see this and other type of scientific discoveries as unnatural when, technically, there's no such thing. One of my favorite quotes is from Sapiens: "Whatever is possible is by definition so natural. A truly unnatural behaviour, one that goes against the laws of nature, simply cannot exist, so it would need no prohibition.”

The death of a toddler carries more weight than that of a 90 year old for a singular reason "they had so much more life to live". Increasing lifespan actually increases the value of each individual life.

I’m in my teen years and this is the best news of my short life. Imagine the technological advancements in 70 years or so!

"What if we had to live with our decision?" Well considering I've been getting worse health for the last 10 years and I keep telling myself I'll work out eventually, I think I know that people won't change things until they face their consequences and then they will wish they did something sooner but never actually do something than prevent it from getting worse, repeating the cycle.

I remember being a kid, looking at my great grandma in pain, getting cancer, breaking bones easily, and thinking that aging is to blame. That it's the disease we all have. It's super exciting thats being explored and worked against.

The most compelling argument for anti-aging to me is as follows: Imagine if we could have some of history's brightest minds contributing to science for ~500 years each instead of ~50 each.

I feel approximately the same as I did at twenty-five. I did get COVID which had a long recovery but none of the complaints that are normally associated with aging. Good genetics - long lived ancestors. Good diet - a choice. Good environment - a choice post childhood. Good mental & physical exercise - a choice and lifestyle. I hope to benefit from the good science that is coming too us in a not too distant future. (Added: I am 60 years old.)

I recall reading an article once by Dr. Tom Rainbow about how we were on the verge of eliminating aging, and that he might be a member of the first generation for whom lifespan was not bounded by aging, as we were "at most 20 years" from eliminating it. The year was 1984. Dr. Rainbow died later that year from cancer.

I think when it comes to anti-aging research you should always credit Dr. Aubrey De Grey who basically pushed for this research and pioneered it for two decades before anyone like Dr. Sinclair (big props to him) could've touch the subject and leave his career intact. These days, everything that De Grey Advocated for decades is actually happening. Surely he deserves at least a shout out.

Extreme longevity runs in my father's family. For well over 150 years, if they survived infancy, no one died under 100, including a great uncle who literally drank a bottle of whisky and smoked two packs of cigarettes a day. One of the things I've noticed is that, where eating is a social highlight for most people, none of the people on the long-living side of the family cares one bit about food. They all will often forget to eat if they get too busy with something. Perhaps it ties into the longevity benefits of fasting.

Thanks! Great video. Just watching it added several years to my life. I feel it!

My whole lab's hypothesis is that AMPK promotes tumor growth in breast cancer (with published work). This video speaks about one side of AMPK, however we might be too fast to regard AMPK as a silver bullet. AMPK is also acts as a stress sensor in cells. But a very good video about the topic indeed.

Something cool: 4 years ago, at the age of 55, I noticed that my hair was actually growing out black instead of gray, along with being full and silky. I found this odd since I have been a brunette most my life, and my siblings were all getting white hair including my sister who is a year younger than me. Even now, at 59, 99% is still growing in black with barely any white hairs (my younger sister is now completely white). Everyone pegs me at 10 years younger than my actual age. My body, however is a completely different story... 😆 Talking with my doctor, we came to the conclusion that it was possibly due to the steroid shot that I have been getting in my right eye, four times a year, for the last 18 years to stave off blindness due to retinal disease (I'm already blind in my left eye). So my hair, technically, doesn't seem to be aging at all. So yes, I'd like a drug that would do the same thing to the rest of my body. 😄😄

I've worked in nursing homes for 7 years and I often has gotten me thinking about aging. Yes, those I take care of tend to live a fairly long life, but their lives are usually lived in poor health towards the end. It seems like it is just suffering

I’m in my early 20s, I just had a brain MRI done and apparently my brain is that of a 70-90 year old physically speaking. I definitely feel that way lol, and my body is falling apart due to genetics… but this is fascinating! If they couldn’t fix my health issues I wouldn’t live any longer than I have to 🥲 life is hell for us chronic pain/illness people, but I definitely don’t want to miss out on life (I already am). So if they can make my quality of life better and delay aging so I can enjoy myself, it would be amazing!

Bingo, you nailed it again, Joe... "Life wants to survive", and yes, those genes responsible for bringing an organism into being in the first place, will do everything in their power to return that body or organism to homeostasis if injured, ill and diseased, and live on until it is physically impossible to do otherwise. This is the power and nature of life. We collectively know this because life can be found literally everywhere on the planet, no matter how cold or hot or unforgiving the environment; life has always found a way to exist and to thrive because of life’s fortitude and resilience to simply be. Life, in some shape, form, or fashion shall always thrive on our planet long after mankind has obliterated ourselves via senseless wars and environmental destruction. The power of life on this planet is in fact, pound for pound the most powerful force in nature and in the entire universe. “Life” is precisely what gave rise to everything known in our universe… and that force, in truth and fact, lives within each of us. The problem is that Western modern society, cultures, and civilizations are designed to be the antithesis of sustaining normal life, mostly political to pit us against each other, which has come to fruition now in America, and around the world can be seen in all the civil unrest, wars, and population displacement around the world. All of these violent, biased, judgmental, and prejudicial forces that have been unleashed against its populations are antithetical to life and harmonious living, where nurturing, living, life, and homeostasis cannot take place or be maintained or sustained, which is why our world is dying in real time every second of every day. The catastrophes that we are witnessing take place around the world shall befall the U.S. sooner than we think, and more powerful than we can defend against. There are zero winners in this deadly and catastrophic game of tug-o-war that nations are playing with one another. Are there solutions and means to prevent these foreseen catastrophes? Oh, you betcha, will they be employed in time to save these nations in conflict around the world, including our own? Not likely, for unfortunately, hate is more powerful than love, history has proven this biological disorder in human genomes since mankind first set foot on Earth. This desire for war and bloodshed against our neighbors is a feature, not a bug, of human evolution that shall never be fully contained nor controlled, for it is eternally buried deep within our DNA/RNA. The most we can do is monitor it and mitigate it when and where we can, if not unleashed for too long. In the case of Israel and Palestine, it has been unleashed for too long to mitigate or control now. Sadly, mankind’s prognosis is not promising; the end of times does indeed appear to be upon us, so live, love, and prosper while we can. ☹

I've been exercising several times a week for 20 years and started intermittent fasting 3 years ago. I am going to do everything in my power to catch the reverse aging train.

i remember reading a popular science magazine back in 2008 on this very subject. they cited three factors for aging. 1) DNA degradation(ie damaged DNA), 2) debris building up in cells due to leftovers from cell division, 3) free radicals. the article covered research into cell debris. basically every time a cell splits, there's left over material that just sit inside the cells afterwards. the cells have the ability to expel these debris, but don't for some reason. overtime the debris builds up to the point that cells can no longer function properly, halting cell division, so no new cells are formed, or if they are they are defective. they found a chemical treatment that would cause the cells to expel the debris, freeing up the space for cell growth and division once more. they tested it on mice. mice have a life span of roughly 2 years. mice treated with this drug regularly, lived to be about 6 years, tripling their life span. they were also healthier for much longer and took much longer to show aging. the left over aging was due to there DNA still getting damaged over time. they tested older mice that were graying and saw surprising results. over time the gray hair went away and they started acting like younger mice. the treatment actually reversed the aging that had already happened. the mice have a relative known as the naked mole rat. unlike most other members of the rodent family, they live about 30 years. so they have 15 times the life span of mice or rats. this is due to them having a special protective coating on special DNA that cells use for error checking when making DNA copies for new cells. over time most animals special DNA gets damaged, errors start compounding, leading to aging and eventually death. since naked mole rats have this coating on their DNA they suffer far less aging effects, they almost never get cancer as a bonus. their DNA is extremely stable. if treated with the previously mentioned drug, they'd likely live longer than your average human. if you could modify human genes to have this coating like the naked mole rat DNA does, and if treated with this drug, you could see human life spans increased to a thousand years or more. it's weird im only hearing about this stuff again after 14 years.

As a caregiver familiar with ageing firsthand, I personally believe it would be humanity's greatest achievement to lessen this terrible suffering. A world where people stopped ageing or aged less wouldn't mean that people will stop dying. People will always die regardless. What it means is, say, you lived until eighty, instead of the last ten, twenty or more years of your life living disabled or in pain, you could live that entire eighty years in a healthier more capable body. You would maintain dignity and independence, and you'd be a lot happier as a result. What's the point of living longer if it means that you will be "old" and sick for longer? No one wants that, really. People want to live longer so that they can extend their experiences, but wouldn't those experiences be better if they didn't involve you watching the people you love grow old and fall apart before your eyes, not to mention you? More time young = more quality time. Let's aim for eighty years in a forty, or thirty year old body! 4:44

I see two possible futures with anti-aging: either medical companies are going to make even more obscene amounts of money selling it at exorbitant markups, or some kind of governing body will step in and provide this technology to anyone who wants it either for free or a reasonably low cost. I desperately hope for the latter but fully expect the former.

I wonder how much of the pushback against this type of research comes directly out of religiosity. It seems that religion has long existed as a way to answer questions about our own mortality. I can’t imagine how hard it would be to see the benefits of anti-aging science when you view aging as some long/painful/necessary road towards your mansion in the sky (obviously this isn’t how everyone views the afterlife, but that isn’t the point).

"learn to live with your pain" is what I usually hear. I just turned 51... I look about 55 and feel about 80.

If such medication was truly implemented one day I would take it without hesitation. I'm already trying to make the world we live in better everyday and I would like to be able to do this as long as I possibly can. I honestly wouldn't mind living 500 years if this was possible.

It surprises me that people don't want to live longer, I've always wanted to live as long as possible, to see society develop.

I am heading to the front of aging research. I want to create a world where everyone can decide for themselves how long they want to live. It is really sad to see most of my friends and family not understanding the implications of the fact that the top killers are only symptoms of aging and that a cure can be created within their livetimes. Often they even think it is a bad thing and should not be done. But I hope they will understand and i am proud to be participating in fighting the biggest source of suffering.

Several years ago, I read about a study in Norway for a drug that targeted and destroyed senescent cells. It had worked in rats and appeared to make them I’ll for a short time as the cells died off, then the vital cells grew back to fill in the blanks. Human trials were supposed to be starting when I read about it but I’ve never heard anything else. Might be a great subject for a video!

I feel like a lot of people find the meaning in their life by the fact that their life is limited and every moment counts. The moment you take that away is the moment they lose meaning in their life.

i love you. your analysis is always spot on. no one makes me wanna be a patreon member. you are worth it

I've been an anti aging advocate for most of my adult life. I became fascinated with it during high school and took a course in anti aging realted biochemistry and cytology when I studied biology in university. Not only is there the benefit of having people live healthy for longer times, wich in itself is great, but for me the biggest draw would be that a person can benefit society for far longer. Just think about it, we spent so much time learning until we're proficient in our work or even just hobbies. For my field, you study til your mid 20s to get a M.sc., at leat three more years for a PhD. That's about the same time you then got to contribute to the field AND train the next generation already. And when you retire, or eventually die, your expertise is lost forever and someone else needs to step up. It's highly inefficient. Imagine all the brightest minds in a field, be it scientists, artisans, or even contemporary witnesses, who together with their knowledge, we lose every day. If we could extend the time we could dedicate to the problems in science and society, we might get a lot better results. Just doubling the time we have would be a huge win already.

I read "Ageless" by Andrew Steele recently which covers most of the same ground as this video, and I have to say it was the first time I ever really concidered quitting my job, going back to college and studying biology so I could get into gerontology.

if i could live 150 healthy years instead of 50-60 I definitely would. I'm in no rush to kick the bucket and its an exciting time of human history, while i may just live long enough to see the important breakthroughs, i would like to live long enough to also see them implemented worldwide. id be more at ease closing the door on my life and leaving my children in that world.

I was thinking about this in 2016 or so when I read some news about this potential. I think people would really start buying only the most durable products. If a house is designed to last about 100 years, and a person has outlasted 2 of those houses, I bet they would start looking at how to get a house that lasts 500 years, or maybe even 1000 years. It seems that human psychology has generally caused a self-limitation of over-population. Of course, some births will still be necessary, since there would still some deaths by unnatural causes. It would also be interesting to see how people realize that they have plenty of time to solve the big problems of the world. Without the impending deadline to build a retirement before being too old to work, people could be more free to take risks on big projects to solve problems. Hey, if I can live 1000 years, why not spend 50 years developing farmland in starving countries? I can always work in an office later, or work in an office now, and still be young enough to join the peace corp after 50 years of this.

Humbling, as always. Whenever you start going into biology (I'm a grad student of immunogenetics), I start out cringing, expecting all the unavoidable inaccuracies of a complex subject broken down into a 20 min video - only to get a few new ideas for the next semesters TA job I'll be doing. Thanks, man, you rule.

Joe! I loved this video, this is the sort of thing that got me to sub in the first place, neat science stuff with a dash of clever and charisma. Much better than the disaster stuff that (unfortunately) gets you more views. I know you gotta play the game homie, but this is the kind of video I love your content for.

The sad thing about consequences-induced behaviour change in light of living much longer, is I don't think that will be enough to induce wise decision making. I always thought that existential threat would motivate people. However the pandemic opened my eyes to this assumption. Denial is incredibly strong, even to the point of one's own demise. Several people even in my family denied Covid-19, and died of it. They inevitably spread it to others too.

"Word salad" - I like that! I shall have to use it. :) :D I work as a care aide in an assisted living facility here in Canada, and I first worked as a care aide in the '90s. I took a long time off from this work. I have noticed differences in people's lives as they get older in the past three decades. People are living healthier longer, and this includes physical and mental healthiness. People are able to stay in their homes longer, and they don't have to succumb to things like diabetes and heart disease and other typical aging conditions nearly as early. Yet like you said, Joe, a lot of focus on life extension is making sure that people live longer as elderly people, despite all the things that happen to our health at that time. Yes, there are people who continue to live fairly healthily a lot longer than others, but even with all our advancements in modern medicine and healthcare, there are still a lot of people who end up with major health issues that make it more difficult for them to continue living as well as they could have. I don't know if I'm making sense here. While it's great to see people living longer and the like, I would love to see a focus on life extension happen more for young adults and those of us in our middle age years. I'm not saying that we shouldn't still care for our elderly folk - we should - but why not focus on having people live with as good health as possible while we're younger instead of focusing on maintaining life when we're older? Why not extend the years when we're physically able to do more and the like? Also, why not focus on trying to find ways to eradicate, or at least lessen a great deal, mental decline and try to work on getting rid of dementia? It's heartbreaking to see people's mental faculties leave them and to see people so confused. I hadn't thought about this topic in the way you're talking about it here until this video. Thanks for giving me and everyone else watching this some much needed food for thought.🤔

I love it that you addressed quiality of life, not just years. This is happening. Cant wait to find out how the fundamentalists handle it.

"Mortality Stockholm Syndrome" that's a very good way to put it, and yes it's crazy there's so much pushback on living longer

When Joe asked, "What if ppl didn't have to live with the consequences of their lifestyles", I assumed he meant indulging in poor diet and lack of exercise. Which is what a lot of folks would do with their de-aged bodies.

Using batteries as a metaphor, the 'cure' for aging would essentially change us from being like NiMH batteries which degrade over time, to being like Alkaline or Li-On batteries which maintain a constant power output until the end if its life cycle. I'm down for that.

Suspended animation, life extension, and a growing population that needs to go somewhere. Getting major long-term space travel vibes and i'm here for it

I did hospice care for both my grandparents. It was an experience I never want to repeat. Nor do I ever want someone to go through that for me.

There is a reason there are so many centenarians in Sardinia, they have a mediterrean diet, have an active lifestyle, and they have an habit of keeping a little hunger without eating to fullness

I have tried Metformin twice when doctors prescribed it, and both times I was convinced I was going to die. It felt as if my chest was about to explode. It was prescribed for pre-diabetes, which went away as I lost some weight, but I was planning to keep renewing the recipe as I knew the substance had anti-aging properties. I probably should have tried the substance for a third time by micro dosing and then keeping on increasing until I reached a normal dose, but I got spooked because it didn't only feel like I was dying; it really had me convinced that I was done with living.

I disagree with the notion that we live longer now a days with the years being added at the end of our life. I think a lot of people (including myself) are gaining years in our 20s 30s and 40s. I’m 37 and everyone thinks I’m 25. people are looking alot healthier in their 50s then they used to. I think it’s more like we are gaining an extra couple years for every 10 year increments

I've been going down this rabbit hole for a few years now and still learned a lot from this video! I'm so glad you covered this. I hope it gets more views because I love your story videos (like that dead Australian beach guy) and deep dives over the doom and gloom!

When you mentioned Mortality Stokholm Syndrome, it makes me think about all the literature and media written over the past few thousand years, talking about how life can only have meaning through death. It's always struck me as a bunch of terrified people trying to make themselves feel better about something awful, that's out of their control, by saying "No, it's good actually!" Colour me unconvinced.

We’ve been doing suspended animation for surgeries for over 25 years. We can cool a person’s temperature and stop their circulation for approximately 1 hr while vital structures are repaired. Then, using machines to re-engage circulation and initiate gradual warming, the heart can then be restarted. It’s a big operation and complex process anesthesiologists can make possible. Impractical unless it is the only option for a surgical problem too risky to undertake otherwise.

It's amazing how things come full circle. I'm 62 and I still remember a BBC documentary I saw when I was young claiming that the main cause of ageing is food. I remembered it into adulthood and decided to only eat when I'm hungry. That turned out to be between 11 am and 8 pm. Still do.

It's quite uncanny how sci-fi is quickly becoming our reality in this century. I hope they manage to figure out this "cure" for aging during what's left of my lifetime. As Freddie Mercury sang: "I want to live forever"...

I wonder how extra long living ppl would be regulated since it would lead to huge increases of population density if it happens in large scale

As someone born with a hereditary autoimmune disease, the idea that aging is a disease feels hard to dispute. Our bodies just have to work well enough for long enough to reproduce successfully. Having a disease that slowly kills you doesn't usually prevent that, so we live and continue to live with it. I don't see any reason why we shouldn't try to prevent our bodies from breaking down as we age since we have the technology to research and eventually cure those processes.

As a graduate student pursuing aging research as a career, I love to see the excitement from the general public about aging research. But oh boy, there’s a lot of things in covered that are either misleading or just plain wrong. The basic biology behind this stuff is probably too complicated to explain in 20 minutes, but I would expect joe to do enough research to know that mTOR doesn’t repair DNA. It doesn’t have any interactions with DNA. It is a kinase that controls growth. The effects of intermittent fasting on health are almost completely attributed to the caloric restriction it induces. And let’s not get started about NAD precursors and resveratrol. I know the Sinclair book was exciting, I read it too and it got me more interested in aging research as a career path. But honestly, it’s very clear that the knowledge protrayed in this video is almost completely from the book. If you see this joe, please consider doing a follow up on this video after spending more time listening to the space beyond that book. Peter attia, brand stanfield, Matt kaeberlein, layne Norton and others will point you in the right direction without hyping up snake oil and over interpreting animal studies and saying it’ll all work in humans.

"Aging research is still in its infancy" is kind of a full-sentence oxymoron, am I wrong? Anyway, the Stockholm Syndrome thing reminded me of a Greg Egan story called "Border Guards" where one character who's lived for untold eons by the time of the story goes on a huge rant about how people used to glorify death with all sorts of insane rationalizations about how it makes us noble or makes our time more precious or whatever. I just realized the whole thing is on the author's website. I'll just copypasta a relevant snippet: “It was the naturalistic fallacy at its most extreme - and its most transparent, but that didn’t stop anyone. Since any child could tell you that death was meaningless, contingent, unjust, and abhorrent beyond words, it was a hallmark of sophistication to believe otherwise. Writers had consoled themselves for centuries with smug puritanical fables about immortals who’d long for death - who’d _beg_ for death. It would have been too much to expect all those who were suddenly faced with the reality of its banishment to confess that they’d been whistling in the dark. And would-be moral philosophers - mostly those who’d experienced no greater inconvenience in their lives than a late train or a surly waiter - began wailing about the destruction of the human spirit by this hideous blight. We needed death and suffering, to put steel into our souls! Not horrible, horrible _freedom_ _and_ _safety_ !”

Ive just turned 60, and only having potentially 20 years left is horrifying.

I was mulling over this video this morning an I realized another positive side effect of being able to live on grander time scales than we currently do: Living first hand memory of historically significant events and social changes being passed down to avoid future missteps or hold authority accountable. It would be much harder for the ruling class to spin a narrative about a significant event or a time period that makes it sound like whatever bad happened as a result of a law or policy wasn't REALLY their fault if you could turn and ask your great-great-great granddad "Hey did they know this was a bad idea at the time and did it anyway or is the documentary/politician telling the truth that this was never considered?" and have your great-great-great granddad be able to confirm or deny the story being told.

My favorite joke about aging is: “Oh my leg hurts when I wake up” Doc “well, just stretch it out in the morning for about 30 minutes” “Okay, how long will I do that” Doc “oh, no…you just do that from now on.”

Joe, thank you. I've been having a ton of exams this week and I come back home at the end of the day to watch your videos. I feel informed and entertained. Thank you Joe

I think much of the resistance to anti aging comes from the fact that so many cultures romanticise aging, associating physical aging with wisdom and knowledge.

My grandfather was Curtis Henderson, a pioneer in cryogenic science and also was extremely interested in life extension. I don’t know if this part is true but I heard from my dad he was apart of an experiment that kept mice alive almost indefinitely. Their immune system became extremely limited and they had to live in a sterilized environment with their food regulated

I’ve been following Dr. Sinclair’s work for some time now, and started taking NMN (an NAD+ booster) 3 years ago when I was 38. It’s a fantastic supplement. I feel less creaky, lighter on my feet, have more energy and my sex drive is higher than ever. I’m about 10-15 pounds lighter and currently chasing my high school 5k time. I can workout longer and harder in the gym. I take 500-1000mg per day. I also take resveratrol, but would attribute most of the positive effects to NMN.

Joe raises a positive possibility of people living much longer lives - greater care for our present actions and their impacts on the future. I’ll give you a negative one that we’re probably already living with considering that average lifespans have in fact more than doubled in the past 200 years. That is that people are MUCH less tolerant of risk. There’s a point at which that risk intolerance turns people toward being fearful and desirous of control over others. We’ve seen both in recent years and might see a lot more of it in a world where we live healthily for much longer than now.

the diet one I can say works iv eaten like that most of my life, i stopped getting ID'ed for aclahol till 30 and at 34 now i still look under 30 while iv been working as a welding and spray painter.

*In 500 Years;* Concerned mother: "You're 102 years old, why don't I have any grandchildren yet?"

3:00 my mom is a vet and she says to people ALL the time- “age is not a disease”. people get worried about their older pets and she constantly tells people that being old isn’t a death sentence. i have a 17 year old cat and whenever i ask how he’s doing, she tells me he doesn’t have a disease, he’s just geriatric. very reassuring.

I've been digging a large project by hand. I'm 52. The ground is rock hard. I use a digging bar to chip thru the rock hard earth. Yesterday I got 50lbs sacks of feed for the farm. I'm swearing the sacks are not 50lbs. I can straight arm them. I think the physical work made me younger.

Your closing question is golden. Makes me reflect.

Hey, this is sort of off topic, but when you mentioned Metformin I did a little research and realised my endocrinologist is not giving me the right treatment for my insulin resistance, and I wanted to thank you, thanks Joe ✌️ Edit: it occurs to me some people are stupid, so I'd like to say google is a tool, not a doctor, it can help you ask your doctor questions, and if you're like me and have struggled for a diagnosis only for doctors to tell you "lose weight", that's not okay, keep digging, challenge them, get a second opinion if you feel you're being dismissed because there are better doctors out there.

I love the topic, but I would suggest looking at the newer research papers (conducted by unbiased researchers) about the ineffectiveness and in some instances adverse effects of healthy people taking Metformin and Resveratrol. Unfortunately, other research labs have been unable to replicate the results from Dr Sinclair's research on Resveratrol.

"a slight state of stress at all times" well good to know that my need for a certain amount of stress at work is actually a good thing. besides that it gives me the opportunity to get the amount of energy I have out of my system. yes, I have ADHD and moving around a lot not just helps to fall asleep before 3am, but also helps me focus. besides my medication besides producing dopamine to help me calm my head down produce adrenalin on the side and also kill your appetite for a couple of hours. I guess it has some benefits to be a neurodivergent hyperenergized bouncy ball if people continue to guess my age to be 5 to 7 years younger than it actually is --- or it's just my height. who knows? edit: tbh I feel like my time of living is way too short. I mean I'm not even 30 yet but imagining that in around 60 years or earlier this vessel will be decayed so much, that it's completely useless is terrifying. like that's just a fraction of time and it's mostly wasted on decaying. I feel like I would've barely seen anything of this world or the universe, how things move and change over time in just 100 years. a 1000 years seem more practical to actually see things evolve and change, yet still quite short. maybe I'm weird, but I really want to know and see what the future beyond one millennium will look like. will humans manage to stop or even reverse climate change at some point or find another solution to save the environment or just end up going extinct due to own selfish greed? I know I will probably be long dead before expanding your lifespan becomes a possibility.

testosterone is the fountain of youth... i feel like im 24 again and im 44... i was run down anad out of energy... doc gave me a testosterone test and it was super low... now i inject it a few times a week and i feel like im 24 agin now..... i started going to the gym, but even before the gym, my body fat went to almost zero, i got 8 pack abs, and looked like i was going to the gym, plus my energy levels went back to my youth, i went out and found a second real high paying job and started several side gigs, and became a lot more active recreationally as well...

I'm sure many of us don't actually care to live forever. I don't think "mortality" disturbs a lot of people - contrary to what psychoanalysts and writers constantly go on about. What disturbs us is that we have SO LOW quality of life for the MAJORITY of our lives. Think how shortly we are young - and I don't even mean being a kid or teenager, but 30s (which is old to children). Most of our lives, we are OLD - unable to do the things we got used to doing as a kid and still love, tortured by constant pain, getting ugly, getting sick... and this continues from 30s for 40-60 YEARS. I am sure most people would be fine with the lifespan they have if we could live well. 80 years WELL LIVED would be so precious and amazing. I'm sure "mortality" is okay for most people if we actually got to enjoy life and not just get a few minutes of yard time at the beginning of life. Excuse my language, I'm an ex con, did 6 yrs in the pen in my relative "youth".

I agree. personally, I think the 3 things that must be fought tooth and nail is aging(inevitability of death), depuration(self destruction), and physicals limitation(space travail/flying/tools).

Personally, I don't want to live longer. I want to take a permanent nap under the dirt before the next century rolls around. Let me live to 60 or 70 and I'll be good with that. I also don't like to think of what this could do for people on the other side of things. People are already obsessed with extending life. We're merciful towards our pets, putting them out of their misery in a painless way rather than forcing them to suffer until natural death grips them, but we don't do the same for humans. The best you can do is a DNR and a medical directive, then hope the universe has mercy on you when the humans won't. And it seems every step we take towards living longer and better... is a step away from accepting death and realizing it's not always the worst thing to happen. So yeah... I'm more worried ideas like this will make it even harder for the elderly and terminally ill to end their life on their own terms. It's still not legal in many places, and difficult to do. But for things like climate change, humans don't change. Not really. Not on a basic level. Those at the top won't regret their actions until they're staring at the results of their behaviors. Even then, they'll have some excuse. If they can't take responsibility now, they probably never will. They can always come up with another excuse. It doesn't have to be "I won't be around to see the world burn."

Since you asked... •They'll be wider age gaps between siblings •Life sentences may be a new form execution since inmates wouldn't have access to living longer •The top 1% would most likely be the only ones to afford it for generations to come. And their lobbyists will push for laws to make it so •Certain religions rely on an afterlife to draw followers. They may have to be revised if they want to survive. •Marriage contracts will have a time limit or a revision clause •Military and corporations would have to offer different incentives other than promotions since the top "brasses" will stay in position of power for a long time •Space travel will be at the forefront of innovation •Therapy for those who've lived too long •For every generation you live through, how much will you remember of your original life? •Riskier life behavior •Suicide would trend on social media •and stuff...

The way I've been taught to think about aging is this: nobody dies of old age. everyone dies of some disease. So yeah, aging is a disease.

Extending a life with a good quality of life sounds great! I have to say that I definitely don't want to dictate who dies and who doesn't. But I do know that some societal progress does happen when the "from a different time" holdouts pass on of old age. I think we can find a way to adjust to it, but I do see that as a negative of longer lifespans. We need actual change at a quicker rate right now, but we're moving at a glacial pace, and sometimes even taking a step back.

I started studing technology program because it teaches you how to change environment for your own pleasure. Just a few years later, I got the idea of maybe we should make ourselves adopt better to the environment rather than changing the environment. 🤔

I'm sitting her wondering what comment I should put about, "is it really a good thing to drastically extend life?" the Joe drops the bomb about how we would act if we had to live with our consequences. That's such a good question. I don't know the answer and I don't know the answer to how we can sustain life if everyone can maintain whatever age the want, but it's such an interesting discussion. Thanks for pointing out an angle I hadn't considered!

I exercise 6 days a week for about 40 minutes. I've been doing this since 2019 and I love it. I'm 41 and I feel like I'm 20 something.

Odd I was literally having this conversation yesterday with a coworker. I don't fear death, I fear the aging that leads to it. I had to get glasses at 26 and the last 2 years of glasses has just been annoying. I just want my body to be healthy for a long time until I'm ready for it to stop.

Volume of my thalamus has not declined/ changed from age 38 to 62 now due to what I have learned about exercise. I take no meds...

Hey Joe, awesome video! Thanks for covering Longevity. ❤

Great video Joe. I've been watching you for years. Love the humour you sprinkle the information. Thanks!

“we've managed to slip evolution's leash now, haven't we? We can cure any disease, keep even the weakest of us alive, and, you know, one fine day perhaps we shall even resurrect the dead. Call forth Lazarus from his cave. Do you know what that means? It means that we're done. That this is as good as we're going to get.” ~ Robert Ford (Westworld Season 1)

"Doesn't matter. Even if we lived 200 years, we'd still be human. We'd still make the same mistakes." - Lt. Cmdr. Susan Ivanova, Babylon 5

Changing our mindsets around aging won't matter much for most of us if we don't change all our mindsets around who deserves quality affordable healthcare and quality of life, and who doesn’t.

Side note: "Intermittent fasting" is literally how most poor families eat daily. One meal, portioned for size and age. Caloric restrictions from day 1

Thank you for highlighting the difference between life span and health span. I've been collecting chronic illnesses for several years now and my interest in extending my life beyond what's expected is nil right now. If that time is spent in good health, that's a completely different ball game - and man, do I want to play.