Learning about replication without actually seeing it makes actually no sense. A must watch for anyone studying biology-related sciences.

Here is a basic & simplified version of the video: BASICS: Adenine --> Thymine Cytosine --> Guanine PREPARING TO REPLICATE: -Helicase splits the DNA for replication -Primase adds RNA bases (primer) to the leading strand. -Why does DNA polymerase require a primer before it adds DNA nucleotides? It is because the RNA primer will have a free -OH group at the end that it can nucleotides to! -DNA Polymerase binds to the primer to start replication! REPLICATION: -The leading strand TEMPLATE will have a daughter strand that is created 5' to 3', in the direction of the REPLICATION FORK (where DNA becomes uncoiled). -The lagging strand TEMPLATE will have a daughter strand that is ALSO created in the 5' to 3' direction, but it will replicate in the OPPOSITE direction of the REPLICATION FORK. -That's not okay! Because it is in the opposite direction of the replication fork, it needs to be made in fragments (Okazaki Fragments). FINISHING TOUCHES: -Exonuclease removes the RNA primers that were added to the start. We don't want RNA in our DNA! -DNA polymerase then adds DNA bases to the missing spots where the RNA primers were. -Ligase makes sure all the fragments are sealed CLOSING: -DNA is described as semi-conservative because there is one old and one new strand of DNA in each DNA. Thanks and hopefully this will help you for your bio test I know it did for me :)

Almost 8 years ago and this is one of the best DNA replication videos I've ever seen so far! Great visualization!

Step 1: Helicase Function: Helicase is the initial enzyme in DNA replication. Its primary function is to unwind the DNA double helix. It accomplishes this by breaking the hydrogen bonds between the complementary base pairs, such as A-T and G-C. By doing so, helicase separates the two DNA strands, creating what is called a "replication fork." This single-stranded DNA region is where the actual replication process will take place. Step 2: Primase Function: Primase follows helicase. Its role is to synthesize RNA primers. Primase adds short RNA sequences, known as primers, to the DNA template strands. These primers are essential because DNA Polymerase, the enzyme responsible for adding new DNA nucleotides during replication, can only extend an existing strand. On the leading strand, primase synthesizes a single RNA primer at the 5' end, providing a starting point for DNA Polymerase. Step 3: DNA Polymerase III Function: DNA Polymerase III is the primary enzyme responsible for DNA synthesis during replication. It adds nucleotides to the growing DNA strand. On the leading strand, DNA Polymerase III synthesizesthe new DNA strand in a continuous manner by extending from the 5' to 3' direction, using the parental DNA strand as a template. This strand doesn't encounter the same challenges as the lagging strand, which requires a more intricate process. Step 4: Exonuclease Function: Exonucleases come into play after DNA Polymerase III. Their function is to remove RNA primers from the DNA template. Once the RNA primers are synthesized by primase, exonucleases degrade them, creating gaps in the DNA strands. On the lagging strand, multiple RNA primers are synthesized at different points along the template to provide starting points for DNA Polymerase. Step 5: DNA Polymerase I Function: DNA Polymerase I is an enzyme responsible for gap-filling. After the removal of RNA primers by exonucleases, DNA Polymerase I replaces the RNA nucleotides with DNA nucleotides. On the lagging strand, DNA Polymerase I works in a discontinuous manner, filling in the gaps created by the removal of RNA primers and synthesizing short DNA fragments called Okazaki fragments. Step 6: Ligase Function: Ligase is the final enzyme involved in DNA replication. Its function is to seal the nicks or gaps in the DNA backbone. It does so by catalyzing the formation of phosphodiester bonds between adjacent nucleotides. On the lagging strand, ligase joins the Okazaki fragments together, ensuring the integrity and continuity of the newly synthesized DNA strand. In conclusion, DNA replication involves two strands: the leading strand, which is synthesized continuously, and the lagging strand, which is synthesized discontinuously in Okazaki fragments. Different enzymes work together to ensure the accurate replication of both strands, preserving genetic information during cell division and ensuring the inheritance of genetic traits.

As a senior bio major I shed a tear watching this... so beautiful

Τhis was actually the only video that made me finally understand it..good job :)

im literally crying because this is so good. merely reading the process just screwed me. thank you so much for the efforts.

I'd lost all the hope that I'd ever understand replication, after watching this precise , short and easy-understanding video , I'm feeling refreshing now. Hats off to that person who made this...

My biology teacher explained really good and now seeing this video makes dna replication totally clear to me. Thank you!

Take notes, biology teachers. This is how you teach this.

This is actually one of the best animations I've ever watched. Super clearly explained in under 4 minutes. Fantastic!

I learnt DNA replication from ritu man seriously telling mam ki lecture ki baad animation ki jarurat nhi hote h pr m ne yeh dekha or bhi clear ho gaya❤️🔥why not school teacher teach like this ??? Fir bol te h bache nhi pdh te

This video is amazingly incredible. It is precise, up to the point and explains everything in 3:28 min with clear voice with synchronized animation. This video is the best that explains Dna replication on KZfaq. It probably deserves a million likes

I’m French and I’ve understood it better in English because professors or unable to EXPLAIN IT CLEARLY IN A SIMPLE WAY !

2024 attendence here ❤

حيا الله طلاب السادس العلمي بويه Final year high school students in Iraq welcome you 🥲🇮🇶

Only video that's straight to the point and explicitly states all the steps .. THANK YOU!

A 3.30 min video made me understand what 3 lectures of 2 hrs each couldn't !

2024-25 students batch😅

this just brings me back to life and makes me forget every "imperfection" I think I have

The best replication animation i have seen yet, thanks a lot!

i just passed my biology daily test today about dna after i watched this yesterday night. I wanna give you a BIG thankyou for helping me study☺

Any neet student here😅

I love how the first strand replication process is very simple, while the second strand replication is 100x more complicated lol.

Finally can understand how lagging strand is replicated. Thank you!

my mind is blown this is the 100th video ive watched tonight and it is the only one i understood god bless

Very helpful animation! Thanks for visually showing the difference between an RNA primer and an Okazaki fragment; that made it easier to understand.

This 3 minutes video was more helpful than my madams 3 hours long class. Failed to understood a single word there Thanks!

It's so interesting to know how our body is made so intricately and it functions in a way that is beyond anything that we would make artificially.

This was by far the best video I've seen of this. Straight and to the point, no annoying music, and simple visuals. Absolutely fantastic!

Anyone here because they're gonna turn spiderman with a new experimented dose of spider genome lol

I am an Egyptian student at my third secondary school year and this video helped me to imagine and understand a topic in my curriculum. Thanks a lot!

Anyone else here because their professor cannot explain things simply?

I don't understand why teachers can't explain like this ; slow and straight to the point . All they do is draw a diagram ( totally not realistic ) and ask us to write notes . And we are like lol what just happened .

I'm in my senior year of high school. I'm learning protein synthesis and DNA replication. I really like this animation, it's great to have universal scientific facts even in a different language! My teacher's voice echoes in my mind

Yep this three minutes video somehow explains the topic better than my teacher on an 1h lecture.......

How on earth did someone discover this and all the details?

Life is so perfect.

Who's here after vipu bhaiya's class 😅?? Lakshya 1.0

As a senior bio major I shed a tear watching this... so beautiful so beautiful so beautiful so beautiful

As a science teacher this is by far the best replication video out there. Thanks for the clear description!

Easily the best replication video I've seen to date, thank you. I don't understand why it's so difficult for professors to explain this in a simple step by step process. I get that it's a complex topic, but damn, just go step by step. Stop talking about random enzymes in no discernible order.

My professor litearlly took 8 lessons to explain this process and almost nobody got it, it’s way simpler than I thought thank you

Best and easy way to understand and better than protracted videos

That's a gem. Three & half a minute is more precious than three & half an hour without seeing the animation.

I think that my biology teacher didn’t actually know how to explain this so he just resorted to this video lol

thank you for doing this - from a Vietnamese student at high school.

The best guidance for DNA replication and anyone can understand smoothly...Thank you

As a 3D artist, I feel it’s awesome to see these types of animations being used in education. Keep up the great work!

Best video ever to show DNA replication! No other video that I could find really explains in a short but well detailed manner. Other videos I feel are for those who are already familiar with the process. This is my first year learning this process and I'm grateful I found this video!!

here from vipin sharma sir pw

'The best things in life are available for free' this video totally proves it. Thank you so much

After 20 minutes of watching videos and re-watching them, this one did the most at helping me understand the process.

한국어 자막 달아주신분 감사합니다 덕분에 잘 공부하고 갑니다

Actually once you see it you can never forget DNA replication, thank you very much.

This 3-minute video explained the concept better than a 90 minute lecture by my professor.

This was very helpful, I've been studying this for a few days now but I've always had a fuzzy picture of how the lagging strand is formed. Your video cleared everything up. Thank you!

this is so magical that i can’t stop rewatching

Crazy 👌👌👌 best explanation of replication I have EVER seen. World class biochemistry textbooks also struggle to explain it the way you did in just over 200 seconds. Amazing video ❤

Perfectly summarises everything.

Excellent animation. I wished it showed how topoisomerase did it's work in separating the overcoiled knots of daughter DNA strands.

The old but gold DNA replication 😁 This is so inspirational. Thank you so much, It helps a lot in learning, but also revising.

Student from Iraq There are two days left until the ministerial exam for biology , I'm here reviewing the subject

Very easy to understand whole process of DNA replication through this video...thanks a lot😊

I'm so glad I speak English. Here in Brazil we have amazing teachers, but i'm a more visual student, so it's a lot easier to learn with 3d videos

Biology teachers should learn how to teach replication and some other topics soo easily as in this video. Finally I understood Replication with the help of this video. Thanks a lot 👍👍👏👏😊😊

DNA REPLICATION (semi-conservative bc each DNA molecule is made up of one old, conserved strand of DNA): 1 - separation of 2 strands (unzipping done by helicase, result: replication fork) 2 - separated strands provide template to create new strand of DNA (started by primase, which creates a piece of RNA called primer --- this is the starting point of the new strand of DNA) 3 - DNA polymerase binds to the primer and adds bases from 5' to 3' (in the leading strand). on the other hand in the lagging strand, DNA polymerase adds bases in a series of small chunks called the okazaki fragments 4 - once the DNA has been made, exonuclease removes all RNA primers from both strands of DNA 5 - another DNA polymerase fills the gaps that are left behind with DNA 6 - DNA ligase seals up the fragments of DNA in both strands to form a continuous double strand

Simple, Effective, and Efficient. This applies to both the Video and the Replication process. Can't Thank you guys enough for making my life easier.

Such a short clip is worth more than a thousand books.

Short and concise! Best explanation I found so far on the internet. It also shows how easy it is for this process to make small mistakes hereby distorting the DNA replication process with all the consequences that follow.

Who is after Vipin's sir class? [Lakshya NEET 2025] ❤ 👇

My god this 3 minute video single handedly gets me though the exam. Thank you so so much for ever making this video.

This is sooooo amazing with 3d visualisation I have chills when watching this... Gonna watch 9-10 times probably to remember it better...

I must say, for the very first time I can really understand what DNA replication is all about.... Thanks a lot for such a amazing video

しっかり海外でも岡崎フラグメントになってるのなんか感動

this is the best explanation I've ever watched!!

Wow you are a life safer. Thank you so much. This animation should be shown in every biology class on this topic. Edit: I suggested it to my teacher. It might have an impact. Good job!!!

Out of all the DNA replication videos this one is so good, very detailed and easy to understand thank you

My teacher teaching 4 hrs understanding 2% Learning from u 3 min understanding 100%

Learned more from the 3 minute video than I did from my professors 2 hour long lecture that mainly consisted of word vomit and pointing at words on a PowerPoint. Thanks

정말정말정말 감사합니다 Thank you sooo much 자막 달아주신분두요ㅜㅜ

What took Biology 12 between 3 - 4 weeks to explain, explained in 3 minutes. All I’ve got to say

Amazing❣!!! You have nailed it in minutes. I love how you explained everything about DNA replication. It was perfectly matched with an animation that adds to the total presentation. Your video is fun to watch and easy to understand👏👏

One of the best videos on the internet, so underrated

can't believe i haven't found this earlier after so much of my time wasted trying to look for a simple explanation like this. thank you so much i finally understand it.

My life I must be a visual learner this is the first time i have ever had a clue about the lagging strand

I can see how i wasted 1night understanding dna replication. And this video did it in 3mins. Wonderful just wonderful explanation.

Aur lakshay valo😅

This is one of the best videos for explaining DNA replication, thank you!

Finally I'll be visualize the process of DNA replication

I said it and repeat : It's the best type of explanation ever.

I think this vedio shoud be a teacher guide for our biology teachers 🙂 hats off to the creator of this vedio♥️

One of the most helpful video I've ever seen. Thanks for it.

god bless the maker of this video.Finally I have understood the process of DNA replication. Its really Owsome!

This video is super good in helping visualize the entire replication process. Although I think there was slight oversight in the direction of the DNA strand because in the beginning of the vid, the top strand was labeled 5' on the left side and 3' on the right side, but when DNA polymerase was introduced, the top strand was suddenly 3' on the left side and 5' on the right side.

Anyone here just because they were curious and are not studying any related majors?) I read about genes from a book but it was only information dump, so grateful to whomever made this animation, very useful 🙏

hands down the best video explaining this concept, and trust me I looked at lots

I learned more biology in this video than 10 lectures worth of biology i am amazed

Simple and comprehensive video .. At first I thought it was an obscure concept , but after watching this video I got it...

Thank you so much, I had to learn for my biology exam today and this video made things al lot easier to understand!!