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UFC 155: dos Santos vs. Velasquez 2 was a mixed martial arts event held by the Ultimate Fighting Championship on December 29, 2012, at the MGM Grand Garden Arena in Las Vegas, Nevada.
A Junior dos Santos vs. Cain Velasquez rematch has been expected since May 26, 2012 at UFC 146, where dos Santos defended his Heavyweight championship against Frank Mir and Velasquez defeated Antônio Silva. Velasquez and dos Santos had already fought once on November 12, 2011 at UFC on Fox: Velasquez vs. Dos Santos, where dos Santos won via knockout in the first round. Alistair Overeem, former DREAM and Strikeforce champion, is expected to face the winner of this bout. He was originally expected to face dos Santos for the title at UFC 146; however, on April 4, 2012, Overeem was revealed to have failed his pre-fight drug test by the Nevada State Athletic Commission (NSAC). He was found to have an elevated testosterone to epitestosterone ratio of 14-to-1, over the allowed ratio rate of 6-to-1.
The rematch with Dos Santos was expected to take place on September 22, 2012, at UFC 152. However, the date for the rematch was later set for UFC 155. In the rematch, Velasquez defeated Dos Santos in a dominant performance via unanimous decision (50-45, 50-43, and 50-44) to regain the UFC heavyweight title. Velasquez became the first fighter in UFC history to post triple digits in significant strikes landed and double digits in takedowns landed in a single fight, landing 111 significant strikes and eleven takedowns.