My beloved late Aunt, Major and Lt. Colonel in the USAirForce, was exposed to Agent Orange and died of multiple myeloma at the age of 79. 😞✨

@@annagreenedellera7864 I so sorry for your great loss. So far I am positive for MGUS in my urine and not my blood. So I feel luckier then most and will see the VA every 6 months to monitor my blood.

How are you doing today?

and doesn't that make the proportion of MGUS developing to MM is very high ? 20%

1 in 5 of the 100 patients total. which is were 1% falls.

@@amyforrest4043 1 in 5 is 20% .1 in every 5 patients of 100 = 100/5 = 20. I think the 1% is of the whole population but it's unclear

As I understand MGUS and MM from reading some webpages, it is a coincidence that in his example both numbers are 1% because he chosed to consider a time span of 20 years. 5% of all people of 60 years have MGUS. Therefore we have 5 out of hundred. Then each of these 5 persons has a risk of 1% PER YEAR to get MM. Since he considered a time span of 20 years (from age 60 to age 80), the risk for each of the 5 persons is 20% which results in one of them to get MM in average. And this is coincidentally 1% of all 100 persons. However, if he would consider a time span of 40 years (from age 60 to age 100), the risk for each of the 5 persons (assuming that each of them becomes old enough) would be 40% which would result in 2 persons to get MM in average. In this case, you have 2% of all 100 persons. Thus because you have 1% PER YEAR, the proportion of MGUS developing MM depends on the time span you consider. Of course, the same holds for all persons when you consider the rate for getting MGUS to be constant. But of course, this is only how I understand this situation.

@@alexanderschulz1731 Alexander, thanks. My point was that they do not seem able to clearly express exactly what they actually mean. As you say.

For me, I went to the doctor feeling sick and was sick for many days with a low grade fever. That's when they drew blood from me. The findings of that blood test said that I had MGUS. So the answer to your question is MGUS is discovered because you went to a doctor for some other problem and this was discovered in the process. That's what happened to my mother who was diagnosed with MGUS and years later progressed to MM and then she died almost 4 years later. I don't know how long she had MGUS before it mutated to MM. For me, I was diagnoses with MGUS about 9 to 10 years ago and have to go to an oncologist for a blood draw every year to see if it has progressed to MM or not. It's like having a time bomb in you. My mother died in horrific pain, towards the last year of her life. She fought it with all the medications they had back then. She was told that she would only have 3 years to live. Getting back to the tests, once the blood tests came back, I had to have other tests done such as a 24 hour urinalysis where you pee into a bottle for one whole day and then a bone marrow aspiration which is an extremely painful procedure to have and I vow, to this day, I'll never have that done again no matter what. Once those other 2 tests come back is when they either tell you you have MM or MGUS. Either way you have to have your blood tested once a year (MGUS) or more (MM).

very brave of.you ...how old are you sir?

f umair syed If that questioned was aimed at me, I will be 60 years old on one week. If your question was for someone else, I apologise.

YES it was for you...recently a lady came to my clinic .she is 82 yrs old and her serum protein results just came back .showing monoclonal gamopathy.apparently MGUS . Iwill be breaking news to her and family in next visit..but before that i wanted to see some valuable groups when i read yr comment here in this video....couldnt resist asking yr age....!!

f umair syed Right. I think I was 48 or 49 years old when first diagnosed. People can get MGUS at any age. I've read somewhere as early as in their 20's and 30's. Remember that there is no treatment for MGUS as it has no symptoms at all except elevated protein levels in the blood. The only time to worry is when MGUS turns to Multiple Myeloma or some other disease. Right now she is fine although it can be shocking and depressing to know that you have MGUS at first. I went through those feelings and it was hard but I got over it. She's 82 years old and has lived a full life already. Most people don't live to be that age, my family, for example. My mother died at age 79 (8 years ago) after being diagnosed with MM at 75. Today, there are a lot more treatments for MM than what was available at the time my mother was alive. I wish your 82 year old female all the best.

It is not asymptomatic! They have just recently changed this in medical books! They need to stop saying it’s asymptomatic. It is not ! I suffered for raynauds, Idiopathic urticaria, regular illnesses, since i was young ! I was diagnosed at age 26 but was advised I acquired mgus at age 15. I wish they would stop saying it has no symptoms because they attributed this disorder in the elderly ! They need to investigate mgus in the young and listen to our symptoms ! Guys we are telling you it ain’t without symptoms! It is not asymptomatic! Mgus is now recognised as a autoimmune disorder.