Chronic Inflammation - T Regulatory Cells (Lecture 4)

Рет қаралды 9,965

Күн бұрын

Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
A good reference diagram in the book:
FIGURE 15.6 Mechanism of action of CTLA-4. A, Cytotoxic T lymphocyte antigen 4 (CTLA-4) expressed on regulatory T cells (Tregs) or activated T cells can inhibit the activation of responding T cells on the same antigen-presenting cells (APCs) (in trans). B, CTLA-4 on regulatory or activated T cells binds to B7 molecules on APCs and removes these molecules from the surface of the APCs, making the B7 costimulators unavailable to CD28 and blocking T cell activation. This action of CTLA-4 is able to suppress immune responses best when B7 levels are low, enabling CTLA-4 to out-compete the lower-affinity receptor CD28.
References:
Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition.
URL list from Wednesday, May. 31 2022
DrBeen: Medical Education Online
www.drbeen.com/
Targeting IL-2: an unexpected effect in treating immunological diseases | Signal Transduction and Targeted Therapy
www.nature.com/articles/s4139...
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients - PubMed
pubmed.ncbi.nlm.nih.gov/16304...
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule - PubMed
pubmed.ncbi.nlm.nih.gov/34305...
Chronic Inflammation - StatPearls - NCBI Bookshelf
www.ncbi.nlm.nih.gov/books/NB...
Inflammation - Wikipedia
en.wikipedia.org/wiki/Inflamm...
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology
www.frontiersin.org/articles/...

Пікірлер: 39

@janemerrittmckenna2386 2 жыл бұрын

Thank you for all you do! These past 2 years would have been pure torture without your information!❤ You were who I listened to. My doctor knew nothing!

@tommyjablonski3281 2 жыл бұрын

So much more to learn how God made the body.God is the greatest scientist Smen

@samhart3897 2 жыл бұрын

Dr Been explains things in a way that is understandable to anyone who has little medical background and no background that would motivate study of the subject.Really good.Wish government advisors would watch his lectures

@rachelmolina3995 2 жыл бұрын

I love that cartoon! Fabulous! Thanks!

@tink_b.u5190 2 жыл бұрын

You’re a genius Bro… THANK GOD FOR MAGNIFICENCE

@libbie2525 2 жыл бұрын

Fascinating! Thank you so much for all your work.

@brendadelcarmen7907 2 жыл бұрын

Thank you for all the excellent information and your time. All your talks make me think of the mastermind who created these mechanisms. There must be a creator behind them, Almighty God that is, whose intelligence is beyond our imagination, All Glory goes to him and the fact he has given people like you the intelligence, patience and love to study and understand these processes so that simpler minds like mine can understand and meditate on who created us and how magnificent the human body is and works. Knowing all of this and how the body is prepared to fight to keep it healthy and the balance that is involved only gives me hope that God will fight for humankind to eventually live a life without illnesses some day soon, especially for all those injured by imperfection and Covid among other diseases. Thank you very very much for your time to teach us.

@ladybug5859 2 жыл бұрын

Dr Been , I remember vividly when I was at UC Berkeley and 19 and in my very curious youthful phase-- my curiousity continues unlike my youth, which post vax took a bit more of😒-- but in all events, I learned that DOCTOR means TEACHER. YOU ARE THE quintessential DOCTOR because you are a TEACHER which is actually the greatest profession in the world. THANK YOU🕊

@rachelmolina3995 2 жыл бұрын

Thank you for good information.

@kenernstzen2407 2 жыл бұрын

Brilliantly presented 👏👏

@zenaalialmohtaseb8340 4 ай бұрын

Wow it's my first time seeing you're video literally I can't stop think you so much I full in love with immunity today ❤

@DrBeenMedicalLectures 4 ай бұрын

You are very welcome. Glad you liked the talk.

@TeacherMom80 2 жыл бұрын

We LOVE you, Dr. Been! 🤗 Thanks for being wonderful you! 💖🕊️🙏🏼

@bhagwanlaldangi4137 2 жыл бұрын

Excellent presentation

@vassargirl1752 2 жыл бұрын

Terrific video, thank you Dr. B. As an aside, what camera are you using now? Fantastic. Also: sugar (fructose from fruit as well) causes massive inflammation. Many are clueless. Intermittent fasting, strategic calorie restriction--powerful weapons/protection against.

@garywillis5790 9 ай бұрын

Beautifully explained!

@tommyjablonski3281 2 жыл бұрын

Dr.beem u r truly.blessef to understand our body's fun too d

@NoName-jr2eo 2 жыл бұрын

FASCINATING ‼️ I don't know what more I could possibly say about it!

@pattyrooney1323 2 жыл бұрын

Thank you Dr.

@sunilsaroha9289 16 күн бұрын

Thanku sir keep continue

@marloes8726 2 жыл бұрын

Two more superb lectures from the Chronic Inflammation series. I share your excitement and appreciation for our complex and precious immune system. A system not fully understood in all it's complexity. I especially liked this lecture nr 4, with the T Regulatory cells which were only identified in the 90's! Needless to say I watched all 4 lectures twice, trying to memorize everything 🙈

@gabriellapetrarulo4443 2 жыл бұрын

Thanks a lot Dr. Syed. Really........

@djelalhassan7631 2 жыл бұрын

GREAT

@tink_b.u5190 2 жыл бұрын

Turmeric,ginger, black pepper in orange juice 🧃

@leoniegray6404 2 жыл бұрын

Thank you again for sharing important info. So glad youre here. Also 'cake or death' by Eddie Izzard was hilarious

@jean-marclasalarie8100 2 жыл бұрын

wonderful How did you dig out all that stuff ?

@alireid5874 2 жыл бұрын

The important questions: does spike protein (natural or vax induced) dysregulate T regulatory cells? If so, is it transient or permanent? What can be done to re-establish homeostasis? I would look for heretical docs who treated HIV/AIDS patients in the 80's and 90's with non-conventional means. They are the ones that understand immune dysfunction

@michaelruffinelli6757 2 жыл бұрын

Chronic inflammation smell test reduction persistent, I hear about an Italian doctor that give 1mg of interleukin (not sure maybe the 2) par day, plus 2 day a week ok Keto diet 2 day of intermitting fasting, omega 3 1000mg a day, q10, resveratrol. What do you think? Thank you for the great video part 2 (stunning I'm wondering how it could be in a Cartoon animation with your cool draw) Video cam Feedback : The video contrast is to high, also color correction need to be done more natural :D, I suggest to use C-log for optimized your video.

@tommyjablonski3281 2 жыл бұрын

Could sam made virus disrupt these cells functions on Purpose to hurt. Us?

@th4tsfilthy 2 жыл бұрын

100% its a bioweapon lol. they knew and lied every step of the way..

@th4tsfilthy 2 жыл бұрын

the v is worse then covid. crimes against humanity trials are starting up. seek the info out. msm will never tell us!

@preciousissah7395 2 жыл бұрын

Gain of function funded by democrats done by fauci and push by bill gates