"Don't blame it for all your weak ass endurance." Priceless.

Dr. Andy, you just gave the BEST explanation I've ever heard! Thanks so much for sharing. Following now!

Very good explanation. I got answer what I wondered for long time.

That is the first explanation I’ve really understood Andy! Thank you!

My professor included this video on our module this week. I was so stoked to my know my professor knows about you, lol.

Your way of explaining things is just so damn beautiful honestly - massive thank you

This made sense and helped a great deal. Thank you!!

tbh you deserve way more subscribers, so much instructive videos

Physiotherapy student here. This explanation is great, thank you!!

Really helpful. Thanks Andy.

You sir are a gem to society. May your brain forever remain intelligent

Dr said lactate is good. I kept hearing that lactate was bad. They said the quicker we can get rid of it, the better we can perform. This explanation reminds me of why so many people struggle with education.

Good video, Dr. Galpin. When trying to build muscle mass, here is what seperates the men from the boys, the women from the girls...motivation and pain tolerance. When you can achieve your anaerobic/lactate threshold, and push that red line up each time, you will activate the maximum amount of motor units in a muscle cell, both red and white fibers. Maximum intensity for 1-2 minutes, right to the edge of the glycolictic pathway. Each time you force the nervous system to continue sending neurons to the neuromuscular junction when it doesn't really want to, you increase the excitation threshold, and can tolerate more discomfort each time. I have found drop sets are the best way to do this, because you can really punish the muscles, but protect the connective tissues by giving them a break on each successive drop. This is also the best way to achieve the possibility of hyperplasia.💪☺

great piece of the big puzzle. the question for me is which kind of hormonal effect it has regarding hunger. how does it affect grehlin, glucagon production, glp-1, .... etc.

Heya Doctor! Thanks a lot for this very easy to follow session, much appreciated!

Hi, I"ve been watching Dr. Heiser's videos for more than a year now. I've learned much from Dr. Heiser and have been blessed by his approach to the Word. I wanted to take the certificate course but need to ask how.

Thanks for this short presentation. I’ve been reading literature that confirms this and seeing so many videos describing something different. I almost argued with someone to say, No, it is not lactic acid that causes metabolic acidosis. I relented and decided to stay out of that fight.

Wow, awesome. What an explanation.👍🏻❤️🙏🏿😀

Great insight on pyruvate to lactate (H+). Thanks!

I might sound really dumb but what is The difference between lactate dehydrogenase and lactate plasma blood tests. Thank you.

Me siento feliz de haber hecho la búsqueda que me trajo a este video

Great video. Thanks!

Dr Galpin a lactate question if you will help. I measure my lactate monthly on my zone 2 training for mitochondrial biogenesis. I keep it 1.7-1.9 mmole for 90 minutes 4 days a week. However, I donate blood every 2 months, the gift of life, and have noticed after donating blood my lactate, at same wattage and heart rate is ridiculously high. How long should it take to arrive at a legitimately accurate level? Your knowledge on Bioenergetics is inspiring. Thank you for sharing!

Finally someone that doesn't make me fall asleep. THANK YOU.

Simple Video! :) Thank You

Good video. But I would disagree about the statement that pyruvate becomes lactate in the absence of O2. Even at rest or low intensity exercise we produce lactate when we have more than enough O2. Lactate production is required to generate NAD molecule, NAD is needed for the glycolysis to keep working.

Understood. Better lecturer than uni lecturers

very helpful, thanks!

Thats powerful and interesting session

Thanks for the great video. I know this was specifically a lactate topic however could you expand and add other fuel sources such as free fatty acids and ketones into the mix please. I always wonder how non glucose fuel sources impact lactate buffering and using lactate as fuel.

Would the Wim Hof method help?

I watched this with hope that I would understand "lactate" more but ended up with more confusing as I there are more jargons mentioned here. It's not your fault at all Dr.Andy but it's mine as my knowledge/education is so limited. I supposed I need to investigate more what those jargons such as ATP, Pyruvate etc means, once understood them I should come back and watch this clip more. Thank you.

Just wondering what are levels of mg/dl or mmol/l for aerobic /treshold and max values?

Thank you. I need this explanation for a research topic. It's using TENS to decrease the pain sensation felt from lactic acid so one can supposedly increase repetitions. Some people stop with the pain, some tolerate the burning sensation and only stop if the muscle really fails. If TENS does work, then it might decrease the pain felt from the lactic acid

You just saved me. I understand so much now

Great video, the easiest way to explain it and lactate is a good thing, hallelujiah

Hello, how it' s called the app where you can drag ? Thanks

what about ingesting lactic acid via some fermented products?

Hi Andy. Dr. Darren Schmidt speaks about lactic acidosis like the cause of all diseases. What is your opinion on this, how to prevent it? Many thanks

Why does the body acidify when we are using anaerobic metabolism? And how does that relate to transportation of Co2 in the form of HCO3 and hyperventilation and exhaliation of Co2? I know the body hyperventilates to deacidify itself during hard exercise (eg. ventilatory threshhold and respiratory compensation) but how is it all connected? Anybody smart out there who can help me? Thanks!

Enjoy your vids Andy. Minor detail: Pyruvate actually picks up 2 protons to become lactate.

Fantastic!

Nice video.... Followig you for a few years... Excelence

What is the other side of the ion that that H came from and what is it doing?

So do you not make lactate if you burn fat or protein for fuel?

Can vit c counter lactic acid?

I would love to know why I feel so tired after compound exercise or high reps weights or calisthenics. Any ideas? I know a personal trainer who just said lift heavier with fewer reps but I want to improve endurance. My main hobby is hiking and I want to feel fitter, more able to keep going for longer without feeling awful the following 2 days.

Great video Andy. I’ve found your videos through Andrew Huberman’s podcast, and it’s a great educational experience. I was wondering though, if lactate acts as a buffer to help increase endurance, what exactly is carnosyn beta alanine doing then if it’s supposed to increase endurance?

My son 3.5months old he have Lactate plasma issue 10.7 . Now he is not able to speak🗣 and he is not identifying if say anything he is not able to understand. My docter said it is genetic problem come from mother she said it is not curable. Please suggest it is curable? What step s we need to take to improve my baby

The feeling when your in desperate need for a good video and Dr. Andy Galpin pops up 😭🙌🙌🙌

how does this work if you're in ketosis?

what about lactic acid?

awesmone doc, I a Triathlete and coach as well, i hav alot of problems with cramps so i have hear story here and there its nuts,, any suggestion

So, I'm not a scientist. But can you clarify if any of these molecules of pyruvate are related to ketones? I'm having a hard time understanding what ketones are.

So I heard from this that lactate isn't bad no matter how much you have in your body is that correct as it can be used for fuel? So what is lactic acidosis? I always heard that it was a bad thing and is it connected to lactate? Is lactate and lactic acid the same thing? I'm a bit confused. 😕

When lactate metabolism is occurring in the brain, which space in the brain does the byproduct of water go?

Great explanation! Thank you!

Awesome

Does lactate concentration increase as a direct result of not being able to take in and circulate enough oxygen for aerobic metabolism? In other words the more out of breath you become the more lactate accumulates?

is not lactose a contributor to sore and or cramped muscles?

You lost me just before ATP

Bless

So lactic acid has no role in creating an acidic environment within the exercising muscle? Its just the H+?

Get it at Galpin

Out of curiosity, is it lactate which is produced or is it lactic acid which is produced which is subsequently rapidly dissociated to a lactate and H+?

Hi Does it mean that if I am fat adapted and use fat as energy, less lactate is produced?

🙏

wonders how eating yogurt with lactobacillus alters the lactate in blood that otherwise gets converted at the liver.

Would this process be the reason you struggle for the first five minutes of your workout, but seems to get easier as it goes on?

Why does my chest burn when I'm running ?

I know this question will probably not get pickup , but does that mean , hydogen ions are only a problem when they don't get pickedup by the pyruvate?? Free floating ions? How does this happen?

👍🏻

A build up of lactic acid without the removal causes muscles to cramp up. To combat this muscle fatigue is to use carnosine.

Lactate and glucose are components of sweat.

You get an A from me.

I blame lactate for my marital problems.

What I want to hear is a sick/high sugar life style does is make YOU the cancer candidate without oxygen/exercise to burn these dirty calories.

Why do athletes produce less lactate than normal people

The big question is If i am fat adapted and eat less than 10% carbs for my 3-4 hours bike ride, will i have a higher lactate threshold than carbs addicted athletes?

uhhh I'm a THIRD year exercise physiology student. Where have you beeeeeen??

Dang life is weird

Andy, your hair has changed since this video, creatine side effect? Jk 👊😎

Maybe it will help if he uses less sarcasm

This is too academic, I am left clueless after I watched the whole video