What drives evolution | Denis Noble | Reason with Science | Darwin | Selfish genes

What drives evolution | Denis Noble | Reason with Science | Darwin | Selfish genes | Richard Dawkins

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Күн бұрын

This episode is with Denis Noble.
He is a renowned biologist, physiologist, and systems theorist, known for his pioneering research in the fields of cardiac physiology and systems biology.
Noble's early work on the electrical activity of the heart was centered on this topic, and he was the first to put forth the notion of the cardiac action potential, which is now generally recognized in the field. He has also contributed significantly to our understanding of cardiac arrhythmias, irregular heart rhythms that can cause serious health concerns.
In addition to his work in cardiac physiology, Noble has been a critical player in the development of systems biology, which aims to comprehend complex biological systems by integrating data from different sources. He has also been a vocal proponent of using mathematical and computational approaches in biology, and his work has contributed to developing a new paradigm for biological research.
In this conversation we talk about the topics related to evolution, including Neo-Darwinism, the role of DNA as information, the use of genes as templates for evolution, the emerging field of epigenetics, the significance of bioelectricity, and potential future directions for evolutionary research.
Guest info:
Website: www.dpag.ox.ac.uk/team/denis-...
Google scholar: scholar.google.com/citations?...
Amazon: www.amazon.com/Books-Denis-No...
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Timestamps:
00:00:00 Introduction
00:00:58 DNA as the information in biological systems
00:20:30 What drives evolution?
01:00:49 Horizontal gene transfer
01:05:03 What is an organism?
01:23:08 Importance of metaphors
01:31:00 What is a gene?
01:31:57 Evolution of species
01:39:03 Artificial life
01:41:04 Thank you!
More on Reason with Science:
1) Chemistry of life and death | Nick Lane | Reason with Science | Origin of life | Biochemistry ( • Chemistry of life and ... )
2) Collective intelligence of cells | Michael Levin | Reason with science | Bioelectricity | Biology ( • Collective intelligenc... )
3) Powering the complexity of life with Michael Levin and Nick Lane | Reason with Science | Biology ( • Powering the complexit... )
4) How multicellularity evolves | William Ratcliff | Reason with Science | Origin and evolution of life ( • How multicellularity e... )
5) The evolutionary origins of a good society | Nicholas Christakis | Reason with Science | Psychology ( • The evolutionary origi... )
More talks/conversations of Denis:
1) Richard Dawkins and long-time rival Denis Noble go head to head on the selfish gene | Who is right? ( • Richard Dawkins and lo... ) ‪@TheInstituteOfArtAndIdeas‬
2) Prof Denis Noble - Dance to the Tune of Life Lecture ( • Prof Denis Noble - Dan... ) ‪@voicesfromoxfordUK‬
3) Can chemistry solve the origin of life? Perry Marshall, Denis Noble and Lee Cronin ( • Can chemistry solve th... ) ‪@PremierUnbelievable‬
#reasonwithscience #evolution #biology

Пікірлер: 119

@syedalishanzaidi1 Жыл бұрын

Whether Prof Denis Noble is proved right or not, what should be applauded here is the fact that he is corageous enough to voice his thoughts in order to provoke the attention of the scientific community in this direction. Like Dawkins himself, he is a great explainer of ideas, and it is amazing how his train of thoughts never wanders, but stays true to the course. Where this kind of thinking in the field of evolutionary biology will lead in the end is difficult to predict. There is a lot going on in the processes which define or determine what life is, and how it came about to begin with. Jim Al Khalili has i think tried to draw the attention of science to what may be happening deep inside living cells, and he points to the intricacies of Quantum mechanics as perhaps having an effect in the way particles inside cells behave. Whether it is specialists in evolutionary biology, or the lay public which takes an interest in these matters, we should welcome the trends in thinking which seem to be bekoning towards as yet untravelled paths. Darwin I think would be with us all the way. And I have to say that I loved the way Jitender Kumar listened without interrupting. Full marks to him for keeping his peace, and never wavering in his attention to what the eminent Prof was saying. Many thanks to them both.

@user-uz8zy8zl4k Ай бұрын

Whether he' right or not '?? He IMO most certainly IS !!! What is the alternative - well Dawkins! Either that or oneself must come up with what Is the alt !!! Noble stays true to his (True) course be-CAUSE (!!) he is Reason incarnate ie of that Natural INTELlgence of which he speaks !! Get with program FFS!!! I can provide the Philosophical reason(s) (sic!!) fr Why he is Right but alas this is not the place fr that here.

@Mousey316 Жыл бұрын

great interview. noble is very knowledgeable and articulate. i applaud the interviewer for giving him the time to develop his thoughts without interruption. well done.

@larryparis925 Ай бұрын

Well said.

@gopra 24 күн бұрын

@@larryparis925❤❤

@archiewebster5034 2 ай бұрын

You hosted a very good interview! I appreciate your patience and great questions :) This is the first video I’ve seen of yours and I will be watching a lot more.

@larryparis925 Ай бұрын

Same here.

@hn6187 3 ай бұрын

I love how prof noble references his speech to show how science is above language and borders, a supra culture unto itself, inspired mostly by its own careful recursion, and art

@tersta1 Ай бұрын

I didn't know of Denis Noble until today. Of course, I have known of Richard Dawkins for decades. His views are the status quo of Neo-Darwinists. I'm glad to hear Denis Noble's POV. It actually aligns better with my own observations and resultant POV. Thanks for hosting Denis Noble on your podcast

@katherandefy 2 күн бұрын

Goodness me. I was not expecting this delightful level of detail. Lots to ponder. So much.

@larryparis925 Ай бұрын

Wonderful session. Mr. Kumar is well-prepared and knowledgeable, and Prof. Noble is an amazing scientific storyteller. Imagine sitting around a campfire and listening to him talk. Thank you... very, very much.

@davidcolby1456 2 ай бұрын

The answer is easy and hard at the same time.The answer is everything drives evolution and a completely related and intertwined complicated way.

@phil3.146 Жыл бұрын

Good interview.

@Spudmay Жыл бұрын

This is a very wonderfully interesting concept. Now I have to investigate this further. It seems weird I haven't heard of this at all (I am also very very new to ingesting science).

@karlbarlow8040 Ай бұрын

This man ranks as a genius of the standard of E O Wilson and James Lovelock. The accepted model of any branch of science can only be at the level that the average scientist can understand. This is why all genius' struggle to be accepted. Only a great interview like this can allow us mortals to glimpse the workings of such a mind. Thank you.

@yp77738yp77739 5 күн бұрын

Very interesting. For me the key is that this might explain the generation of novel species which, I understand as being mathematically problematic with passive mutation processes. I need to listen several more times. We mustn’t lose sight that molecular biology is a very young science.

@rustycalvera977 Жыл бұрын

what an interesting discussion this is....how beautifully put forth by denis noble.

@MrSolonolo 2 ай бұрын

A very clever dancing around the principle question which was "what DRIVES evolution” which differs from the question "what PRECIPITATES or FACILITATES evolution". Informative and enjoyable, nonetheless. Thank you.

@TheMargarita1948 Ай бұрын

Are you looking for a teleological explanation?

@MrSolonolo Ай бұрын

@@TheMargarita1948 Or even a causal one. Yes.

@TheMargarita1948 Ай бұрын

Matter and energy. Magnetism and vast amounts of time.

@MrSolonolo Ай бұрын

@@TheMargarita1948 Which is the "driver”?

@TheMargarita1948 Ай бұрын

@@MrSolonolo random mutation acted upon by natural selection. Please don’t give the old argument that all this senseless beauty could not have been brought about “at random.” Natural selection is relentless.

@bertrandthebault6899 11 ай бұрын

Denys Noble is a star

@patod4 11 ай бұрын

Not yet listened to all of it. But why isn't Lamarck mentioned, after all he supported what today we call somatic inheritance, am I wrong?

@bastiaanschouwink3562 11 ай бұрын

the weissman barrier is the same as anti neolamarckism, i believe. noble is i think a lamarckist

@larryparis925 Ай бұрын

Lamarck and Lamarckism is mentioned. You didn't listen far enough. It's quite interesting.

@robertbryant4485 9 күн бұрын

I'd like to see the mathematical probability. behind C,H,O,N P atoms randomly arranging into self replicating DNA. which is more complicated than any computer we know

@planetdog1641 8 күн бұрын

me too! Darwinism is dead.

@robertagajeenian7222 29 күн бұрын

I wonder what Darwin would have said (perhaps he even knew of this already - he wrote a book on orchids) about the very great hybridization industry with orchids. There exist cross-genera hybrids wherein 3-5 (anyway) different genera are hybridized. These hybrids (where typically hybridization produces sterile offspring) are generally fertile. The orchid hybridization process is with pollinia to stamen directly. This practice is very ancient in food plants and some farm animals, I guess, but the fact of its happening is already very interesting. I wonder if orchids are particularly labile genetically?

@ferrantepallas Жыл бұрын

brilliant and fascinating presentation, thank you

@sergiosatelite467 Ай бұрын

11:34: Immune System Selects

@ValidatingUsername 2 күн бұрын

Cells and system adaptation to homeostatic conditions trying to form barriers or connective tissue with shells and bones and such 😊

@ericjohnson6665 Ай бұрын

Re. Immune system "choosing" nucleotides... this sounds a lot like Michael Levin's assessment of cells: 'Life has congnition all the way down to the individual cell.' Which begs the question: how did that cell come by that "cognition", when life first started?

@imwelshjesus Ай бұрын

Cos the baby jesus dun it I red it in a book that's why.

@ericjohnson6665 Ай бұрын

@@imwelshjesus - Not the answer I was hoping for. 😇 [It was bait for the atheists.] The being that incarnated as Jesus, Paradise Creator Son Michael of Nebadon, has a partner called the Universe Mother Spirit, and she is the one responsible for providing an allotment of mind (on a varying scale) to all life forms. And 'mind' is the source of that 'cognition'. And is the reason why 'life' cannot happen by accident.

@komolkovathana8568 Ай бұрын

05:38. DNA (DeoxyriboNucleic Acid ; Double Helix) Base-Pairs Protein, named : (1) A--T (or T --A) ; Adenine -- Thymine (2) C--G (or G--C) ; Cytocine -- Guanine

@clivejenkins4033 29 күн бұрын

The origin of life is the big question

@keaton718 10 ай бұрын

Humble looking home. You’d think a household name like Denis, in biologist households anyway, he’d have a grand home. In movies famous biologists are rich.

@hn6187 3 ай бұрын

Value creators don't get rich ££££££, that's not what money is. the people who Own their ideas with accountancy grifts do... Do you see what money is? Indeed Noble can thank his lucky stars his fate wasn't that of Turing Socrates Spinoza Nietzsche ... "Ownership" / appropriation is of course violence on a scale. As a Brit I'm particularly ashamed of what the British police did to Turing our greatest war hero and innovator

@imwelshjesus Ай бұрын

The police merely did what Christian society instructed them to do, hound homosexuals. Nothing special about your hero's treatment, all gays around the world are or have been treated abysmally and in many places even today are killed simply for being different.

@alexnewton7484 11 ай бұрын

Wonderful interview. Our environment/habits determining our evolution is the single most important piece of knowledge in the world today. The obesity epidemic, myopia epidemic, dental occlusion epidemic, and mental health epidemic are all being driven through environment and passed on to future generations via these transgenerational effects. If you aren't convinced by Noble, look up "Dias and Ressler 2014"

@lokeshparihar7672 9 ай бұрын

21:30 julian huxley book

@SeyedMohammadMostafaviDialecti Ай бұрын

What drives evolution is the universe tends to be ORGANIC

@mykrahmaan3408 Ай бұрын

Once we derive the mathematical model of the mechanism how the 3 entities (PLANTS, ANIMALS and HUMANS) could cooperate at present through our own programming of the gaseous, liquid and solid substances each individual of the latter two entities release to the surrounding (environment), all these analyses of the "origin of species" as a historic process that happened in the distant past through a process called EVOLUTION would become superfluous, as we could then use that MODEL in actual practice to influence events inside the earth that shape the weather as well as development of, and growth on, plants to suit our requirements in real time for evil free sustenance of life function, benefiting all life ~ including animals, not just humans. Reproductive appearance of beings is a displaced natural function, which can (and MUST) be rectified by us to compel the earth to deliver and sustain new beings (animals and humans) through plants only as it originally did, without involving any other being. This would be the real INDEPENDENCE, which in fact is a misnomer (a negative concept), for no being could ever be INDEPENDENT of the earth. What the word actually implies is INDEPENDENT of "other beings". So the correct (positive) word for that concept should be: EARTHDEPENDENCE. Even to leave this earth, we have no other means than to use the substances available on (and in) it.

@komolkovathana8568 Ай бұрын

At first, it's not just survival of the fittest.. but pure struggling to survive.. eg when water level was down by vaporizing heat from the sun, some fish came out of pool to blindly crawl out hopefully finding new (Better) pond. Many just died, very few success and survived.. and breeding. Many generations of that survival group (not only one of them passed the (many, many)tests & you can called it Practices, they became more durable more agile, more breathable in dry air, even adapted longer or stronger (hand-ike) Fins.

@komolkovathana8568 Ай бұрын

I only know of Macro (Outside: Overall) Evolution, which is the product of deep-down Molecular Biology (bio-chemistry) inside the Cells' nucleus... which i know Nothing about.

@ALavin-en1kr Ай бұрын

Without an understanding of consciousness (the hard problem) and mind, positing the elemental as causal is premature and comes up with some unlikely scenarios such as genes having a point of view. This is biological reductionism at its silliest.

@hn6187 3 ай бұрын

Prof noble is right to point out his debt to neo Darwinists, their extreme position provides the fodder for his Scepticism, and so vice versa. By positing top down causation is not possible we can then frame hypotheses to attempt to disprove this. So a more nuanced set of models that describe life can emerge

@clivejenkins4033 29 күн бұрын

He saying bacteria is like the borg

@tedgrant2 23 күн бұрын

The secret of life is no longer a secret. Chemistry

@hn6187 3 ай бұрын

Genes are the piano keys we play... To explore the possibilities of music ... To paraphrase Prof Noble. The science of the Metaphysics of panpsychism

@keaton718 10 ай бұрын

I still think Denis is reaching here. But that he’s got a sense of something that is actually going on. But it’s not quite what he says it is.

@arthurwieczorek4894 Ай бұрын

What drives evolution? Just as there are laws of nature like conservative of energy, so there are laws of nature involving conservation of structure. The structure I have in mind in regards evolution is the chemical structure DNA. Per Richard Dawkins.

@zbuchus Ай бұрын

Are the laws of nature random and do they emerge from a vacuum? Is our existence just another coincidence? What a hype and pride

@fcalin21 21 күн бұрын

It is so sad that he is old.

@clivejenkins4033 29 күн бұрын

Interesting theory, going to great lengths to disprove god

@MuradBeybalaev Ай бұрын

Clickbait. Does not feature Richard Dawkins.

@gemishedinterviews Жыл бұрын

I wonder if Mr. Noble knew my Grandpa, R. Schwyzer. He reminds me of the way he spoke to me when I was young.

@djelalhassan7631 29 күн бұрын

Brilliant, everything is conscious and life

@skyemac8 2 ай бұрын

Survival drives evolution.

@clivejenkins4033 29 күн бұрын

You can create AI, you will never create self conscious beings, period.

@whatabouttheearth 20 күн бұрын

Well...what is a "self conscious" being? You're not "self conscious", you were built by a mechanism. You didn't make yourself or your consciousness. We have already made living mice from skin flakes from male mice without a mother. Hypothetically, with a sufficient amount of deep biomimicry of a structure that has a mechanism that reproduces that structure, it could possibly be done. We are starting to develop biomimicry at a much faster rate, artificial biomimicked skin for skin grafts, artificial limbs, studied even on limb regeneration through studying stem cells in Axylotyl limb regeneration, etc. The technology is just getting better and better. It's only a matter of time when mimicked biotechnology will get bizarrely simmilar to the real flesh, leaf, or organ...🤷 and then how do you think it could develop from there?

@whatabouttheearth 20 күн бұрын

@stephenbrown9998 Ай бұрын

White van man

@nancymatro8029 4 ай бұрын

Noble seems to suggest that every organelle has its own DNA which is passed on to it's offspring. How this is accomplished he doesn't say. I can't find anyone else who corroborates this point of view.

@markwrede8878 2 ай бұрын

Evolution is a passive effect. It is not driven.

@komolkovathana8568 Ай бұрын

Sorry, no intentionally intruding ; here's one question, nobody will EVER ask you, sire. The Reproductive (sex) Cell division of base-pairs ... called MIOSIS ; Father Cell (eg.). Mother Cell (eg.) A ----- T. T ----- A T ----- A. C ----- G G ----- C. A ----- T C ----- G. G ----- C Both Cut in Half.. and Recombined, as... ( Left to Right ). ( Left to Right ) A --x-- A. T --x-- T T --x-- G. C --x-- A G --x-- T. A --x-- C C --x-- C. G --x-- G All were WRONG and Unpair-able (!!?!!) How can any Gene-corrector work of such randomly "choose" whether you wanna keep the Left or the Right as Pivot protein, and abandon another (create a new suitable "half") to match the chosen side.? Some kids got the Father's Hair but mother 's eyes; some got Father's eyes but mother 's hairs.; Random Pivot genes 're chosen ? Then discarded another Half, yes? The recombination then just make prominent genes from either Dad or Mom only.!?!

@tomato12terra Жыл бұрын

hmmm, is Noble advocating directionality of selecting and evolution? Does not convince me

@Iwansidi Жыл бұрын

Me neither...I am even a little annoyed that he is running victory laps as if the case was already settled. The condescending way in which he talks about the "writer" Dawkins is actually embarrassing.

@tomato12terra Жыл бұрын

@@Iwansidi yes, and without providing any evidenced alternative to the self replicator as unit of selection

@homer1273 Жыл бұрын

Clearly you 2 kids don’t understand anything about what he is talking about and should stay silent and finish school

@vikkumar9301 Жыл бұрын

@@tomato12terra I thought he did provide a lot of evidences.

@alexnewton7484 11 ай бұрын

He provided plenty of evidence, both here and in his debate with Dawkins. If you'd like more, look up "Dias and Ressler 2014."

@wulphstein 3 ай бұрын

What drives evolution? Bad math.

@peterkiedron8949 2 ай бұрын

Broken record. Time to retire and let the ego get some rest.

@forgetful3360 Ай бұрын

You're having difficulty with information processing, I see. Maybe some gene repair will help you overcome your impediment.

@DrMichael-T-7777 Ай бұрын

Need to publish or perish and excuse for federal grants …

@JungleJargon 2 ай бұрын

Imagination drives evolution along with speculation conjecture assumption assertion and irrational fantasy.

@matthewstokes1608 2 ай бұрын

The word is GOD

@arthurwieczorek4894 Ай бұрын

Is there any question you can't answer with that word?

@matthewstokes1608 Ай бұрын

@@arthurwieczorek4894 no

@arthurwieczorek4894 Ай бұрын

@@matthewstokes1608 So you are saying there is no question that cannot be answered by invoking God.

@matthewstokes1608 Ай бұрын

@@arthurwieczorek4894 Look - God created you, all matter//space/time/light/consciousness - the fact you ARE - and then set you ‘free’ into a world of miraculous wonder with a free-will and a compass… He made your soul - your spirit is free - but you cannot escape decay which He hardwired into an inescapable process of apparent mortality in the mere material realm culminating in death. You are born in blood to the binary matter of a unique familial tree - but you will die an individual utterly alone - and as such you will be judged. All men of all ‘time’ and from all tribes will be judged by the Christ alone. Why? Because this visible material world is (at most) half the REAL picture. The purposefully invisible, spiritual realm is far more real - and you do not die. I know the body dies and rots and stinks - worm food - we all see the ‘obvious’… but it is a ruse. The reality is mind-blowing. Only Jesus Christ can set you free. Obviously I am saying there is no question that cannot be answered by God… it is not about your invoking Him - but about His invoking you. Your faith in Him is not the main concern for a man nearly as much as whether He has any faith left in you. “Fear of God is the beginning of all human wisdom.”

@karlbarlow8040 Ай бұрын

If you are speaking about the God of Spinoza and Einstein, then I would agree. (They both used "God" as a metaphor for the laws of nature).

@MarkoMakela-kk7qf 2 ай бұрын

Short answer to the topic is completely nonsense! You can of course make theories what has happened before according the test and theorioes you now have, but that won't make any difference to anything. You weren't observer as these things happened, so you don't know a fuck about them. You are just guessing like all the people who deseperately after lost religious beliefs are seeking for scientific resurrection which never comes. Changing religion, no matter if it is the most common one to think or the scientific approach that is almost as unrelialble as the first one, we will face some questions that are beoynd our capabilities to comfirm. Almost all we know of all extince is mainly from the past. We don't even know what our universe right now is. We see only what it was in the past... Tell that story if you are a wittness of an car accident to the police men... yes indeed... I wasn't there but I see that this car went too fast and violited the traffic rules... possible of course, but that's all it is. You can't make theories from the end results coming back to the explanation. I know this well as in some maths you can actually do that, not all, but some. But this way too complex to use that merthod. Before anyone asks, I couple of times didn't remember the simplest way aka right formula to calculate something difficult 'cos I was overtrohwn by girls at the time... beats all of us.. but as I wasn't completely useless with maths I broke the formula to pieces and calculated every single thing separately... it is exhausting, and I don't recomen that to anyone, but especially in physics you need desperately those mathics and formulas...:)

@MarkoMakela-kk7qf 2 ай бұрын

And now when we finally have equipments out of our planets interfierence and athmosphere and can see some things as they 'were'... It doesn't look quite what we expected? I suggest a reroll.. and a little break. From your mediavel thoughts.

@RunnerThin Ай бұрын

A theological belief that there is no Creator drives the fantasy cult of evolution.

@karlbarlow8040 Ай бұрын

The "Creator" is still in the process of creating himself and he's using evolution to do it. When he's finished, he may start answering prayers. I know a few good church goers who got no answers and had tragic ends.