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@annaso6747
@annaso6747 11 сағат бұрын
Incredible video! Loved the focus and re-emphasis on the mechanistic steps, really helped drill it in!!
@DrMahmoudinshallah
@DrMahmoudinshallah 3 күн бұрын
fructose-2,6-bisphosphate (F-2,6-BP) is the enzyme that inhibits Gluconeogenesis. Thank you for your video
@rm_ii66
@rm_ii66 7 күн бұрын
THANK YOUUUUUU!!!! you saved a lot of us
@FrontierThesisYU
@FrontierThesisYU 9 күн бұрын
Does gluconeogenesis happen in the fed state as well?
@thebox3291
@thebox3291 9 күн бұрын
Thank you so much for imparting your knowledge and connections in a clear and direct way, you're amazing for sharing this!
@patches4170
@patches4170 9 күн бұрын
I wish my university professors were like this :D Such a fun, maniacle way of explaining
@Brokenboy2350
@Brokenboy2350 10 күн бұрын
z
@sheylanigrey
@sheylanigrey 12 күн бұрын
"can't we take acetyl-COA to go in this direction to form this guy to then be used to make glucose?" "well nOoOoOOO!"
@kerrykalia2076
@kerrykalia2076 13 күн бұрын
amazing video
@kerrykalia2076
@kerrykalia2076 13 күн бұрын
He mentions the focal length is positive for Concave mirrors and negative for Convex but google says the opposite?
@fossetteful
@fossetteful 14 күн бұрын
Thanks!
@2minning
@2minning 15 күн бұрын
thank you for all that you do, science simplified!!!!! always love the enthusiasm in your voice when teaching us content
@adambasheerakkad1095
@adambasheerakkad1095 16 күн бұрын
Sir you are a flipping GOAT may God bless you!!!!
@coldblaze100
@coldblaze100 16 күн бұрын
Anyone else watching this for vibes and not MCAT prep?
@theegress3131
@theegress3131 16 күн бұрын
Do you have a comprehensive video on sound?
@hakimnasir2989
@hakimnasir2989 17 күн бұрын
u my sir are so beautiful
@attlattila09
@attlattila09 18 күн бұрын
This content is amazing, I have never seen somebody explain this so thoroughly to me
@user-iu5qi8jh8s
@user-iu5qi8jh8s 18 күн бұрын
i think im in love
@pinkymonika5619
@pinkymonika5619 19 күн бұрын
Thank you
@srussifordwilliams
@srussifordwilliams 22 күн бұрын
❤thank you very educational
@theegress3131
@theegress3131 23 күн бұрын
I love you bro
@duub1528
@duub1528 23 күн бұрын
amazing
@JamieFinan
@JamieFinan 24 күн бұрын
Really like the simplicity! However, I didn't hear you discuss steric hindrance of electrophilic reactivity (aldehydes = least hindered and most kinetically favored/strongest) or resonance stabilization of your formal charges. Thanks!
@shawalbhalli9076
@shawalbhalli9076 26 күн бұрын
When we calculate theoretical yield using the moles of the limiting reactant, do we use the moles before dividing with the coefficient?
@sciencesimplified3890
@sciencesimplified3890 26 күн бұрын
As opposed to what? But yeah I believe so I’m a bit confused exactly what you’re asking
@hanhai8515
@hanhai8515 28 күн бұрын
Basically it's guessing at this point, 2 steps of "theoretically" and "maybe" the margin of error is huge, the conclusion is just how you guess it would be.
@phoenix13971
@phoenix13971 29 күн бұрын
Is the GHK equation giving the same result as the chord conductance equation?
@phoenix13971
@phoenix13971 29 күн бұрын
Very good thank you, but somehow your tone irritates me hahaha
@brianhartger
@brianhartger Ай бұрын
Amazing video! You have very intelligently separated out the key factors that distinguish a diet for growth/reproduction from a diet for longevity. That is no small feat with all the noise, apparent contradictions, marketing, politics, and evangelism in nutrition. Easily one of the best nutrition videos I’ve ever watched. I hope the KZfaq algorithm will soon add some zeroes to the end of its view count.
@sciencesimplified3890
@sciencesimplified3890 29 күн бұрын
Yes, I swear literally almost no one appreciates that exact point you just mentioned. That general phenomena is so common that it has a term in evolution called “antagonist pleiotropy”. It can occur in many different context, but it’s my speculation that certain interventions in the short term “burn through stem cell reserves” to produce many new fresh somatic cells, thus optimizing reproduction, however do not optimize for long term health. We absolutely evolved eating high protein, but there was never a selective pressure to select for longevity under that context
@user-kc1in5gg4w
@user-kc1in5gg4w Ай бұрын
Please, may I see the spoken words written down simultaneously?
@jaym9846
@jaym9846 Ай бұрын
Is it best to only increase protein intake after workouts?
@DrMahmoudinshallah
@DrMahmoudinshallah Ай бұрын
Is this on the mcat ?
@Yesuuh
@Yesuuh 14 күн бұрын
nah
@Yesuuh
@Yesuuh 14 күн бұрын
one pro tip. Download the Aidan anki deck (most comprehensive MCAT deck available and has some of the most lowest yield info). Whenever you are not sure if something is covered or not on the mcat, just do a quick search function on that deck and if the term is not popping up, you are good.
@arlenedatiles5804
@arlenedatiles5804 Ай бұрын
What will happen if the temperatures are negative/below zero?
@SladkaPritomnost
@SladkaPritomnost Ай бұрын
I suspect that even fat or lipid availability can activate mTOR (together with glucose and protein)
@sciencesimplified3890
@sciencesimplified3890 Ай бұрын
So lipids are burned through beta oxidation, raising ATP, which inhibits AMPK, which has many effects, including the activation of mTOR. It is not potent or direct mTOR activation, however these systems are related to
@cryptodeath854
@cryptodeath854 Ай бұрын
At the beginning I was like..here comes the plant based Longo stuff. Listened to whole video though. I’d call it fair, but if we wait to “elderly” age to consume higher protein diets, have we already lost the battle with sarcopenia and too weak, frail, and low energy have good quality of life. What good is it to live longer, if we can’t do the things we what because of physical limitations?
@supremebodytv
@supremebodytv Ай бұрын
Thank you for sharing your thoughts and listening to the entire video. It's great to see such engagement! Your point about the importance of higher protein intake earlier in life to combat sarcopenia is crucial. Sarcopenia, or the loss of muscle mass with age, can indeed lead to frailty, weakness, and reduced quality of life. It's important to highlight that incorporating strength training and consuming sufficient protein throughout life, not just in older age, can help maintain lean muscle mass. This not only supports physical capabilities but also enhances overall well-being and energy levels. By building and preserving muscle, we can ensure a more active and fulfilling life, allowing us to enjoy the activities we love. Your insight adds a valuable perspective to the conversation, emphasizing the balance between longevity and maintaining a high quality of life. Thank you again for your comment; it was thoughtful and enriching! Keep up the great engagement and focus on your health journey.
@sciencesimplified3890
@sciencesimplified3890 Ай бұрын
Thank you for the respectful comment. I agree quality of life is a completely different conversation and 100% valid (I think doctors often discount the important of quality of life. And I hope the video did not come off as “no protein”, rather I wanted to defend the standard of care diet guidelines
@cryptodeath854
@cryptodeath854 29 күн бұрын
@@supremebodytv thanks for taking out the time to write such thoughtful comment.
@comangball
@comangball Ай бұрын
As someone with limited organic chemistry knowledge, your "we FORM a bond, and we BREAK a bond" is really helping me out. Thank u so much for these awesome videos!!
@violinsheetmusicblog
@violinsheetmusicblog Ай бұрын
High or low protein, doesn’t matter. The body is smart when given the right environment. If you stop eating protein, you will start craving protein rich foods.
@sciencesimplified3890
@sciencesimplified3890 Ай бұрын
I agree protein is needed in the diet, especially if it helps satiate appetite and one has the goal of maximizing muscularity. I agree with the nutrition guidelines.
@thesixthcourier
@thesixthcourier Ай бұрын
Return of the King!
@alfredalvarez1857
@alfredalvarez1857 Ай бұрын
the king is back
@DrMahmoudinshallah
@DrMahmoudinshallah Ай бұрын
thanks for the vid but a suggestion if you can put this video above capacitance formula as it confused me when i played other one first 😅
@xthatswhatsuppx9772
@xthatswhatsuppx9772 Ай бұрын
Can someone help! At 1:35, he adds electrons to the OH group so that it can leave. However, I though OH- was a bad leaving group so how does that work??
@sciencesimplified3890
@sciencesimplified3890 Ай бұрын
There are biological enzymes that stabilize the OH, therefore facilitating the OH to leave as a leaving group… a common example is an enzyme protonates OH so it can leave as H2O
@xthatswhatsuppx9772
@xthatswhatsuppx9772 Ай бұрын
​@@sciencesimplified3890 I apologize as I realize you answered this in a different comment!! But thank you so much for such a quick response!
@samantharaymonddd
@samantharaymonddd Ай бұрын
omg this is the best explanation ever. thank you so much!
@alexaldosari1545
@alexaldosari1545 Ай бұрын
This is a better explanation than the Princeton review damn I am impressed fr
@amaliasanches2951
@amaliasanches2951 Ай бұрын
thank you so much for this
@abrahamhamadi2804
@abrahamhamadi2804 Ай бұрын
Amazing video!
@getitdone0010
@getitdone0010 Ай бұрын
thank youuuu
@getitdone0010
@getitdone0010 Ай бұрын
thank youuuuuu
@brittnhuli
@brittnhuli Ай бұрын
Awesome videos. Just wish you would crop out the “undo paint stroke” portion, i can’t stop looking at that instead of your lecture.
@sadprose651
@sadprose651 Ай бұрын
guys i think it’s because the water is orderly
@wdre2we2eweqwe12
@wdre2we2eweqwe12 Ай бұрын
schooch downn gang
@VarshaKatoju
@VarshaKatoju Ай бұрын
this video is absolutely amazing oh my god thank you so much