CAR T-Cell Therapy: How Does It Work?

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CAR T-Cell Therapy: How Does It Work?

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Күн бұрын

CAR T-cell therapy, like all forms of cancer immunotherapy, seeks to sharpen and strengthen the immune system’s inherent cancer-fighting powers. It involves treating patients with modified versions of their own immune system T cells - white blood cells that help protect the body from disease. Learn more: blog.dana-farbe...

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@Rockhound6165 6 жыл бұрын

My father-in-law was the first person to go through this trial. He has been completely cured of cancer. It's been 8 years since his first infusion and he's doing great.

@manuela.menjivar853 6 жыл бұрын

Hi... I have Linfoma No Hogdkin and live in El Salvador. This notice is amazing... Congratulations for your father-in-law... God bless the Scientist

@hedgehogthesonic3181 5 жыл бұрын

@Studa Baker Amazing !!!! is he still fine ?????

@maryannurban4567 5 жыл бұрын

I am in a clinical trial car t 22. I hope n pray I hear REMISSION. I go the beginning of March to have my cells put back in ❤❤ so happy for your father.

@hedgehogthesonic3181 5 жыл бұрын

@@maryannurban4567 How do you feel right now ?

@TheHondaJunkie 4 жыл бұрын

How was the side effects? Did he have any CRS if severe how long in the ICU

@charlesbroadway6864 6 ай бұрын

My wife had lymphoma and was the 26 person to have the infusion at the Cleveland clinic this April 2024 will be 5 years. Totally cured.

@jwim3969 3 жыл бұрын

I’ve battled multiple myeloma since 2014. I’m going to have this treatment soon. Thank God for miracles 🙏

@SevtapThurston 3 жыл бұрын

Good luck!

@jwim3969 3 жыл бұрын

Thank you 🙏

@sonamtomar3815 3 жыл бұрын

Good luck

@Flipper86 2 жыл бұрын

A friend just got home from this treatment - it was a long haul and he’s pretty weak right now. He, too, has had MM since 2014. Best of luck.

@aljon5947 2 жыл бұрын

How are u now

@LemonJJuicy 2 жыл бұрын

These cells have been inside me for 6 years already and I can say that this therapy definitely worked for me.

@WoundedSnake Жыл бұрын

What was your diagnosis?? I hope you are fully recovered for good

@gaborios5637 Жыл бұрын

Do you recieve this treatment at US? please could you please give me details? I apreciate very much.

@szaragoza4818 5 жыл бұрын

Tears just flow as I watch this amazing miracle. In January, I completed my chemo treatment. I am now a Cancer Survivor but am very aware of recurrences. So reassuring that if and when I do have a recurrence, there are outstanding treatments out there.

@DMH031956 2 жыл бұрын

I've been battling Pancreatic Cancer, since 2020-October. The traditional FDA approved Chemotherapies of which I had 3 separate Tiers of them. FOLFIRINOX, then Gemcitabine/Abraxane then finally Capecitabine with Radiation. I am so grateful to my Oncologist, Surgical Oncologist, Radiation Oncologist and Thoracic Surgeon. They kept me alive this far. I will be entering a CAR T Clinical Trial in 2 weeks,as my Pancreatic Cancer has Metastasized. I pray this buys me more time on this side of heaven. I have a 1 and a half year old grandson, and I wish him to know who I am and not who I was. God willing, I'll take him fishing. 🎣

@chompet123 Жыл бұрын

How have you been? I hope it yielded good results and have recovered!

@baldguykarna Жыл бұрын

God is good. Trust the process 🙏

@proudman6651 Жыл бұрын

Hope you’re doing well now

@Gcruzy 7 ай бұрын

🙏🙏🙏

@joycebroadway16 6 ай бұрын

My prayers 🙏 are with you

@naenaew.7442 2 ай бұрын

My Sister wS blessed enough to receive this. She has been on her deathbed for 8 weeks in the hospital . I blv she got every side effect possible .. Im Praying hard they figure this out b4 she passes. If she did get her blood cancer bk, it would be the quickest ever in this history's. Blessings and Peace To You All

@jackobi14 Жыл бұрын

My grandpa had Non-Hodkings lymphoma and took part to this clinical trial in France. He's been on total remission for 6 months now.

@jonathansilva6045 6 жыл бұрын

This made me cry can’t believe where almost beating it !!

@StaceNyourFace 4 жыл бұрын

Me too! ;-)

@quinnlaya331 4 жыл бұрын

Its not 100% yet. But were close, within 20 years we probably can fix this asshole of a disease. Until then, eat healthy and take care.

@lukebatson5946 3 жыл бұрын

Not even close to a cure lol

@raf221 3 жыл бұрын

The common mistakes people make when talking about cancer is that they think is one disease. There is over a 100 different cancer, each one are very specific and are not equally treatable. So no we're not almost beating "it", we are on good way to beating "some of them" (which is equally great i reckon)

@celticjordan1 3 жыл бұрын

@@lukebatson5946 so we are screwed then now days is what your saying? Might as well say no to chemo and radiation cause that’s a living hell that will probably kill you slowly or transform your life to where you wish you were dead. You think it’s funny?

@TheDreadwolfMetal 7 жыл бұрын

Amazing cutting-edge technology. I am planning to become hematologist and I am really glad of this new approach for leukemia.

@tomdeaardappel8303 4 жыл бұрын

I'm currently an operator for this process, and I do this daily. The process I'm working on takes 7 to 10 days from fresh apheresis to frozen CAR-T cells.

@virtualsnipe9191 3 жыл бұрын

What a job you have man saving lives.👏👏

@SevtapThurston 3 жыл бұрын

Great job! I realy would love to learn the mechanism. You also must know what makes this therapy so expensive.

@roxydelafuente3512 3 жыл бұрын

Hi what do i need to study to do that kind of job? I want to learn about this. Hope you will reply. Thank you!

@tomdeaardappel8303 3 жыл бұрын

@@roxydelafuente3512 Hello Roxy! I studied Biotechnology in The Netherlands. I'm Dutch myself. But actually any kind of laboratory/biology education will do :). Hope this helps.

@shreyas4419 3 жыл бұрын

@@tomdeaardappel8303 do you have any idea on which type of cancer it is mostly effective,have u done this gist patients?

@bratwizard 5 жыл бұрын

Great presentation, good graphical representation, easy to follow. Thanks!!

@gracemassala7729 4 жыл бұрын

Simply amazing. I'm doing a CAR-T platform training at the moment and I'm loving it. Good stuff

@lemayanelisha9867 3 жыл бұрын

I also liked the video and I was asking if the technology can be use for stimulating the immune cell attacking the virus. Sorry for bad English

@dwightfindlay8605 3 жыл бұрын

Where are you doing your course?

@WoundedSnake Жыл бұрын

Are you hamtologist?? I have some questions regarding the training, is there a way I can contact you??

@ianpatrick23 Жыл бұрын

This is such a great explanation of CAR-T cell therapy. Thank you!

@peanutbutterisfu 3 жыл бұрын

Every single person that has a deadly illness should not have to pay a dime to be treated. A sick child in a poor family should get the same care as a rich family! That poor child did not ask to be poor it makes me so sad to think about that.

@NicholasWongCQ 2 жыл бұрын

In an utopian world yes.

@danielmino1690 2 жыл бұрын

the access to a good hospital and medication have to be free to anyone as you said, it has to be universal

@Naofacoideka Жыл бұрын

@@NicholasWongCQ Free health is utopian for you? You can search about UK, Brazil and Portugal health sisteam. Moreover, in my opinion, free health sisteam is a matter of humanity

@naranjo5277 Жыл бұрын

@@NicholasWongCQ in Europe we have UNIVERSAL healthcare, its not a utopia at all and its being used right now

@danielmino1690 2 жыл бұрын

why this isnt the first treatment given to person with cancer?

@tonygray6183 2 жыл бұрын

Good and clearly explained, well illustrated. Irritating, unnecessary computer "music".

@robhansen6553 4 жыл бұрын

I’m having this done in a few weeks I’m kinda scared, but also hopeful

@ariellaaginis5534 4 жыл бұрын

Rob Hansen how are doing ?

@Avokeing 2 жыл бұрын

Did it go well ?

@gaborios5637 Жыл бұрын

Are you going to recieve this treatment at US? please could you please give me details? I apreciate very much

@joycebroadway16 6 ай бұрын

God bless you! I pray you will be fine. I am going on 5yrs since mine. It does work.

@vvvgff1181 3 жыл бұрын

does this also can fix hodgkin stage 4 after autologe sct ?

@paulMcGlothin 2 жыл бұрын

Excellent, easy-to-understand presentation.

@kflashcarr1992 6 жыл бұрын

My dad had stage 4 cancer, we live in Oklahoma City, Ok. does anyone know of any clinical trials that he can participate in?

@danafarber 6 жыл бұрын

Hi Kenneth, Thanks for your question. You can find current clinical trials offered through Dana-Farber here: www.dana-farber.org/Research/Clinical-Trials.aspx You can also search for clinical trials on this website: clinicaltrials.gov/ However, the website isn't constantly updated, and data is constantly changing. Hope that helps! -DFCI

@tonitonimariexray 6 жыл бұрын

Kenneth Carr you could try contacting cancercommons.org it’s free & via their website they take medical info & tell you what trials may be available & where. Good luck to your dad!

@SimonCU 5 жыл бұрын

Also, not all cancer can be treated using modified T cells. Currently, the FDA has only approved treating leukemia using CAR-T cells against the CD19 receptor on the B cells. Organ Cancer such as lung, brain, etc .. are still in the early stages because T cells do not stay (or even multiply) in the organ long enough to kill all the cancer cells. You have to specially make modified T cells for each type of cancer because difference cancer expresses different proteins. For example, you cannot treat prostatic cancer with CAR-19 T cells.

@kristyc4712 4 жыл бұрын

@Zyzz only ALL (acute lymphoblastic leukemia) and B cell non-Hodgkins lymphoma right now x

@youtubeshorts-uy8yx 3 жыл бұрын

My father suffered from acute myeloid leukaemia and passed away on 2nd September 2019 after chemotherapy.... could this process would be able to save him at that time ..

@TheHondaJunkie 4 жыл бұрын

How do we know the long term effects or effectiveness? If it's only been around 6yrs or so

@B4iGo2it 4 жыл бұрын

this study and statistics will last our lifetime. It someone is spared another day to be with their loved ones .... it is worth it.

@TheHondaJunkie 3 жыл бұрын

@@B4iGo2it I hope one day there is a at home Immunoglobin instead of doing 6hrs in a hospital setting especially with covid risk

@ryanmonroe94 3 жыл бұрын

Just in the beginning stages. It will improve in the next coming decades.

@imbored4615 4 жыл бұрын

I hoped in something more specific. Basically, this is a long way of saying "we take lymphocytes and put magic receptors on them"

@Evantrop 2 жыл бұрын

This is a science that needed.

@shichengguo8064 3 жыл бұрын

1:38 How to know which chimeric antigen receptor should be projected to T-cells? Thanks.

@Explore_with_sreya 3 жыл бұрын

The corresponding tumor cells are also sequenced to get information about antigens on their surface. Accordingly only those constructs specific to produce tumor specific antigen are put induce the T cells to generate effective receptors. I hope it makes sense.

@shamsaaraf5190 Жыл бұрын

Is this the same as AARSOTA therapy (Autologous Antigen Receptor Specific Oncogenic Target Acquisition) ?

@deekshitham814 Жыл бұрын

I have question, Can u do this therapy using another person's t-cells for the patient ?

@kazutoyamamoto8844 Жыл бұрын

Do anyone know how the process going through Car T therapy? What is the duration u need to stay in hospital?

@joeamrine7450 3 жыл бұрын

Does anyone know, how does the car T cells specifically target only cancer cells? How do they avoid killing normal tissue? For example with breast cancer, how does it target cancerous cells while leaving normal breast tissue alone?

@JasmineDCarter Жыл бұрын

hi there! you asked this Q a year ago, so sorry for the late reply. I am researching cancer immunotherapy for my PhD. The T-cells are genetically engineered to produce a receptor that recognizes a specific antigen produced on the surface of ONLY your cancer cells. So this technique is highly personalized - therefore expensive. The receptor can be antigen specific chemically and/or based on molecular structure of the antigen target. hope this helps.

@proudman6651 Жыл бұрын

@@JasmineDCarter hi Jasmine, any idea of how this treatment is being investigated in autoimmune diseases?

@texaschainsawmass 6 жыл бұрын

Will this work on stage 03 or 04 cancer?

@silent.killerr5770 4 жыл бұрын

Saw Hack Duggan yes

@bomaroua4442 Жыл бұрын

Yes

@ThePeople-dj1of Ай бұрын

With so much gratitude I want to appreciate Dr ekpe on KZfaq for showing up in my life at the right time. I have been down with HSV for almost a year, coming across Dr ekpe KZfaq channel and purchasing his medication was the best news of my life. Thank you doctor

@theworldthroughmyeyes26 2 жыл бұрын

How much does it cost?

@lsuthichai1 Жыл бұрын

How it’s cost

@ambrocio4105 2 жыл бұрын

Maybe it will be more effective if people know their family cancer history and correct the possible development of active cancer. And early treatment at age of 35 to 40y/o.

@gaborios5637 Жыл бұрын

¿Where in the U.S ?

@Evercrisp-hn8bd 3 жыл бұрын

Shocking, the humandkind is amazing

@Wabuh-Wabuh 3 жыл бұрын

you can use this for viruses too?

@user-ol1zb7rj8v 2 жыл бұрын

very good video.. and the concept

@debaratighosh8182 5 жыл бұрын

It's very innovative...

@MEGMBalaji Жыл бұрын

Is it active or passive immunity

@kd-hl6qz Жыл бұрын

think of it as enhanced active immunity

@tamilthendralchannel1126 4 жыл бұрын

Can it cures carcinomas

@carolinaespinoza9203 6 жыл бұрын

Póngalo en español por favor

@farehazahid5986 2 жыл бұрын

Amazing!

@tonyconsolini7861 2 жыл бұрын

Amazing

@paulinacamargo906 4 жыл бұрын

Por que no hay subtitulos?! ;c

@ricodsanchez6792 3 жыл бұрын

why should there be? learn english ffs.

@erikacassio118 2 жыл бұрын

rico d’sanchez Because cancer does not discriminate and the information must also be in Spanish, you should not answer that way. SANCHEZ!!!!!!!!!!

@Gambitheart 2 жыл бұрын

This is it the future of disease cure.

@marlop4779 3 жыл бұрын

T cells be like red cell sus

@Zakariah1971 Жыл бұрын

NK cells

@theHerathrig 4 жыл бұрын

Sadly this only works on liquid tumors. Its Still a long way to go before it can work on solid ones.

@kristyc4712 4 жыл бұрын

gamma delta T cells target solid tumours!!

@varoujan78 4 жыл бұрын

non understandable spoken too fast

@gabrielromero8097 2 ай бұрын

Resident evil if u ask me

@almightyhimself9284 Жыл бұрын

I am preparing for Indian Civil Services and I have to study this too. wtf

@saibb2556 2 жыл бұрын

😶😶😶😶😶😶🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔🤔

@jakim1360 3 ай бұрын

이거 넣어라 를 다 취소 취소 사하소서 사하소서 천만번 천만번

@USSJ2Otaku3084 6 жыл бұрын

I need to hurry up and find one for my parent. They're not that popular here.

@radtkl5008 4 жыл бұрын

This treatment works well for B-ALL and CLL, Basically B-Cell blood malignancies, research is under progress for solid tumors. what cancer your parent is suffering from ? I am a CART Scientist at University of Pennsylvania the institution where CART originally developed.

@B4iGo2it 4 жыл бұрын

@@radtkl5008 Thank you for your hard work and dedication. You are making a positive impact on many humans. Love you.

@radtkl5008 4 жыл бұрын

@@B4iGo2it Thank you

@silverstone9952 3 жыл бұрын

@@radtkl5008 Sir can this process work for stage 3/4/terminal cancer patients

@radtkl5008 3 жыл бұрын

@@silverstone9952 which cancer you are refering to ? This therapy works well for B cell malignancies such as B cell acute lymphoblastic leukemia (B-ALL)