What's THC Doing in There?

Рет қаралды 25,079

3 ай бұрын

How the brain works has always been a particular source of wonder to me. I was fascinated in how the dynamics of literal brain chemistry can change the entire computational process.
Recently I have been wondering more and more about what exactly "being high" means. What is happening on a biomolecular level when we ingest cannabis? What changes in neurons that causes things to be perceived so differently?
This video wound up requiring the most reading I've ever done on a topic. The exact biomolecular mechanisms are nuanced and still not completely fleshed out. Especially with regards to processes beyond the dopaminergic pathways.
But this should be a pretty comprehensive overview of getting you up to speed on what's happening.
Used Sources:
The endocannabinoid system - doi.org/10.1042/ebc20190086
Review of the Endocannabinoid System - doi.org/10.1016%2Fj.bpsc.2020.07.016
An Introduction to the Endogenous Cannabinoid System - doi.org/10.1016/j.biopsych.2015.07.028
Sustained Elevation of Dendritic Calcium Evokes Widespread Endocannabinoid Release and Suppression of Synapses onto Cerebellar Purkinje Cells - doi.org/10.1523%2FJNEUROSCI.1280-06.2006
Adenylyl Cyclase - www.vivo.colostate.edu/hbooks/pathphys/topics/cyclase.html
NEUROTRANSMITTER IDENTIFICATION AND ACTION: IONOTROPIC RECEPTORS VERSUS METABOTROPIC RECEPTORS - openbooks.lib.msu.edu/introneuroscience1/chapter/neurotransmitter-action-ionotropic-receptors/
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review - doi.org/10.3390%2Fbrainsci13020325
Endocannabinoid modulation of dopamine neurotransmission - doi.org/10.1016%2Fj.neuropharm.2017.04.033
CB1 Cannabinoid Receptors and their Associated Proteins - doi.org/10.2174%2F092986710790980023
Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits - doi.org/10.1038/380255a0
VTA GABA Neurons at the Interface of Stress and Reward - doi.org/10.3389/fncir.2019.00078
Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice - doi.org/10.1523/JNEUROSCI.1493-22.2022
Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice - doi.org/10.1111%2Fadb.13005

Пікірлер: 166

@ButWhySci 3 ай бұрын

At @2:30 I say we will focus on Anadamide today. Initially I had read significantly more papers and wanted to discuss the role of endocannabinoids in depression, anxiety, and stress. However, after writing and recording the sections on cellular mechanisms. I realized to adequately discuss what I wanted to, the video would be significantly longer. Since my schedule has been giving me less time to work on videos I removed that section. This line is a missed remnant from the original scope of the script.

@Piccolo_Sun 3 ай бұрын

ahh makes senses

@gahfwa3541 3 ай бұрын

What are some other types of neurons that are primarily regulated by GABA? And do they also fire more frequently when CB1 is bound by cannabinoids?

@ButWhySci 3 ай бұрын

@@gahfwa3541 Another place with a decent amount of GABA production is the hippocampus. Our memory center. There are very few concrete papers on THC and it's effects on the hippocampus. But one theory is that the GABA in the hippocampus is there to suppress neuronal 'noise' so only important and strong memories stick around. When you have chronic THC exposure the hippocampus becomes more noisy and it's harder to identify and consolidate memories. However, there wasn't any concrete proof/experiments I could find proving this one way or the other.

@Eulers_Identity 3 ай бұрын

Why is this video not getting recommended to people? Does KZfaq discourage potentially problematic topics despite the content having purely educational value?

@ImpossibleEvan 3 ай бұрын

So this is why bro hasn't uploaded in a while

@ENDESGA 3 ай бұрын

Lmao

@DwightMoses 3 ай бұрын

😵‍💫

@ButWhySci 3 ай бұрын

Ha! The real reasons were: I've had much less free time. I had to read a lot more than usual as biological processes are not as concrete as other fields of science. So papers are sometimes not super straightforward. Also I just didn't seem to enjoy animating this one as much as others.

@ENDESGA 3 ай бұрын

@@ButWhySci despite my "Lmao" I think you did a great job on the video. Thank you for doing your research!

@jtgd 3 ай бұрын

@@ButWhyScianimations are 👌

@MIKAEL212345 3 ай бұрын

Biology has to be some of the craziest, most time consuming complicated stuff to research. I literally can't even imagine how you even begin to approach researching something like a complex interconnected chain of reactions and biological processes. With physics I can at least understand the big picture of "better telescope to see things further away" or "faster accelerator to see smaller particles" but I can't even imagine how they would've researched this and isolated the biological system enough to understand it.

@marios1861 3 ай бұрын

"better imaging to see things in more details" "better chemical imaging to understand the landscape in which these reactions operate"

@yayaya4345 3 ай бұрын

Puzzles are done starting from the edges and then connecting distinct looking pieces together until it all slowly starts to look like something. I imagine biology is the same with each of the thousands of pieces being the life work of a team of scientists.

@mikzin630 3 ай бұрын

This is why people become so hyperspecialized in biology. In my major (biochemistry), I see faculty seemingly devote their lives to understanding just one protein or one pathway. It makes me question if I'll ever have enough obsession to make it in this field.

@GLOKI. 3 ай бұрын

@PBnFlash 3 ай бұрын

My cells are filled with ribbons, blobs and little acronyms.

@ch33zyburrito36 3 ай бұрын

Epic biology moment

@ahobimo732 3 ай бұрын

Biblically accurate cellular biology. It's surprisingly unhorrifying. 😃

@Gelatinocyte2 3 ай бұрын

Visual inconsistency, am I right! That's why I chose to look for Drew Berry/WEHI animation videos for biology lessons. The Protein Data Bank channel is there, too.

@pjaworek6793 3 ай бұрын

Fantastic much detail in short accessible video.

@Gelatinocyte2 3 ай бұрын

Dafuq happened to my comment? I had one here previously.

@freeridin 3 ай бұрын

i got stoned and watched this and i thought i could feel the shift from tonic firing to phasic firing in my brain.

@charlestaylor3195 3 ай бұрын

You have the most comprehensive graphics , the best I've ever seen.

@kinetic-cybernetic 3 ай бұрын

This was way more technical than I expected. The algorithm clearly overestimates my intellect.

@abavariannormiepleb9470 3 ай бұрын

A bit sad: 16 years ago I was assigned a talk in biochemistry class at university about this exact topic and it seems only very little new knowledge has been discovered since then :(

@mrlilhanna 3 ай бұрын

It could just mean that we figured it out. Weed might not be that deep.

@hi-im-morgan 2 ай бұрын

@@mrlilhannathat’s unlikely given the complexity of the metabolic pathway. Source: I study biochemistry

@existencegaming524 3 ай бұрын

This one of my favorite channels for information. You go into way more detail than anyone else and i love it.

@mastershooter64 25 күн бұрын

I love this channel because you actually read the papers of the field and go into some detail about the physical/biological processes behind the topic you're exploring! Never stop doing that!

@TheKiwijord 3 ай бұрын

These attention to detail and accuracy of the animations and explanations are top notch!

@nachocheese132 3 ай бұрын

I love this level of detail on the mechanism of action. Keep it up man!

@johnathancorgan3994 3 ай бұрын

What an outstanding video! It goes beyond the surface level "summary" and explains the details involved, without oversimplifying or condescending. The GPCR activation cascade in particular was nice to see. It would be great in a future video to look at the feedback loop from GPCR activation via beta-arrestin that results in tolerance and dependence.

@Idrizze 3 ай бұрын

I got more questions than I started with😭 What happens when THC is saturated in the receptors? Do the receptors become somewhat resistant or it’s something else entirely? Why do some people have tolerances more than others? Adversely, why do some people always get high every single time every day after many years without fail? What does weight and height have to do with it? What’s its or does it have an interaction with our adipose tissue? Why do some people have bad trips but others have great times smoking the same spliff? Why is it that some people, including myself, lack the ability to digest and feel the effects of THC in all formats, purity, and different time? Why does smoking and working out or working out and then smoking work so well together???? or is that a lie we all collectively believe or want to believe at least? What are the effects of the other phytocannabinoids in the human body in greater detail? What are the effects of the phytocannabinoids in the human body at different concentrations and with different consumption methods? Are there any benefits to them? if yes, what and how? Although it’s nearly impossible to OD on weed, what would be the negative effects (beyond lacing) of phytoc’s over the period of one’s life? With that same question in mind, how does this interact with one’s physical activity levels and cardiovascular and vagus health? Why does weed in all its glory work so well with people with ADHD and other neurological conditions that self medicate with it? How exactly do cannabinoids help people with conditions like ASL? Or completely unrelated conditions like anxiety and depression but also not helpful at the same time for people with schizophrenic symptoms? Last one might be unrelated but idk and a stretch. I got ALLLL the questions, i hope i can finally get answers for some of these questions. Outside my realm of answering but within my grasp of inquiry. And I wouldn’t even know how to test it. Can’t even ask my friends cuz I want science!! There’s so many more questions but the best answer is without it ✨✨✨

@randombreg-kv5pj 3 ай бұрын

generally, too much of a ligand will downregulate the production of the corresponding receptors. Receptors are just proteins, and are continuously produced. The rate of production will decrease. Some people have a higher tolerance because they are fat/tall -> more of the drug gets absorbed in other places besides where its intended effects are. (Increased volume of distribution for the same amount of drug necessarily means there is a lower concentration of the drug in any given place) Others have taken the drug for too long, and their receptor production have been downregulated. The concept that you should dive into that addresses most of your questions is pharmacokinetics.

@Idrizze 3 ай бұрын

@@randombreg-kv5pj thank you for replying bro/brodette. I’m already familiar with it but it would make for an amazing video if he went into further details as for a part 2. I’m sure there’s points i didn’t even mention that should be added in there too but it’s not really necessary. If someone really wants more info, google is right theree

@99jdave99 3 ай бұрын

I’m so sad that this video is very likely gonna get less views than your typical stuff due to delving into biology instead of physics! This is just as good as (if not better than, for such a great explanation you give here!) everything else you make! A seriously great video, I learnt so much! Never knew that there were endocannibinoids, let alone the slightest bit about all the neuro-stuff! I’m glad you touched on the lack/presence of CB1 receptors on dopamine, I was wondering why the GABA producers were getting suppressed but not the dopamine producers! I find it interesting how when they removed the CB1 receptors on dopamine the effects of cannabis lessened, I would’ve assumed removing the inhibitor’s receptors would’ve made the dopamine production/effect skyrocket, not the inverse! Maybe I misinterpreted things though, haha. Genuinely mind boggling how complex biology is when you get real deep into it like this, it’s awesome to get a guided tour into a tiny part of it! Thanks for the video, I’m sure there was a *lot* of research put into this, especially since it isn’t your usual affair! (Unless medical stuff was your “day job” prior to making physics KZfaq videos, haha; even in that case though, I’m sure a lot of research went into it regardless!)

@ButWhySci 3 ай бұрын

"I would’ve assumed removing the inhibitor’s receptors would’ve made the dopamine production/effect skyrocket, not the inverse! Maybe I misinterpreted things though, haha." You did not misinterpret things! Yes it is very strange. It is important to note that these experiments though are for mice and not humans. So things are likely not perfectly comparable. But still, it doesn't make straight forward sense right?

@FranBunnyFFXII 3 ай бұрын

Further question, why does THC make some people "trip" like they took a smaller dose of Acid? This is a rare but recognized phenomenon that happens to only certain people. Some people experience it only after using another psychedelic like Psilocybin, or LSD. For others causing a trip is the only thing THC does for them. Why does this happen in some people but not all people? What interaction causes a psychedelic experience when THC is involved?

@Pickelhaube808 3 ай бұрын

I happen to be one of these people, and I think it comes down to me being moderately schizophrenic. My first time doing THC was only a few months ago, but it was an incredible experience I will never forget... it was the only time I had an out of body experience and some aspects of it mimiced the times I've had psychotic breaks. I haven't had any out if body experiences since the first time, but the hallucinations continue (mostly visual, audio, and tactile) and it is quite a fun experience. I would want to try a small dose of a "real psychedelic" at some point, though they say that may not be a smart idea in my case.

@Piccolo_Sun 3 ай бұрын

interesting i would like to see a sample of these type of people so i could speculate based on their traits before dinging into the difference in function taking places in their bodies on ingestion

@a2pabmb2 3 ай бұрын

Psychedelic effects and mode of action are even less well understood than cannabinoids, though it was my, perhaps outdated, understanding and experience that THC (perhaps along with an entourage of other phytocannabinoids) is simply weakly psychedelic and people may be more or less susceptible to those effects as they are to many other drugs.

@FranBunnyFFXII 3 ай бұрын

@@Pickelhaube808 I am also one of these people, but I do not have schizophrenia. This has always happened to me on THC and nothing else. This is why it's such a fascinating question for me. What is the common link, if any, between people who use THC and their experiences differing from the expected outcome.

@SuperKamiGuruu 3 ай бұрын

*L i g h t W e i g h t s*

@tekjess_ 3 ай бұрын

Not the video I was expecting, but still really cool information! Great stuff.

@SuperKamiGuruu 3 ай бұрын

Because it's some good shit

@TheNotoriousDUDE 3 ай бұрын

This is the only valid answer 😂

@Jan12700 3 ай бұрын

A week to early for Weed Day on April 20th Also weed is now legal in Germany

@avondras 3 ай бұрын

Literally been waiting this video to drop 😮

@anthonynicoli 3 ай бұрын

Great explanation. It is very complicated.

@stockstreamtwitch 2 ай бұрын

This is awesome! I could totally get down with an ongoing cannabinoid series. Cannabigerol is a very interesting one.

@Aliberation 3 ай бұрын

Awesome content, please keep it up!

@sicfxmusic 3 ай бұрын

You mean "keep it high".

@reefchri 3 ай бұрын

watching while high really hits differently....also, finally, a video that explains the questions I have in good detail.

@kdeuler 3 ай бұрын

Great graphics and explanations. However, I'd have liked a high level conclusion statement that answers the videos title. (I'm synapse lacking.)

@ButWhySci 3 ай бұрын

THC binds to specific receptors that make it harder for those neurons to fire. This means some inhibitory processes in the brain are stopped allowing other processes to function at higher capacity.

@snowcat9308 3 ай бұрын

This is why I'm subscribed to this channel

@rushi2529 2 ай бұрын

Amazing video!

@eloquentvirtualacademy 2 ай бұрын

Great explanation

@snappycattimesten 3 ай бұрын

It’s amazing biological systems have homeostasis with these thousands of complex ongoing interactions.

@dappersnail8792 3 ай бұрын

Great video!

@Australian_Made 3 ай бұрын

Welcome back ✌

@Witcheridoo 3 ай бұрын

This video is slept on

@relentlessmadman 3 ай бұрын

great explaination however "I know no more that I did before but now I know all that I need!

@Jayderzomb 3 ай бұрын

Nice video very interesting

@FabioMarziali 3 ай бұрын

Yes a new video! And yes cannabis!!!! ❤

@TAWIDY 3 ай бұрын

Terrific video! Watching lit asf lol

@iulianandries2647 3 ай бұрын

Good video ❤

@48exa 3 ай бұрын

As a computer scientist, these kinds of videos only make me feel more and more like the brain is a type of computer running on code written in proteins that are assembled to atom blobs

@aymanibrahim1646 3 ай бұрын

love your videos

@abhayDBZ 3 ай бұрын

In future, could you create a similar video to describe (on a molecular level) on how addiction occur in humans? It would be quite helpful. Thanks.

@Pyronormalactivities 3 ай бұрын

Amazing 🔥

@MrEpic-97 3 ай бұрын

Sad that youtube doesn't recommend certain topics no matter what, even though so much effort went into this video😢

@TheTrueValkyrie66 3 ай бұрын

KZfaq subscribed me to this channel out of nowhere, thanks I guess?

@shaynemaskall6984 3 ай бұрын

Part 2 please!

@ahobimo732 3 ай бұрын

Great video. Very thorough. So... why do we get high?

@SteedRuckus 3 ай бұрын

"Now it should be clear that..." Me: Ah, yes, of course, absolutely understood all of that 👌

@boerhae 3 ай бұрын

zooted right now learning some cool info i might not remember

@RafaCB0987 3 ай бұрын

Biochemestry is soo cool

@lemonke8132 2 ай бұрын

I saw in a comment you said you were applying machine learning to climate science. I was wondering if it's possible to use a protein folding model (like alpha fold) to engineer an enzyme that would capture and store co2?

@imhollywood101 28 күн бұрын

At 4:45 i realized i was to high to watch this video. 😂

@mazthehe 3 ай бұрын

My question is can a person have a not reaction to stimulants like caffeine or cannabis to act Like a non stimulant and the contrary too

@azorthegreat2112 3 ай бұрын

I think it has something g to do with the receptors growing. First times you use TCH you don't get high.

@HUEHUEUHEPony 3 ай бұрын

ok now give us the video files

@Irondragon1945 3 ай бұрын

Babe wake up ButWhy uploaded

@urahara228 3 ай бұрын

Yeah

@user-fj2me7wp4k 3 ай бұрын

Did this video get age restricted or something? I would have really liked to see it when it came out but it wasn't recommended to me.

@BurnoutDurb 3 ай бұрын

Algorithm really smothered this.

@jtgd 3 ай бұрын

Be me. Be high. Watch this

@robertridley-fj8zz 3 ай бұрын

I have enjoyed many of your videos, but I prefer your physics based content.

@razercp9322 3 ай бұрын

At 3:45 it says GCPR

@benruniko Ай бұрын

Thc doesnt do anything for me except help me get some really good sleep. Makes me tired and dumb. I wouldnt personally describe that as a “high” since no elevated feeling or mood is associated. But im aware this is probably just me and how screwy my brain is.

@cw6043 3 ай бұрын

the lil' animated guys are high

@drklrsn 3 ай бұрын

Hell yeah

@exoendo 3 ай бұрын

magic, got it.

@tylerfrankel5374 Ай бұрын

I’m wayyyy to high to understand this but the graphics are cool

@vinniepeterss 3 ай бұрын

❤❤

@TeslaElonSpaceXFan 2 ай бұрын

😍

@jbtechcon7434 3 ай бұрын

I still don't know why they get us "high"

@ryanatkinson2978 3 ай бұрын

*blinks* ... wait what

@OrchidNectar 3 ай бұрын

I know why but I'm watching this video to celebrate

@Chfrchko-144 3 ай бұрын

damnm it ecplsine alot

@Benson_aka_devils_advocate_88 3 ай бұрын

You can't leave us with "recently deceased people" and not tell us about that research...

@whyres5381 3 ай бұрын

cause smoke flies up as it lighter than air 💥💥💯💨

@BakaPheeze 3 ай бұрын

He Just waited Till it's legal in German to smoke it

@WaxPaper 3 ай бұрын

Are you comfortable saying if you've been high a substantial number of times? Because as someone who has, this explanation is wholly unsatisfying. The dopamine angle seems sus, because there really isn't any euphoria or feeling of contentness with THC. Unless you're saying the reward pathways are learning to select for the novelty of a THC high over time, because it's novel in the same way as anything that gives us a dopamine hit, then I don't get it... And what I was really interested to know is, what causes the actual feeling of being high, which is so unique from other drugs? Is it the slowing-down of synaptic firing, that you touched on? Does it have something to do with GABA mediation? What mechanism is actually being induced when those receptors are activated? What evolutionary function did that serve? These are the types of answers I was hoping for.

@imVersa 3 ай бұрын

Us?

@CraftyF0X 3 ай бұрын

Dude, Im on yt for a while now, I saw quite a few things. Nothing competes with this, the animation, the detailed research, this is something else... congratulation you are going to be huge ! I predicted the rise of channels before like Captain Disillusion, 3blue1 brown, or Veritasium and many others, back when they had a few 1000 subs. You are firmly on that track !

@tbird81 3 ай бұрын

Doesn't have the "killer instinct" of a narcissist like V.

@YeloPartyHat 3 ай бұрын

This goes very low level without much context. I got lost very quickly.

@methylmike 3 ай бұрын

i do love me some good cannabis

@excfontec6272 3 ай бұрын

Video was hidden from my feed prolly bc of drugs

@Piccolo_Sun 3 ай бұрын

there is so much going on. i feel if it is broken into parts like this the bigger picture understanding of what is going on will be hard to grasp. i feel it will be easier to to top down approach like a tree. or a van-diagram set theory big picture first then effects of the high group into factors that cause those effects. any who good stuff ill need to watch this a few times

@michaelgilchrist6255 2 ай бұрын

i love weed can you do more on the other molecules please

@andromeda8505 3 ай бұрын

the way you say endocannabinoid makes me laugh

@Hecarim420 3 ай бұрын

👀ツ

@Vinni-2K 3 ай бұрын

tsu

@matttrophy1 3 ай бұрын

All I can say is, Huh!

@KurusuPanda 3 ай бұрын

Couldn't've waited a week? Lol

@Yezpahr 3 ай бұрын

8:52 I'm gonna be a total Dunning Kruger here and come with a theory, I personally think the difference in cb1 receptor counts between the two papers could be due to the plasticity of the brain, in combination with either natural resistance or built up resistance. Would this make sense? I have absolutely no idea really, that's why I started with the Dunning Kruger approach. Brains are naturally random in nature, because they're built from experiences that are random in nature, a bit of tweaking in vito by the brain itself isn't unheard of.

@yayaya4345 3 ай бұрын

I don't know any more than you, but I would assume the papers had a sample group large and diverse enough to account for variance in receptor spread between individuals.

@Yezpahr 3 ай бұрын

@@yayaya4345 That's a fair assessment, the information we were given didn't lean in any particular direction so we're left with theories. My theory only works if both studies were done correctly, and that's not necessarily true so my theory is on wonky ground. The problem is that if both studies had that diverse sample group they would have eliminated the extremes and those extremes could be random in nature, leading to a difference in the properties of sample groups. I only see it as a possible point of failure, but it's impossible to say that definitely was responsible for the differences.

@abhinaym1017 Ай бұрын

This level of research and content for free feels illegal to someone who pirates stuff, Do you have any pateron or something of that sort? Would be happy to pay whatever I can.

@antoniopacelli 3 ай бұрын

You're speaking to the wrong person... I Delta Tested this 30 years 2:10 You missed CB3 Receptors

@Vinnie_728 3 ай бұрын

weed

@kunai9809 3 ай бұрын

I have a criticism, but it's hard to put together. I don't know how, but sometimes, it is only at the end of a sentence that I understand what you wanted to say and until there, I can't connect what I'm hearing with what I'm seeing. for example 0:26 the new scene is there, I need a moment to process what I can newly see but you instantly start to talk. And you don't start with what I see, you start with "the endocanabinoid system", which doesn't refer to the thing on screen so it doesn't help explain what I see... In this case me reading "endocanabinoid system" (not a common word to read) does not line up with you saying it, making it harder to follow. And the moment you say what I see - "synaptic communication" - is when the scene changes away, resulting in a "wait, what? let me rewind" moment. To be clear, it's not really hard to follow because of the topic... I know neuro science basics, but the way you phrase things interacting with what's on screen is sometimes sub optimal. I hope you get what I'm trying to say...

@kunai9809 3 ай бұрын

compare that to 0:35 "these are released" - you see particles being released a second later you say "synapse" - the word appears on screen a second later this is perfect to follow!

@Chfrchko-144 3 ай бұрын

еееееееееееее

@Nightscape_ 3 ай бұрын

Just had Delta 8 flower for the first time here in Kentucky. It was the worst tasting thing I had ever experienced and made me sick to my stomach. What they did to this flower is a crime against nature. I miss the real farms back in Oregon and Cali.

@piconano 3 ай бұрын

Are you telling me our bodies with this level of complexity rose from only a few million years of random mutations? And the same thing happened to all the animals? They are all close to perfect for their role! Where was Murphy and his law in all this time? Whatever happened to entropy? As far as I've be taught, the universe goes from order to disorder/chaos. Not the other way around. I enjoyed watching your video stoned. 🙃

@babynautilus 3 ай бұрын

disinhibition woo

@benwaffleiron Ай бұрын

cabbage brain

@EricCatlin425 3 ай бұрын

Weed makes us high because we smoke it.

@jaydeep-p 3 ай бұрын

This is what I would expect from someone who's high 😂😂

@Piccolo_Sun 3 ай бұрын

@@jaydeep-p no way some one who is high has very deep thought about everything it is just when you are high it take effort to control the focus

@Gamemake 3 ай бұрын

0 views

@adampezzuolo5618 3 ай бұрын

This video is way too complicated, i understood maybe 2% of what you said

@yayaya4345 3 ай бұрын

I also have trouble following biochemical pathways in cells. It's like reading a sentence with double negatives. "I ain't never found no way to not be nervous"