Thank you so much! More content coming very soon!!

Thank you so much! Best of luck on your journey!!

I’m so happy to hear it helps! Thank you so much for the kind words, you made my day!

Thank you so much! I definitely will!

Thank you so much!!

Thank you so much! So I have one video out for neuro now on strokes, and I'm going to be releasing a second one in the next few days on seizure disorders. MSK will be next in line. Thanks again!

Happy to help! Thank you!!

UW PA Students

Thank you so much!!!

You're very welcome!

Thank you! Working on the next video now, hope to have it out soon!

No problem! Thank you!

So happy to hear that! Thanks so much!

Thank you!

Thank you!

Sorry, the way I worded this in the video is very confusing. The ATCH level is a baseline, meaning before the high dose dex, where as the cortisol level is after. Definitely need to rework this video in the future to make this more clear. Sorry about that.

Its not so much the adrenal responding to the high dose of dexamethasone, but the pituitary waking up and responding. The principle behind the high-dose test is that overproduction of ACTH in Cushing disease (but not ectopic tumors) can undergo partial or full suppression with high doses of dexamethasone (pituitary sees the high dose of dexamethasone (manmade cortisol essentially) and responds by decreasing the production of acth, which in turn tells the adrenal gland to decrease production of cortisol). So when the problem is the pituitary overproducing ACTH, it still cooperates and responds to the feedback loop, you just have to turn the volume high enough (high dose of dexamethasone). In ectopic acth producing tumors (ex. small cell lung cancer) theres no feedback loop, and it doesn't matter how high you turn up the volume, they're not listening and will not suppress. Let me know if that makes sense.

@@cramthepance In your video time stamp 13:52 you have for cushing disease (pituitary) high dose dexamethasone having the results of Increased ACTH and suppression of cortisol. But if im understanding what you said above wouldnt the result have decreased ACTH too? Since the high dose would inhibit the pituitary??

@@nicoleb7711 Sorry I definitely could have presented that in a way to be a little less confusing. So the ACTH is a "baseline" meaning prior to the administration of the high dose dexamethasone. The cortisol levels are obtained after the administration of high dose dexamethasone which will result in a suppressed cortisol level (as well as a suppressed acth) but generally only the cortisol levels are tested as it is assumed the acth is suppressed if the cortisol levels decrease.

Thank you…great presentation

Thank you for the feedback

Gosh, you should ask for your money back.

Pretty sure that 99% of that is from his mouse and keyboard.

Pretty critical for a guy who can't figure out when to use "too" in a sentence.