The application of hydrophobically conjugated siRNAs represents a groundbreaking approach in treating skin and muscle diseases. This method enhances cellular uptake and stability, allowing for more efficient gene silencing and therapeutic effects. However, challenges remain in optimizing the delivery systems to target specific tissues and minimizing off-target effects. What advancements in delivery technologies and molecular design could further improve the specificity and therapeutic outcomes of hydrophobically conjugated siRNAs for these conditions?

The exploration of nucleic acid-based approaches to antibody therapeutics has shown promising potential, offering a novel avenue for targeted and efficient treatments. This method leverages the precision of genetic engineering to produce antibodies with high specificity and reduced immunogenicity. However, challenges such as delivery mechanisms, stability of nucleic acids in the body, and large-scale manufacturing hurdles still need to be addressed. Given these obstacles, what innovative strategies could be developed to overcome these barriers and enhance the efficacy and accessibility of nucleic acid-based antibody therapeutics?

This would be a lot better if you didn't say umm every 15 seconds

Amazing informative video, I liked it a lot! And props to the speaker, she's really clear and experienced while delivering difficult points throughout the video.

Based on this video, we're now in the prime time for gene editing.

any inroads into MPN blood disorders?

Very informative and in-depth lecture on oligonucleotides

so what recourse is there for those of us who have Myeloproliferative neoplasms, like Polycythemia Vera?

Thank you.

Congratulations to Dr. Sudhir Agarwal, a giant in the field!

🤣 P r o m o S M

Yet again, the next white overly praised guy. What a surprise.😮😮😮

Sweet universe of nonsense!! How is it possible uni professors are REQUIRED to actually speak the language in which they deliver a conference!?? For crying out loud, the French are truly the worst! And I am bilingual myself!!!

thanks

5:29

17:00

really nice work!

Amazing work...

Great Talk, and great job. Dr. Lee.

A beautiful lecture with the benefit of hindsight.

The absolute GOAT

Incredible speaker with a very comprehensive presentation, thank you for this!

Thank you so much very helpful. May I ask about some of the design tools or software for miRNA/ anti-miRNA that I can use, please? I am a beginner in this field. Thank you so much.

It’s quite obvious that science is just beginning to understand the function of RNA and DNA for that matter. So maybe someone can explain to me, why the world would be receiving An mRNA vaccine that has no long term testing. That has skipped animal trials. Unless your objective is genocide, why in the world would this be released onto the public

what type of software do you recommend while working with aptamers

Thank you for making this available to the public.

The same way you synthesize or use gain of function on new virus species. I mean, the coronavirus shares a part of the same sequence as Moderna mRNA vaccine. Gotta love this plandemic.

Always look forward to these vids!

18:15 So that's why Moderna used a "platform approach" to assume tox and biodistribution data of similar LNPs while stating the payload inside is irrelevant? [Source] Joseph Senn Labroots Webinar _(had to screencap bc they deleted off YT)_

Chemist, back to the bench!

Wow. amazing speaker. Great talk!

The MBBS (Bachelor of Medicine and Bachelor of Surgery) is a course that involves 4 years of study

Need hemophilia A, cure hurry up

to much "uuhmmm"

I don't trust anyone who uses uh uh uh in every sentence. If it were a drinking game you would die.

Kinda like how fast they built the bomb.

Hemophilia A hurry up

Great talk. Thanks for this presentation!

Hello mam

hemophilia A

hemophilia A cure need hurry

we need more data 🤓

I am super excited that Dr Madida 's herbal medicine that my boyfriend found on KZfaq was able to cure us of our herpes virus.

It was a great talk.Thanks

Hepatitis B can be treated reach out to Dr.Ayomede on his KZfaq channel for permanent cure

Thanks for sharing! In my opinion, it is ASO's that will fix diseases like ALS, MS, etc. It seems promising in treating SMA.

Can we get the slides?

Great presentation :-) Thanks.

Thank you, it's so clear

Hi, can Ataxia Telangiectasia be treated with antisense oligonucleotide gene therapy ?