What is the Cori Cycle? | Gluconeogenesis Explained Simply

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What is the Cori Cycle? | Gluconeogenesis Explained Simply

Рет қаралды 53,764

The Movement System

Күн бұрын

Пікірлер: 78

@TheMovementSystem 2 жыл бұрын

Follow along on Instagram to learn more: instagram.com/themovementsystem/

@armycats6642 Жыл бұрын

Yeah, you’re great, Matt, I trying to understand if I can bodybuild and do keto. I know nothing and your making me feel very clever as I learn from you!

@MzAlexZ 3 жыл бұрын

Bro not even my lecturers at med school explain it as clear as you do. Thank you!!

@TheMovementSystem 3 жыл бұрын

Thank you!

@radhaparashar6204 6 ай бұрын

From which country are you? We study this in 11th grade

@ambermillerstrengthco 2 жыл бұрын

I have a masters degree in ex physiology and have never had a professor explain this as clearly as you 🙌🏻💪🏻👍🏻

@TheMovementSystem 2 жыл бұрын

Thank you!

@MsGigiiiiiGoNZalEZ 2 жыл бұрын

I really appreciate how you think of including questions we might have and how certain concepts can be applied to clients. This all really helps with the overall picture.

@TheMovementSystem 2 жыл бұрын

Thanks for the kind comment!

@vairaggya 3 жыл бұрын

Nice explanation sending love from India ❤

@TheMovementSystem 3 жыл бұрын

Appreciate it! Sending love back from the USA❤️

@hanumavattem3106 3 жыл бұрын

Helped me understand the concept easily and clearly,thanks man

@basedstruggler3436 2 жыл бұрын

KZfaqrs always explain things so clearly and quickly haha, one of the best ways to study. Thank you.

@TheMovementSystem 2 жыл бұрын

I appreciate that

@raininglavender 3 жыл бұрын

such a great yet simple explanation, thank you for this!

@TheMovementSystem 3 жыл бұрын

You're welcome!

@lizasem4184 3 жыл бұрын

appreciate the nice drawings. Helps me visualise better! keep the content coming Matt!

@TheMovementSystem 3 жыл бұрын

Thanks! We work really hard to make simple easy to understand visuals. Glad they are helpful

@tranedTurtle 3 жыл бұрын

Keep up the great content man so much valuable info in such a short video🙏

@TheMovementSystem 3 жыл бұрын

Thank you!

@birdscrytoo 3 жыл бұрын

Loved the diagram!! Made it so much simpler

@radhaparashar6204 6 ай бұрын

Thanks, that diagram was so good , I will definitely add it in my notes , Love from India✨♥️

@smileunice8822 11 ай бұрын

This is SIMPLE and STRAIGHTFORWARD. THANK YOU!

@bic1349 Жыл бұрын

AMAZING EXPLANATION!!!

@TheMovementSystem Жыл бұрын

Thanks!

@rdance3 4 ай бұрын

I've been a gym rat since I was 10 years old, 1975. I retired at age 53 due to extreme metabolic fatigue but learned to hack several of my genetic SNPs. I was so successful that I dropped below 10% bodyfat and gained more muscle. I was on the way to physique competitions when things started going South. One of the things that happened was that I would get extreme muscle soreness from workouts that wouldn't normally cause me to get sore. I also became more and more fatigued. I believe now, that I have it figured out. I believe that I have a Thiamine deficiency. I think this is causing two things. Since Alpha Ketoglutarate Dehydrogenase (Thiamine Dependant) is the rate limiting enzyme to the TCA cycle, my Oxidative Phosphorilation is being inhibited. Also, Pyruvate Dehydrogenase (Thiamine Dependant) is causing Pyruvate to build up, leading to increased Lactic Acid Fermentation. Do you agree with this possibility? I have many more symptoms that aligin with Thiamine Deficiency. I just want to know if my reasoning makes sense.

@yomnaosama3859 3 жыл бұрын

This helped ALOT ! simple yet effective explanation , thanks . Happily subscribed.

@TheMovementSystem 3 жыл бұрын

Thanks!

@Emily-ku5wi 3 жыл бұрын

So incredibly helpful, thank you!!

@TheMovementSystem 3 жыл бұрын

You’re welcome!

@amasood_ 2 ай бұрын

Extremely helpful, thank you

@wendyhansen2487 Жыл бұрын

Thank you!! This is a great explanation.

@TheMovementSystem Жыл бұрын

You’re welcome

@drmitofit2673 Жыл бұрын

I am in great shape from hill repeat bicycling with weight loss, increased muscle tone, increased endurance, increased performance/speed, and BMI dropped from 25 to 22.8 in a year. It seems like hill repeat cycling (with its high levels of mixed aerobic/anaerobic energy expenditure and cyclical recovery/lactate clearance) might be the best way to trigger the Cori cycle AND trigger mitochondrial biogenesis.

@zinaidavicol5172 3 жыл бұрын

thank you! you are awesome, keep coming with great content

@TheMovementSystem 3 жыл бұрын

Thanks!

@taste0ftruthtuesdays 2 жыл бұрын

SO WELL DONE!! Wish i had you when I was studying biochem in college!

@TheMovementSystem 2 жыл бұрын

Thanks!

@dipubolke7647 11 ай бұрын

You made this very easy to understand.

@yuta2349 2 жыл бұрын

This was explained pretty well. Thanks !

@jfelipebarquero5202 2 жыл бұрын

Thank you!! Making easier my PT certification, tons of help!!

@TheMovementSystem 2 жыл бұрын

You’re welcome!

@heavenlybreeze 3 жыл бұрын

You're very good Sir, Thanks

@TheMovementSystem 3 жыл бұрын

Thank you!

@operatorerick1450 9 ай бұрын

I really enjoyed this interesting easy to understand video sir! \

@violettedelforge5103 3 жыл бұрын

Nice video ! Very helpfull 😁👍

@TheMovementSystem 3 жыл бұрын

You're welcome!

@choudharysandhya227 3 жыл бұрын

Can you explain the citric acid cycle

@rahulkhadka9461 2 жыл бұрын

You are AMAZING!!!!!!!!!!!!!!

@TheMovementSystem 2 жыл бұрын

Thanks!

@Durgaetz 3 жыл бұрын

Great 👍 one

@TheMovementSystem 3 жыл бұрын

Thank you!

@AlanOliveBranch 3 жыл бұрын

Great video! Can you explain how lactate is metabolized by type 1 fibers to produce ATP?

@TheMovementSystem 3 жыл бұрын

The lactate dehydrogenase enzyme turns lactate back into pyruvate then the mitochondria rich environment of the type 1 fiber allows for oxidation through the Krebs cycle

@rahafherzallah7069 Жыл бұрын

That is AMAZING thank you so much!

@TheMovementSystem Жыл бұрын

Glad it was helpful for you👍🏼

@sarahaghani7663 11 ай бұрын

great video!

@clockedinathletics Жыл бұрын

after 10 years of trying to learn this. I finally get it.

@lauras7409 Жыл бұрын

I love u, this was really helpful

@TheMovementSystem Жыл бұрын

💛

@lenavoyles526 16 күн бұрын

Question: After emerging from the CORI Cycle as glucose, if there are not enough mitochondria/oxygen to take that glucose through the Crebs Cycle, does it potentially just keep going round and round the CORI Cycle through the liver, taxing the liver but never really providing much energy?

@henryg3702 3 жыл бұрын

What happens, what does acetly-coA do after being converted from Pyruvate?

@TheMovementSystem 3 жыл бұрын

Goes to the Krebs cycle! I actually made a video on that: kzfaq.info/get/bejne/abuen5lq3q7NdZ8.html

@ryanmulhall6588 2 жыл бұрын

Hey Matt, Feel like I'm always asking you questions haha. When Lactate releases the Hydrogen ion to become Pyruvate, does this increase acidity of the liver? Thanks for your work man!

@fingerprintingservicesofau938 2 жыл бұрын

Can too much protein in a type 2 diabetic cause this cycle ? I’ve noticed higher Protein keto diet keeping blood sugars high and can’t figure out why ?

@jordanwilliams3045 2 жыл бұрын

Does the Cori cycle get more efficient or "turn on" faster with long term training?

@michaelsrowland 3 ай бұрын

At 1.56 how do we get lactate?

@radhaparashar6204 6 ай бұрын

From which country are you guys and in which grade are you studying about Cori cycle?

@amalinsyakira4484 3 жыл бұрын

i have a question, why cori cycle is always happen even we are not doing exercise?

@TheMovementSystem 3 жыл бұрын

Because there's always some amount of lactate production. It's just that with exercise lactate production can exceed the ability to clear it.

@mohitj4356 Жыл бұрын

Can cori cycle result in liver glycogen formation?

@radhaparashar6204 6 ай бұрын

I guess yes , I had same doubt but in my notes it's written that after going into liver lactic acid converts into glycogen

@user-cn9tu3gr7b Жыл бұрын

Why does gluconeogenesis is important in the Cori cycle?

@WolfgangLizana 3 жыл бұрын

According to studies done by Jeff Volek & Stephen Phinney, this process can upregulate substantially after a prolonged period of Carbohydrate scarcity or nutritional ketosis. I would LOVE to see a video from you breaking down your thoughts on the following lecture: kzfaq.info/get/bejne/eMuDkseZsp7Io40.html

@TheMovementSystem 3 жыл бұрын

Dr. Volek does great work. I've spoken to him a number of times and attended a few of his lectures in person. I'm not a nutrition expert so I will have to do a fair bit of research to put together a video about ketogenic diets and ketosis but I'll put it on my future videos list.

@WolfgangLizana 3 жыл бұрын

@@TheMovementSystem Wow thats awesome! Volek is one of my biggest inspirations the past two years, I own both of his books he wrote alongside Stephen Phinney as well as the book they wrote with doctor westman. I see a lot of exercise science authorities "debunking" ketogenic diets, especially for athletes because they seem to believe the body just stops producing glucose or refueling glycogen when exogenous carbohydrates are cut from the diet. They completely leave out the Cori Cycle, and don't seem to be aware that glycerol and free fatty acids can also contribute to endogenous glucose and glycogen supply in the absence of exogenous Carbohydrate. I really want to hear someone like yourself who understands physiology on a deep level and is at least familiar with the work of ketogenic pioneers like Volek, discuss glycogen supply and demand in keto-adapted athletes. Specifically, do you believe there can be severe limitations on athletic performance in a keto-adapted state for heavily glycolitic sports such as BJJ or MMA? How exactly would converting lactate & glycerol be different than utilizing exogenous glucose directly? Does the cori cycle and gluconeogenesis just take more time to produce glucose/atp? Or do you think after long term keto-adaptation its possible that gluconeogenesis could be enough to sustain Performance?