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On the contrary - SGLT are one of the safest glucose lowering agents for kidneys. But they can predispose to UTI. Which is not the most dangerous side effect.

@@Foxterrier But SGLT cannot lower proteinuria and creatinin which are the main causes of renal decline and renal failure.

@@kevinwellwrought2024 First of all increase in creatinine is the consequence of renal failure and not the cause. Proteinuria can affect kidney function, but usually it's also the consequence of renal failure and not the cause. For example - In diabetes high blood glucose level - causes glycosylation of glomerular membrane - which leads to nephrotic syndrome with proteinuria. So in most cases, proteinuria is not the main cause it's just a manifestation. And SGLT can lower proteinuria. SGLT2 inhibitors reduce glucose and sodium reabsorption in the proximal tubule. This increases sodium delivery to the distal tubule. The increased sodium delivery to the macula densa enhances tubuloglomerular feedback, leading to afferent arteriolar constriction. This reduces intraglomerular pressure. Lower intraglomerular pressure reduces hyperfiltration, which is beneficial for reducing glomerular damage and subsequent proteinuria.

Its impossible to suggest something straight out of the box without seeing blood analysis, anamnesis of patient etc. Sorry, but if individual has thalassemia, I can only recommend to consult with local health provider.

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Sir ,can you please explain moa of mianserin?

Most of cancer cells have insulin receptors and their glucose uptake can be stimulated by insulin . But at the same time cancer cells can take up glucose efficiently even in the absence of insulin .

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@Andrew-ny1dl glad to see that my video helps you, your comment really motivates me to keep doing, thanks)

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Thank you very much. About music noted, though in my recent videos i removed music, and instead added short cuts from films, maybe it will be better. Kind regards R.S. 💙

Thank you for the question, it is challenging, concept that I represented in video called repolarization theory of brugada syndrome but unfortunately not all details are completely understood. Another theory that can explain the Brugada syndrome is depolarization theory which based on conduction delay in RVOT as a crutial part of pathogenesis.

@@Foxterrier thanks a lot for the reply! Will check that out. This video was really excellent, made ECG translation from action potential more intuitive for me

@krishvasa7644 you welcome, this is exactly thing that I try to achieve go from mutation to ecg changes and symptoms, happy that you like it)

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I think that if you have a complains, it should be detailed and find the reason for arising of complains, additional conversation with physician possible additional lab test and instrumental examination can define the reason for your condition, I am happy that my video helps you

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Thank you very much. I have video on gca, and i am determined to cover all vasculitis. Thank you for sharing my videos, its the best thing you can do for me. Asante.

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Yes you are correct, but feature of Ca2+/Na+ exchanger is an ability to work in reverse direction even under normal condition, most of the time Ca2+/Na+ works is calcium efflux direction (1 Ca2+ out from the cell/ 3 Na in the cell) but during the phase 0 of action potential when the sodium concentration rise rapidly, exchenger swiches to reverse direction (3 Na+ out from the cell/1 Ca2+ in the cell) this mode lasts wery short until the phase 2 (opening the L-type calcium channel) occurs So the work of exchangers is less about calcelation of the each other more about the regularion of ions concentration inside the cell)

You are absolutelly right, there are some other forms of functuinal re-entry, but for avoiding to make too long video, I decided not mention it and make the accent on basics re-entry aspects. By the way, next cardiology/ECG video will also describe phase 2 re-entry)

@@Foxterrier it's understandable, I'll make sure to watch that video. Also, do you mind sharing resources, where you find this information? Cause I can't really find a lot of info about those types of re-entry on Pubmed and LITFL

@Andrew-ny1dl for preparing to reentry video I used clinical arrhythmology and electrophysiology Ziad F ISSA and electrophysiological foundations of cardiac arrhythmias Andrew L Wit)

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Aberrant conduction by it self is benign, according to supraventricular premature complexes it depends on quality and quantity, I think 24-hour should be performed to estimate this, lyme carditis mostly impair the conduction system, injury should disappear after treatment, other depends on your specific situation

@@Foxterrier The doctor in question says that these plots are much seen with stress, as I have this for some years because of nabure trouble, but also I think I have a chemical sensitivity like materials used here, I had a 24 hours plot done with the cardiologist and earlyer with the regular doctor, I had a echo and stresstest also. I did not think however that ectopics can be so scary, it feels sometimes like I have carry a child in me who is kicking me, or fibrates, if feels like it is complete chaotic. I had it als when bycicle riding, but did just go on with the sport and I have/had no problems getting dizzy or tired, just a strange scary feeling. What is remarcable is that I get also symtoms when there are pollen in the air, I have a hey fever unfortanely, and not to forget I have a histamin intolerance problem, like biogene aminen, I get to much histamin because I do not remove properly, I do miss a enzyme for that, maybe a idea to use this enzyme in a pill. Also I did see that when I ly down, it just dissapairs, but when stand up for urinate for example I get them back, and then lessen again, when I have sleep for a night, I have no problems anymore, so today, still I have no ectopics yet, I have a very steady 58 beats who differ slightly when breathing (coherence) and feels like sinusoidal of nature. That is feel like a constand movement, not a quick pulse. Bloodpressure this morning was 107/69 (measurement when wake up). So do not sound very bad. But oke, still, these symtoms are sooooo annoying and scared. No wonder so much people are involved, cure them all with ablation will bankrupt the whole world care systems. We need to bring the world into more relaxing states, we need to switch down what concerns economics and not to forget radiation from all kind of satelites and phones, I am electrosensive, 5G I do not now what it does, maybe it is lees problematic as lover frequencies,. have a nice day.

@audiokees4045 There are a lot of details in your story, it looks like you had a complete cardiological examination, I hope that the situation will get better and ectopics finish to bother you, supraventricular premature contractions can also be due to extra heart reasons. it is an interesting point of view on pollution have a good day.

@@Foxterrier I have or still lyme, can use a test course of antibiotics, I had 2 times a swollen lymphe in the neck, I have a bad tooth, this I have already for some time, the tendist did not see trouble inside it, I use a agent to clean keep it from inflammation, I go to a tendist specialist in hospital for making photo,s these are a lot better then in the dentist office, but I do not think it is reason of heart effects. I use now antihistamin, see what it does, yesterday I have non ectopics, but later on the evening it did start again, multiply after each other, and when ly down it was gone, I have measure blood pressure in daytime after some work, was 118/78 68 beats, I have now start vitamin k7, d3, arginine/citruline, b12, I have now non trouble, I did discover when I get ectopics it always start with a very unresty feeling in the body, I have some kind of spasms in the chest, who feel like heart palpitations but that is not, the heart just beats fine, but the spams feel bad, so it is coming from the stomach and diaphragm, the unrest I do feel is kind of shaky feeling like al kind of movements in the body, I do ignore them as I can. Possible because of mine experience with nabure and mucho treats I have chronical stress who do cure in time, and that can last years. I go to doctor 11th abd do wask for stomach examination because of I have reflux. Well more I can not tell, I am not tired and bow I feel quite oke with a very relax sinusoidal heartbeat of 62

I understood your situation, hope you will get better

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@@sgill4833 I'd be interested in this too. I have been told this problem only occurs with Nicotinamide, not with Nicotinic Acid aka flush Niacin. But I haven't been able to corroborate.

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