I ended up down a really interesting rabbit hole when reading about drugs derived from natural sources. I thought I'd drag you in with me. Hope you like it! Check out Dom's channel: kzfaq.info/love/GI000V6ZIAQf97MNybAaLQ Sorry for the big gap between videos! I had a book deadline then went on Holiday :)

"I collected this myself" Oh cool "From a website" Oh "Called eBay" *Oh*

For any pedants out there, the precise Tim Minchin quote is: "By definition...alternative medicine... has either not been proved to work or been proved not to work. Do you know what they call alternative medicine that's been proved to work? Medicine." I can wholeheartedly recommend Storm, the poem from which this quote comes.

thought this was gonna be a video about people throwing pills in the ocean. was pleasantly surprised

There is also a dull logistical reason why the ocean is such a rich source for new medicine: humans live predominantly on land so most of the medicine we've stumbled upon in large quantities through human history has been sourced from there. Thus, if you want to find something new, look in the ocean where we haven't looked as much so far. It's the same reason why new species are discovered in remote areas, it's not that all those areas have a greater diversity of life, it's just that less people have been around to look for them until now.

Only legends make 9:58 videos

"Scientists going down in submersibles and collecting samples with their robotic arms." I can't get the image, that all scientists are equipped with robotic arms, out of my head :) -You call yourself a scientist? Then where are your robotic arms!?

The animations were very noticeable, in a "has Steve been learning animation? He's pretty good at it already." way.

I studied medicine and I got to say that, your topic was not an easy topic to explain or even a fun one but I have to admit you made it into all of that and was educational in many ways. Great job keep up the good work.

I've read the title so I think I have a good grasp of the content of the video. You're saying we need to chuck cancer patients in the ocean for medical reasons?

The difference between medicine and poison is dosage.

Yet another quality 9:58 minutes spent. Your videos never get old, always top quality content.

Big fan of yours keep going with more experimental videos... Absolutely love them

Thanks for the shout out for Every Think. I haven't found that channel previously. I think it would be cool to recommend one channel that you find worth watching at the end of your every video.

Another fantastic video, thanks for the upload Steve!

This is my new favorite channel. I also appreciate Curious Droid, Smarter Every Day, Scott Manley, Smithsonian Channel, and IntlSpyMuseum.

Why couldn't my school biology lessons be like this?

3:21 "There's no such thing as poison, only poisonous doses".

This video was awesome!! The quality is amazing, love your videos :)

There is so many who will be so great full for your findings. The work you do is amazing and life changing. Thank you

Incredible. So much data in such a short time, and so well explained. Thank you so much!

That was an amazingly fascinating video! Great job!

They cleaned you up real good for that Body Shop commercial. hahaha. Steve Mould smizing.

Minchin shoutout! Great video as usual Steve, thanks.

Animations were awesome! Also very cool video.

This was absolutely fascinating. Really succinct and easily digested explanation of something that, I imagine, is incredibly complex when diving down into the details.

Loved your video bro

Top content as usual! Very interesting!

I really enjoy how you take the time to do recaps midway through. Great video Steve!

This is really intrasting. Thank you!

I didn't think you could up the game in your videos. These animations did it. You two should collaborate more. :)

Saw three videos over the span of 3 weeks and subscribed...

Nice video! Keep doing them😊

Wow that was an excellent video, interesting facts and excellent explanations

Dosing is important when using medicines like this. Curare, mentioned in the video, lends a derivative medicine called generically cisatracurium (Nimbex), which we use in medicine to paralyze patients (for example when their breathing is disynchronous with a ventilator). Snakes, of course, want their prey to overdose so they are paralyzed and die. Just the right amount is useful, however. The same is true of the blood thinner coumadin (Warfarin), derived from sweet coumarin, a grass. If an herbivore were to eat too much, the blood is thinned too much, it dies, and there's one less thing eating that plant, the plant lives on. With the right dose titration, someone who's had a heart valve replacement, for instance, can have their blood thinned to perfection and not form clots around the new valve. Coumadin was also used as a rat poison, injected into apples, the rats would overdose and bleed to death. So there's that: rat poison for heart patients. And on and on in nature: salicylates (where from aspirin is derived) in willow bark (Latin _salus_ means willow; salus, salicylates). The ancients knew willow bark would cure a headache and also make you bleed more. Defensive -- sometimes merely harmful, sometimes fatal -- mechanisms from the natural world, sometimes tweaked with a small change in chemical functional groups, and dosed properly, can be life saving.

As a biologist who studies nudibranchs and the sea floor here in Thailand, I love that you're talking about this! I never thought I'd see this on your channel as I subscribed before the saga of the Mould effect. Great stuff!

Great video! You have just taken my attention down a new rabbit hole where I will be hyper-focusing. LOL...

Thanks for your sharing 👍

Oh yeah, that eBay site... I have heard of that site before, doesn't seem too well-known though.

I was already going to like this video when I finished watching, but then you quoted Tim Minchin and I had to pause and immediately like it!

From the title and thumbnail of the video, I assumed that this video was going to be about how a freighter carrying pharmaceuticals had a mishap and dumped its contents into the ocean. Regardless, I enjoyed the video! Always a pleasure to watch your content.

Just great video

I like the videos you make

6:00 Oh I love that quote, and that guy (Tim Minchin) 😊 Thank you Steve for bringing that up

SIMPLY AMAZING!!

you earned a follower by mentioning Tim

really educative

This is so interesting!

As a chronic pain patient this is super interesting

The fact that I've just studied this and it gets recommended to me is quite interesting

Tea tree oil is used in the aquarium hobby as a treatment for mild infections. I'm convinced it works, helped one of my green severums out of the woods once, the second time I had to ruin the aquarium cycle and does kanamycin as well though.

Super interesting 👍🙏💪

I saw an article about some new cancer medicine just this morning on reddit, it might be what Steve talked about here.

Omg sponsored by the body shop. Very noice

I collected this myself..... From a website... All by myself. Like a big boy. Im just taking a piss. I think Matt Parker loves your videos. That's good enough for me sometimes. 👍

Great video. Do you have a typical researching process you go through when you go deep down a rabbit hole on a particular topic? I find that, after reading through dozens of nested links on Wikipedia, but before pulling up academic journal articles, I lack a go to resource which is lighter and broader than journal articles but more rigerous and reliable than Wikipedia pages.

Really enjoyed the video and noticed the great animations. If you allow a small criticism, I missed the names of the drugs you mentioned written on the screen. Since English is my second language, it's quite hard for me to make out the names just from sound, so it would really help to be able to read them (I know you put on the description, but I don't look there while the video is playing). Thanks a lot for the content!

I like ur videos

This is so cool 🤯🤯🤯

Something I think is worth considering is that there's very little economic incentive to do research on herbal remedies because they aren't usually patentable. It's wonderful that we have so many drugs that could only have come from industrial infrastructure and we would definitely be worse off without them, but I think there's something to be said about drugs which could be reasonably manufactured and distributed with less industrial infrastructure. I hope that we do more research on herbal medicine because it is legitimately superior in terms of accessibility.

hey, thanks for the video. would you mind stabilizing the vlog shots a bit in the future? there's good software for it nowadays and i find it quite annoying.

Interesting video. I was watching Blue Planet II the other day and they mentioned medicinal properties being found in ocean creatures, so your video is timely. But I feel the same reaction having watched your video and that is that our oceans don't need another reason for people to pillage them, because they are already in such peril from people.

3:35 If you focus on the spinning molecule you can sometimes see it rotate in both directions. One of them feels a bit weird and the ilussion brakes.

Those dang crabs are getting high again

I'm an M.D. That quote from Tim Minchin is an excellent way of restating something I've been telling my patients for 40 years: There are two kinds of treatments -- those that work, and those that don't. Once an "alternative" treatment is proven to work, we all use it, and it becomes "mainstream". If it doesn't work, it stays "alternative".

There is also another type of drug, now most commonly used for chemotherapy or therapy of rheumatic diseases: Immunoglobin. There are a lot of start-ups now looking for a specific immunoglobin, which specifically binds to a receptor/enzyme etc to stop a growth signalin the cell. There has been a lot of success recently with different types of cancer and led to a better understanding of cancer as well. For instance "Her2/neo - positive breast cancer" can be treated with a monoklonal antibody called trastuzumab, which has greatly reduced the mortality of this specific cancer type

Curare is used (as far as I know) only in general anesthesia, when you don't have to move your diaphragm, cause a machine does it for you. It prevents patient from moving or contracting muscles in reflex to some kind stimulation when he is undergoing surgery. Other then that it is not used.

The eBay jokes was really good

I honestly thought this was gonna be about a lost container full of cancer drugs or something like that.

I love how diverse and inclusive cancer and virus tend to be.

A pharmacist once said that there is nothing poisonous or medicinal inherently, it's all about dosage

Hmmm very interesting

Wow new video

4:57 it shoud be ,"transmition up the neurons that transmit pain" sensations and info flows up to the brain, movement flow down

The title makes it sound like we’re finding residue of cancer drugs in ocean water, which is much less interesting than what the video is actually about hahahaha not sure it’s criticism, just a little tip

I quite like the tim minchin quote (look up "Storm - Tim Minchin" for those who want to know more) I think it holds some truth although the quote is, as the rest of the song is (i guess willingly), quite incisive ^^

There is a folk remedy against constipation in Slavic countries (such as Russia and Ukraine) for children. It basically is a garlic juice enema. It varies a little depending on region: some use onion instead of garlic some administer minced or sliced garlic instead of it's juice.

I thought he was going to say that we find these compounds in nature because they're much too complicated for us to synthesise ourselves

I think some people use different definitions for alternative medicine just like with the word theory. So some will say they are using alternative medicine, when using some medicine that actually works but wasn't prescribed by a doctor.

4:40 ha ha ha really clever idea

How do you find these rabbit holes man?

It's fascinating there is a cure for everything in the oceans.

just a calm video :D

Well, they still do the same thing for us and for the organism it created it. Effect is the same but dosage is what makes it beneficial or detrimental.

Let me get some of that conch dope

Psilocybin is a snail poison but is a psychedelic for humans

Damn I thought I could get drugs on the beach

Ocean a.k.a. the big "Sea"

It sounds natural that we find useful molecules in the nature because we live in the nature and we evolved in the nature.

Usually when you hear about drugs being found in the ocean it's not for good reasons.

Another reason why we're finding cancer treatments in the ocean is probably that among the treatments we're looking for, cancer is the one we're most looking for and most funded... That reasoning with real estate would also apply outside the ocean. The liquid for discemination is a strong point for marine research though.

The problem with the cone snail is that there are 100 different types of toxins that they produce and each snail has different selections of those 100 than every other snail kinda like a snowflake except they can develop either paralytic (for hunting) or pain (defense) depending on what's going on in their life (if they're being hazed by other animals or left alone)

Lucky we are overfishing and leaving nets in the ocean to destroy all the competition for pharmaceuticals

Rabbit holes are my favorite

there are many benefits to being a marine biologist

cool

I’d be interested to see nanobots that assist in maintaining DNA integrity, break down foreign threats, maintain the nerve system, brain, and bones. Could you see the length of lives increase, the ability to heal from wounds more easily, look younger for longer, and the ability to remember more of what you learn.

i collected this shell myself...from a source called eBay lol

Bayer Pharmaceuticals created and marketed Heroin to be a "non-addictive" substitute for Morphine as well. As it turned out, effective painkillers will always be addictive to humans, no matter how much we might want to believe otherwise. Saying that a new drug will be a better painkiller free of addiction is a dangerous bit of speculation to be spreading around.

Where can I get that I have spine tumors and am in so much pain!