2013 an MRI showed a cyst on my right ovary that was likely an endometrioma. Follow up scan 2 yrs later no change. MRI 2018 endometrioma decreased in size so after that then covid came and follow ups and screening took a back seat. Even in nursing school I don't remember learning about endometriosis. GP did not seem concerned about it either. Fast forward to 2023 I got diagnosed with clear cell ovarian ca. Kicking myself for not being more vigilant .

My wife is suffering from BRCA2 +Ve and HRD +Ve High Grade Serous Stage 3c Ovarian Cancer since last one year, currently she is on maintenance doses of Olaparib. Unfortunately my daughter is also BRCA2 +Ve, my question is that can my daughter start Olaparib in minimum doses as a prophylactic?

Do you recommend Parp maintenance for patients that are BRCA neg and HRD proficient? If so wjat is the benefit? Does the risk outweigh the benefit?

Do you recommend Parp maintained for patients who are BRCA neg and HRD proficient. And if so what are the benefits? Is the benefit worth the risk?

Congratulations!! Absolutely inspirational and providing such "hope" for all of us!

Congratulations 🎈

I’m fortunate that Dr. Grisham is my oncologist. Runsi, thank you for raising the topic of physical appearance and saying it should not be discounted. It often feels it’s not even a consideration.

How can I sign up for this clinical trial?

HGS is 70 of cases …keep going

Is the 9 years the same if I have low grade?

I hear NED but is that cured?

Amen to 'cured'! I was first told that an ovarian cancer recurrence isn't 'curable' - that it's a matter of when, not if it will recur. I refuse to accept that statement! This talk has been so encouraging!!

Sharon Hoffman. Mirv worked well for me for 8 mos. Now in a P1 trial Rinas-1

I am so grateful as a survivor dealing with recurrence for this series, Runsi and her behind the scenes team, and all of the experts that are so giving of their time! When first diagnosed with recurrence and upon discovering this resource, it has been so nice to have a massive library of helpful information, rather than getting lost on "Dr. Google". It truly is a priceless resource, and provides me so much hope in terms of advancements in OC research and treatment and more targeted detection and therapies for myself and women in the future as well. The B.E.A.C.H. symptoms and awareness are no doubt saving lives!

My mom she has cancer now she is in serious cancer because of this Tata hospital don’t look at their go at Mumbai hospital

Excellent 👍🏿

Thank you Dr for sharing your knowledge My grand daughter has ovarian cancer She had 3surgeries no help She has a DNA mutation

While mucinous ovarian cancer is more rare, there does seem to be a large population amongst us that is caught in either this pre-cancerous or Stage 1. Is there a particular Center that is focused on this subtype? Essentially, how do we get our samples to the right researchers, as survivors?

Thank you. I have just been diagnosed with serous carcinomas and starting my research . I had a full hysterectomy 😮 and a stint from my kidneys to my bladder. The tumor from my right ovaries has left a skinny dry fallopian tube and climbed up towards my right kidney via my bladder. The really amazing thing is I feel really well 10 days after surgery. I feel really positive about my future. A different perspective.

Thank you. I appreciate the information.

I really appreciate the explanation of the graphs in the trial results. Thank you for presenting a huge amount of information in a short time.

I really got a lot of sensible advice from this thank you so much.

Dr Priya nice presentation. It is said MRI has better resolution than CT with contrast. Why CT is used for total assessment eg. LN , diaphragmatic deposit ,etc. Can MRI give these involvement?.

Where can someone sign up to be a candidate for SURPASS-3 trial (NCT05601752/ (GOG-3084)

Thank you for this talk. I’ve been in a clinical trial for 14 months and tomorrow’s ct scan will determine if I stay on it or not. Scanxiety is real even after 7 years at this game. HGSC

Very interesting, feeling how the bloating and pain receded within approximately two months made all the difference, I simply go’ogled the latest by Tilly Strankten and her Ovarian Cyst Guide and although it really took about 10 weeks for it to totally shrink and vanish I’ve never felt so light and relaxed.

This was very informative and helpful! Thank you so much, Dr. Grisham!

What about Clear Cell ovarian cancer? the Ovarian Cancer world hasn't developed a single treatment that has shown effectiveness for Clear Cell, and they are treated with treatments developed for high grade serous, and those treatments don't work because clear cell has a completely different molecular structure. So gyn onc knowingly treats patients with the wrong treatment with sideeffects but then death.

How about fewer CTs for trial participants if you’re concerned about secondary cancers? Seriously!

Thank you for this conversation! It is providing incentive for me to reestablish my yoga practice. It was very helpful in my bout with stage one breast cancer 15 years ago and I know it would help as I deal with stage four ovarian cancer at two years out from diagnosis . Issues of anxiety, scanxiety and neuropathy remain! I look forward to seeing the resources that are listed as part of this conversation

How do I follow. On phone.

Am I the only one who needs a medical dictionary for all of the terms Drs throw at us? I so badly want to understand all of this, but even after 6+ years I’m confused, as if a foreign language is being spoken and I haven’t studied amount to understand.

What about recurrence containing NRAS mutation? There a lot of talk about kras mutation, but no nras mutation :(

Uni bhagwan.... amar ato risky o.t chilo annyo dr bolechilen ami o.t te expire kore jete pari.... but dr babu ato sundor o.t korechen....aj ami natun jibon fire pyechi..... onake amar sata koti pranam namaskar

I was wondering what your thoughts are on the clinical trial AVB -001 through MD Anderson?

Thank you so much for doing this!!!!!

What about TP53-mutated BRCA cancers (HRD positive)

My wife is BRCA2 Pathogenic and HRD positive, my daughter is of 27 also BRCA 2 PATHOGENIC. She ( daughter ) is in Toronto, can she enroll for TAV trial to prevent ovarian cancer?

My mom has ovarian carcinosarcoma with no targetable weakness per her gene testing. Are there any treatment options outside of standard of care chemo?

I am hrd+ but brca- should i add durvalum with bev and olaparib or just bev and olaparib is good. please ask him

I had clear cell 1.6 years ago and only had one surgery. No chemo no full abdominal hysterectomy. I was only offered chemo and a second surgery not immunotherapy.

How about stage 1 clear cell ovarian that did NOT do chemo and did NOT have a hysterectomy.

Very informative

Elahere worked great fo 5 months then stopped and my cancer csme back hard.

Great discussion!!! Thank you both!!

Dr. Sood is the absolute best! He is brilliant but also kind, compassionate and ever so patient.

I am working on my thesis on this, thank you for sharing yuor knowledge!

Granulosa cell tumor stage1a is it curable?

I was diagnosed with clear cell carcinoma ovarian cancer stage 3b, surgically removed 8 lbs tumor with total hysterectomy in September of 2023. Didn’t go through chemotherapy as my heart didn’t agree with it. I have recovered and doing well so far. This was an excellent interview and when he mentioned the link between acute depression/ stress and the ovarian cancer it hit close to me as I was going through problems and was often depressed prior to the diagnosis. There are other added factors like diet and not having clean bowel movements and bladder can also be the cause for progression of the disease. Having positive outlook, good diet and rest, clean bowel movements, besides good support system has helped post surgery and during recovery. I believe and hope I’ll recover fully without any recurrence. I hope my experience helps anyone out there going through this

Hi, really the discussion was very interesting and very informative. My wife is suffering from Stage 3c high grade Serous Ovarian Cancer. She has just completed last neoadjuvant chemotherapy, after surgery the surgeon told me, what Dr Sood told, that there are some unresectable back scares or spots left on small intestine, if my doctor could have a pen as Dr Sood mentioned, I would be rest assured that there is total removal of all visible tumors , She may get a better chance of Progression Free Survival