Chromosome 6 - Mutant Worms and RUNX genes

Рет қаралды 19,499

10 жыл бұрын

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When cells divide and multiply to generate an entire organism, each cell must at some point decide whether to make more cells (proliferate) or stop in order to become a specialised cell type (differentiate). This process is one of the most important in developmental biology, especially since when it goes wrong it can result in cancer.
Chromosome 6 contains a gene which plays a key role in the control of cell proliferation and differentiation. Sam Hughes, from the University of Oxford, explains how researchers at the lab of this year's Christmas Lecturer Dr Alison Woollard are using tiny mutant worms to try to understand what causes this process to go wrong and how over-expression of this gene can lead to tumors. It is hoped these valuable insights will help us in the fight against cancer.
With thanks to BBSRC: bbsrc.ac.uk/
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Пікірлер: 18

@svartfrasr9755 10 жыл бұрын

"So what I've done is given these worms a tumor, which isn't very nice." lmfao

@whatif5532 10 жыл бұрын

What a wonderful video! Fun science fact about these glow in the dark worms: the protein that makes them glow is called GFP (green fluorescent protein) and it is the same stuff that makes jellyfish glow! Cool, huh?

@Puzzler363 10 жыл бұрын

But what do they do now that they know there's a connection between the gene and the number of cells?

@RBuckminsterFuller 10 жыл бұрын

It's not just one worm, obviously. They have a family of unmodified worms as a control, a family of worms with the gene knocked out (deactivated) and a family of worms with the gene overexpressed. This way you can see exactly what phenotype (in this case the growth of cells) is affected by the change.

@MilMike 10 жыл бұрын

This is awesome keep up the good work!

@reprimand33 10 жыл бұрын

great stuff keep them coming

@mirusvet 10 жыл бұрын

So what the net effect of both mutations? Did they live longer/shorter? Were they able to divide or heal faster?

@josephfox9221 10 жыл бұрын

science, because giving worms tumors isnt very nice, but seriously I love your series :D

@sageyash 10 жыл бұрын

How do they manipulate the genes in the first place?

@RussianAsian8D2 10 жыл бұрын

I'd like to do some developmental biology with her haha

@xapemanx 10 жыл бұрын

science rules

@ajtronic 10 жыл бұрын

Damn cool. Science!

@azure9886 3 жыл бұрын

this is so old

@StephenMortimer 10 жыл бұрын

DrSam you are nice enuf but ya nae got that "irish lilt" to your speech !! RI bring back the "babe"!!

@darkbearmoon 10 жыл бұрын

I swear I have seen you comment on every advent video

@RBuckminsterFuller 10 жыл бұрын

darkbearmoon I know, right? It's always something slightly creepy as well.

@StephenMortimer 10 жыл бұрын

RBuckminsterFuller It would help if the both of you had a wee bit of the "blarney" in your sad STIFF selves!! (from the greatgrandson of Mrs O'Toole)