Hi there, Pro-ficiency focuses on supporting later-stage or complex clinical trials that revolve around human patients.

@gongchen6679 - yes the time units can be in minutes. It can be changed from the Units pulldown menu where you can select ug, ng, or pg per minute.

Currently we only provide the simulated concentration profile. User could find the Cmax and Cmin from the profile. Any other parameters may require other software for the analysis such as PKanalix.

@@SimulationsPlusInc Thank you

That is a great question! In short, a fully mechanistic PBPK model focuses on mechanistically describing and predicting where a small molecule or larger protein is going and how much is there. It can include upstream components related to formulation, dosage routes, and absorption, through systemic exposure and elimination. A QSP model focuses on what the drug does as it relates to altering a patient state, such as how it alters a disease. So, PBPK focuses on where and how much of the drug is there, and QSP focuses on what the drug does.

It is working for me!

Working now...thx.

Unfortunately, MembranePlus can only model specific transporter (apical or basolateral membrane) and enzyme kinetic interactions (intracellular space) that the user defines with a set of kinetic constants (Km/Vmax). You can model non-specific protein binding by setting a fraction unbound in the cytosol; however, we don’t have any binding kinetics to proteins or any specific kinetic equations for binding to specific proteins. We do have the ability to model concentration dependent binding to albumin in the apical and basolateral fluid but again this isn’t the intracellular space.

You're very welcome. We're glad you found it helpful.

Hello. Thanks for your interest in purchasing a license. You can fill out this form to be connected to one of our experts who can assist you. www.simulations-plus.com/discuss-project-needs/

​@@SimulationsPlusInci can design psychoactive molecules.

Hi Maryam, You can add a new drug by importing the structure of the molecule of interest directly into the software: Go to file > import > structure

Hello and thank you for your interest. We do not have any webinars planned now but please check our webinars page frequently for new webinars to be added. www.simulations-plus.com/webinars/. Additionally, you may be interested in attending one of our GastroPlus workshops. You can view the full course schedule here. www.simulations-plus.com/events/event-category/workshops/#categoriesmenu

Hello Bhuvana. We have several job openings that may be of interest to you. Please visit our careers page for more information at www.simulations-plus.com/career-center/. If you are interested in learning more about the use of GastroPlus, we offer many workshops for beginners, both complimentary and paid. You can view our full schedule or workshops at www.simulations-plus.com/workshops/. If you have additional questions please don't hesitate to reach out.

The units for models in ADMET Predictor can be seen in the tooltip for each column. For example, if one hoovers the mouse over the S+Sw column header then the tooltip below is displayed: Water solubility (mg/mL). RMSE/MAE = 0.59/0.45 (2D) and 0.57/0.43 (3D) in log units. Thus, the units for our model is mg/mL.

In this demo we're using our ADMET Predictor software. You can find more information here: www.simulations-plus.com/software/admetpredictor/

Happy holidays to you as well!

Hi Rasha, You can request an evaluation here: www.simulations-plus.com/software/gastroplus/ and someone from our team will reach out.

Hi Unays, You can request an evaluation here: www.simulations-plus.com/software/admetpredictor/

Glad it helped!

You're most welcome

You are so welcome!

You're welcome