Bioelectricy: the Software of the Body | Michael Levin

  Рет қаралды 4,058

SEMF

SEMF

9 ай бұрын

Extract from "Evolution, Basal Cognition and Regenerative Medicine", kindly contributed by Michael Levin in SEMF's 2023 Interdisciplinary Summer School (semf.org.es/school2023
).
Full talk: • Michael Levin | Evolut...
TALK ABSTRACT
Each of us has made the remarkable journey from a single cell (a quiescent oocyte) to a complex embodied mind. How do cells, which were once independent organisms, work together to pursue the anatomical and physiological goals that enable form and function to reliably self-assemble? In this talk, I will tell the story of the collective intelligence of cellular swarms that embodies William James' definition of intelligence: same ends by different means. I will describe the amazing competencies of the morphogenetic process that builds bodies and minds, and our discoveries on bioelectricity - the cognitive glue that implements embryogenesis, regeneration, and cancer suppression. I will end with a perspective on how biophysical, informational, and behavioral sciences are coming together to redefine the boundaries of the possible in biomedicine and beyond.
MICHAEL LEVIN
Department of Biology, Tufts University: as.tufts.edu/biology
Tufts University profile: ase.tufts.edu/biology/labs/le...
Wyss Institute profile: wyss.harvard.edu/team/associa...
Wikipedia: en.wikipedia.org/wiki/Michael...)
Google Scholar: scholar.google.com/citations?...
Twitter: / drmichaellevin
LinkedIn: / michael-levin-b0983a6
SEMF NETWORKS
Website: semf.org.es
Twitter: / semf_nexus
LinkedIn: / semf-nexus
Instagram: / semf.nexus
Facebook: / semf.nexus

Пікірлер: 97
@raajanmudaliar
@raajanmudaliar 8 ай бұрын
Amazing
@SEMF
@SEMF 8 ай бұрын
Indeed!
@friedrichjunzt
@friedrichjunzt 8 ай бұрын
I love those videos! Everytime I realize how little I know and understand! 😁
@SEMF
@SEMF 8 ай бұрын
Hopefully we can contribute to your further knowledge and understanding!
@ZapataCarratala
@ZapataCarratala 8 ай бұрын
It was a real pleasure to host Michael as usual!
@hindugoat2302
@hindugoat2302 8 ай бұрын
that guy has clearly never touched a female in his life, but that could be part of why he got so smart.
@ZapataCarratala
@ZapataCarratala 8 ай бұрын
@@hindugoat2302 That would be strange knowing that he has a few biological children ;)
@hindugoat2302
@hindugoat2302 8 ай бұрын
being a nerd and a virgin, he may have grown the children from a test tube.@@ZapataCarratala
@anmolagrawal5358
@anmolagrawal5358 8 ай бұрын
The title says "biolelectricy" instead of "bioelectricity". I tried entering the term "bioelectricity" on KZfaq and filtered for uploads within the past day to see if it indexes this upload. Fortunately, it does.
@SEMF
@SEMF 8 ай бұрын
Fixed!
@anmolagrawal5358
@anmolagrawal5358 8 ай бұрын
@@SEMF still shows up the same for me
@julianholman7379
@julianholman7379 19 күн бұрын
The SEMF programme looks fascinating, but as I look around in wikipedia with the relevant keywords and find articles with titles like 'neuroethology', I realize that there has long been this field called 'Cybernetics' that lacks a 'popular' treatment of its foundational perspective, though I guess Wiener hoped his eponymous book might accomplish this; and I wonder why I've never met anyone who has read it ! Still, at least he managed to deposit his neologism 'cybernetics' in educated parlance - though maybe without the subtitle that defines it. I have long noticed, about the world, that there is scarcely any sense in the superb popular literature on evolution, of that essential empirical feature of living things, that they BEHAVE - the essense of which must be processing information from the other side of the semipermeable surface that de-fines them. Isnt it funny how our basic perception of any thing (organism or not) tends to bracket everything external to these *surfaces* that appear to us. Insofar as these appearances puzzle perception, the perceiver's curosity is almost strictly directed at what could be *inside* this surface, never thinking that the Main thing inside an organism is going to be its own curiosity about what is *outside* that surface.
@SEMF
@SEMF 18 күн бұрын
Nice thoughts. Can you expand?
@Ejacunathan
@Ejacunathan 8 ай бұрын
Ive been on a path for a couple years that sounds similar to this. Kidneys failed a few years ago and everyone tells me they can't heal. Well, I've demonstrated the ability to at least recover most of my health back so im convinced my body actually knows how to heal I just have to do the alchemy right through correct mind-body experiences. That once i adapt the correct lifestyle conducive to the healing process, the body will simply do the rest
@SEMF
@SEMF 8 ай бұрын
What mind-body experiences?
@incognitotorpedo42
@incognitotorpedo42 9 ай бұрын
I wonder what would happen if you applied an electric field across a developing face?
@SEMF
@SEMF 8 ай бұрын
That would be really interesting to see. As Michael Levin puts it, Picasso organisms :)
@paulhaube
@paulhaube 8 ай бұрын
Is it a steady unique current that is going-on or it has variations depending on where, when and what type of cells? If steady, it is like a spark-plug, if it is variable, then there is something that modulates the electricity, hence some form of master-processor or a processor-specific to cells but attuned to a master one. Fundamentally, energy is the potential to do and electricity the drive to exact the potential. Is there a heat variation during the growth, because the more heat the more a biological body is active or accelerates. Thank you
@SEMF
@SEMF 8 ай бұрын
Those are all very relevant questions. I welcome you to join our community here: semf.org.es/participate/join.html
@tejaK
@tejaK 9 ай бұрын
❤🧡❤🧡❤
@SEMF
@SEMF 9 ай бұрын
Thank you Teja!
@tejaK
@tejaK 7 ай бұрын
@@SEMF You're welcome. :)
@alexanderefremov4701
@alexanderefremov4701 6 ай бұрын
Я предлагаю очень обширный план по расшифровке кода управления эмбриогенезом и морфогенезом. Можно создавать множество ксеноботов (подобных тем, которые создает проф Левин) из разных клеток эмбрионов разных организмов I propose a very extensive plan to decipher the code for managing embryogenesis and morphogenesis. It is possible to create many xenobots (similar to those created by Prof Levin) from different cells of embryos of different organisms Далее, поставить флуоресцентные метки на интересующие нас гены и исследовать процессы взаимодействия генов в процессах существования ксеноботов. Next, put fluorescent labels on the genes we are interested in and investigate the processes of gene interaction in the processes of xenobots' existence.
@SEMF
@SEMF 5 ай бұрын
Sounds like something the community would love to hear more about. You may join it using the online form at : semf.org.es/participate/join.html
@audreydugan9668
@audreydugan9668 3 ай бұрын
🤯
@SEMF
@SEMF 2 ай бұрын
A vert appropriate concise summary! Perhaps you'd like to share your thoughts within our online community? You can join here: semf.org.es/participate/join.html
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
Morphogenesis is probably controlled by very complex and mixed sequence of various genes turned up and down in different near-by cells. This sequence is a Super-hyper-great puzzle.
@SEMF
@SEMF 8 ай бұрын
The evidence seems to suggest that although those play a role, just bioelectricity patterns also play a fundamental role.
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF But what is more important. what will give a real key to regeneration?
@hhwippedcream
@hhwippedcream 8 ай бұрын
Indicator/accessory process or primary mechanism? What intrinsic or environmental processes modulate or impact this bioelectric mechanism in practical terms? Frogs were mentioned and as an aside it's interesting that fluctuations in water quality/contaminant load effect development with a great deal of leverage. Water affecting conductivity and such- probably irrelevant. Fascinating as heck! Thanks for sharing these findings!
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
​@@hhwippedcream Well, basic causes of regeneration and embryogenesis must be rather hardly enciphered in genom so as to do stable software of the whole organism.
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 General regeneration seems far away but localized one may be possible soon.
@hosoiarchives4858
@hosoiarchives4858 8 ай бұрын
. 0:01 frog face. Scramble the face and they normalize. How do they scramble the face? 1:42 how do they do it? The old gene based model 3:09 brain
@SEMF
@SEMF 8 ай бұрын
They scramble by applying external electricity to the embryo.
@julianholman7379
@julianholman7379 19 күн бұрын
'we made a picasso tadpole, scrambled . .' - How ?
@SEMF
@SEMF 19 күн бұрын
With electrical interventions during development
@charlesbrightman4237
@charlesbrightman4237 8 ай бұрын
Body parts going to where they 'need' to be: Consider the following: a. "IF" my view of 'space' and 'time' are correct, (see 2 more posts after this one), b. And "IF" my theory of everything is correct, (currently dependent upon the results of my gravity test for the TOE idea, but 'if' true), then the pulsating, swirling 'gem' photon is the eternally existent energy unit that makes up everything in existence, including space, time, numbers, you, me, everything. c. Everything in existence is energy interacting with itself, that energy possibly varying only in energy modality (gravity, electrical, magnetic), energy density (pressure), and energy frequency (temperature). d. Based upon how energy interacts with itself is 'why' body parts go to where they go to.
@charlesbrightman4237
@charlesbrightman4237 8 ай бұрын
'Space': Consider the following: a. Modern science claims that all matter is made up of quarks, electrons and interacting energy. Quarks and electrons being considered charged particles, each with their respective magnetic field with them. b. Light, 'electromagnetism', in the visual light portion of the spectrum fills outer space as well here on this Earth. That is why we can see things here on this Earth as well as far away stars, galaxies, etc. c. 'Electromagnetism' ('em') also comes in other energy frequencies besides visual light: Radio waves, Microwaves, Infrared waves, Visual light waves, Ultraviolet waves, x-rays, and gamma waves. (Also in outer space and here upon this Earth at various locations). d. Modern science claims that 'em' can interact with matter. QED (Quantum Electro Dynamics) whereby 'em' interacts with electrons in atoms and molecules and QCD (Quantum Chromo Dynamics) whereby 'em' interacts with the nucleus of atoms. e. 'Gravity' also appears to actually exist, with at least varying densities if not even varying frequencies. So, 'space' is energy itself, primarily energy fields with the primary modalities of gravity, electrical and magnetic. 'Time' most probably is the 'flow of energy', 'spacetime' being 'energy and it's flow'. And the current analysis indicates that both space and time always existed and never had a beginning (also as modern science claims that energy cannot be created nor destroyed). Learn to see, come to know, understand, acquire wisdom in energy that can be applied for various agendas.
@charlesbrightman4237
@charlesbrightman4237 8 ай бұрын
SPACE and TIME: 'Space' is energy itself. Wherever space is, energy is. Wherever energy is, space is. They are one and the same thing. And for me, the 'gem' photon is the energy unit of this universe that makes up everything in existence in this universe. 'Space' is most probably energy itself in the form of gravitational fields, electrical fields and magnetic fields, varying possibly only in energy modality, energy density (pressure) and energy frequency (temperature). 'Time' is the flow of energy. 'Time' (flow of energy) cannot exist unless 'space' (energy itself) exists. And 'space' (energy itself) that does not flow (no flow of time / energy) is basically useless. An entity cannot even think a thought without a flow of energy. If all the energy in the universe stopped flowing, wouldn't we say that 'time stood still'? Time itself would still exist, it would just not be flowing, (basically 'time' stopped). But then also, how space and time are linked in what is called 'space time', (energy and it's flow). * And everything in existence currently appears to be eternally existent energy interacting with itself. There is truly only 1 single 'eternal day', the day of eternally existent ever flowing energy.
@SEMF
@SEMF 8 ай бұрын
@@charlesbrightman4237 "Wherever space is" seems redundant, doesn't it?
@charlesbrightman4237
@charlesbrightman4237 8 ай бұрын
@@SEMF Well, not really. "IF" my theory of everything is correct ( currently dependent upon the results of my gravity test, but 'if' true), and 'if' my view of the universal shell is correct, 'then' non-existence outside of existence does not contain any space. (copy and paste from my files): THE UNIVERSAL SHELL: Existence and non-existence, side by side for all of eternity: "IF" my Theory Of Everything is really true, (that what is called 'gravity' is a modality that is a part of the currently recognized 'em' photon, 'gravity' acting 90 degrees to the 'em' modalities, which of course act 90 degrees to each other, 'gravity' actually causing the sine wave pattern of 'em'), AND "IF" my view of space and time are correct, ('space' being energy itself [which is the 'gem' photon], 'time' being the flow of energy), then I could see where it might be possible that the inner spherical shell of the universe could possibly be made up of the 'gravity' modality of the 'gem' photon which is 90 degrees to the electrical modality of the 'gem' photon, which are both 90 degrees to the magnetic modality of the 'gem' photon, the magnetic modality existing both inside of and outside of the inner shell, the complete 'gem' photon interactions making up the entire spherical shell of all of existence itself. And then of course, non-existence would exist beyond existence. So, existence and non-existence might possibly exist side by side for all of eternity. It all depends upon whether the gravity test for my TOE is really true or not and whether my view of space time is correct or not, and whether the universal spherical shell exists as I believe it might or not. But 'if' true, and as no photons (currently 'em', 'gem' in my view) would be absorbed nor reflected by the spherical universal shell, then when we look at the blackness in the night sky that is beyond the light of the stars and galaxies, we might actually be perceiving in part the limits of existence and the universal shell of existence itself, with non-existence beyond.
@charlesbrightman4237
@charlesbrightman4237 8 ай бұрын
@@SEMF Consider also these items: THINGS MODERN SCIENCE DOES NOT APPARENTLY KNOW: Consider the following: a. Numbers: Modern science does not even know how numbers and certain mathematical constants exist for math to do what math does. (And nobody as of yet has been able to show me how numbers and certain mathematical constants can come from the Standard Model Of Particle Physics). b. Space: Modern science does not even know what 'space' actually is nor how it could actually warp and expand. c. Time: Modern science does not even know what 'time' actually is nor how it could actually warp and vary. d. Gravity: Modern science does not even know what 'gravity' actually is nor how gravity actually does what it appears to do. And for those who claim that 'gravity' is matter warping the fabric of spacetime, see 'b' and 'c' above. e. Speed of Light: 'Speed', distance divided by time, distance being two points in space with space between those two points. But yet, here again, modern science does not even know what space and time actually are that makes up 'speed' and they also claim that space can warp and expand and time can warp and vary, so how could they truly know even what the speed of light actually is that they utilize in many of the formulas? Speed of light should also warp, expand and vary depending upon what space and time it was in. And if the speed of light can warp, expand and vary in space and time, how then do far away astronomical observations actually work that are based upon light and the speed of light that could warp, expand and vary in actual reality? f. Photons: Modern science claims that energy cannot be created nor destroyed, it's one of the foundations of physics. First Law Of Thermodynamics: "Energy can neither be created nor destroyed." A photon is usually depicted in a sine wave pattern with the 'e' and 'm' energy fields 90 degrees to each other. The 'e' and 'm' energy fields go out together and come back in together, over and over and over, doing so even across the vast universe as far as we can see. Where does the energy in the energy fields go when both the 'e' and 'm' energy fields go to zero? And what causes the 'e' and 'm' energy fields to come back to 'full' from zero? Also, 'if' a photon actually red shifts, where does the red shifted energy go and why does the photon red shift? And for those who claim space expanding causes a photon to red shift, see 'b' above. Why does radio 'em' (large 'em' waves) have low energy and gamma 'em' (small 'em' waves) have high energy? And for those who say E = hf; see also 'b' and 'c' above. (f = frequency, cycles per second. But modern science claims space can warp and expand and time can warp and vary. If 'space' warps and expands and/or 'time' warps and varies, what does that do to 'E'? And why doesn't 'E' keep space from expanding and time from varying?). g. Energy: Modern science claims that energy cannot be created nor destroyed, it's one of the foundations of physics. Hence, energy is either truly a finite amount and eternally existent, or modern science is wrong. First Law Of Thermodynamics: "Energy can neither be created nor destroyed." How exactly is 'energy' eternally existent? h. Existence and Non-Existence side by side throughout all of eternity. How? * Note: My theory of everything idea, 'if' true (currently dependent upon the results of my gravity test, but 'if' true), can potentially answer all of the above items.
@julianholman7379
@julianholman7379 19 күн бұрын
'feet forward' (?)
@SEMF
@SEMF 19 күн бұрын
What is that referring to?
@julianholman7379
@julianholman7379 19 күн бұрын
@@SEMF a phrase i often hear Michael Levin using (without understanding)0
@julianholman7379
@julianholman7379 19 күн бұрын
i'll listen again and note time
@SEMF
@SEMF 19 күн бұрын
@@julianholman7379 "feed-forward"
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
Every tiny step in morphogenesis must be genetically deciphered. Otherwise regeneration is a bioelectrical magic.
@SEMF
@SEMF 8 ай бұрын
Genetics only seem to play a role at the compression level of information processing.
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF Yes, compression level but this is the basic, controlling and defining level. Bioelectric phenomena are not causes. they are intermediate effects in the process of morphogenesis.
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 They were shown to have causal power though. That's Michael's main contribution.
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF So I dont understand how Prof.Levin could decipher all process of embryogenesis and morphogenesis?
@BR-hi6yt
@BR-hi6yt 9 ай бұрын
I don't think that the eyes, nostrils etc are pulled to their correct positions by a magnetic or electric forces like little ball-bearings. Right, its laughable eh? It will be along the lines of certain proteins are shaped by other neighbouring proteins and maybe electrical fields too and nearby protein sense the shapes. They "know" they are in wrong place by detecting miss-folded proteins and will follow a folded-protein-topological gradient until they reach the correct neighbours. I can't think how to test this because I have not enough experience with these cell-behaviors
@SEMF
@SEMF 8 ай бұрын
What other forces are there at that scale?
@psionic111
@psionic111 8 ай бұрын
@@SEMF Great point. However, I think chemical factors are more at play, more at the correct scale when considering morpho-space. Even though chemistry is fundamentally electrical in nature, it's more accurate or useful to say that chemistry determines final protein folding shapes than electromagnetism does.
@SEMF
@SEMF 8 ай бұрын
@@psionic111 That's certainly possible. Michel's point was that the role of electricity may be fundamental here.
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF Then let professor Levin decipher the bioelectricity. What every bioelectrical signal stimulates as morphological effect? Probably bioelectrical signals only transmit the information about necessary cell movements and cells implement movements by their own means, moving organelles?
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 All the internal movement is processed in a similar way. External or internal morphic development is shown to be equivalent.
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
You know very little even about morphogenesis of one separate cell - genetics of cell division, cell differentiation. Learn about it beforehand, may be bioelectricity are understood better.
@SEMF
@SEMF 8 ай бұрын
What do you mean?
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF I mean - learn the sequence of genes turned on and off to control processes of cell division and cell differentiation.
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 That's analogous to changing lines of code in software.
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF But you must beforehand found this lines of code.
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 They may be written in a non-genetic language!
@opipico9144
@opipico9144 8 ай бұрын
do it with mammals and then we'll talk
@SEMF
@SEMF 8 ай бұрын
What's the fundamental difference?
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF If there is no difference than do it lightly and we applause with Great joy!
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 In what sense?
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF In the sense of reality.
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 Reality as in realism?
@rage_fusion
@rage_fusion 9 ай бұрын
And people believe there is no architect or designer to all this 😂 that’s crazy to me
@DavidJJJ
@DavidJJJ 8 ай бұрын
So true, it's amazing how complex things have become in the last two decades. We've gone from junk DNA making up 90% of the genome, to this, body plans not being part of the DNA code. Yet they (mainstream scientists) still mention evolution as if it could have any agency in creating basic life or the ability to determine or alter the body plan of an animal.
@SEMF
@SEMF 8 ай бұрын
Well the work shown in this video precisely points at the evidence of a self-arranging system, no need for architect!
@DavidJJJ
@DavidJJJ 8 ай бұрын
The need for an architect in all this is well and truly established. Neo-darwinism is slowly being abandoned by mainstream scientists as we need another theory which correctly describes the huge complexity we see in all aspects of nature, as well as the lack of evidence for transitional fossils and the molecules-to-broccoli -to-man theory, in addition to the probabilistic resources required to achieve anything close to proper evolutionary theory (amongst other issues...). More time MAY help, as 4 Billion years currently isn't enough based on the mathematics of probability. Even with more time though, we are still stuck with how this happened, which we haven't been able to determine. People like Lee Cronin are doing a great job in trying to work out the origin of life problem, but are no where near close.
@rage_fusion
@rage_fusion 8 ай бұрын
@@SEMF which nothing made ? 😂 absolute nothing made something. Ok 👍
@rage_fusion
@rage_fusion 8 ай бұрын
@@DavidJJJ I concur, and in my opinion, there is no question in mind that something created all of this. Mathematics alone is evidence of that as far as I’m concerned
@uknoono7603
@uknoono7603 8 ай бұрын
Barack Obama Jimmy Fallon 2019 Never Forget Save Yourselves!!
@SEMF
@SEMF 8 ай бұрын
What is the context for this?
@anmolagrawal5358
@anmolagrawal5358 8 ай бұрын
how did you end up on this vid to promote rando stuff?
@SEMF
@SEMF 8 ай бұрын
@@anmolagrawal5358 exactly! Thanks Anmol ;)
@Mitchell_is_smart._You2bs_dumb
@Mitchell_is_smart._You2bs_dumb 8 ай бұрын
so, are we going to cut the 3 year old presentation up perpetually, or could we, idunno, apply it to something and talk about the results?
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
Yes, we wanted more movie.
@SEMF
@SEMF 8 ай бұрын
What do you mean specifically?
@alexanderefremov4701
@alexanderefremov4701 8 ай бұрын
@@SEMF For instance regeneration in mammals would go rather well. Or at least, decipher bioelectricity of first cell divisions in zegota.
@Mitchell_is_smart._You2bs_dumb
@Mitchell_is_smart._You2bs_dumb 8 ай бұрын
@@SEMF or perhaps just not the same specific topics with the same words and phrases from the ted talk years ago. but I'd like to see the increase and decrease in voltage along with the corresponding expressions, like a progression between forms. it would be nice to chart out which cells and tissues have predictable results between species and between genus, families, orders, or classes. really anything new, this is amazing stuff.
@SEMF
@SEMF 8 ай бұрын
@@alexanderefremov4701 First divisions are a really important problem.
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