In cases of overdose, hospitals may prescribe IV acetylcisteine to protect against liver damage. This supplements depleted glutathione stores to help mop up the excess paracetamol.

Professor Dave is the best thing about Mondays!

Yep, it took a lot of reading before I finally understood why America’s “wonder drug” Tylenol was nowhere to be seen in Europe ...

Awesome stuff. I really don't understand the chemistry behind it, but it's still extremely fascinating

I really love Science. I'm so curious to learn every type of science. Thank you so much professor. You're an amazing teacher. Love the way you teach us. Your new subscriber here❤️🙏🏼

AWESOME! YOU ARE AN INSPIRATION! Hi from Liverpool, UK.

5:05 Malnutrition is often seen in alcoholism, and they are both risk factors for overdose.

Sir, please continue your IIT JEE series, I know it wasn't getting much views but was very helpful in boosting my morale, I solved all question in 30 min and am looking for question of organic and inorganic. Thank You

Thanks Dave, well done.

Mesmerising Mr.Dave sir ... Thanks

Amazing, dear Prof Dave, thanks, please tell about its Structure Activity Relationship (SAR), its pharmaceutical chemistry aspect, IF CONVENIENT, I do repeat, if convenient

Oh god plz don't tell people deoxygenated blood is blue....its a brownish maroon

I'm not gonna lie, I was kind of thinking your anti-vax debunk would come out today. I will be patient 😁. Try to not go crazy with all the comments on your debunk videos. It's good that you respond, but it can't be good for your mental health, dealing with that volume of craziness and negativity. Thanks for all your hard work and all you do to bring us high quality science videos.

N acetyl cysteine is used in treatment for liver damage from paracetamol overdose. It also helps me with my adhd and autistic traits!

we enjoy your words Mr. Dave

Thank you for your service sir

👍taking more than the recommended dose - or taking acetaminophen with alcohol - increases your risk of kidney damage and liver failure over time.

good video ..Do you have another video that deals with the codeine component of this drug..

Thanks for the video

Very helpful, thanks a lot!!

I cant wait to learn about ibuprofin because I take it every day for muscle pains, and it works well. I used to be prescribed hydrocodine(generic for vicodin) and I found that simple ibuprofin works wayyy better for the pains I have to deal with than the hydrocodine ever did, and the ibuprofin is not addictive....

Hai hai.. I'm from Indonesia.. and i love this video

Glad you included Paracetamol as a reference, seeing as it is the *proper* name for this drug!👏👏 Before you Americans get angry, an *International Nonproprietary Name* (INN) is an *official, generic, and nonproprietary* name which is given to a pharmaceutical drug or an active ingredient. INNs are intended to make communication more *precise* by providing a *unique standard name* for each active ingredient, to avoid prescribing errors. The INN system has been coordinated by the WHO since 1953. So where you lot decided to pluck ‘acetaminophen’ from, who knows. Regardless, once the INN name was decided upon, why didn’t America use that name?! I would imagine that the US is probably the biggest single contributor (of both finance and resources) to the WHO (by a single country) on Earth, so why the US doesn’t use that name is a unique American oddity. When you Americans blow & wipe your nose, you seem to always say you wipe your nose with a “Kleenex.” No, you don’t! You wipe your nose with a *tissue!* Kleenex is just a brand name, not the name of the actual item you are using. Having unambiguous standard names for each drug (standardisation of drug nomenclature) is important because a drug may be sold by many different brand names, or a branded medication may contain more than one drug. Take ADHD medication as an example. Ritalin is a brand name of only *one* type of ADHD medication (Methylphenidate Hydrochloride). There are several different brand names of that exact same drug (Concerta being one), plus, there are several different ADHD stimulants out there (Dexamfetamine Sulfate being one). Mercifully, the colloquial name we use for what we drive in is a ‘car’, or ‘truck’, or ‘bus’, because otherwise it would be really confusing (and pretty fucking stupid) if you defined what you drive by manufacturer name. Mercedes is just one example of a manufacturer that makes cars, trucks, and busses, hence why it would be stupid and confusing to only use the manufacturer’s name. Each drug's INN is unique but may contain a word stem that is shared with other drugs of the same class; for example, the beta blocker drugs Propranolol and Atenolol share the -olol suffix, and the benzodiazepine drugs Lorazepam and Diazepam share the -azepam suffix. (Diazepam is the proper name for what Americans refer to as Valium, which is just one old brand name). Alprazolam is the proper name for the drug Americans refer to as Xanax, which is (you guessed it), just a brand name. I could maybe understand it if there is a new drug where the patent is still in force, which would mean that there is only one brand name for a drug until the patent runs out. However, continuing to use the original brand name long after the patent has run out is just stupid. La Roche (the manufacturers of Valium) now *have* to have “Diazepam” on their boxes of Diazepam by law. The WHO issues INNs in English, Latin, French, Russian, Spanish, Arabic, and Chinese, and a drug's INNs are often cognate across most or all of the languages, with minor spelling or pronunciation differences, for example: Paracetamol (English) Paracetamolum (New Latin), Paracétamol (French) and парацетамол (Russian). Americans supposedly speak English, but decide to throw out normal standardised customs present in the rest of the world, for reasons which either don’t matter, are illogical, or because they decide to carry on with the errors that people made long before them. Following suit doesn’t do anybody any favours though, the rest of the world has to second guess what Americans are referring to, and Americans will likely be confused if they ever visit other countries because they will be exposed to names they have never been taught. It makes travelling a massive ball-ache. Noah Webster was, essentially, a massive dick by changing the English dictionary based on *his preferred phonic* spellings, and has at *best* complicated things a lot, and at worst partly succeeded in ruining a language by changing it so much that it may as well be a foreign language now.

Great stuff!

Advil’s new dual action with Tylenol works wonders for pain relief... but I took it on an empty stomach several times and it gave me gastritis, was nauseous and wanted to throw up for 2 weeks... just because it’s over the counter, doesn’t mean it can’t have serious side effects. TAKE IBUPROFEN/ADVIL WITH FOOD ALWAYS, OTC or prescription strength!!!

Hi Prof, I always greatly enjoy your videos. I believe there is a good body of evidence for indirect endocannabinoid agonism as a mechanism of action for paracetamol, resulting in descending inhibition in spinal serotonergic pathways. It's a complicated story but includes the charmingly named 'bliss molecule' - anandamide - whose action is enhanced by a paracetamol metabolite.

Small nitpick: It's also called Acetaminophen in Canada, which is technically outside of the U.S.

Hello Professor Dave

It's crazy that we have yet to figure out the exact mechanism of action for one of the most prescribed medications of all time.

Is the best video keep going our legendary

Now I know that if I am in a foreign country and I have a headache I can look for Paracetamol at the store

Love this!

really good

could that N-acetyl parabenzoquinone imine be a flat molecule? should I learn the Hückel rules again? (A: yes)

Hi, could you make a video explaining what joules are please?

Hey! I actually was wondering which masters or bachelor you got in University? Just because I'am thinking of choosing one myself, and the study of drugs and its chemically components really interest me! You got awesome videos! Thanks

I never knew about N-acytl parabenzoquinone imine product. It's amazing how our bodies work yet scary. I wonder, can this be reversed if someone has damaged their liver abusing painkillers or could there be permanent damage left?

Thank u man

Morn'n Dave.

Lifesaver!!

I used to think that chemistry was a complete headache until I watched this.

Can anyone explain me why does the drug in USA called acetaminophen and in uk or according to WHO is paracetamol????

Hey why do I sweat when I take Tylenol

Wow, i always thought the intro goes like so science stuff it is? :D

I didn't even know what acetaminophen is lol

Osm sr ❤❤

Dutch doctors will tell you to take paracetamol even if you break your leg.

👏🏻

So the only differences between paracetamol and acetaminophen is because of their naming? They're basically same chemical, same substance?

Basically for also committing fraud I don't think I would take anybody seriously that either went there or hails an education from there.

Professor I don't understand political science? Do you have any intension to make videos explaining politics?

Can't wait for a advil video

They should close the entire college of dupage to high level corruption like not giving a textbook for class giving bad accounting assignments with no textbook as well as not providing me a copy of my scantron test that everybody including taxpayers wanna pay for via government money/ policy

I love medicine

Acetaminophen so close to being carcinogenic wtf

I just took a paracetamol

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professor bok droll .....

first