There is currently no cure for AIDS. Finding safe and effective methods to prevent the spread of HIV is our best hope for stopping the epidemic. With more than 35 million people living with HIV and 2 million new infections worldwide in 2012, the need for HIV prevention research remains urgent. Charlize Theron, actress and Goodwill Ambassador, and Kweku Mandela, Co-founder of Africa Rising Foundation discuss a combination of essential prevention strategies. Effective prevention approaches depends on the understanding, trust, support, and participation of all communities. Working together, we can all be the generation to end the AIDS epidemic.