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Les antioxydants sont des moyens de défense contre les radicaux libres. On les retrouve principalement dans les légumes et les fruits mais également dans les fruits à coque (noix, ...), le chocolat, le café et le thé... Les antioxydants peuvent donner ou recevoir des électrons sans se transformer eux-mêmes en espèce réactive.
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Sources :
Carlsen (2010). The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide nutritionj.bio...
Carocho et al. A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food and Chemical Toxicology 51 (2013) 15-25
Essais randomisés contrôlés sur les antioxydants :
- Lee et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA. 2005 Jul 6;294(1):56-65.
- Jae Hee Kang et al. Vitamin E, vitamin C and β-carotene and cognitive function among women with or at risk of cardiovascular disease: the WACS study. Circulation. 2009 Jun 2; 119(21): 2772-2780.
- Jennifer Lin et al. Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial. J Natl Cancer Inst. 2009 Jan 7; 101(1): 14-23
- Nancy R Cook et al. A Randomized Factorial Trial of Vitamins C, E, and Beta-Carotene in the Secondary Prevention of Cardiovascular Events in Women. Arch Intern Med. 2007 Aug 13; 167(15): 1610-1618.
- Michael Gaziano et al. Multivitamins in the Prevention of Cancer in MenThe Physicians' Health Study II Randomized Controlled Trial. JAMA. 2012;308(18):1871-1880. doi:10.1001/jama.2012.14641
- Age-Related Eye Disease Study Research Group. A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss. Arch Ophthalmol. 2001 Oct; 119(10): 1417-1436.
- Klein et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011 Oct 12;306(14):1549-56. doi: 10.1001/jama.2011.1437.