In this video I go over what are reference genomes, how are they build and what are some uses of having a reference genome. In addition, I talk about what are different builds (versions) of reference genomes i.e. GRCh38 (hg38)/GRCh37, what makes them different and which one should be used to perform genomics analysis.
I hope you find this video helpful! Leave your thoughts in the comment section below!
Chapters:
0:00 Intro
0:31 What is a reference genome?
1:41 Human reference genome is NOT...
2:05 Why sequence full human genome?
3:24 How is a human reference genome created?
5:08 Reference genome builds (versions)
6:22 What's with multiple names - GRCh37, hg19 or b37?
7:21 Types of sequences found in a human reference fasta file
8:24 What are alternate loci?
10:13 GRCh37 (hg19) vs GRCh38 (hg38) - which one should I use?
10:56 Visualizing a gene in both versions of reference genome in IGV
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Website: bioinformagician.org/
Github: github.com/kpatel427
Email: khushbu_p@hotmail.com
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