Clozapine: Benefits, Reducing Side Effect Risks, and Alternatives

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Clozapine: Benefits, Reducing Side Effect Risks, and Alternatives

Рет қаралды 6,782

Күн бұрын

This is a recorded lecture. It was given at the monthly Psychosis Education Event in January, 2023. The monthly Psychosis Education Event consists of a free lecture on some mental health related topic, followed by an open-forum question/answer session with a psychiatrist and clinical psychologist. It is free of charge and open to the public. If you would like to join, send me a note via askapsychiatri...
Clozapine is the most effective medication for schizophrenia. It is the only medication with FDA approval for reducing suicide risk. About 30% of people with schizophrenia do not get significant benefit from standard antipsychotic medication -- yet in that subset of individuals, clozapine is successful in about 50% of cases (the success rate of other antipsychotic medications is about 7% to 14%).
This lecture discusses:
1. Why do some people with schizophrenia-like symptoms not respond to standard, first-line antipsychotic medications?
2. What are the unique advantages of clozapine?
3. What are the most common or worrisome clozapine side effects, and how can their risks be minimized?
4. Are there any alternatives to clozapine?

Пікірлер: 19

@Gtrellis 10 ай бұрын

You are a saviour in clearly explaining from A to B clozapine. I'm uneducated with an ongoing heart problem issues to deal with, my daughter with mental problems, about to start her treatment with cloza pine. I only understand the cycle of a combustion engine, so thanks for the complete with analogue explanation.

@Natalie_Coy Жыл бұрын

Just found your channel and so glad I did! I am a clinician and appreciate videos/education that go in-depth with the psychopharmacology.

@alanspicer500 2 ай бұрын

Clozapine is the only drug that has fully treated my psychosis I have schizophrenic affective disorder and still suffer from depression I will never stop taking clozapine only issue is discomfort from monthly blood draw you are a cool guy thanks

@hahahahxo 14 күн бұрын

how long did it take, how long did it take to treat negative symptoms I am on clozapine just over a year i think

@George_uh_Glass 7 ай бұрын

From the bottom of my heart thank you for making this information available. Thank you so much. “Insight can arise where there wasn’t any before”. That gives me hope for my son.

@shanandbob8311 5 ай бұрын

Great content. I appreciate the reference to research.

@germainedenon311 24 күн бұрын

Dr pls help me. I was normal only with panic attack and anxiety. I was placed on ssri and benzo, developed adverse reactions and had severe insomnia from withdrawal. I developed psychosis : non stop mind eye visual hallucination earworms after a short 2 weeks dose of Zoloft to treat what the psychiatrist believed was "anxiety induced insomnia and ocd". Then I was placed on risperidone and luvox and it didn't help. In short, I was polydrugged and developed chronic, worsening chronic psychosis and bedridden with poor health. I did MRI scan, lumbar puncture , even did one round of ivig but nothing help. What should I do now? Psychosis is worsening and I hallucinate non stop . Genomind tests shows that I have poor metablolism of the ssri which was given to me. Is my Brain broken forever? My brain just generate non stop multi sensory hallucinations and jumbled thoughts at a worsening rate some 17 months after stopping risperidone. I don't have a family history of schizophrenia.

@unraveledultimatefate 3 ай бұрын

Greetings, fellow Psychiatist. What is the most prevalent substance that results in individuals presenting to emergency departments with acute psychosis or anxiety? Which substance out of all most commonly represents a significant mental health challenge to a user?, encompassing both recreational substances and classes of prescription drugs? which are the most common priorities, which priority is the 1st place, and which are secondary, or third?

@estellawip Ай бұрын

How much Lithium will be a good dosage to use to help schizophrenia?

@sisi2754 Жыл бұрын

Alternatives for treatment resistant (non Dopaminrelevat) schizophrenia.

@sisi2754 Жыл бұрын

Please make a video about tests What kind of test are recommendable - blood and urinal. what to test , wich Hormons , vitamins insufficiencies , blood sugar heavy metals, Lupus ....? Especially test to make for treatment resistant (Non Dopamin relevant ) psychoses! My dear one was put on many antipsychotics 7 and Cocktails of meds but nothing worked since years, only horrible and life threatening side effects. How to find what causes the Psychose with tests ?

@littlewhitetrees6129 Жыл бұрын

Hi Dr. my son has been hospitalized 3 times in the past six years. The last hospitalization was in July of 2021. He has been on lithium (now at 1200) and Zyprexa (15 mg). Both of these were reduced in December 2022. He is relatively stable (not manic) yet maintains delusions that are keeping him housebound (he thinks he’s a god and that if he goes out someone is chasing him and wants to kill him). In the past he has tried Latuda, abilify, seroquel, Depakote, Invega with clozapine (though his clozapine levels were always 125 and below-perhaps because he was smoking a lot) so I don’t know if the clozapine ever had a chance to work. He hated the Invega and I too noticed that it took away his personality. Would you suggest trying clozapine again? Unfortunately he likes the Zyprexa and believes he is perfectly healthy and does not see that his delusions are unrealistic and holding him back. I am at a loss. Any suggestions?

@Fred-Faizi 10 ай бұрын

Wow…3 times in the past 6 years? This is good news. My son is 6 times within a year and we still havent tried Clozopine and not sure why. He tried zyprexa, seraquel, abilify, lithium but none working. Do you think clozopine is for him? He is 17 years old.